Shane Wright, Michel Bouvier, et al., for their work on Conformation- and activation-based BRET sensors

GPCR Calcium Assay Cell Models from Eurofins DiscoverX® Selecting the right cell model can be just as

Maria Majellaro’s story, shared in Episode 168 of the Dr.

Jens Carlsson shares how GPCR modeling is moving from explanation to real prediction in drug discovery Yamina Berchiche to share his unconventional journey from aspiring engineer to GPCR modeler. From virtual screening of billions of molecules to leveraging AlphaFold for structure prediction, Jens shares his team uses structure-based modeling to identify novel GPCR ligands The value of failure—and how it shaped Why collaborations between modelers and experimentalists are more vital than ever How AlphaFold is shaking

Keeping GLP1 receptors at the membrane can shape the therapeutic profile Building on work from Stephen In diet induced obese mice, the lead matched semaglutide weight loss with less frequent dosing, and no :26 The cAMP hypothesis that resurrected the program - 37:42 Biased GLP1 agonists, trafficking, and weight Martin Marro "It was inevitable to ask myself whether I had made the right decision.

: Building a Lab That Doesn't Shut Down Conversations that happen when a research community faces a shared That dual lineage — extramural academic and intramural NIH — shapes how he thinks about research infrastructure A small language correction with structural weight. Dr. pandemic, not further apart — the physical space contracted, but the community expanded through Zoom, shared The discipline is not in being right, but in being willing to let go of the framework you built when