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- Dr. Richard Premont | Dr. GPCR Ecosystem
In 1992, he won a Helen Hay Whitney Foundation fellowship to support his post-doctoral work with Robert
- Dr. Richard Premont | Dr. GPCR Ecosystem
In 1992, he won a Helen Hay Whitney Foundation fellowship to support his post-doctoral work with Robert
- Dr. Richard Premont | Dr. GPCR Ecosystem
In 1992, he won a Helen Hay Whitney Foundation fellowship to support his post-doctoral work with Robert
- Dr. Richard Premont | Dr. GPCR Ecosystem
In 1992, he won a Helen Hay Whitney Foundation fellowship to support his post-doctoral work with Robert
- Session IV | Adhesion GPCR Workshop 2024 | Dr. GPCR Ecosystem
ADGRB1-mediated Regulation of Mitochondrial Morphology in Axons Joseph Duman Bai1 Is A Novel Neuronal Substrate Joseph Duman on the web Baylor College of Medicine Kimberley Tolias Lab Bai1 Is A Novel Neuronal Substrate Mihaylov Abstract Only available for AGPCR 24 Attendees Authors & Affiliations "Flynn, Helen R.2, Sampedro-Castaneda , Marisol1, Claxton, Suzanne1, Skehel, Mark2, Ultanir, Sila K.1 1Kinases and Brain Development Laboratory
- Session VIII * | Adhesion GPCR Workshop 2024 | Dr. GPCR Ecosystem
Auger, Helen Strutt, David Strutt" About Tobias Langenhan "1997-2004: Medical school and Dr. med. Additionally, the bacterium Vibrio fischeri also induces mating in S. rosetta cultures, suggesting that Together, our results suggest that Cupidon prevents sexual reproduction in S. rosetta under high nutrient
- Dr. Sudha Shenoy | Dr. GPCR Ecosystem
Sudha Shenoy About Dr. Sudha Shenoy Dr. Sudha Shenoy is currently an Associate Professor in Medicine & Cell Biology in the Division of Cardiovascular Sudha Shenoy on the web Duke University Personal Reflections and Words of Wisdom: Story From Dr. Sudha Shenoy LinkedIn Pubmed Dr. GPCR Ecosystem Enjoying the Dr. GPCR Podcast? Leave a Review.
- 10 GPCR pharmacology lessons. Zero fluff. Launching July 1, Terry’s Corner gives you the clarity and confidence to make better decisions—starting with: • The role of pharmacology in discovery strategy • Black & Leff’s operational model—finally made practical • Binding curves, orthosteric vs allosteric function, and real vs apparent affinity • Molecular dynamics and how they guide ligand design • Why Terry built this—and how it sharpens your next move 📅 Learn anytime. New course every week. 📬 Subscribe to The Kenakin Brief → https://www.terrykenakin.com #GPCRscience #drugdiscovery #TerrysCorner #GPCRpharmacology #ligandbinding | Dr. GPCR Ecosystem
. 📬 Subscribe to The Kenakin Brief → https://www.terrykenakin.com #GPCRscience #drugdiscovery #TerrysCorner New course every week. 📬 Subscribe to The Kenakin Brief → https://www.terrykenakin.com #GPCRscience
- 🚀 Science and finance aren't opposites—they’re partners. In this Ep.165 of the Dr.GPCR Podcast, Joe St. Germain & Chuck DeWeese reveal what it really takes to build sustainable startups and nonprofits behind the scenes. Grant accounting, character-first hiring, mission-driven growth—it’s all here! 🎧 Listen now: Ep 165 with Chuck DeWeese & Joe St. Germain #gpcr #DrGPCR #ScienceStartup | Dr. GPCR Ecosystem
Germain & Chuck DeWeese reveal what it really takes to build sustainable startups and nonprofits behind Germain & Chuck DeWeese reveal what it really takes to build sustainable startups and nonprofits behind
- Game-changer for GPCR research! 🔬🧪 Molecular glues offer a new way to fine-tune receptor signaling, opening doors for next-gen drug discovery Subscribe to the Dr. GPCR Newsletter 📰 and get the latest GPCR News delivered to your inbox ➡️https://www.ecosystem.drgpcr.com/reviews/molecular-glues%3A-a-new-approach-to-modulating-gpcr-signaling-bias #gpcr #drgpcr | Dr. GPCR Ecosystem
Molecular glues offer a new way to fine-tune receptor signaling, opening doors for next-gen drug discovery Subscribe Molecular glues offer a new way to fine-tune receptor signaling, opening doors for next-gen drug discovery Subscribe
- GPCRs regulate key biological processes, but how exactly do inhibitory Gαi proteins control signal transduction beyond adenylyl cyclase suppression? New research sheds light on these pathways! ✨ Want to learn more? Did you know that we work hard to bring you the most recent GPCR News, weekly? Catch up today in the Ecosystem using your free site membership! | Dr. GPCR Ecosystem
processes, but how exactly do inhibitory Gαi proteins control signal transduction beyond adenylyl cyclase suppression processes, but how exactly do inhibitory Gαi proteins control signal transduction beyond adenylyl cyclase suppression
- Class B GPCR drugs are reshaping treatment for migraine, diabetes, and obesity- but did you know ligand bias plays a key role in their success? This new review explores how tweaking peptide drugs can boost efficacy, reduce side effects, and unlock next-gen therapies. Subscribe to the Dr. GPCR Newsletter 📰 and get the latest GPCR News delivered to your inbox ➡️https://www.ecosystem.drgpcr.com/reviews/where-are-we-now%3F-biased-signalling-of-class-b-g-protein-coupled-receptor-targeted-therapeutics #gpcr#drgpcr | Dr. GPCR Ecosystem
treatment for migraine, diabetes, and obesity- but did you know ligand bias plays a key role in their success Subscribe to the Dr. treatment for migraine, diabetes, and obesity- but did you know ligand bias plays a key role in their success Subscribe to the Dr.
- Did you know? 🌟 Researchers have developed reversibly photoswitchable allosteric modulators for Class A GPCRs! 🧬💡 These innovative compounds, “Photo-BQCisA” and “Photo-BQCtrAns,” offer subtype-selective precision by combining allosteric modulation with light control, paving the way for new therapeutic strategies targeting muscarinic receptors (M1-M5). 🔬✨ Learn more about this breakthrough in the Ecosystem! | Dr. GPCR Ecosystem
🧬💡 These innovative compounds, “Photo-BQCisA” and “Photo-BQCtrAns,” offer subtype-selective precision “Photo-BQCtrAns,” offer subtype-selective precision by combining allosteric modulation with light control
- How do GRK-specific phosphorylation barcodes influence β-arrestin binding to GPCRs? New cryo-EM structures from Chen et al. (Nature, 2025) reveal that β-arrestin1 and β-arrestin2 form distinct complexes with ACKR3 depending on whether it's phosphorylated by GRK2 or GRK5, shaping arrestin conformation, complex stability, and engagement mode. Surprisingly, arrestin’s finger loop didn’t dive into the receptor core. Instead, it latched onto the micelle surface, breaking canonical expectations. Also, β-arrestin2 lacks a membrane anchor, making it more dynamic — a potential clue to its functional specialization. These findings underscore how barcode location + arrestin isoform = unique signaling outcomes. open book Read the full study: Inside Out: Mapping GPCRs from Membrane Codes to Market Moves #GPCRs #Arrestin #ACKR3 #GRKs #CryoEM #StructuralBiology #SignalingBias #Phosphorylation #DrGPCR | Dr. GPCR Ecosystem
Surprisingly, arrestin’s finger loop didn’t dive into the receptor core. Instead, it latched onto the micelle surface, breaking canonical expectations. Surprisingly, arrestin’s finger loop didn’t dive into the receptor core. Instead, it latched onto the micelle surface, breaking canonical expectations.
- How does a superagonist activate M2 muscarinic receptors? New simulations reveal the conformational changes from inactive to active states to highlighting how ligand dynamics drive GPCR activation! Catch the full story in the Ecosystem! https://www.ecosystem.drgpcr.com/structural-and-molecular-insights-into-gpcr-function/visualizing-agonist-induced-m2-receptor-activation-regulated-by-aromatic-ring-dynamics #GPCR #drGPCR #M2R #drugdiscovery #moleculardynamics | Dr. GPCR Ecosystem
Home → Flash News → How does a superagonist activate M2 muscarinic receptors? #drugdiscovery #moleculardynamics Published on March 31, 2025 Category GPCR Weekly News How does a superagonist
- 🔍 Running a GPCR lab? Applying for grants? Launching a nonprofit? Ep.165 of the Dr.GPCR Podcast is your finance + operations crash course—delivered by two experts who support early-stage mission-driven teams like Dr. GPCR. 🎧 Smart, practical, and full of real talk: Ep 165 with Chuck DeWeese & Joe St. Germain #gpcr #DrGPCR #ScienceStartup | Dr. GPCR Ecosystem
Ep.165 of the Dr.GPCR Podcast is your finance + operations crash course—delivered by two experts who support Ep.165 of the Dr.GPCR Podcast is your finance + operations crash course—delivered by two experts who support
- A high-resolution deep mutational scan of MC4R reveals how thousands of genetic variants impact obesity-linked signaling pathways and highlights new opportunities for precision drug discovery Subscribe to the Dr. GPCR Newsletter 📰 and get the latest GPCR News delivered to your inbox ➡️ https://www.ecosystem.drgpcr.com/receptor-activation-and-signaling/high-resolution-deep-mutational-scanning-of-the-melanocortin-4-receptor-enables-target-characterization-for-drug-discovery #gpcr#drgpcr | Dr. GPCR Ecosystem
impact obesity-linked signaling pathways and highlights new opportunities for precision drug discovery Subscribe impact obesity-linked signaling pathways and highlights new opportunities for precision drug discovery Subscribe
- Subscribe to the Dr. GPCR Newsletter 📰 and get the latest GPCR News delivered to your inbox Unlocking the activation process of PTH1R: New computational insights into its molecular interactions bring us closer to better osteoporosis treatments! ➡️https://www.ecosystem.drgpcr.com/receptor-activation-and-signaling/key-interaction-changes-determine-the-activation-process-of-human-parathyroid-hormone-type-1-receptor #gpcr #drgpcr | Dr. GPCR Ecosystem
Home → Flash News → Subscribe to the Dr. key-interaction-changes-determine-the-activation-process-of-human-parathyroid-hormone-type-1-receptor #gpcr #drgpcr Published on February 6, 2025 Category GPCR Weekly News Subscribe
- Dr. Sudarshan Rajagopal | Dr. GPCR Ecosystem
Sudarshan Rajagopal About Dr. Sudarshan Rajagopal Dr. Sudarshan Rajagopal obtained his B.S. in Chemistry from The University of Chicago in 1998. He subsequently enrolled in the Medical Scientist Training Program at The University of Chicago. Sudarshan Rajagopal on the web LinkedIn Website Google Scholar LinkedIn Dr.
- What if you could map GPCR-RAMP interactions across the entire superfamily in a single experiment? That’s precisely what Dr. Kotliar from the Sakmar lab made possible! In Ep.167 of the Dr. GPCR Podcast, we chat with Drs. Tom Sakmar and Ilana Kotliar about how their lab developed: A multiplexed Luminex assay to screen hundreds of interactions at once A 220-clone DUET-tagged GPCR library, available on Addgene An online interface to search GPCR-RAMP data and antibody validations This is open-access science at its best, built for the GPCR research community. ✳️ Listen to the episode: Ep 167 with Drs. Tom Sakmar & Ilana Kotliar #GPCRresearch #DrGPCRecosystem #GPCRdrugdiscovery #GPCRtrainingprogram #GPCRpodcast | Dr. GPCR Ecosystem
Home → Flash News → What if you could map GPCR-RAMP interactions across the entire superfamily in a single GPCR Podcast What if you could map GPCR-RAMP interactions across the entire superfamily in a single experiment
- Distinct sub-cellular signal propagation as a component of functional selectivity
Program Registration Logo Contest Committee Sponsors GPCR Retreat Program < Back to schedule Distinct sub-cellular He has supervised the research work of 75 graduate students and 40 post-doctoral fellows.
- A new study from the Hudson Lab at the University of Glasgow shows that the FFA receptor antagonist AH7614 is actually an inverse agonist - suppressing fat cell formation, boosting lipolysis and reducing glucose uptake. Explore how targeting FFA4 could help fight metabolic disorders. Catch up with the latest research conducted in the Hudson lab in Ep. 161 of the Dr. GPCR Podcast. Subscribe to the Dr. GPCR Newsletter 📰 and get the latest GPCR News delivered to your inbox ➡️https://www.ecosystem.drgpcr.com/gpcrs-in-cardiology-endocrinology-and-taste/inverse-agonism-of-the-ffa4-free-fatty-acid-receptor-controls-both-adipogenesis-and-mature-adipocyte-function #GPCR #drGPCR #FFA4 #metabolism #adipocytes” | Dr. GPCR Ecosystem
University of Glasgow shows that the FFA receptor antagonist AH7614 is actually an inverse agonist - suppressing Subscribe to the Dr. University of Glasgow shows that the FFA receptor antagonist AH7614 is actually an inverse agonist - suppressing Subscribe to the Dr.
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- Partners Submition Form | Dr. GPCR Ecosystem
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- Dr. GPCR Summit 2022 | Dr. GPCR Ecosystem
GPCR Summit 2022 Dr. GPCR Summit This year the Summit will be held between October 10th and 16th. GPCR Summit Dr. GPCR Summit 2022 Dr. GPCR Summit 2022 Schedule Dr. GPCR Summit 2022 Details Dr. GPCR Summit 2022 Submit Live Talk Presentation for Dr. GPCR Summit 2022 Submit Poster Presentation for Dr. GPCR Summit 2022
- Dr. GPCR Podcast Audience-Survey | Dr. GPCR Ecosystem
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- Did you know allosteric modulators can change the GPCR G protein subtype selectivity? Have a look at this study to dive deep into its molecular mechanism. Subscribe to the Dr. GPCR Newsletter 📰 and get the latest GPCR News delivered to your inbox. | Dr. GPCR Ecosystem
Home → Flash News → Did you know allosteric modulators can change the GPCR G protein subtype selectivity Subscribe to the Dr. GPCR Newsletter 📰 and get the latest GPCR News delivered to your inbox. 12, 2024 Category GPCR Weekly News Did you know allosteric modulators can change the GPCR G protein subtype Subscribe to the Dr. www.ecosystem.drgpcr.com/gpcr-binders-drugs-and-more/design-of-allosteric-modulators-that-change-gpcr-g-protein-subtype-selectivity
