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.- Jan Steyaert, scientific director of the VIB-VUB Center for Structural Biology, Vlaams Instituut Biotechnologie Jan Steyaert will be presented with the Gabbay Award at Brandeis University on October 27 when he will

🤗 Hi GPCR Friends, Get ready because we’re thrilled to remind you about Dr.  Terry Kenakin's  upcoming  1-day workshop  on The Practical Assessment of Signaling Bias ! Have you heard about our incredible Affiliate Program ? Dive into the details and earn some extra money! And this might be the last time (or maybe not) that we eagerly ask you to fill out this DrGPCR Survey pleeease pleeease pleeease! Last but not yeast , if you're part of our  Premium Community , you can start snooping through the GPCR News of the Week and stay ahead of the game! 📡 The Practical Assessment of Signaling Bias Feb 20, 2025 | 10:00 AM – 12:00 PM EST Online | Advanced 1-Day Workshop Dive deep into GPCR ligand signaling bias  with an engaging, expert-led session designed for academia and industry professionals. What You’ll Gain: ✔️ Comprehensive understanding of bias in pharmacology ✔️ Hands-on techniques for measuring and quantifying bias ✔️ Insight into real-world applications Topics Include: 📍 What is Bias? 📍 Origins & Implications of Bias 📍 Practical methods for assessing signaling Premium Members, secure your Early Bird Discounts now! Signing up for our courses is now easy and open to all! 🤝💰 Join the Dr. GPCR Affiliate Program and Earn Extra Cash! 🎉 Be a GPCR Ambassador! Share your passion for GPCR science and earn $50 for every qualified Premium Membership referral. 💼 Why Join? Help grow the GPCR community. Share your unique expertise. Promote cutting-edge tools and resources. 💡 It's Simple! Sign up for free. Get your personalized affiliate link. Share it with your network. Earn commissions for every qualifying sale! 🌍 Open to GPCR professionals worldwide! ❓ Dr. GPCR: Yay or Nay? Spill the beans! Your feedback helps us grow—Plus! We want to tell people what our Community thinks of us :) Stop Missing on GPCR Fun - Become a Premium Member! Dr. GPCR University On-Demand Full GPCR Weekly News  and Articles Full GPCR Events and Job Listings 🔎 GPCR PAPER KEYWORDS A(2A)R ,  GPCR ,  Molecular dynamics ,  Oligomerization ,  mGlu(5)R , Biased agonist ,  Functionally-selective ,  KOR ,  Kappa opioid receptor ,  Multiple sclerosis ,  Remyelination , Biased agonism ,  Biased ligand drugs ,  Biased signaling ,  Purinergic receptors , Cancer ,  Expression ,  Function , Resonance energy transfer ,  RET ,  Drug discovery ,  Protein-protein interactions , Biosensor Classified GPCR News  Let’s dive into the   Classified GPCR News from January 20th to 26th, 2025 Industry News Andrew Ratz, Ph.D., Joins Neurocrine Biosciences as Senior Vice President of Drug Development, Delivery and Device Research could lead to better medicines and new tools in synthetic biology AI, data, and the acceleration of drug discovery Computational tool designs proteins with water-mediated interactions in mind GPCR Events, Meetings, and Webinars February 8 - 9, 2025 | The Chemistry and Medicine of Nitric Oxide and Sulfur Species February 9 - 14, 2025 | Nitric Oxide and Sulfide in Redox Signaling and Medicine February 15 - 16, 2025 |GRS Molecular Pharmacology : Structural and Functional Approaches in GPCR Drug Discovery February 16 - 21, 2025 | GRC Molecular Pharmacology: Harnessing the Power of Advanced Multimodal Approaches to GPCR Drug Discovery February 15 - 19, 2025 | BPS 2025 March 19, 2025 | Advancing obesity drug discovery: Cell-based assays for GLP-1 and the G-Suite April 3 - 6, 2025 | ASPET 2025 April 24 - 27, 2025 | American Physiology Summit 2025 April 25 - 30, 2025 | AACR Annual Meeting 2025 May 12 - 15, 2025 | PEGS 2025 May 15 - 17, 2025 | 23rd GPCR Retreat 2025 May 20 - 22, 2025 | SLAS Europe 2025 June 22 - 26, 2025 | G Protein-coupled Receptor Kinases and Arrestins July 12 - 17, 2026 | 20th World Congress of Basic and Clinical Pharmacology GPCR Jobs NEW Associate Director/Director, Platform & Hit-ID Chemistry Lead Junior associate position and a PhD/post-doc level position Postdoctoral Position And PhD Position GPCR Molecular Pharmacologist Scientist - Biology Scientist I Cell Biology - Tectonic Therapeutic Senior Principal Scientist, Medicinal Chemistry PhD fellowship in GPCR mechanosensing Senior Scientist, GPCR Pharmacology Research Associate - Professor Graeme Milligan Postdoc in Molecular Pharmacology - The Hauser Group GPCR Activation and Signaling GPCR oligomerization across classes: A2AR-mediated regulation of mGlu5R activation GRK5 is required for adipocyte differentiation through ERK activation GPCR Binders, Drugs, and more Novel tertiary diarylethylamines as functionally selective agonists of the kappa opioid receptor Reviews, GPCRs, and more Attributes novel drug candidate: Constitutive GPCR signal bias mediated by purinergic receptors An update on regulation and function of G protein-coupled receptors in cancer: A promising strategy for cancer therapy Early intervention with daratumumab improves survival for patients with high-risk smouldering myeloma GPCR Biosensors to Study Conformational Dynamics and Signaling in Drug Discovery

🎉 Welcome back, GPCR enthusiasts! The momentum is strong, and the discoveries keep rolling in! We're diving into another week of groundbreaking research, exciting updates, and everything you need to stay ahead in GPCRs. So, buckle up, and let's keep the wheels of innovation turning together! 💌 What Do You Think About DrGPCR? Your feedback is invaluable! We are constantly working to improve DRGPCR and would love to hear your thoughts. Whether it’s suggestions for new features, insights on usability, or your love for the site, please share your ideas with us. Together, we can make DRGPCR even better! 🎙️ DrGPCR Podcast is Back! Check out Episode 157 , where we chat with Dr. Nagarajan Vaidehi about the exciting role of quantitative sciences in GPCRs! You won’t want to miss it! 🌟 Enhance Your GPCR Experience with a Premium Membership! Advance your GPCR exploration by becoming a Premium Member! Enjoy exclusive access to the latest research, expert-led courses, members-only events, and a worldwide community of GPCR enthusiasts. Stay at the forefront of the field, engage with top experts, and elevate your knowledge. Classified GPCR News  Let’s dive into the   Classified GPCR News from January 6th to 12th, 2025 Industry News Exploring the Connection Between the Endocannabinoid System and Rituals of Open-Air Cremation: A Path to Community Healing UNITY Biotech appoints new chief medical officer Crinetics Pharmaceuticals Announces January 2025 Inducement Grants Under Nasdaq Listing Rule 5635(c)(4) Septerna Expands Leadership with Appointment of Industry Veteran Gil Labrucherie as Chief Financial Officer GPCR Events, Meetings, and Webinars January 25 - 29, 2025 | SLAS 2025 February 8 - 9, 2025 | The Chemistry and Medicine of Nitric Oxide and Sulfur Species February 9 - 14, 2025 | Nitric Oxide and Sulfide in Redox Signaling and Medicine February 15 - 16, 2025 |GRS Molecular Pharmacology : Structural and Functional Approaches in GPCR Drug Discovery February 16 - 21, 2025 | GRC Molecular Pharmacology: Harnessing the Power of Advanced Multimodal Approaches to GPCR Drug Discovery February 15 - 19, 2025 | BPS 2025 April 3 - 6, 2025 | ASPET 2025 April 24 - 27, 2025 | American Physiology Summit 2025 April 25 - 30, 2025 | AACR Annual Meeting 2025 May 12 - 15, 2025 | PEGS 2025 May 15 - 17, 2025 | 23rd GPCR Retreat 2025 May 20 - 22, 2025 | SLAS Europe 2025 June 22 - 26, 2025 | G Protein-coupled Receptor Kinases and Arrestins July 12 - 17, 2026 | 20th World Congress of Basic and Clinical Pharmacology GPCR Jobs NEW Junior associate position and a PhD/post-doc level position Postdoctoral Position And PhD Position GPCR Molecular Pharmacologist Scientist - Biology Scientist I Cell Biology - Tectonic Therapeutic Senior Principal Scientist, Medicinal Chemistry PhD fellowship in GPCR mechanosensing Senior Scientist, GPCR Pharmacology Research Associate - Professor Graeme Milligan Postdoc in Molecular Pharmacology - The Hauser Group Postdoctoral Scholar – iPSC in cardiac and endothelial cell function Protein Biochemist/Structural Biologist Adhesion GPCRs Novel Isoforms of Adhesion G Protein-Coupled Receptor B1 (ADGRB1/BAI1) Generated from an Alternative Promoter in Intron 17 N-terminal fragment shedding contributes to signaling of the full-length adhesion receptor ADGRL3 GPCR Activation and Signaling Adopting GPR75 in treating obesity: unraveling the knowns and unknowns of this orphan GPCR Noncanonical RGS14 structural determinants control hormone-sensitive NPT2A-mediated phosphate transport Arrestin-independent internalization of the GLP-1 receptor is facilitated by a GRK, clathrin, and caveolae-dependent mechanism GPCR Binders, Drugs, and more A lipidated peptide derived from the C-terminal tail of the vasopressin 2 receptor shows promise as a new β-arrestin inhibitor GPCRs in Cardiology, Endocrinology, and Taste LGR4 is essential for maintaining β-cell homeostasis through suppression of RANK GPCRs in Neuroscience Comparing adenosine A2A receptor modulation of cannabinoid CB1 receptor-mediated inhibition of GABA and glutamate release in rodent striatal nerve terminals GPCRs in Oncology and Immunology A New Strategy in Modulating the Protease-Activated Receptor 2 (Par2) in Autoimmune Diseases Methods & Updates in GPCR Research The influence of phosphoinositide lipids in the molecular biology of membrane proteins: recent insights from simulations Reviews, GPCRs, and more Biochemistry, G Protein Coupled Receptors Structural and Molecular Insights into GPCR Function Molecular mechanisms of inverse agonism via κ-opioid receptor-G protein complexes Become a Premium Member! Get your 5-day free trial TODAY!

Instructors at the course included Marc Chabre , Harden McConnell , Richard Henderson , Martin Rodbell , Jean-Pierre Changeux , and Martin Karplus . This work involved active long-term collaborators, including Richard Mathies and Fritz Siebert , and sampling approaches for membrane proteins in collaborations with Thomas Huber , Xavier Periole , and Siewert-Jan Marrink .

https://www.ecosystem.drgpcr.com/dr-gpcr-podcast/ep-148-with-dr-arthur-christopoulos #gpcr #drgpcr Jan 🙌 ✳️Go to https://www.ecosystem.drgpcr.com/account/my-account and update your profile #gpcr #drgpcr Jan ✳️Visit https://bit.ly/4fY4UHV today #gpcr #drgpcr Jan 14, 2025 Did you know that cell types can affect -nagarajan-vaidehi Jan 8, 2025 Let’s connect the dots! Update your Dr. #gpcr #drgpcr Jan 7, 2025 New cryo-EM insights reveal how extracellular domains communicate with transmembrane

P Bernardes , Neha Mishra , Thomas Bahmer , Jeanette Franzenburg , Bimba F Hoyer , Andreas Glück , Martina Guggeis , Alexander Ossysek , Andre Küller , Derk Frank , Christoph Lange , Jan Rupp , Jan Heyckendorf