Terry Kenakin's career tracks what happened when that picture came apart. He also describes flying back to London to show James Black the lab he had built, and being asked a single be quantified so that the numbers travel between systems rather than describing only the cells they came Kenakin frames probe dependence as the mechanism and biased signaling as the name pharmacology later than expected - 24:55 Chemokine redundancy, CCR7, and why GLP1 is the favorite - 30:10 Dinner with James

University School of Medicine in 1975 and then returned to join Duke’s faculty, where he remained as a James

University School of Medicine in 1975 and then returned to join Duke’s faculty, where he remained as a James

University School of Medicine in 1975 and then returned to join Duke’s faculty, where he remained as a James

the Heinz Lehmann Award from the Canadian College of NeuroPsychopharmacology and the distinguished James

Slosky’s work has been recognized through several travel and research awards, including the William James

The same system yielded the discovery of beta-adrenergic receptor kinase (now GRK2) and the beta-arrestins Lefkowitz is James B. Bob is James B.

through multiple intracellular pathways, and ligands do not necessarily engage those pathways to the same University of Alberta and completed postdoctoral work at University College London in the laboratory of Sir James

The same approach distinguishes what an allosteric modulator does to affinity versus efficacy, including Two assays with different sensitivities can report different behavior for the same molecule. University of Alberta and completed postdoctoral work at University College London in the laboratory of Sir James

Slosky’s work has been recognized through several travel and research awards, including the William James

Pharmacologists and Toxicologists; the British Pharmacological Society’s Gaddum Memorial Award; the IUPHAR Sir James Since 2014, Clarivate Analytics have annually named him a Highly Cited Researcher in ‘Pharmacology & Toxicology’, and in 2021 also named him a Highly Cited Researcher in the additional category of ‘Biology

Pharmacologists and Toxicologists; the British Pharmacological Society’s Gaddum Memorial Award; the IUPHAR Sir James Since 2014, Clarivate Analytics have annually named him a Highly Cited Researcher in ‘Pharmacology & Toxicology’, and in 2021 also named him a Highly Cited Researcher in the additional category of ‘Biology

Pharmacologists and Toxicologists; the British Pharmacological Society’s Gaddum Memorial Award; the IUPHAR Sir James Since 2014, Clarivate Analytics have annually named him a Highly Cited Researcher in ‘Pharmacology & Toxicology’, and in 2021 also named him a Highly Cited Researcher in the additional category of ‘Biology

His team treats opioid signaling as a problem of circuit organization: the same kinases and second messengers He came to this field because a signaling cascade felt like a puzzle he could not stop thinking about Streicher's recurring example: the same molecule promotes opioid antinociception in one context, drives In the spinal cord, the same chaperone acts as a brake on ERK activation. Brian Blagg at Notre Dame on β-and-GRP94-selective compounds has produced proof-of-concept IV data that

was never whether to stay open — it was how to stay open safely, and how to absorb the stress that came reflects that the most significant advances in his career didn't come from confirming a premise — they came The breakthrough came from getting deeper into why." About this episode Dr. J.

. << Back to podcast list Strategic Partner(s) Jane Lamerdin and Gaurav Agrawal: Building GPCR Assays About the Guests Jane Lamerdin is VP of R&D at Eurofins DiscoverX, where she oversees development of The guests frame their work as talking to peers who understand the same pains, not selling a catalog.

In my free time I like to play the guitar, sing and play board games. " Gáspár Pándy-Szekeres on the

In my free time I like to play the guitar, sing and play board games. " Dr.

His numerous awards include: 2008 Sato Award; 2009 Medicinal Chemistry Hall of Fame (American Chemical

my doctoral studies, I joined the lab of Dr Andreas Russ at the Department of Biochemistry and first came

headache, while preclinical evidence points to delta opioid receptor agonism as a candidate to relieve the same Scientific Themes of the Conversation The mu/delta asymmetry in migraine — why two receptors in the same Delta opioid agonists appear to relieve the same symptoms — pain, negative affect, and aura-related signs They're not in the same state as they were if they were naïve. Her career path-defining moment came from a third postdoctoral experience with Dr.

Gutkind's most cited papers came from results that directly contradicted the textbook: βγ subunits (not The 2020 Cell paper on G protein coupling specificity came from a Gordon Conference hallway conversation

What came next was a series of papers reframing severe COVID-19 as a disease of signaling imbalance: Not casual, not opinion-writing; dry-lab pharmacology done with the same seriousness as bench work, just A figure can travel further than the paper it came from.

GPCR drug discovery, the GABA-B heterodimer, the acetate that rewrote a receptor family, and why the same names keep filling GPCR conference agendas. << Back to podcast list Strategic Partner(s) Fiona Marshall Thirty Years, and the Same Names Keep the Mic One of Dr. "Having worked in GPCRs for 30 years and I look at the conferences, the same people are speaking now One of her career path-defining moments came when she visited Dr. Chris Tate and Dr.

outputs when expressed in HEK293 cells versus vascular smooth muscle cells, even when challenged with the same The pattern is consistent: the most important findings came from results that initially looked like mistakes Terry Hebert "The things that they originally came into place for get sampled for many other functions

The answer came from an unexpected source: a paper on thermostabilization of an unrelated membrane protein It came from Tate's habit of spending Friday afternoons in the library reading outside his immediate

Anonymous This came at just the most perfect time.

My name is Anita. I’m currently a senior scientist at a biotech in Toronto, Canada. When it came time to choose my major for undergrad, I wanted something that combined both biology and But when I came across bioinformatics, I thought, “This is it.” It combined both things I liked. Another moment came during my postdoc while working on the ligand bias project.

The same compound may produce a functionally meaningful shift in one cell type and a negligible one in the receptor conformation in that membrane environment, and what other proteins are competing for the same The question that followed was immediate: why hadn't anyone done the same with G-protein C-termini? Gilchrist now teaches - follow the unexpected result, ask why it happened, do not repeat it away - came The years of research that followed came directly from not dismissing it.

Network or Miss Out One powerful shift came when Sokhom leaned into networking—despite being an introvert “What fascinates me is how the same molecule behaves differently depending on one amino acid.”