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This week's highlight includes congrats to: Remi Janicot, and Dr.

🎇 This Week’s Highlights: Congrats to: Remi Janicot , and Mikel Garcia-Marcos for their excellent

Georgios Skiniotis, et al. for their research on Time-resolved cryo-EM of G-protein activation by a GPCR Remi Janicot, Alex Luebbers, Mikel Garcia-Marcos, et al. for their work on Direct interrogation of context-dependent

Janicot, R., et al., Direct interrogation of context-dependent GPCR activity with a universal biosensor

What if the static models we've relied on for decades have been hiding the truth?

You’ll learn why calcium signals are inherently transient—giving rise to a “hemi-equilibrium” window

or treatment research based on GPCR targets Beyond Classic ELISAs Traditional autoantibody testing relies

regulates β-arrestin recruitment  across glucagon family receptors, revealing that GLP-1R and GIPR rely

The reported ACKR1 expression by macrophages in Hur et al. relied on using commercial anti-ACKR1 antibody

Homology modeling relies on using the known structure of a homologous protein as a template to model

amino acid identity, and identical posttranslational farnesylation of their Gγ subunits, rods and cones rely

Yet most discovery teams still rely on classic affinity metrics alone, often overlooking how kinetic

The stakes are too high to rely on assumptions.

GPCR Allosteric Thinking Changes the Game in Drug Discovery For decades, drug discovery pipelines have relied

Traditional radioligand protocols rely on filtration assay or on scintillation proximity technologies

Welcome back GPCR fans, If your drug discovery strategy still relies on static GPCR models, you’re already

The future According to the authors, the future of AI relies in 6 main areas: 1. Greater application of unsupervised machine learning: most applications of ML in GPCR drug discovery have relied

Yet too many programs rely solely on affinity metrics—Kd—as proxies for in vivo behavior, missing a critical

the plasma membrane, enabling it to independently reach clathrin-coated pits (CCPs) without solely relying

note that this scavenging role does not occur in all chemokine receptor systems such as CXCR4, which relies

Thus, in order to complete the studies, quantitative live cell microscopy assay relies on cell segmentation

Bioassays for interrogating GPCR structure and function typically rely on protein tags or modifications