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Results found for "Hye Jin Kang"
- GPCR News Flash! Top Updates You Can't-Miss! + University CheatSheet is finally available! ❄ Dec 2 - 8, 2024
Structure-guided design of a peripherally restricted chemogenetic system Hye Jin Kang , Brian E Krumm
- Nanobodies: New Dimensions in GPCR Signaling Research
References: Jin, B. K., Odongo, S., Radwanska, M., & Magez, S. (2023).
- Decoding β-Arrestins: from Structure to function
detection, receptor activation initiates conformational changes, exposing an intracellular cavity (Kang Despite multifocal signaling, recent studies indicate that signaling occurs within a 100 nm range from high-resolution protein structures, illuminating side chain orientations and overall conformational states (Kang
- β-arrestin1 and 2 exhibit distinct phosphorylation-dependent conformations when coupling to the...
associate with the active parathyroid hormone 1 receptor (PTH1R) in different complex configurations ("hanging
- Newly launched antibody libraries put hard-to-drug targets within reach
The drugs also target relatively low-hanging fruit: like cytokines or tyrosine kinase receptors.
- Applications of Fluorescent Probes in Confocal Imaging of GPCRs: From Live to Fixed Cells
Jang W, Senarath K, Feinberg G, Lu S, Lambert NA.
- The Five Traps of Ignoring Kinetics
Suddenly, at higher doses, you see an exaggerated ‘bang’ of effect.
- Unlocking the Therapeutic Potential of Previously Undruggable GPCRs
However, the receptors that these medicines target have been described as the ‘low-hanging’ fruit, and There are approximately 800 human GPCRs in the superfamily, controlling a broad range of physiological Orion’s receptor antagonist analogs have demonstrated powerful efficacies across a range of animal models
