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- Crinetics Pharmaceuticals announced the formation of an independently operated new company...
December 2021 Crinetics Pharmaceuticals announced the formation of an independently operated new company, Radionetics Radionetics aims to develop a deep pipeline of novel, targeted, nonpeptide radiopharmaceuticals for the Crinetics’ Core Nonpeptide Platform and Includes Drug Candidates and Leads Against 10 Oncology Targets – Radionetics Frazier Healthcare Partners, today announced the formation of an independently operated new company, Radionetics Radionetics aims to develop a deep pipeline of novel, targeted, nonpeptide radiopharmaceuticals for the
- 📰 GPCR Weekly News, June 24 to 30, 2024
heart failure drug following reverse merger with Avrobio Lilly signs $140M upfront partnership with Radionetics
- The Truth About GPCR Product Launches: Years in the Making
Radioactive and cumbersome. The gold standard was still radioactive tracers and purification columns. They benchmarked it against the radioactive gold standards—and it held up.
- Radioligands vs. Fluorescent Ligands: Binding Assays
They are ligands labeled with radioactive isotopes which can be used in binding assays to quantify other Another common radioactive atom, 125I, with a higher specific activity, but a shorter half-life (60 days
- Signals in Motion: Pain, Metabolism & Terry’s Corner
Learn how these tools help retain assay integrity while eliminating radioactivity—perfect for next-gen
- Dr. GPCR and Celtarys Research Join Forces to Expand Access to Innovative GPCR Tools
high-quality, fluorescently labeled ligands and innovative chemical biology tools to support real-time, non-radioactive
- Pharmacology at Your Fingertips: Terry’s Corner Launches
With nanomolar affinity, high specificity, and a strong signal-to-noise profile, this non-radioactive
- Orthosteric vs Allosteric Interactions— and the pHSense Shift in Internalization
that moment came when they watched GPCRs internalize in native beta cells—without engineered tags, radioactive Safety: a non-radioactive alternative, sidestepping regulatory hurdles.
- From Pipettes to Platforms: The Evolution of GPCR Research
Just her, radioactive ligands, and steady hands.
- Why “Displacement” Misleads You: Allosteric Binding Demystified
No matter how much non-radioactive ligand you add, the binding curve levels off —because the receptor
- Innovative Data-Driven Solutions: The pHSense Revolution
They achieved this without complex imaging or radioactive materials.
- How Breakthroughs Happen: Eric Trinquet on Innovation, Serendipity & GPCRs
began with an unmet need: how to track Gq-coupled GPCR activity without the mess of calcium flux or radioactive
- Optimizing HTRF Assays with Fluorescent Ligands: Time-Resolved Fluorescence in GPCR Research
binding assays or calcium flux measurements have significant drawbacks in this context: one is limited by radioactivity-related
- Targeting GPCRs in the CNS: Advances in Drug Discovery Strategies
Avoid safety concerns and regulatory hurdles: Non-radioactive alternative to screening In the context
- From Snapshots to Predictions: Why Mechanism of Action Matters
You add a non-radioactive analog of a ligand, expecting it to displace binding.
- High-Content Screening for GPCR Programs: Overcoming Assay Limitations with Fluorescent Ligands
Non-Radioactive Workflow By removing isotopes, researchers gain safer, more scalable, and more environmentally
- A robust and Efficient FRET-Based Assay for Cannabinoid Receptor Ligands Discovery.
The most used probe right now is the radioactive CP-55940, [3H-CP-55940].[11] Figure 1.
