December 2021 Crinetics Pharmaceuticals announced the formation of an independently operated new company, Radionetics Radionetics aims to develop a deep pipeline of novel, targeted, nonpeptide radiopharmaceuticals for the Crinetics’ Core Nonpeptide Platform and Includes Drug Candidates and Leads Against 10 Oncology Targets – Radionetics Frazier Healthcare Partners, today announced the formation of an independently operated new company, Radionetics Radionetics aims to develop a deep pipeline of novel, targeted, nonpeptide radiopharmaceuticals for the

heart failure drug following reverse merger with Avrobio Lilly signs $140M upfront partnership with Radionetics

Radioactive and cumbersome. The gold standard was still radioactive tracers and purification columns. They benchmarked it against the radioactive gold standards—and it held up.

They are ligands labeled with radioactive isotopes which can be used in binding assays to quantify other Another common radioactive atom, 125I, with a higher specific activity, but a shorter half-life (60 days

Learn how these tools help retain assay integrity while eliminating radioactivity—perfect for next-gen

high-quality, fluorescently labeled ligands and innovative chemical biology tools to support real-time, non-radioactive

With nanomolar affinity, high specificity, and a strong signal-to-noise profile, this non-radioactive

that moment came when they watched GPCRs internalize in native beta cells—without engineered tags, radioactive Safety:  a non-radioactive alternative, sidestepping regulatory hurdles.

Just her, radioactive ligands, and steady hands.

No matter how much non-radioactive ligand you add, the binding curve levels off —because the receptor

They achieved this without complex imaging or radioactive materials.

began with an unmet need: how to track Gq-coupled GPCR activity without the mess of calcium flux or radioactive

binding assays or calcium flux measurements have significant drawbacks in this context: one is limited by radioactivity-related

Avoid safety concerns and regulatory hurdles: Non-radioactive alternative to screening In the context

You add a non-radioactive analog of a ligand, expecting it to displace binding.

Non-Radioactive Workflow By removing isotopes, researchers gain safer, more scalable, and more environmentally

The most used probe right now is the radioactive CP-55940, [3H-CP-55940].[11] Figure 1.