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23 items found for "Jean Martin Beaulieu"
- Dr. Juan José Fung - Dr. GPCR Podcast
Juan Jose Fung, Principal Scientist, at GPCR Therapeutics.
- Professor Charlotte Deane Joins Exscientia as Chief Scientist of Biologics AI
January 2022 "OXFORD, England--Professor Charlotte Deane, Ph.D., of the University of Oxford, has joined Professor Deane joins Exscientia’s technology leadership team, reporting to Chief Technology Officer, Professor Deane is one of the UK’s most accomplished bioinformaticians. Prior to this, Professor Deane was Deputy Executive Chair of the Engineering and Physical Sciences Research Professor Deane holds a B.A. in Chemistry from the University of Oxford and a Ph.D. in Biochemistry from
- Genome-wide identification of 216 G protein-coupled receptor (GPCR) genes from the marine water ...
Genome-wide identification of 216 G protein-coupled receptor (GPCR) genes from the marine water flea Here, we identified a total 216 full-length GPCR genes in the marine water flea Diaphanosoma celebensis
- Jan Steyaert Named 2022 Jacob and Louise Gabbay Award Winner
.- Jan Steyaert, scientific director of the VIB-VUB Center for Structural Biology, Vlaams Instituut Biotechnologie Jan Steyaert will be presented with the Gabbay Award at Brandeis University on October 27 when he will
- Structural dynamics of Smoothened (SMO) in ciliary membrane and its interaction with membrane lipids
We have carried out MARTINI coarse-grained molecular dynamics simulations of SMO in POPC and in ciliary
- Ode to GPCRs
The 1994 Nobel Prize in Physiology or Medicine was awarded to Alfred Goodman Gilman and Martin Rodbell Martin Rodbell – Facts - NobelPrize.org. https://www.nobelprize.org/prizes/medicine/1994/rodbell/facts Martin Rodbell – Nobel Lecture - NobelPrize.org. https://www.nobelprize.org/prizes/medicine/1994/rodbell
- Chemokine receptor-targeted drug discovery: progress and challenges
In fact, the requirements in terms of safety margin, oral bioavailability, and frequency of administration
- AELIS PHARMA launches their IPO for €25 million
The €25 million fundraising gives us the means to achieve our ambitions: to become a leading player in
- In vivo metabolic effects after acute activation of skeletal muscle G s signaling
Results: Acute stimulation of GsD signaling in SKM impaired glucose tolerance in lean and obese mice Clenbuterol injection improved glucose tolerance by increasing insulin secretion in lean mice.
- Structure of Mycobacterium tuberculosis Cya, an evolutionary ancestor of the mammalian membrane...
acts as a functional component of Cya, guiding the assembly of the catalytic domain and providing the means
- The complicated lives of GPCRs in cardiac fibroblasts
Finally, we explore what such connections between the cell surface and nuclear GPCR signaling might mean
- The regulation of PKA signaling in obesity and in the maintenance of metabolic health
While limited, human studies infer differential regulation of the PKA system in obese compared to lean
- Fluorescent Ligands Targeting Intracellular Allosteric Binding Site of the Chemokine Receptor CCR2
By means of these studies, we developed 14 as a fluorescent CCR2 ligand, enabling cell-free as well as
- Newly launched antibody libraries put hard-to-drug targets within reach
November 2021 "Target class-specific libraries mean you need to screen less to identify high-quality
- Helix 8 in chemotactic receptors of the complement system
By means of molecular dynamics we explained why C5aR2 cannot transduce signal through the G protein pathway
- Comparative studies of AlphaFold, RoseTTAFold and Modeller: a case study involving the use of...
predicted models were then aligned with the experimentally solved structures and evaluated by the root-mean-square
- Neurocrine Biosciences Announces Positive Phase 3 Data for KINECT-HD Study Evaluating Valbenazine...
Unified Huntington's Disease Rating Scale (UHDRS®) Total Maximal Chorea (TMC) Score- Placebo-Adjusted Mean
- 📰 GPCR Weekly News, July 3 to 9, 2023
Methods & Updates in GPCR Research Profiling of basal and ligand-dependent GPCR activities by means of
- Unlocking the Therapeutic Potential of Previously Undruggable GPCRs
to optimize transmembrane domain providing significantly increased binding affinity and providing a means molecules in the library are specific for the target receptor rather than irrelevant cell surface targets, meaning Since shape space exploration is specifically focused on the ‘message’ site in the TM domain, this means This leads to strikingly long in vitro receptor occupancy durations (at least seven days), meaning that
- 📰 GPCR Weekly News, February 5 to 11, 2024
Financial Expectations for 2024 Domain Therapeutics further strengthens leadership team with appointment of Sean
- 📰 GPCR Weekly News, April 15 to 21, 2024
Drug Discovery Nexus Salipro Biotech will participate in BioKorea2024 Domain Therapeutics Appoints Sean
- New role of β-arrestins in MOR signaling
., combatting the opioid overdose epidemic has become a mean challenge for the scientific community. Biochem Biophys Res Commun. 2023 Jan 15;640:64-72. doi: 10.1016/j.bbrc.2022.11.098.
- Structural landscape of the Chemokine Receptor system
viral CKR US28 and “Chemokine Scavenger” ACKR3 Both US28 and ACKR3 are constitutively active receptors, meaning