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Results found for "Hidde Ploegh"
- Nanobodies: New Dimensions in GPCR Signaling Research
O., Ploegh, H. L., & Garcia, K. C. (2015). Structural biology.
- Unlock the Hidden Lives of Receptors – Are You Ready?
What if the static models we've relied on for decades have been hiding the truth?
- Target Residence Time: The Hidden Driver of In Vivo Efficacy
occupancy, even post-clearance ✅ Insight into why half-life can be misleading when volume of distribution hides A drug hiding in fat tissue may stay in the body for days, but if it never reaches the target site, the
- The Five Traps of Ignoring Kinetics
Curves that “look fine” may hide non-equilibrated systems. The fix?
- Mechanism vs. Assumption: A Model-First Path to Getting GPCR MoA Right
Set ranges, controls, and system sensitivity to surface mechanism—before you lock in a screen that hides
- The One Reason Why Biotech Startups Fail More Often Than They Should
They make uncertainty explicit rather than hiding it behind optimism or additional experiments. ✅ They
- Orthosteric Binding Experiments: How to Avoid the Most Common Data Pitfalls
Even the familiar saturation experiment hides traps.
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