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Home → Flash News → Lighting up a native pancreatic islet isn’t just a technical win it’s a shift in what GPCR imaging can reveal Lighting up a native pancreatic islet isn’t just a technical win — it’s a shift

Shivani Sachdev About Dr. Shivani Sachdev "Dr. Shivani Sachdev on the web NIDDK ReseachGate Google Scholar LinkedIn Twitter Dr.

Premium Strategic Partners Lighting up a native pancreatic islet isn’t just a technical win — it’s a shift This shift — from thinking about “pathways” to understanding localized signaling architecture — is what In this clip, Jens unpacks a mindset shift that every computational scientist should hear. decades, molecular modeling focused on explaining — rationalizing why a ligand binds, why a mutation shifts The mindset shift? Stop explaining experiments after they happen. Start designing them to happen.

Carlsson reveals how computational modeling is evolving from explanation to real prediction—and how that shift

This shift — from thinking about “pathways” to understanding localized signaling architecture — is what

Shivani Sachdev Dr. Shivani Sachdev on the web NIDDK ReseachGate Google Scholar LinkedIn Twitter Dr. GPCR About Dr.

Why receptor localization and scaffolding dramatically shift functional readouts in disease models.

“We found something incredible — a tenfold shift in the methadone dose-response with our PAM.” 10.

“It was my shift from the lab to leadership.

strategies for analyzing large compound screening data, emphasizing robust assays and addressing issues like shifting

Family First, Always The decision to shift from academia to industry wasn’t driven by disillusionment—it Network or Miss Out One powerful shift came when Sokhom leaned into networking—despite being an introvert His unwavering dedication through these cycles became an asset—many others shifted focus, leaving a smaller

In addition to paradigm shifts including inverse agonism, biased signaling, and pharmacological chaperones

Miller 1, Shijiao Huang 1, Elizabeth S. Dean 1, and Scott F. Leiser 1 1.

More recently, I have shifted my focus to identifying allosteric modulators of host G-protein-coupled

In addition to paradigm shifts including inverse agonism, biased signaling, and pharmacological chaperones

What shifted the team’s strategy from traditional calcium assays to IP1 accumulation—and why it mattered

blocking antibodies, some autoantibodies activate GPCRs , potentially driving pathophysiology — a paradigm-shifting The Shift Toward Technology-Driven Biology “Today’s students want to multiplex, miniaturize, and engineer Sakmar reflects on the generational shift in research culture.

But when timelines shift, expectations blur, or feedback loops break down, even the best work can lose

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GPCR Logo in different marketing materials, such as a new T-shirt design, a toy, software packaging,

The mindset shift? Stop explaining experiments after they happen. Start designing them to happen.

In this clip, Jens unpacks a mindset shift that every computational scientist should hear. decades, molecular modeling focused on explaining — rationalizing why a ligand binds, why a mutation shifts

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Understanding these shifts can revolutionize drug development!