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Despite the availability of modern tools, Ben stresses the enduring value of classical methods like GTPγS assays , radioligand binding , and basic PK/PD models . Using site-directed mutagenesis and pharmacological synergy assays , his team aims to understand how

His focus is on expanding commercial reach and accelerating the adoption of the company’s GPCR assay from Celtarys Research Dec 9, 2025 5 min read High-Content Screening for GPCR Programs: Overcoming Assay interactions in intact cells offers advantages that extend far beyond traditional biochemical or radioligand assays fluorescently labeled ligands and innovative chemical biology tools to support real-time, non-radioactive GPCR assays GPCR Functional Assay Fluorescent GTPγS enables sensitive, non-radioactive GPCR activity assays for drug

Discover pHSense™ portfolio From binding to signaling to internalization: Cell-based fluorescence assays This results in high sensitivity and specificity in no-wash, plate-based live-cell assays. pHSense™ Eu G-Protein Activation Quantify Gs, Gi, and Gq activation in real time with cAMP, GTP, and IP-One assays Arrestin Recruitment Detect β-arrestin recruitment with TR-FRET and luminescence assays tailored for Build Your GPCR Assay Workflow Meet the Team behind pHSense™ Eric TRINQUET Sr Director Life Sciences

Get custom, fast, and functional ligands backed by real scientists solving real assay problems. 🧪 “We We solve assay problems.” – Dr. Maria Majellaro, CSO, Celtarys Listen to Ep. 168 now and meet your new assay partner 😉 ✳️ https://www.ecosystem.drgpcr.com Get custom, fast, and functional ligands backed by real scientists solving real assay problems. 🧪 “We We solve assay problems.” – Dr.

By using signalling assays, radioligand binding assay, and microscopy, Gaidarov et al. suggested that By using signalling assays, radioligand binding assay, and microscopy, Gaidarov et al. suggested that

Trinquet discusses the science and story behind pH Sense, Revvity’s innovative GPCR internalization assay product R&D. << Back to podcast list Strategic Partner(s) From Rare Earth Probes to Internalization Assays Eric Trinquet What does it take to design a breakthrough GPCR assay—from idea to industrial impact? With a career spanning two decades at the intersection of fluorescence chemistry, functional assays, What shifted the team’s strategy from traditional calcium assays to IP1 accumulation—and why it mattered

Check out the development of a NanoBRET assay platform to detect intracellular ligands for the chemokine Check out the development of a NanoBRET assay platform to detect intracellular ligands for the chemokine ➡️ https://www.ecosystem.drgpcr.com/methods-and-updates-in-gpcr-research/development-of-a-nanobret-assay-platform-to-detect-intracellular-ligands-for-the-chemokine-receptors-ccr6

DiscoverX leads GPCR research innovation with 25+ years of expertise and provides you with cell-based assay These industry-standard assays, designed for regulatory submissions, are backed by partnerships with kits Cell lines Qualified bioassays eXpress assay kits Membrane preps Detection kits Custom products Assay Principle of Eurofins DiscoverX Cell-based Assays Whether you are developing small-molecule or These assays use the same platform as the Eurofins DiscoverX assays and beyond.

Home → Flash News → Exploring the combination of molecular simulation, pharmacological assays, and NMR , 2024 Category GPCR Weekly News Exploring the combination of molecular simulation, pharmacological assays

✳️Celtarys is ready to support your assay development. Get to know more: Celtarys Research | Dr. ✳️Celtarys is ready to support your assay development. Get to know more: Celtarys Research | Dr.

GPCR to support assay development worldwide. GPCR to support assay development worldwide.

Tom Sakmar and Ilana Kotliar about how their lab developed: A multiplexed Luminex assay to screen hundreds Tom Sakmar and Ilana Kotliar about how their lab developed: A multiplexed Luminex assay to screen hundreds

Michelle Halls reveals how organized GPCR signaling drives assay innovation and new therapeutic insights This conversation is especially valuable for scientists developing functional assays, fluorescence-based What early cyclic AMP assays revealed about spatial signaling long before high-content technologies existed development and GPCR research. ⸻ Why It Might Hit Home If you’ve ever: Faced unexpected assay behavior Get behind-the-scenes conversations, advanced assay development strategies, and practical GPCR tools

Gain deep insights into GPCR drug candidates and learn the critical assays and techniques required to Gain deep insights into GPCR drug candidates and learn the critical assays and techniques required to

Johannes Broichhagen reveals how fluorescent probes transform GPCR imaging, internalization studies, and assay He explains what chemical design can solve that antibodies can’t, how to validate functional assay systems , and why fluorescence-based assays paired with careful synthetic planning open doors for both high-resolution How parallel synthesis and side-by-side functional assays accelerate probe optimization and reduce false Tried to build assays that behave in living cells—not just on paper.

During my PhD, I learnt radioligand binding assays, behavioral assays, autoradiography, stereotaxic surgeries

Discover how Celtarys Research is transforming GPCR assay development with fluorescent ligands in this focus is on enabling fast, customizable development of fluorescent ligands and chemical probes for GPCR assays GPCR, Celtarys will bring those lessons to the broader community, providing insight into assay development Each probe must retain activity, remain soluble, and be compatible with a given assay format. Whether you're designing assays, developing probes, or seeking better tools for GPCR drug discovery,

Whether you’re refining assay strategy or evaluating data, these lessons give you the tools to think Yamina’s Corner—GPCR consulting to de-risk and accelerate your pipeline ♦️ Celtarys’ validated TR-FRET assay

GPCR Podcast Back when GPCR assays were performed with single channel pipettes, failure wasn’t cheap. Michelle Halls still remembers pipetting one sample at a time, holding her breath to keep the assay alive

How academia and biotech collaborate to scale GPCR tools—covering fluorescence assays, GPCR internalization The episode explores gpcr internalization , fluorescence-based probe design, and how functional assay tools lose impact when distribution and access aren’t planned from the start Why fluorescence-based assays from academic tool development to real-world adoption Balancing innovation with validation in GPCR assay Her work centers on GPCR modulators, synthetic chemistry, and enabling robust biological assays through

David has over 20+ years of experience working in a drug discovery environment mainly in a specialist assay His current interests include the development of HTS fluorescence-based kinetic binding assays specifically

biotech company specializing in fluorescent ligand technologies and real-time, non-radioactive GPCR assays biotech company specializing in fluorescent ligand technologies and real-time, non-radioactive GPCR assays

Khorana’s lab made early key contributions and developed strategies to express, reconstitute and assay He also went on to discover a “counterion switch” in visual pigments and to develop strategies to assay Howard Hughes Medical Institute appointment, Tom advanced a series of novel biochemical and biophysical assay

Curiosity to Collaboration “We decided to evaluate the multiplexing methods... and found this Luminex assay ” – Tom Sakmar After exploring several screening techniques, the lab adopted the Luminex bead-based assay could accelerate discovery of therapeutic targets by combining multiplex data with focused downstream assays focusing on a single receptor, students now gravitate toward platforms , biosensors , and data-rich assays Keyword Cloud GPCR-RAMP interactions , multiplex assays , GPCR research community , Dr.

He also discussed the evolution of the field, from biochemical radioligand binding assays to cell-based functional assays, and the influence of Terry Kenakin and chemical programs on his later work. They discussed strategies for analyzing large compound screening data, emphasizing robust assays and Arthur recounted a 2004 visit to a pharma company using replicates in assays. conversation highlighted the importance of establishing the correct disease context, setting up appropriate assays

Accelerated Program Progression: Design robust assay cascades and establish key go/no-go points to speed Optimization For Contract Research Organizations Elevate Scientific Offerings: Refine and optimize your GPCR assay Define Actionable Objectives Together, we clarify specific, measurable goals, from target validation and assay Accelerated Preclinical Progression I streamline critical operational processes, from advanced assay Small missteps can derail entire programs: underperforming assays, off-track CROs, and data that fails

engagement in intact islets and neuronal circuits — insights that inform next-generation functional assay on biological context Balanced innovation with the need for reproducible, well-controlled functional assays

MRAP2 regulates GHSR1a signaling; this project brought forth our NanoBiT-based arrestin recruitment assay This powerful tool allowed us to create an assay that kinetically measured the arrestin recruitment to I joined the lab, I became proficient in many In-vivo techniques, I adapted my arrestin recruitment assay

Michelle Halls reveals how organized GPCR signaling drives assay innovation and new therapeutic insights

Prioritize assays based on project phase and decision points Map go/no-go logic that guides program momentum they’ll change outcomes No More Strategy Swirl I build structure that sticks—from CRO engagement to assay