training that spanned chemokine receptor conformational dynamics at the Université de Montréal, CXCR3 splice-variant Tom Sakmar's lab, where she characterized the signaling diversity of three alternative splice variants Conversation Chemokine receptor redundancy and the shift toward functional selectivity as a framework Splice Splice variants aren't just structural — they signal differently. Her Rockefeller work on the three alternative splice variants of CXCR3, initially prompted by a simple

deal of challenges given that they are highly polymorphic proteins expressed as various alternatively spliced His lab highlighted the importance of splicing events in biasing latrophilins’ regulation of cyclic AMP

Some of these studies resolved a major question regarding the signaling differences in G protein splice

why a decade of preclinical mGlu2 evidence has not yet reached clinical success The limits of brain slice For most of the history of GPCR electrophysiology, researchers used electrical stimulation in brain slices