This week's highlight includes congrats to: Remi Janicot, and Dr.

🎇 This Week’s Highlights: Congrats to: Remi Janicot , and Mikel Garcia-Marcos for their excellent

Georgios Skiniotis, et al. for their research on Time-resolved cryo-EM of G-protein activation by a GPCR Remi Janicot, Alex Luebbers, Mikel Garcia-Marcos, et al. for their work on Direct interrogation of context-dependent

Janicot, R., et al., Direct interrogation of context-dependent GPCR activity with a universal biosensor

What if the static models we've relied on for decades have been hiding the truth?

You’ll learn why calcium signals are inherently transient—giving rise to a “hemi-equilibrium” window

or treatment research based on GPCR targets Beyond Classic ELISAs Traditional autoantibody testing relies

The first trap in drug discovery is relying on visual inspection. Scatter can masquerade as signal. Instead of relying on debate—or worse, intuition—you can calculate an F-value that objectively shows

Insights into applying it to partial, inverse, and hemi-equilibrium systems. Inverse Agonists and Hemi-Equilibria In systems with constitutive receptor activity , inverse agonists

to confirm equilibrium the right way, detect time-dependent occupancy and complex activity, leverage hemi-equilibrium Protect your screening funnel:  Use hemi-equilibrium readouts to flag artifacts before they inflate your

For receptor assays and the biological interpretation of ligands, he relies on a network of collaborators Experimentalists often hesitate to rely on computational predictions, especially when burned in the past

Get a preview of Terry’s teaching style and see why drug hunters worldwide rely on his frameworks. Here, you’ll get: Weekly lectures  that sharpen the exact tools you rely on in discovery.

regulates β-arrestin recruitment  across glucagon family receptors, revealing that GLP-1R and GIPR rely

you think you measured Understanding Orthosteric Binding Foundations Orthosteric binding experiments rely Earlier decades relied on Scatchard, Hanes, and other linear transforms to “clean” nonlinear data.

While early stages of a project often rely on virtual screening from commercial compound libraries, the Until better datasets emerge, predictive modeling will continue to rely on creative integration of computational

For decades, GPCR localization relied on: Antibodies of inconsistent specificity Fixed tissue sections

Homology modeling relies on using the known structure of a homologous protein as a template to model

The reported ACKR1 expression by macrophages in Hur et al. relied on using commercial anti-ACKR1 antibody

It is a quietly common story wherever people rely on GPCR antibodies, and it is where our conversation

Yet most discovery teams still rely on classic affinity metrics alone, often overlooking how kinetic

amino acid identity, and identical posttranslational farnesylation of their Gγ subunits, rods and cones rely

With Premium, you move faster, smarter, and more confidently than peers relying on scattered signals.

Traditional radioligand protocols rely on filtration assay or on scintillation proximity technologies

The stakes are too high to rely on assumptions.

GPCR Allosteric Thinking Changes the Game in Drug Discovery For decades, drug discovery pipelines have relied

Researchers, pharmacologists, biotech teams, and decision-makers who rely on accurate, efficient, interpretation-first

From Bench to Breakthrough: Why pHSense Matters Decades of GPCR research have relied heavily on engineered

Premium Members rely on this intelligence weekly—and here’s your curated preview.

Avoid wasted resources:  Stop relying on “n=3” by default.

Welcome back GPCR fans, If your drug discovery strategy still relies on static GPCR models, you’re already