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This week's highlight includes congrats to: Remi Janicot, and Dr.

🎇 This Week’s Highlights: Congrats to: Remi Janicot , and Mikel Garcia-Marcos for their excellent

Georgios Skiniotis, et al. for their research on Time-resolved cryo-EM of G-protein activation by a GPCR Remi Janicot, Alex Luebbers, Mikel Garcia-Marcos, et al. for their work on Direct interrogation of context-dependent

Janicot, R., et al., Direct interrogation of context-dependent GPCR activity with a universal biosensor

What if the static models we've relied on for decades have been hiding the truth?

You’ll learn why calcium signals are inherently transient—giving rise to a “hemi-equilibrium” window

or treatment research based on GPCR targets Beyond Classic ELISAs Traditional autoantibody testing relies

The first trap in drug discovery is relying on visual inspection. Scatter can masquerade as signal. Instead of relying on debate—or worse, intuition—you can calculate an F-value that objectively shows

to confirm equilibrium the right way, detect time-dependent occupancy and complex activity, leverage hemi-equilibrium Protect your screening funnel:  Use hemi-equilibrium readouts to flag artifacts before they inflate your

Get a preview of Terry’s teaching style and see why drug hunters worldwide rely on his frameworks. Here, you’ll get: Weekly lectures  that sharpen the exact tools you rely on in discovery.

regulates β-arrestin recruitment  across glucagon family receptors, revealing that GLP-1R and GIPR rely

The reported ACKR1 expression by macrophages in Hur et al. relied on using commercial anti-ACKR1 antibody

Homology modeling relies on using the known structure of a homologous protein as a template to model

amino acid identity, and identical posttranslational farnesylation of their Gγ subunits, rods and cones rely

Yet most discovery teams still rely on classic affinity metrics alone, often overlooking how kinetic

With Premium, you move faster, smarter, and more confidently than peers relying on scattered signals.

Traditional radioligand protocols rely on filtration assay or on scintillation proximity technologies

The stakes are too high to rely on assumptions.

GPCR Allosteric Thinking Changes the Game in Drug Discovery For decades, drug discovery pipelines have relied

From Bench to Breakthrough: Why pHSense Matters Decades of GPCR research have relied heavily on engineered

Premium Members rely on this intelligence weekly—and here’s your curated preview.

Avoid wasted resources:  Stop relying on “n=3” by default.

Welcome back GPCR fans, If your drug discovery strategy still relies on static GPCR models, you’re already

cAMP assay, Trinquet’s team took a risky bet: develop a functional readout for Gq signaling without relying

The Hemi-Equilibrium Problem Calcium assays look simple.

The company’s scientific approach relied on targeting GPCRs — specifically opioid receptors — using biased

The future According to the authors, the future of AI relies in 6 main areas: 1. Greater application of unsupervised machine learning: most applications of ML in GPCR drug discovery have relied

Yet too many programs rely solely on affinity metrics—Kd—as proxies for in vivo behavior, missing a critical

Determining Mechanism of Action: Your Edge If you’re still relying on descriptive observations—“looks

From Bench Frustrations to Breakthrough Design For decades, GPCR trafficking research relied on overexpression