📰 GPCR Weekly News, August 28 to September 3, 2023

Hello, hello! Stay informed with our GPCR roundup.

Mark your calendars for these important events:

• September 22: Save the date for the Dr. GPCR Symposium on 'GPCRs as Therapeutic Modalities' Showcase your project with a 1-minute abstract video using this form. Our poster session is now an engaging Kumospace discussion.

• November 2 - 4: Get ready for the upcoming GPCR Retreat! We are excited to share that we are sponsors of this event. You can submit your poster abstracts using this form and short talks will be selected from abstracts. Please remember that the early-bird registration deadline ends tomorrow, the abstract submissions deadline is October 2nd, and the final registration cutoff is September 21st.

Subscribe to Dr. GPCR Newsletter to gain access to further insights!

Don’t forget to check out the weekly Classified GPCR News from August 28th to September 3rd, 2023.

GPCR Activation and Signaling

• Cell death signaling in Anopheles gambiae initiated by Bacillus thuringiensis Cry4B toxin involves Na+/K+ ATPase

• GPCR Promiscuity Reshapes Islet Physiology

• TGR5 supresses cGAS/STING pathway by inhibiting GRP75-mediated endoplasmic reticulum-mitochondrial coupling in diabetic retinopathy

GPCR Binders, Drugs, and more

• The Leu/Val6.51 Side Chain of Cannabinoid Receptors Regulates the Binding Mode of the Alkyl Chain of Δ9-Tetrahydrocannabinol

GPCRs in Cardiology, Endocrinology, and Taste

• Cholecystokinin-A Signaling Regulates Automaticity of Pacemaker Cardiomyocytes

• Dopamine Receptor D1 Is Exempt from Transforming Growth Factor β-Mediated Antifibrotic G Protein-Coupled Receptor Landscape Tampering in Lung Fibroblasts

GPCRs in Neuroscience

• System-wide mapping of peptide-GPCR interactions in C. elegans

• GPCR interactions involving metabotropic glutamate receptors and their relevance to the pathophysiology and treatment of CNS disorders

GPCRs in Oncology and Immunology

• From outside to inside and back again: the lysophosphatidic acid-CCN axis in signal transduction

• NPFF stimulates human ovarian cancer cell invasion by upregulating MMP-9 via ERK1/2 signaling

• CCR7 acts as both a sensor and a sink for CCL19 to coordinate collective leukocyte migration

Methods & Updates in GPCR Research

• 3DDPDs: describing protein dynamics for proteochemometric bioactivity prediction. A case for (mutant) G protein-coupled receptors

Reviews, GPCRs, and more

• RGS2 and female common diseases: a guard of women's health

• β-Arrestins: Structure, Function, Physiology, and Pharmacological Perspectives

• COVID-19, G protein-coupled receptor, and renin-angiotensin system autoantibodies: Systematic review and meta-analysis

Structural and Molecular Insights into GPCR Function

• Analysis of the Dynamics of the Human Growth Hormone Secretagogue Receptor Reveals Insights into the Energy Landscape of the Molecule

• Focused classifications and refinements in high-resolution single particle cryo-EM analysis

• Structure-based drug discovery of a corticotropin-releasing hormone receptor 1 antagonist using an X-ray free-electron laser

• Structural insight into the selective agonist ST1936 binding of serotonin receptor 5-HT6

Industry News

• Septerna Bolsters Leadership Team as the Company Advances its Multi-Product Pipeline Toward Clinical Studies

• Confo Therapeutics Appoints Dieter Weinand, Former CEO Of Bayer Pharmaceuticals, As Independent Chairman

• Addex Adx71149 Phase 2 Epilepsy Study Expected To Readout Data In Q2 2024

• Addex Announces Participation In The H.C. Wainwright 25th Annual Global Investment Conference

• X4 Pharmaceuticals to Participate in the Morgan Stanley 21st Annual Global Healthcare Conference

• CEO Raymond Stevens to Speak at STAT Future Summit on Obesity Therapeutics

Call for GPCR Papers

• NEW opnMe GPCR Route 66+ project. Deadline September 27, 2023

GPCR Events, Meetings, and Webinars

• September 25 - 28, 2023 | Discovery On Target

• September 27 - 28, 2023 | Training Seminar "The Renaissance in GPCRs as Drug Targets: Allosteric Function and Biased Signaling" at the DOT

• NEW October 3, 2023 | FREE Seminar: Changing paradigm on Therapeutics targeting Membrane Proteins: from antigen production to candidate validation

• October 25 - 27, 2023 | 3rd Annual Meeting IRN I-GPCRNet

• November 2 - 4, 2023 | GPCR Retreat

• November 15 - 17, 2023 | MPGPCR Conference

• November 20 - 23, 2023 | ASCEPT Annual Scientific Meeting

• February 3 - 7, 2024 | SLAS2024 International Conference and Exhibition

• March 23 - 24, 2024 | Ligand Recognition and Molecular Gating Seminar

• March 24 - 29, 2024 | Ligand Recognition and Molecular Gating Conference

• April 5 - 10, 2024 | AACR Annual Meeting

• May 13 - 17, 2024 | 20th Annual PEGS Boston Summit

• May 16 - 19, 2024 | ASPET 2024

• May 27 - 29, 2024 | SLAS Europe 2024 Conference and Exhibition

• June 2 - 4, 2024 | Chemotactic Cytokines

GPCR Jobs

• Researcher / Senior Researcher in Structural Biology

• Research Specialist

• Science Research Writer

• Postdoctoral Fellow

• Research Laboratory Specialist Associate

• Postdoc Research Associate

• Director, Regulatory Affairs

• Research Scientist/Senior Scientist I - Molecular Pharmacology

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