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inter-subunit latch to an unexpected discovery of phospholipids inside the transmembrane bundle, and what class C drug design. << Back to podcast list Strategic Partner(s) Qing Fan: Inside the Architecture of Class C GPCRs Class C GPCRs are structural and mechanistic outliers within the GPCR superfamily. which bind orthosteric ligands within their transmembrane domain and can function as monomers, class C SCIENTIFIC THEMES OF THE CONVERSATION The structural architecture that sets class C GPCRs apart from

David Sibley (1988) Memories our panelists shared with us https://video.wixstatic.com/video/93ce84_92e3a06139244357b0823e3ecc294e27

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intracellular calcium mobilization: Cell type-dependent involvement of Gi, Gq, Gs proteins and protein kinase C intracellular calcium mobilization: Cell type-dependent involvement of Gi, Gq, Gs proteins and protein kinase C Adipocytes Derivation of hiPSC line (ICADRB2i007-A-3) from an individual with osteoporosis linked to ADRB2: c.46G

two GPCR-focused biotechs with Heidi Hamm - CUE Biotech and Caden Biosciences - developing G-protein C-terminal missing experiment While a postdoc in Heidi Hamm's lab, Gilchrist read a paper describing how BARK C-terminal The question that followed was immediate: why hadn't anyone done the same with G-protein C-termini? Prize 12:39 Co-founding CUE Biotech and Caden Biosciences - allosteric modulator screens and G-protein C-terminal

described the molecular mechanisms of MRAP2 regulation of the GHSR1a, and where I notably developed the C-terminal This theory states that the post-translational modification of GHSR1a’ C-terminal tail is not a docking

Josh C Snyder (2012) Dr.

molecular mechanisms involved in the opposite regulation of dopamine D1 and D5 receptors by protein kinase C. As part of Bouvier’s team, Bianca used Bioluminescence Resonance Energy Transfer (BRET)-based technology

A. cAMP dose–response; B. β-arrestin recruitment showing ligand bias; and C.

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bulls Derivation of hiPSC line (ICADRB2i007-A-3) from an individual with osteoporosis linked to ADRB2: c.46G

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I started learning C and C++ programming and I really loved it.

The answer lies somewhere in the diversity of receptor architectures — long C-termini versus long ICL3s "Initially we thought — I personally thought — that this is not what we want.

This conversation covers the arc of that career: the personal loss that drew Bouvier toward the sympathetic His lab's contributions include the development of BRET (Bioluminescence Resonance Energy Transfer) technology How the tools available define the questions a lab can ask - and the questions that have to wait The personal body of work that spans adrenergic receptors, chemokine receptors, vasopressin receptors, and class C including inverse agonism, biased signaling, and pharmacological chaperones, his work on bioluminescence resonance