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Biosensors for monitoring G protein-coupled receptors (GPCRs), the most drugged class of proteins in

October 2022 Intermolecular Interactions in G Protein-Coupled Receptor Allosteric Sites at the Membrane Simulations and Quantum Chemical Calculations "Allosteric modulators are called promising candidates in G

October 2022 Dual loss of regulator of G protein signaling 2 and 5 exacerbates ventricular myocyte arrhythmias Cardiac contractility, essential to maintaining proper cardiac output and circulation, is regulated by G Previously, the absence of regulator of G protein signaling (RGS) 2 and 5, separately, was shown to cause G protein dysregulation, contributing to modest blood pressure elevation and exaggerated cardiac hypertrophic Whether RGS2 and 5 redundantly control G protein signaling to maintain cardiovascular homeostasis is

G. Aditya Kumar About Dr. G. Aditya Kumar Dr. G.

Alfred G. Gilman, at the University of Texas Southwestern Medical School as a post-doctoral fellow. proteins by G protein-coupled receptors (GPCRs). The Sunahara lab utilizes biochemical, biophysical and pharmacological methodologies to study GPCR-G for agonist-mediated activation of G proteins. changes in G protein structure.

Marc G. Caron at Duke University (1994-1997), where he and his colleagues investigated the role of G protein-coupled receptor kinases and beta-arrestin in regulating G protein-coupled receptor endocytosis, trafficking His research career has focused on the investigation of the regulation of G protein-coupled receptors