Search Results

explicitly interested in GPCR signaling... but the thing about GPCRs... is you always kind of end up landing at a GPCR as a major target." GPCRs in the Background, But Always Present Even though his primary focus wasn’t GPCRs themselves, Serafini Takeaway Forget what you think you know about GPCR drug targets. data platform , GPCR training program , pain research , opioid signaling .

mutated GPCRs. Terry's Corner – How Enzyme Inhibition Shapes Every Discovery Program Every molecule meets an enzyme Your Membership Gives You: Proven frameworks used in real discovery programs On-demand lessons built insights across biotech, pharma, and academia 💎 $2,999/year — one conference cost = a full year of expert training If your program depends on seeing around corners—enzyme liabilities, signaling bias, translational risks—Premium

GPCR – Precision Tools for GPCR Assays Dr. GPCR and Celtarys Research have teamed up. features a discussion about a scalable GPCR-RAMP assay. Their global resource is now helping labs decode GPCR biology at scale. It’s exciting to see how the GPCR field is evolving. GPCR Team

Welcome GPCR Fans,   In GPCR-targeted drug discovery, precision isn’t optional—it’s a requirement. GPCR Premium Members this week gain curated, early access to: Industry insights : GPCRs and mRNA in drug The interpretation of high and low affinity binding sites on GPCRs. GPCR Premium Membership Gives You an Edge Dr. GPCR Premium gives you an edge in a fast-moving field.

His work highlights how foundational GPCR science can drive therapeutic innovation. The GPCR Angle Ben sees GPCRs as untapped goldmines for drug discovery. Ready to dive deeper into GPCR drug discovery? Want to push the boundaries of GPCR drug discovery? Start learning with our GPCR University today. _______________ Keyword Cloud: GPCR research community , GPCR drug discovery, mu-opioid receptor, positive allosteric modulators, GPCR training program, GPCR

But your GPCR program still isn't moving at the pace it should. So, I created a new path—one that allows me to embed, optimize, and accelerate GPCR programs from the The GPCR Data Dilemma: The Lego Bucket Problem I've seen promising GPCR programs generate massive volumes Ready to Move Your GPCR Program Forward? If you're navigating a stuck GPCR program, planning your next crucial milestone, or struggling to gain

operational strategy and investment goals, even the most promising program can falter. This fundamental disconnect between the lab and the boardroom  is precisely where programs get stuck—not This is the essence of de-risking GPCR programs through operational excellence. the entire GPCR program as a single, interconnected entity. If you're ready to move beyond the articles and build these systems for your own GPCR program, let's

Target-based screening is now a fundamental pillar of drug development, and GPCRs are key targets for How Fluorescence Polarization Assays Work: Principles and Applications in GPCR Research FP assays work Optimizing GPCR Drug Discovery with Fluorescence Polarization: Key Advantages and Future Perspectives Compatible with various sources of GPCRs. Contact us  to drive further advancements in GPCR drug discovery!  

we explore how computational tools—especially AlphaFold —are helping crack the mystery of olfactory GPCRs The Problem: Hundreds of Receptors, Almost No Ligands Alessandro’s work focuses on olfactory GPCRs—nearly : Predicting the “Face” of a Receptor When Alessandro began his PhD, structural models of olfactory GPCRs —Alessandro Nicoli A New Era of GPCR Research AlphaFold didn’t just fill a gap—it shifted the focus of Start with our GPCR training program and get hands-on with virtual tools shaping the future of drug discovery

His group is trained to explain exactly what a model can predict and where its limits are. to stay plugged into the fast-changing needs of biotech while keeping his academic mission intact: training The GPCR Challenge What makes collaboration non-negotiable in GPCR research is the biology itself. The most effective discovery programs are structured like Carlsson’s: modeling designed with downstream GPCR Models Don’t Discover Drugs—People Do In GPCR research, the biggest breakthroughs won’t come from

GPCRs pose a critical challenge in drug discovery: a vast therapeutic potential with many targets yet However, over half of non-sensory GPCRs do not have drugs available in the clinic, opening the door to This means fluorescent probes enable a dynamic observation of GPCRs. common starting point for employing fluorescent probes in GPCR assays. Fluorescent ligands: Bringing light to emerging GPCR paradigms.

Is Your GPCR Program Slowing Down—Even With Good Data? You’re not alone. My Consulting Philosophy Every successful GPCR program is a blend of scientific excellence  and operational Program Moving Again Whether you’re building from scratch or recovering from a stall, I’ll help you program needs. 👉 https://calendly.com/drgpcr/yamina-corner Or explore how we can work together: 👉 Let’s talk through your program—no pitch, just clarity.

That’s exactly why we created GPCR Happy Hour . GPCR’s nonprofit mission to unite and empower the GPCR community worldwide FOMO is real: if you’re not Be Part of the GPCR Community Dr. GPCR is a nonprofit global community  dedicated to building a strong, connected GPCR ecosystem. GPCR Happy Hour is more than a social event.

GPCR signaling wasn’t linear. It wasn’t clean. For years, the GPCR community wrestled with unreliable antibodies. And some simply misled entire research programs. Why GPCR Collaboration Is Essential for Modern Science Hodson makes the point bluntly: modern GPCR science Together, they push GPCR science faster.

GPCR and Revvity. But there was a pivot: the tech had untapped potential for GPCRs. GPCR internalization isn’t just a trafficking readout—it’s pharmacology. GPCR   Dr. GPCR X Revvity Collaboration ⸻ Want more like this? 👉 Join the Dr. GPCR Premium Ecosystem  for behind-the-scenes access to GPCR innovators, exclusive deep-dives, and practical

space focused on GPCR pharmacology. – GPCR mutations in cancer—drivers, passengers, or both?  GPCR Updates Learn Pharmacology That Drives Discovery  – From Dr. GPCR Podcast appearance. GPCR Team

Most GPCR programs don’t fail because of weak molecules—they fail because biology behaves differently teams from the costly misinterpretations that derail programs. you see the distortions baked into the system, you interpret your data differently and protect your program GPCR Podcast: Chemical Probes for GPCR Imaging with Dr. Programs: Overcoming Assay Limitations with Fluorescent Ligands High-content screening (HCS) is now

High-content screening (HCS) has become a cornerstone in GPCR and phenotypic drug discovery, enabling For GPCR-focused programs, the ability to visualize receptor localization, internalization kinetics, Programs High-content screening integrates automated microscopy, multiplexed imaging, and computational The resulting multiparametric datasets are well-suited for GPCR research, where receptor trafficking, For GPCR assay developers, HCS supports:  Quantitative visualization of receptor internalization and

s latest lecture delivers high-impact insight crafted for teams navigating the complex behaviors of GPCR-targeting As Kenakin explains, all GPCR signaling is allosteric , and pretending otherwise introduces risk at every You’ll see how this manifests in real data from muscarinic receptors, CCR5 chemokine programs, and NMDA But without understanding how GPCR state changes  influence that affinity—or vice versa—drug discovery Corner  is your trusted, expert-led guide through the evolving landscape of GPCR science.

traditional displacement logic breaks down in allosteric systems, and how overlooking this can derail entire programs Sharpen your discovery decisions ➤ Yamina’s Corner - The Hidden Cost of Busy A GPCR program can collapse—not Read the article now ➤ Discovery on Target - The Next Wave of GPCR Drug Discovery The 20th Annual GPCR-Based GPCR Premium Membership Gives You an Edge The GPCR field is advancing at breakneck speed. a masterful teacher and communicator." — DrGPCR University Attendee The difference between stalled programs

Many GPCR scientists trace their origin story back to a single unexpected spark. Not a grand plan. early curiosity led her to pursue a PhD in Molecular Pharmacology at Monash University, and later to train Luck, Leadership & GPCR Signaling Michelle is clear: luck played a role. But so did choice. GPCR Podcast 🔓 Want to go deeper? Join   Dr. GPCR Premium  for exclusive tools, deep dives, and expert access.

Get your space suits on, GPCR cadets! up with a series of cosmic GPCR events for the year ahead. Exclusive access to private groups  Over 30 recorded talks from Symposia - that's a lot of brain food Classified GPCR News  Let’s dive into the   Classified GPCR News from October 28th to November 3rd, 2024 - Targeted Antibody Therapeutics Using Generative AI Zombie Fungi Hijack Hosts’ Brains GPCR Therapeutics

Welcome back GPCR fans, The pace of GPCR innovation is accelerating at a rate that can be difficult to Terry's Corner : Unlock the Power of Intracellular GPCR Drugs For years, GPCR drug discovery has focused GPCR Podcast : The Future of GPCR Drug Discovery with Molecular Modeling The field of GPCR research is Kenakin) teaming up with the best GPCR community platform to help train and inspire the next generation GPCR Course Attendee FAQ: What You Get with Dr. GPCR Premium What’s included?  

The central role of GPCRs in Neurological Disorders GPCRs are the largest family of membrane receptors Over 30% of FDA-approved drugs target GPCRs, with many targeting CNS located GPCRs. GPCR Structure, Activation, and Signaling Pathways in the Brain An understanding of GPCR structure is GPCR signaling: (A) an orthosteric ligand (orange) binds an inactive GPCR, the β2 adrenergic receptor Emerging GPCR Therapeutic Targets in CNS Drug Discovery GPCRs have been studied for decades, but there

This week Terry's Corner unlocks a simple lever that separates signal from storytelling, moving programs Breakthroughs this week: C. elegans avoids EGCG via SRXA-7 GPCR; a bidirectional GPCR switch modulates drug discovery program. Watch our new trailers for a preview of expert-led GPCR training designed for scientists and drug hunters 7-day free trial to explore the corner   💎 $2999/year — one conference cost = 12 months of expert training

Welcome GPCR Fans,   Every discovery-phase decision you make shapes your entire pipeline trajectory—and Must-read publications:  GPCRchimeraDB: Database of engineered GPCR designs. Yet too many programs rely solely on affinity metrics—Kd—as proxies for in vivo behavior, missing a critical GPCR University Course Attendee Dr. The pace of GPCR innovation is accelerating.

The Overlooked Step in Every Discovery Program So what does that mean for discovery scientists designing the next generation of GPCR ligands? Your Membership Includes: Frameworks proven in real discovery programs On-demand lessons  designed for trusted by biotech, pharma, and academia 💎 $2999/year — one conference cost = a full year of expert training Kenakin with your own enzyme or GPCR interaction puzzles.

Watch Episode 175 From failed assays to breakthroughs in GPCR modeling , Dr. At that point, very few GPCR crystal structures had been determined. For Carlsson, this marked a shift in how his lab approached GPCR research. This perspective influences how his lab trains students. protein sequences, small molecule data are often fragmented, inconsistent, or unavailable, making model training

GPCR Ecosystem. GPCR Podcast To mark the spotlight, Dr. GPCR  invited Dr. Eric Trinquet  to the Dr. GPCR. GPCR Dr. Through our podcast, training programs, and partner content, we help scientists connect, collaborate,

Eric Trinquet, a veteran innovator behind functional GPCR assays like HTRF and IP-One, believes rigid If you’re building tools or careers in GPCR science, this is your playbook. It began with an unmet need: how to track Gq-coupled GPCR activity without the mess of calcium flux or GPCR   Dr. GPCR X Revvity Collaboration ⸻ Want more like this? 👉 Join the Dr. GPCR Premium Ecosystem  for behind-the-scenes access to GPCR innovators, exclusive deep-dives, and practical