O., Ploegh, H. L., & Garcia, K. C. (2015). Structural biology.

What if the static models we've relied on for decades have been hiding the truth?

occupancy, even post-clearance ✅ Insight into why half-life can be misleading  when volume of distribution hides A drug hiding in fat tissue may stay in the body for days, but if it never reaches the target site, the

Curves that “look fine” may hide non-equilibrated systems. The fix?

 Set ranges, controls, and system sensitivity to surface mechanism—before you lock in a screen that hides

They make uncertainty explicit rather than hiding it behind optimism or additional experiments. ✅ They

Even the familiar saturation experiment hides traps.

. 👉 This kind of failure is hard to detect because it hides behind familiar patterns: Incremental scope