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Each of these receptors activates G protein-coupled inwardly rectifying potassium (GIRK) channels. have shown that co-activation using saturating concentrations of agonists results in occlusion of the GIRK The results indicate that a low tonic level of G βγ results in facilitation of GIRK current and a high The results suggest that the cooperative interaction between G βγ subunits and GIRK channels determines Activation of either D2 or GABAB receptors also acutely desensitized the GIRK channel current induced

We kick off with a question that cuts deep: What if your models could actually predict the future?

Ligands come and go, feedback loops kick in, and what you see in vitro rarely tells the whole story.

Kirk Druey at NIAID/NIH, where I characterized the role of RGS4 and RGS5 in airway hyperresponsiveness

The Power of Inclusion in the GPCR Field This episode kicks off with a celebration of early-career scientists

🎓 Kicking Off Today: Dr.