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explicitly interested in GPCR signaling... but the thing about GPCRs... is you always kind of end up landing at a GPCR as a major target." GPCRs in the Background, But Always Present Even though his primary focus wasn’t GPCRs themselves, Serafini Takeaway Forget what you think you know about GPCR drug targets. data platform , GPCR training program , pain research , opioid signaling .

GPCR – Precision Tools for GPCR Assays Dr. GPCR and Celtarys Research have teamed up. features a discussion about a scalable GPCR-RAMP assay. Their global resource is now helping labs decode GPCR biology at scale. It’s exciting to see how the GPCR field is evolving. GPCR Team

GPCR’s nonprofit mission to unite and empower the GPCR community worldwide FOMO is real: if you’re not Be Part of the GPCR Community Dr. GPCR is a nonprofit global community  dedicated to building a strong, connected GPCR ecosystem. Their areas of focus include structural biology, protein production from Proteos, and nanoparticle characterization The company has long-standing expertise in G protein–coupled receptor (GPCR) biology—one of the most

Nicholas Kapolka , Geoffrey Taghon , and Daniel Isom  for their research on Advances in yeast synthetic biology for human GPCR biology and pharmacology Dr. to connect with fellow scientists and explore the latest in adhesion GPCR biology. synthetic biology for human G protein-coupled receptor biology and pharmacology Industry News Muscarinic in drug discovery October 2024 | Biologics US 2024   October 2 - 4, 2024 | 9th GPCRs in Medicinal Chemistry

Celtarys Research develops high-quality, fluorescently labeled ligands and innovative chemical biology biology with greater precision and speed. GPCR. will help accelerate the adoption of our chemical tools and foster collaborations that turn receptor biology GPCR empowers scientists and companies advancing receptor biology and drug discovery.

Career opportunities:  GPCR Biology; Protein Science. GPCR Podcast: Visualizing GLP-1 & GIP Receptors in Islets and Brain Understanding incretin biology depends Listen to the episode ➤ Quick Links Assess GPCR Biased Signaling of Agonist How GPCR Collaboration Built GPCR innovation is accelerating. GPCR Team

Enhance your GPCR research with deeper assay insights for more effective results. Breakthroughs this week: C. elegans avoids EGCG via SRXA-7 GPCR; a bidirectional GPCR switch modulates allosteric site on an orphan GPCR. 🔍 This Week in Dr. biology gets measured. GPCR innovation is accelerating.

The GPCR Data Dilemma: The Lego Bucket Problem I've seen promising GPCR programs generate massive volumes My Approach: Biology, Execution, Systems My consulting approach uniquely blends deep pharmacology expertise Here's how I bring a fresh perspective: Biology-First, Data-Driven Strategy:  I help you focus on the GPCR As the co-founder of Dr. GPCR, we've built a global hub connecting over 1,300 GPCR scientists dedicated to this field.

Broichhagen aka JB, the goal was bold and elegant: Create a photo-switchable ligand to remotely control GPCR They had a tool that did bind the GPCR… but not in the light-controlled way they wanted. The Moment a Failed Tool Became a GPCR Imaging Breakthrough What the compound did reliably do was label This solved a long-standing problem in GPCR biology: You can't understand signaling if you can’t see  The Larger Lesson for Scientists and Innovators This story isn’t just about a GPCR imaging tool.

Target-based screening is now a fundamental pillar of drug development, and GPCRs are key targets for How Fluorescence Polarization Assays Work: Principles and Applications in GPCR Research FP assays work Optimizing GPCR Drug Discovery with Fluorescence Polarization: Key Advantages and Future Perspectives Compatible with various sources of GPCRs. Contact us  to drive further advancements in GPCR drug discovery!  

GPCR Premium: Sneak Peek Want the full classified brief? GPCR , our mission is simple but urgent: Accelerate GPCR biology and drug discovery by connecting scientists GPCR Podcast, the Revvity team built pHSense™ from the ground up by listening to what GPCR scientists GPCR innovation is accelerating. GPCR and the offered resources in my work sphere." — DrGPCR University Attendee GPCR innovation doesn

Why This Matters GPCR research demands integration — pharmacology, structural biology, signaling pathways The lab went from project-level thinking to platform-level strategy  — a critical shift for GPCR biology This ecosystem outlasted individual PIs  and became a GPCR innovation hub  with global reach. GPCR science thrives in complexity — meaning no single lab or company can do it alone. GPCR Premium  for deep dives, strategic tools, and behind-the-scenes conversations shaping the GPCR field

GPCR research requires turning data into insights for drug discovery Hi GPCR Friends, Every week, critical decisions in GPCR research hinge on subtle shifts in data. GPCR Podcast – Ajay Yekkirala on GPCR Innovation In this episode, Dr. Understand how AI/ML and GPCR biology meet to unlock safer drugs. The pace of GPCR innovation is accelerating.

That perspective changed the moment he entered GPCR research . The GPCR Challenge What makes collaboration non-negotiable in GPCR research is the biology itself. Structural biologists may capture snapshots of receptor conformations, but lack large-scale screening GPCR Models Don’t Discover Drugs—People Do In GPCR research, the biggest breakthroughs won’t come from GPCR Podcast 🌱 Build a career with purpose, not just papers The Dr.

discovery of DNA's double helical structure was a scientific milestone that revolutionized molecular biology GPCR biology, the development of GPCR-targeted drugs, and the exploration of GPCRs as key regulators The integration of genomics with structural biology, pharmacology, bioinformatics, and clinical research has opened new avenues for exploring GPCR biology, developing targeted therapies, and translating genomic Time-resolved cryo-EM of G protein activation by a GPCR. bioRxiv : the preprint server for biology, 2023.03.20.533387

GPCRs pose a critical challenge in drug discovery: a vast therapeutic potential with many targets yet However, over half of non-sensory GPCRs do not have drugs available in the clinic, opening the door to This means fluorescent probes enable a dynamic observation of GPCRs. common starting point for employing fluorescent probes in GPCR assays. Fluorescent ligands: Bringing light to emerging GPCR paradigms.

GPCR Event Highlight 11th Adhesion GPCR Workshop Hosted by the Adhesion GPCR Consortium, this event will Join fellow scientists and researchers in person to stay updated with adhesion GPCR biology. in drug discovery October 2024 | Biologics US 2024 October 2 - 4, 2024 | 9th GPCRs in Medicinal Chemistry Director GPCR Drug Discovery Biologist Post-Doctoral Scientist- Molecular Pharmacology (FDE) Join Dr. GPCR Ecosystem

Is Your GPCR Program Slowing Down—Even With Good Data? You’re not alone. GPCR Ecosystem. Strong science. Promising data. But no systems to turn it into momentum. Here’s what I bring: Biology-First Strategy I’ve designed GPCR assays, led collaborations across research GPCR, I’m connected to 1,300+ scientists and decision-makers worldwide. Who I Work With ✅ Biotech Teams  – Especially those lacking in-house GPCR leads or overwhelmed by CRO

Tom Sakmar didn’t set out to map GPCR-RAMP interactions across hundreds of receptors. , multiplexed platform to investigate GPCR-RAMP biology  like never before. Why It Matters This isn’t just a dataset, it’s a shift in how GPCR biology is approached : Study known interactions , Family B GPCRs , GPCR scientist network , GPCR data platform , Dr. GPCR ecosystem

If you want your molecules to survive first contact with biology, enzyme inhibition must be part of your mutated GPCRs. signaling, opsins, and melanocortin receptors to behaviors and skin biology. If you care about compartmentalized signaling and native-state biology, this is a sharp, readable tour The pace of GPCR innovation is accelerating.

GPCR and Revvity. It started not with biology—but with chemistry. Revvity and academic collaborator Prof. It’s a strategic tool for decoding GPCR behavior in drug discovery and systems biology. GPCR   Dr. GPCR X Revvity Collaboration ⸻ Want more like this? 👉 Join the Dr. GPCR Premium Ecosystem  for behind-the-scenes access to GPCR innovators, exclusive deep-dives, and practical

Welcome aboard, GPCR Crew! GPCR Event Spotlight 11th Adhesion GPCR Workshop    📍  Mexico City 📅 October 23 - 25, 2024 Get ready biology! Emerging Voices in GPCR Biology in Special Issue of Molecular Pharmacology GPCR Events, Meetings, and Postdoctoral Scholar – iPSC in cardiac and endothelial cell function Protein Biochemist/Structural Biologist

space focused on GPCR pharmacology. – GPCR mutations in cancer—drivers, passengers, or both?  GPCR Updates Learn Pharmacology That Drives Discovery  – From Dr. GPCR Podcast appearance. GPCR Team

Get your space suits on, GPCR cadets! Classified GPCR News  Let’s dive into the   Classified GPCR News from October 28th to November 3rd, 2024 Jobs Scientist I Cell Biology - Tectonic Therapeutic PhD fellowship in GPCR mechanosensing Senior Scientist Postdoctoral Scholar – iPSC in cardiac and endothelial cell function Protein Biochemist/Structural Biologist Senior Scientist/Staff Scientist, Computational Chemistry GPCR Activation and Signaling GPCR signalling

s latest lecture delivers high-impact insight crafted for teams navigating the complex behaviors of GPCR-targeting As Kenakin explains, all GPCR signaling is allosteric , and pretending otherwise introduces risk at every If you’re still treating GPCRs as passive targets, your screening filters may be blind to key liabilities But without understanding how GPCR state changes  influence that affinity—or vice versa—drug discovery Corner  is your trusted, expert-led guide through the evolving landscape of GPCR science.

Welcome GPCR Fans,   In GPCR-targeted drug discovery, precision isn’t optional—it’s a requirement. GPCR Premium Members this week gain curated, early access to: Industry insights : GPCRs and mRNA in drug The interpretation of high and low affinity binding sites on GPCRs. GPCR Premium Membership Gives You an Edge Dr. GPCR Premium gives you an edge in a fast-moving field.

The central role of GPCRs in Neurological Disorders GPCRs are the largest family of membrane receptors Over 30% of FDA-approved drugs target GPCRs, with many targeting CNS located GPCRs. GPCR Structure, Activation, and Signaling Pathways in the Brain An understanding of GPCR structure is Orphan GPCRs in Neurodegenerative Disorders: Integrating Structural Biology and Drug Discovery Approaches Orphan GPCRs in Neurodegenerative Disorders: Integrating Structural Biology and Drug Discovery Approaches

Hello GPCR Enthusiasts, Interpreting binding data isn’t optional—it’s career-defining. GPCR Premium: Sneak Peek Every week, Premium Members get curated intelligence they won’t find in open Read the article now ➤ Discovery on Target - The Next Wave of GPCR Drug Discovery The 20th Annual GPCR-Based GPCR Premium Membership Gives You an Edge The GPCR field is advancing at breakneck speed. The pace of GPCR innovation is accelerating.

her to pursue a PhD in Molecular Pharmacology at Monash University, and later to train in single-cell biology By 2011, she had established her own group within the Drug Discovery Biology theme at Monash Institute Her work sits at the intersection of fundamental biology and therapeutic strategy. GPCR Podcast 🔓 Want to go deeper? Join   Dr. GPCR Premium  for exclusive tools, deep dives, and expert access.

Greetings, Pioneers of GPCR Science! into the latest developments in adhesion GPCR biology. for its First-in-class GPR68 Inhibitor Asengeprast (FT011) AlphaProteo generates novel proteins for biology Emerging Voices in GPCR Biology in Special Issue of Molecular Pharmacology GPCR Events, Meetings, and Postdoctoral Scholar – iPSC in cardiac and endothelial cell function NEW Protein Biochemist/Structural Biologist