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Target-based screening is now a fundamental pillar of drug development, and GPCRs are key targets for How Fluorescence Polarization Assays Work: Principles and Applications in GPCR Research FP assays work Compatible with various sources of GPCRs. research through the development of novel fluorescent probes and advanced imaging techniques. Contact us  to drive further advancements in GPCR drug discovery!  

Celtarys Research Joins Dr. GPCR – Precision Tools for GPCR Assays Dr. GPCR and Celtarys Research have teamed up. Full Breakdown of the Latest in GPCR Research Want detailed insights? Dive into this week’s research, tools, and biotech updates all in one place. GPCR Team

activity biosensors Marta Lopez-Balastegui, Antonella Di Pizio, Jiafei Mao, Jana Selent, et al. for their research GPCR Event Highlight 11th Adhesion GPCR Workshop Hosted by the Adhesion GPCR Consortium, this event will Join fellow scientists and researchers in person to stay updated with adhesion GPCR biology. Research High-throughput G protein-coupled receptor-based autocrine screening for secondary metabolite and Clinical Pharmacology 2026 GPCR Jobs NEW Postdoctoral Research Associate Senior Scientist - Discovery

GPCR, the global knowledge hub for G protein-coupled receptor (GPCR) research and education, is proud community,”  said Dr. GPCR provides a unique platform to reach scientists at every stage of GPCR research,”  said Wilson Gomes “We’re excited to support the GPCR community with tools that deliver clarity, sensitivity, and speed, GPCR is a nonprofit organization connecting the global GPCR community through training, curated news,

GPCRs pose a critical challenge in drug discovery: a vast therapeutic potential with many targets yet This means fluorescent probes enable a dynamic observation of GPCRs. common starting point for employing fluorescent probes in GPCR assays. Our scientific team can guide you choose or design the right fluorescent ligand for your research.   Fluorescent ligands: Bringing light to emerging GPCR paradigms.

proteins Nicholas Kapolka , Geoffrey Taghon , and Daniel Isom  for their research on Advances in yeast Research GPCR Signaling: A Study of the Interplay Between Structure, Energy, and Function Engineering   Postdoctoral Position Postdoctoral research position Senior or Lead Researcher   Senior Scientist, Cryo-Electron Microscopy   Postdoctoral Research Associate Join Dr. GPCR Ecosystem

That perspective changed the moment he entered GPCR research . The GPCR Challenge What makes collaboration non-negotiable in GPCR research is the biology itself. Whether in academia or biotech, the future belongs to research groups that can orchestrate ecosystems GPCR Models Don’t Discover Drugs—People Do In GPCR research, the biggest breakthroughs won’t come from access to leaders in the field. 🎓 Mentorship that matters. 🧭 Decisions with clarity. 💬 Exclusive community

GPCR , the global nonprofit platform dedicated to advancing GPCR science through education, community A GPCR Internalization Tool Designed for Real Research Needs Built on more than two decade A GPCR Internalization Tool Designed for Real Research Needs s of GPCR assay innovation , pHSense™  was developed to overcome “It’s a leap forward in how the community studies GPCRs at scale and in context.” 🔗 About Dr. GPCR  is a global nonprofit platform advancing GPCR research  through education, community, and platform

Drum rolls, we’ve got 15 GPCR research papers, updates, industry news events, and GPCR ads curated just in downstream pathway activation Chiara D Mancinelli, Joshua Levitz, David Eliezer, et al. for their research It is an opportunity to connect with like-minded scientists and researchers and gain valuable insights Research A combination treatment based on drug repurposing demonstrates mutation-agnostic efficacy in NEW Senior or Lead Researcher NEW Senior Scientist, Cryo-Electron Microscopy Postdoctoral Research Associate

In the realm of molecular research, precise interpretation is crucial; a misread curve can lead to lost Read the article now ➤ Discovery on Target - The Next Wave of GPCR Drug Discovery The 20th Annual GPCR-Based GPCR Premium Membership Gives You an Edge The GPCR field is advancing at breakneck speed. The pace of GPCR innovation is accelerating. Kenakin is a masterful teacher and communicator." — DrGPCR University Attendee The difference between

The GPCR Data Dilemma: The Lego Bucket Problem I've seen promising GPCR programs generate massive volumes GPCR As the co-founder of Dr. GPCR, we've built a global hub connecting over 1,300 GPCR scientists dedicated to this field. and evolving needs across the entire GPCR community. Ready to Move Your GPCR Program Forward?

The GPCR Angle Ben sees GPCRs as untapped goldmines for drug discovery. With collaborations across medicinal chemistry and neuropathic pain research, Ben is bridging molecule Ready to dive deeper into GPCR drug discovery? Want to push the boundaries of GPCR drug discovery? Start learning with our GPCR University today. _______________ Keyword Cloud: GPCR research community , GPCR drug discovery, mu-opioid receptor, positive allosteric modulators, GPCR training program, GPCR

Watch Episode 170 What We’re Missing in Pain Research In GPCR drug discovery, receptors typically steal explicitly interested in GPCR signaling... but the thing about GPCRs... is you always kind of end up landing at a GPCR as a major target." GPCRs in the Background, But Always Present Even though his primary focus wasn’t GPCRs themselves, Serafini data platform , GPCR training program , pain research , opioid signaling .

This makes it an ideal candidate for GPCR research, where accuracy in detecting subtle signaling changes Enhancing HTRF Assay Performance in GPCR Research Using Fluorescent Ligands GPCRs are involved in numerous GPCRs are not always the most numerous in cells. By using donor-acceptor pairs with different emission spectra that don’t overlap, researchers can design technologies by providing high-performance fluorescent ligands designed specifically for pharmacological research

They have also been used as biosensors to monitor conformational changes of GPCRs in living cells. Some Nbs that have been use for GPCR research are: Nb80: This nanobody stabilized an active-state conformation Nb7: This nanobody improves the diffraction quality of the constitutively active GPCR US28·CX3CL1 complex5 Nature communications, 14(1), 5209. https://doi.org/10.1038/s41467-023-40911-9

Is Your GPCR Program Slowing Down—Even With Good Data? You’re not alone. GPCR Ecosystem. Strong science. Promising data. But no systems to turn it into momentum. Here’s what I bring: Biology-First Strategy I’ve designed GPCR assays, led collaborations across research GPCR, I’m connected to 1,300+ scientists and decision-makers worldwide. in their portfolio. ✅ Contract Research Organizations (CROs)  – Wanting to better align with biotech

It’s where partnerships spark, ideas collide, and the GPCR community grows stronger — together. GPCR’s nonprofit mission to unite and empower the GPCR community worldwide FOMO is real: if you’re not Be Part of the GPCR Community Dr. GPCR is a nonprofit global community  dedicated to building a strong, connected GPCR ecosystem. Our mission is simple: bridge science and industry  by connecting researchers, biotech, CROs, and pharma

Get ready for an expedition, GPCR explorers! Embark on another exciting exploration of the unknown realms of GPCR research. Welcome back to your weekly GPCR quest! Therapeutic Senior Scientist, GPCR Pharmacology Research Associate - Professor Graeme Milligan Postdoc Research Generation of CRISPR/Cas9 modified human iPSC line with correction of heterozygous mutation

Riding the GPCR Rollercoaster Early in his career at DuPont and BMS, GPCRs were red hot. The Payoff of Staying Focused Today, GPCRs are making a comeback in popularity. A Career Built on Consistency From CGRP receptor antagonists at BMS to opioid receptor research at Alkermes drug discovery , G protein-coupled receptors , GPCR webinar series , GPCR scientist network , GPCR research community

mutated GPCRs. He argues that early-career researchers often fall into the trap of over-rationalizing too soon—missing The pace of GPCR innovation is accelerating. Become a Premium Member today. ➤ 🎓 Full GPCR University + 🔬 200+ expert talks 🗞️ Weekly research, field 🧠 Designed for researchers at every career stage

Celtarys Research expands its assay tools with CELT-419 for D3 receptor studies, and Dr. The Kenakin Brief Fluorescent Probe CELT-419 Powers D3R Binding Assays Across Platforms   Celtarys Research Maria Majellaro’s path from lab research to co-founding Celtarys, as told in her recent Dr. Explore this week’s research, tools, and biotech insights in one place. GPCR Team

In the high-stakes world of GPCR drug discovery , breakthrough science isn't enough. GPCR, we recognized this core problem. the entire GPCR program as a single, interconnected entity. or communication gaps in cross-functional collaboration , lead to critical costs. The GPCR Precision Blueprint is more than a concept.

Career opportunities:  A curated list of new positions, including a Research Associate, a Senior Research Scientist, and a Post-doctoral Researcher position focused on GPCRs and Mitochondria. We’ve also highlighted the latest research on non-canonical internalization mechanisms of mGlu receptors the actionable intelligence you need to make sense of these trends and integrate them into your own research Join the community of informed, empowered GPCR professionals who are shaping the future of drug discovery

GPCR and Revvity. It’s when you invite the community in. GPCR   Dr. GPCR X Revvity Collaboration ⸻ Want more like this? 👉 Join the Dr. GPCR Premium Ecosystem  for behind-the-scenes access to GPCR innovators, exclusive deep-dives, and practical tools to accelerate your research or career. 👥 Build connections. 🧪 Get insights. 🎧 Stay ahead.

Welcome GPCR Fans,   In GPCR-targeted drug discovery, precision isn’t optional—it’s a requirement. Symposium (Sept 3–4); neuroGPCR Symposium (Sept 17) Career opportunities : Lead/Senior Researcher at GPCR University Learner Celtarys Research Recap: Medicinal Chemistry Highlights You May Have Missed The : Hire for attitude and team fit—not just credentials Design workflows that enable curiosity-driven research s Corner  digital pharmacology courses Priority access to insights from major conferences, emerging research

Get your space suits on, GPCR cadets! for the treatment of metabolic disease Milena Malcharek , Graham Ladds , et al. for their extensive research Exciting event listings to keep you on your toes  Direct line to all the cool cats in the GPCR community This transition will enable us to invest in higher-quality content and resources, ensuring our community , GPCR Pharmacology Research Associate - Professor Graeme Milligan Postdoc in Molecular Pharmacology

Read more at the source #DrGPCR #GPCR #IndustryNews

The central role of GPCRs in Neurological Disorders GPCRs are the largest family of membrane receptors Over 30% of FDA-approved drugs target GPCRs, with many targeting CNS located GPCRs. GPCR Structure, Activation, and Signaling Pathways in the Brain An understanding of GPCR structure is GPCR signaling: (A) an orthosteric ligand (orange) binds an inactive GPCR, the β2 adrenergic receptor More research into the endocannabinoid system (ECS) will let us access these GPCRs in a safer manner

Research; Lab-in-the-Loop Hit Discovery advances. Kenakin is a masterful teacher and communicator—and a leading expert in our field.” — Dr. unconventional path—from patient to scientist—exemplifies why personal mission matters in translational research Redefine your playbook:  Why Serafini believes that pain research needs to start from clinical phenotype s Corner  digital pharmacology courses Priority access to insights from major conferences, emerging research

s latest lecture delivers high-impact insight crafted for teams navigating the complex behaviors of GPCR-targeting As Kenakin explains, all GPCR signaling is allosteric , and pretending otherwise introduces risk at every If you’re still treating GPCRs as passive targets, your screening filters may be blind to key liabilities But without understanding how GPCR state changes  influence that affinity—or vice versa—drug discovery Corner  is your trusted, expert-led guide through the evolving landscape of GPCR science.