October 2022 GPR125 (ADGRA3) is an autocleavable adhesion GPCR that traffics with Dlg1 to the basolateral GPR125 (ADGRA3), an orphan adhesion GPCR, has been shown to modulate planar cell polarity in gastrulating Here, we show that human GPR125 likely undergoes cis-autoproteolysis when expressed in canine kidney Furthermore, in polarized MDCK cells, GPR125 is exclusively recruited to the basolateral domain of the The recruitment likely requires the C-terminal PDZ-domain-binding motif of GPR125 and its interaction

presented this important pre-clinical work at SIRS2022 confirming the ability of the highly selective novel GPR52 important interplay between the adenosinergic and dopaminergic systems and suggests the potential for GPR52

October 2022 GPR15 expressed in T lymphocytes from RA patients is involved in leukocyte chemotaxis to GPR15 is a G protein-coupled receptor (GPCR) located on chromosome 3 and has similarity in its sequence The expression of GPR15 and c10orf99/gpr15l mRNA was analyzed by RT-qPCR. +GPR15+ T cell frequency comparing RA patients versus control subjects by flow cytometry. A higher expression in the mRNA for GPR15 was identified in early RA subjects.

< GPCR News < GPCRs in Oncology and Immunology GPR15 expressed in T lymphocytes from RA patients is involved The expression of GPR15 and c10orf99/gpr15l mRNA was analyzed by RT-qPCR. +GPR15+ T cell frequency comparing RA patients versus control subjects by flow cytometry. A higher expression in the mRNA for GPR15 was identified in early RA subjects. Tags C10ORF99; GPR15; GPR15L; T lymphocytes; chemotaxis; rheumatoid arthritis; synovium.

< GPCR News < GPCRs in Oncology and Immunology Activation of orphan receptor GPR132 induces cell differentiation To explore the therapeutic potential of GPR132 signaling, we screened and validated a natural product 8-gingerol (8GL) as a GPR132 agonist. Notably, GPR132 activation by 8GL promoted differentiation and reduced colony formation in human AML In summary, this study demonstrated that activation of orphan GPR132 represents a potential strategy

activation sensor in arrestin In silico and in vitro screening for potential anticancer candidates targeting GPR120 Phototransduction Pathway G Protein-Coupled Receptor Heteromers as Putative Pharmacotherapeutic Targets in Autism GPR52 Determination of the G-protein coupling profile of ADGRG6(GPR126) Hedgehog pathway activation through