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Some of these are GPR6, GPR37 and GPR139 , which participate in motor control, neuroprotection and metabolic GPR6 has been linked to neuroprotective functions and is now being investigated for its role in Parkinson

August 2022 GPR3 expression in retinal ganglion cells contributes to neuron survival and accelerates GPR3 is unique in its ability to constitutively activate the Gαs protein without a ligand, which elevates Our earlier reports suggested that GPR3 enhances both neurite outgrowth and neuronal survival. GPR3 was relatively highly expressed in retinal ganglion cells (RGCs). Evaluation of the effect of GPR3 on axonal regeneration using GPR3 knockout mice revealed that GPR3 in

Our previous work demonstrated that GPR3-mediated β-arrestin signaling modulates amyloid-β (Aβ) generation in vitro and that Gpr3 deficiency ameliorates Aβ pathology in vivo. However, Gpr3-deficient mice display several adverse phenotypes, including elevated anxiety-like behavior consequences of selective elimination of GPR3-mediated β-arrestin signaling in vivo. In contrast to Gpr3-deficient mice, G protein-biased GPR3 mice do not display elevated anxiety levels

Curie PostDoc Fellowship in order to investigate and find better ligands for the orphan class A GPCRs , GPR3 , GPR6 , and GPR12 .

New cryo-EM structures of GPR4 and GPR68 reveal how extracellular histidines act as proton sensors-trigger New cryo-EM structures of GPR4 and GPR68 reveal how extracellular histidines act as proton sensors-trigger

Find out in our latest episode featuring Ian Chronis, where we explore the surprising ways GPR65 signals Find out in our latest episode featuring Ian Chronis, where we explore the surprising ways GPR65 signals