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recognition motifs for the MRGPRD GPCR Chunyu Wang ,  Yongfeng Liu ,  Marion Lanier ,   Brian K Shoichet ,  Esther Martinborough ,  Jonathan F Fay ,  Can Cao ,   Bryan L Roth , et al.

Esther 2023). The 30s-loop of chemokines can bind either on top of the extracellular loop 2 (ECL2) or inside the major

byproduct obtained by the O-acylisourea rearranging intramolecularly into the N-acylurea.[ 2]     NHS ester NHS esters are not very stable even in aqueous environment but they only need a slightly basic medium

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MD simulations with the parameterized ester intermediate reveal a protonation-dependent dynamic desolvation of the GPS for subsequent ester hydrolysis by restricting water conformations.

Hence, Remo is proteolytically processed, either by the GAIN domain or an alternative protease that cleaved