Search Results

diffusion, offset kinetics, and rebinding ✅ Real-world examples of how residence time—not potency—predicts therapeutic coverage ✅ Insight into cryptic intracellular GPCR sites, including allosteric modulators only accessible Drugs Change the Game For decades, drug design has treated GPCRs as surface targets. The slow-offset compound stays on target longer, maintains therapeutic effect as concentrations drop, GPCRs now have validated intracellular  allosteric sites.

May 2022 "Seoul, South Korea, 28 April 2022 – GPCR therapeutics, Inc., a venture-backed clinical stage company with an innovative approach to drug discovery based on targeting G Protein Coupled Receptors (GPCR GPCR just had a very successful first meeting including all the Scientific Advisory Board." Read more at the source #DrGPCR #GPCR #IndustryNews

Dr Brennan has extensive experience across all phases of clinical development, and across multiple therapeutic #biotech #lifesciences #appointment #GPCR #Oncology" Read more at the source #DrGPCR #GPCR #IndustryNews

GPCR – Precision Tools for GPCR Assays Dr. GPCR and Celtarys Research have teamed up. features a discussion about a scalable GPCR-RAMP assay. Their global resource is now helping labs decode GPCR biology at scale. It’s exciting to see how the GPCR field is evolving. GPCR Team

and the complexity of the central nervous system (CNS) pose a challenge for developing successful therapeutics Emerging GPCR Therapeutic Targets in CNS Drug Discovery GPCRs have been studied for decades, but there Of the traditional GPCRs, CBRs are gaining ground as potential therapeutic targets in several CNS diseases One of the best tools to study therapeutic targets are fluorescent ligands , which are very useful in G-Protein-Coupled Receptors in CNS: A Potential Therapeutic Target for Intervention in Neurodegenerative

But your GPCR program still isn't moving at the pace it should. The GPCR Data Dilemma: The Lego Bucket Problem I've seen promising GPCR programs generate massive volumes GPCR As the co-founder of Dr. GPCR, we've built a global hub connecting over 1,300 GPCR scientists dedicated to this field. Ready to Move Your GPCR Program Forward?

Get your space suits on, GPCR cadets! et al. for their fantastic review on Molecular and structural insights into the 5-HT2C receptor as a therapeutic - Targeted Antibody Therapeutics Using Generative AI Zombie Fungi Hijack Hosts’ Brains GPCR Therapeutics Jobs Scientist I Cell Biology - Tectonic Therapeutic PhD fellowship in GPCR mechanosensing Senior Scientist proteins in obesity and diabetes mellitus Molecular and structural insights into the 5-HT2C receptor as a therapeutic

GPCR Podcast is back this week with a brand new episode. Our guest is none other than Dr. Juan Jose Fung, Principal Scientist, at GPCR Therapeutics. https://buff.ly/32fzGbO #gpcr #drgpcr #podcast

compounds that interact with molecular targets involved in disease pathways is where the development of new therapeutics Target-based screening is now a fundamental pillar of drug development, and GPCRs are key targets for How Fluorescence Polarization Assays Work: Principles and Applications in GPCR Research FP assays work Compatible with various sources of GPCRs. Contact us  to drive further advancements in GPCR drug discovery!  

GPCRs Re-Enter the Story — Not as Theory, but as Tools GPCRs have always been powerful drug targets — That partnership eventually produced fluorescent GPCR tools  that allow researchers to visualize GPCR The Future of GPCR Therapeutics in Metabolic Disease Even with GLP-1 and GIP agonists reshaping diabetes Emerging direction: Multi-target GPCR + myostatin-pathway combinations. Can GPCRs act as “delivery ZIP codes” for targeted therapies?

That perspective changed the moment he entered GPCR research . The GPCR Challenge What makes collaboration non-negotiable in GPCR research is the biology itself. They offer extraordinary therapeutic promise —but their complexity makes them one of the hardest targets GPCR Models Don’t Discover Drugs—People Do In GPCR research, the biggest breakthroughs won’t come from GPCR Podcast 🌱 Build a career with purpose, not just papers The Dr.

GPCRs pose a critical challenge in drug discovery: a vast therapeutic potential with many targets yet However, over half of non-sensory GPCRs do not have drugs available in the clinic, opening the door to This means fluorescent probes enable a dynamic observation of GPCRs. common starting point for employing fluorescent probes in GPCR assays. Fluorescent ligands: Bringing light to emerging GPCR paradigms.

GPCR activity, enabling greater specificity and fewer side effects. systems such as free fatty acid receptors (FFARs), now regarded as targets for therapeutic intervention and β-arrestin coupling, enabling the development of biased agonists and antagonists with distinct therapeutic Allosteric modulation is gaining prominence in GPCR therapeutics, with the discovery of an intracellular Biased allosteric modulators can enhance the safety and efficacy of GPCR-targeted therapeutics by selectively

GPCR’s nonprofit mission to unite and empower the GPCR community worldwide FOMO is real: if you’re not Be Part of the GPCR Community Dr. GPCR is a nonprofit global community  dedicated to building a strong, connected GPCR ecosystem. delivers cutting-edge imaging and analysis that accelerates the discovery of new and life-changing therapeutics comprehensive approach enables Axxam to support clients worldwide in identifying and optimizing new therapeutic

Is Your GPCR Program Slowing Down—Even With Good Data? You’re not alone. GPCR Ecosystem. Strong science. Promising data. But no systems to turn it into momentum. GPCR, I’m connected to 1,300+ scientists and decision-makers worldwide. Who I Work With ✅ Biotech Teams  – Especially those lacking in-house GPCR leads or overwhelmed by CRO data chaos. ✅ Venture Capital Firms  – Looking to accelerate, troubleshoot, or validate GPCR assets

Enhancing scientific exploration by concentrating on understanding inhibition to advance GPCR drug discovery mutated GPCRs. , and concise reads on β-agonists, phospho-barcodes, and GPCR allostery. When “inhibition” becomes activation—and how that insight fuels next-gen therapeutic design. The pace of GPCR innovation is accelerating.

space focused on GPCR pharmacology. – GPCR mutations in cancer—drivers, passengers, or both?  – CXCR4 oligomer disruption boosts therapeutic response in lymphoid neoplasms Dr. GPCR Podcast appearance. GPCR Team

GPCR and Revvity. But there was a pivot: the tech had untapped potential for GPCRs. GPCR internalization isn’t just a trafficking readout—it’s pharmacology. GPCR   Dr. GPCR X Revvity Collaboration ⸻ Want more like this? 👉 Join the Dr. GPCR Premium Ecosystem  for behind-the-scenes access to GPCR innovators, exclusive deep-dives, and practical

Welcome GPCR Fans,   In GPCR-targeted drug discovery, precision isn’t optional—it’s a requirement. GPCR Premium Members this week gain curated, early access to: Industry insights : GPCRs and mRNA in drug discovery; new strategies for inflammatory disease treatment; growth strategies from Tectonic Therapeutics GPCR Premium Membership Gives You an Edge Dr. GPCR Premium gives you an edge in a fast-moving field.

GPCR Podcast, we have Dr. Pina Cardarelli, CSO of GPCR Therapeutics. ecosystem.drgpcr.com/dr-gpcr-podcast/ #gpcr#drgpcr #podcast

Hello GPCR Enthusiasts, Interpreting binding data isn’t optional—it’s career-defining. Breakthroughs this week: Decoding ADGRE5 signaling; Eli Lilly’s obesity pill vs Novo’s Wegovy; Certa Therapeutics Read the article now ➤ Discovery on Target - The Next Wave of GPCR Drug Discovery The 20th Annual GPCR-Based GPCR Premium Membership Gives You an Edge The GPCR field is advancing at breakneck speed. The pace of GPCR innovation is accelerating.

s latest lecture delivers high-impact insight crafted for teams navigating the complex behaviors of GPCR-targeting As Kenakin explains, all GPCR signaling is allosteric , and pretending otherwise introduces risk at every If you’re still treating GPCRs as passive targets, your screening filters may be blind to key liabilities But without understanding how GPCR state changes  influence that affinity—or vice versa—drug discovery Corner  is your trusted, expert-led guide through the evolving landscape of GPCR science.

For innovators building tools, platforms, or therapeutics, these origin moments are where tomorrow’s receptors control localised signaling, how disease hijacks these systems, and how to target them for therapeutic Her work sits at the intersection of fundamental biology and therapeutic strategy. Knowing where  signals occur could unlock new therapeutic strategies, better efficacy, and fewer side GPCR Podcast 🔓 Want to go deeper? Join   Dr.

We have gathered 24 new research papers on GPCRs and updates on industry news related to GPCRs. Bryan Roth and Brian Krumm for their study on Molecular glues as potential GPCR therapeutics Drs. breast cancer progression by suppressing the MMP8-mediated antitumorigenic effects GPR56: A potential therapeutic GPCR therapeutics A high-affinity, cis-on photoswitchable beta blocker to optically control β2-adrenergic GPCR Ecosystem

Welcome GPCR Fans,   Every discovery-phase decision you make shapes your entire pipeline trajectory—and Upcoming events:  5th MMCS New Trends in Drug Discovery; GPCR-UK Network Meeting; neuroGPCR Symposium Must-read publications:  GPCRchimeraDB: Database of engineered GPCR designs. GPCR University Course Attendee Dr. The pace of GPCR innovation is accelerating.

Enhance your GPCR research with deeper assay insights for more effective results. This Week’s GPCR Intelligence: If you want cleaner decisions, start with the system—then the ligand. Breakthroughs this week: C. elegans avoids EGCG via SRXA-7 GPCR; a bidirectional GPCR switch modulates allosteric site on an orphan GPCR. 🔍 This Week in Dr. GPCR innovation is accelerating.

Before your GPCR ligand ever meets its receptor, it meets the enzymes that determine whether it survives Even the most elegant GPCR ligand can fail if it never reaches its receptor. These nuances define therapeutic potential and side-effect risk. Each mode reshapes both potency and therapeutic window. Kenakin with your own enzyme or GPCR interaction puzzles.

Watch Episode 175 From failed assays to breakthroughs in GPCR modeling , Dr. At that point, very few GPCR crystal structures had been determined. For Carlsson, this marked a shift in how his lab approached GPCR research. He came to see that effective GPCR research requires true interdisciplinary integration. those who can unite modeling with experimentation, turning predictions into real therapeutic breakthroughs

Eric Trinquet, a veteran innovator behind functional GPCR assays like HTRF and IP-One, believes rigid If you’re building tools or careers in GPCR science, this is your playbook. It began with an unmet need: how to track Gq-coupled GPCR activity without the mess of calcium flux or GPCR   Dr. GPCR X Revvity Collaboration ⸻ Want more like this? 👉 Join the Dr. GPCR Premium Ecosystem  for behind-the-scenes access to GPCR innovators, exclusive deep-dives, and practical

Hello GPCR people! Check out our GPCR roundup now, and be the first to read! This week's highlight: Congrats to our partner GPCR Therapeutics, on their expansion into fibrosis with selectivity Industry News Sosei Heptares and Verily Nominate First G-protein-coupled receptor Target for Therapeutic Therapeutics Expands Pipeline into Fibrosis with a Combination Approach Targeting LPA1 GPCR Events, GPCR Ecosystem