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Juan Jose Fung, Principal Scientist, at GPCR Therapeutics.

January 2022 "OXFORD, England--Professor Charlotte Deane, Ph.D., of the University of Oxford, has joined Professor Deane joins Exscientia’s technology leadership team, reporting to Chief Technology Officer, Professor Deane is one of the UK’s most accomplished bioinformaticians. Prior to this, Professor Deane was Deputy Executive Chair of the Engineering and Physical Sciences Research Professor Deane holds a B.A. in Chemistry from the University of Oxford and a Ph.D. in Biochemistry from

Genome-wide identification of 216 G protein-coupled receptor (GPCR) genes from the marine water flea Here, we identified a total 216 full-length GPCR genes in the marine water flea Diaphanosoma celebensis

.- Jan Steyaert, scientific director of the VIB-VUB Center for Structural Biology, Vlaams Instituut Biotechnologie Jan Steyaert will be presented with the Gabbay Award at Brandeis University on October 27 when he will

We have carried out MARTINI coarse-grained molecular dynamics simulations of SMO in POPC and in ciliary

The biological validation came from Jean-Philippe Pin’s group at the Genomic Functional Institute in

layered collaborations—with Durham University chemist David Parker on the probe chemistry, and with Jean-Philippe

→ Discovery of pH-sensitive dual response (brightness + lifetime) → Application to GPCR models with Jean-Philippe

Kawthar Belkacemi, Philippe Rondard, Jean-Philippe Pin, and Laurent Prézeau, for their research on Heterodimers

The 1994 Nobel Prize in Physiology or Medicine was awarded to Alfred Goodman Gilman and Martin Rodbell Martin Rodbell – Facts - NobelPrize.org. https://www.nobelprize.org/prizes/medicine/1994/rodbell/facts Martin Rodbell – Nobel Lecture - NobelPrize.org. https://www.nobelprize.org/prizes/medicine/1994/rodbell

This means they can be more selective, avoid pathway saturation, and preserve physiological nuance. For drug discovery teams navigating safety margins, biased signaling, and combination therapy design, This means you can design molecules that potentiate beneficial pathways without shutting down basal signaling Recognizing how your ligand interacts with the receptor lets you predict safety margins, dose–response

How does this translate into a clear safety margin? These aren’t just documentation issues. FDA is actually optimizing for, and where most early-stage teams fall short: 1️⃣ Predictable safety margins This is the principle of strategic reverse engineering . 👉 It means designing your development path This doesn’t mean turning your CEO into a regulatory affairs expert. It means shifting how your leadership team evaluates options. ✅ Every strategic decision, from indication

Values represent the mean ± SEM of triplicate determinations. Values represent the mean ±SEM of triplicate determinations. R.; Martin, B. R.; Abood, M. E. J Pharmacol Exp Ther   1996 , 278 (3), 989–999. (12)      Martín-Fontecha, M.; Angelina, A.; Rückert , B.; Rueda-Zubiaurre, A.; Martín-Cruz, L.; Van De Veen, W.; Akdis, M.; Ortega-Gutiérrez, S.; López-Rodríguez

Elucidation, and Biological Activity of the Selective TACR2 Antagonist Tumonolide and its Aldehyde from a Marine disordered C-terminal domains Industry News Novartis continues to deliver strong sales growth and core margin

In fact, the requirements in terms of safety margin, oral bioavailability, and frequency of administration