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<< Back to podcast list Strategic Partner(s) Dr. Stephen Ferguson The History of the Great Lakes GPCR Retreat with Dr. Stephen Ferguson About Dr. Stephen Ferguson Dr. Stephen Ferguson is a Professor in the Department of Cellular and Molecular Medicine at the University Stephen Ferguson on the web Carlton University Canada Research Chairs Twitter ResearchGate LinkedIn Dr

<< Back to podcast list Strategic Partner(s) Dr. Stephen Ferguson About Dr. Stephen Ferguson Dr. Stephen Ferguson is a Professor in the Department of Cellular and Molecular Medicine at the University Marc G. receptor kinases and beta-arrestin in regulating G protein-coupled receptor endocytosis, trafficking Stephen Ferguson on the web Carlton University Canada Research Chairs Twitter ResearchGate LinkedIn Dr

<< Back to podcast list Strategic Partner(s) Dr. Khaled Abdelrahman About Dr. Stephen Ferguson’s laboratory in the Departments of Cellular & Molecular Medicine and Neuroscience at the University of Ottawa as a Postdoctoral Fellow to explore novel G protein-coupled receptor (GPCR)

<< Back to podcast list Strategic Partner(s) Dr. Stephen Ferguson’s laboratory in the Departments of Cellular & Molecular Medicine and Neuroscience at the University of Ottawa as a Postdoctoral Fellow to explore novel G protein-coupled receptor (GPCR) Sakmar’s laboratory at The Rockefeller University, where she study’s the signaling and degradation of G

<< Back to podcast list Strategic Partner(s) Dr. G. Aditya Kumar About Dr. G. Aditya Kumar Dr. G.

Elva Zhao on biased agonism at the GLP-1 receptor, G protein regulation, and building a mechanistic picture of GPCR pharmacology from the inside out. << Back to podcast list Strategic Partner(s) Elva Zhao: G Her PhD at Western University focused not on receptors but on G protein cycle regulation - RGS proteins Peter Chidiac, where her work focused on the kinetic regulation of G protein cycling by RGS proteins I want to know how the G protein got activated. So receptor is a natural choice."

<< Back to podcast list Strategic Partner(s) Dr. Roger Sunahara About Dr. for agonist-mediated activation of G proteins. changes in G protein structure. forms, specifically the short and long forms of the stimulatory G protein, Galpha-s(s) and Galpha-s( We demonstrated that Galpha-s(l), but not Galpha-s(s), regulates extracellularly regulated kinases (ERK

<< Back to podcast list Strategic Partner(s) Dr. Caron Tribute Part 2 About Marc Caron Dr. Steve Ferguson (1995) Dr. Neel Freedman (1994) Dr. Jacob Jacobson (2003) Dr. Stephane Laporte (1999) Dr. Stuart Maudsley (1997) Dr. Richard Premont (1993) Dr.

<< Back to podcast list Strategic Partner(s) Dr. Richard Premont About Dr. Richard Premont "Dr. For this, we have worked in three main areas: the regulation of G protein-coupled receptor signaling particularly by the G protein-coupled receptor kinase (GRK) – beta-arrestin system, the coordination of heterotrimeric G protein, small GTP-binding protein and protein kinase pathways by GIT/PIX scaffolding complexes during cellular signaling, and characterizing the role of protein S-nitrosylation as a signaling

<< Back to podcast list Strategic Partner(s) Dr. Richard Premont About Dr. Richard Premont "Dr. For this, we have worked in three main areas: the regulation of G protein-coupled receptor signaling particularly by the G protein-coupled receptor kinase (GRK) – beta-arrestin system, the coordination of heterotrimeric G protein, small GTP-binding protein and protein kinase pathways by GIT/PIX scaffolding complexes during cellular signaling, and characterizing the role of protein S-nitrosylation as a signaling

<< Back to podcast list Strategic Partner(s) Dr. Richard Premont About Dr. Richard Premont "Dr. For this, we have worked in three main areas: the regulation of G protein-coupled receptor signaling particularly by the G protein-coupled receptor kinase (GRK) – beta-arrestin system, the coordination of heterotrimeric G protein, small GTP-binding protein and protein kinase pathways by GIT/PIX scaffolding complexes during cellular signaling, and characterizing the role of protein S-nitrosylation as a signaling

<< Back to podcast list Strategic Partner(s) Dr. Richard Premont About Dr. Richard Premont "Dr. For this, we have worked in three main areas: the regulation of G protein-coupled receptor signaling particularly by the G protein-coupled receptor kinase (GRK) – beta-arrestin system, the coordination of heterotrimeric G protein, small GTP-binding protein and protein kinase pathways by GIT/PIX scaffolding complexes during cellular signaling, and characterizing the role of protein S-nitrosylation as a signaling

<< Back to podcast list Strategic Partner(s) Dr. Gregory Tall About Dr. Gregory Tall " Dr. Tall moved upstairs to conduct his postdoctoral work on heterotrimeric G proteins and the novel interactor the Tall lab are to understand the basic mechanism by which Ric-8 proteins fold all heterotrimeric G protein alpha subunits, to exploit a Ric-8-based technology to purify recombinant G proteins and to use the G proteins in assays to explore the mechanisms of action of the 33-member adhesion GPCR family or

Silvio Gutkind on G protein hotspot mutations, why the canonical GαQ pathway fails in uveal melanoma, and how CXCR3 may gate immunotherapy response. << Back to podcast list Strategic Partner(s) Silvio Gutkind Roughly 20% of tumors now show mutations in GPCRs or their coupled G proteins, and specific cancers — Cancer genomics rewrote the role of G proteins. "There are cancers that are driven by G proteins.

Gunnar Schulte of Karolinska Institute makes the case that frizzled receptors are GPCRs — through G-protein and the first small molecule shown to activate frizzled 6. << Back to podcast list Strategic Partner(s) His lab investigates the molecular mechanisms of frizzled receptor activation, including G-protein coupling evidence that disheveled undergoes conformational selection at the receptor — analogous to the way G This would mean the receptor itself determines whether a signal flows through disheveled or through a G

<< Back to podcast list Strategic Partner(s) Dr. Lauren M. Slosky About Dr. Lauren M. Slosky’s research is focused on understanding how neuropeptide G protein-coupled receptors (GPCRs) regulate Marc G. Caron at Duke University. Dr. These ligands stimulate receptor β-arrestin recruitment without activating canonical G protein signaling

<< Back to podcast list Strategic Partner(s) Dr. Marta Filizola About Dr. Marta Filizola Dr. Klingenstein-Nathan G. dynamics, and function of important classes of membrane proteins and prominent drug targets, including G

intracellular receptor targeting are reshaping drug discover << Back to podcast list Strategic Partner(s) caged ligands designed to drug receptors on the nuclear membrane, and the unexpected discovery that G-proteins His contributions span GPCR dimerization, nuclear receptor signaling, and the emerging role of G-proteins G-Proteins as Transcriptional Regulators — The observation that G-proteins enter the nucleus and interact Knocking Out G-Proteins Reveals Cellular Rewiring When individual G-proteins are knocked out in HEK293

<< Back to podcast list Strategic Partner(s) Irfan Dhanidina, Dr. Kathleen Caron and Dr. With a special emphasis on G protein coupled receptors and receptor activity modifying proteins in vascular Slosky’s research is focused on understanding how neuropeptide G protein-coupled receptors (GPCRs) regulate Marc G. Caron at Duke University. Dr. These ligands stimulate receptor β-arrestin recruitment without activating canonical G protein signaling

. << Back to podcast list Strategic Partner(s) Annette Gilchrist: Native Cell Systems, Biased Agonism The question that followed was immediate: why hadn't anyone done the same with G-protein C-termini? Running a small-molecule screen in Heidi Hamm's lab, looking for compounds that would block G-protein binding, she found agonists: compounds that made the G-protein bind better, some of which trapped the into GPCR biology 07:25 Entering GPCR research through Heidi Hamm's lab - and why the committee said G

<< Back to podcast list Strategic Partner(s) Anything BUT GPCRs with Dr. My research aims to understand the mechanisms and consequences cell communication via heterotrimeric G-proteins Spain, Belgium, and a postdoctoral fellowship at UC San Diego, where he navigated a career focused on G

<< Back to podcast list Strategic Partner(s) Dr. Prasenjit Saha About Dr. Specifically, I am interested in understanding dysregulated G-protein coupled receptor (GPCR) signaling More recently, I have shifted my focus to identifying allosteric modulators of host G-protein-coupled

<< Back to podcast list Strategic Partner(s) Dr. Bianca Plouffe About Dr. Bianca Plouffe Dr. Robert Lefkowitz , which led to the finding that both β-arrestin and G protein can simultaneously bind Funded by a Wellcome Trust Seed Award, she investigated biased and compartmentalized G protein signaling

<< Back to podcast list Strategic Partner(s) Dr. Simone Prömel & Dr. Ines Liebscher About Dr. on the different modes of action of Adhesion GPCRs and found that they do not only mediate classical G Starting with proving and characterizing G-protein coupling, Ines spends several years studying the activation

<< Back to podcast list Strategic Partner(s) The Scientist's Compass: From Academia to Entrepreneurship University of Nottingham, where he provides leadership in structural and biophysical pharmacology of G Scherrer Institute and ETH Zürich in Switzerland, changing his attention to structural pharmacology of G

. << Back to podcast list Strategic Partner(s) Antony Boucard: Adhesion GPCRs and the Molecular Code Only recently has the field established, with confidence, that adhesion GPCRs couple to G proteins at Whether they functionally coupled to G proteins remained genuinely open, and for much of the field's Alfred Gilman , Nobel Laureate for his discovery of G proteins, Dr. Boucard´s lab focuses on molecular and cellular mechanisms underlying the function of adhesion GPCRs

<< Back to podcast list Strategic Partner(s) Chloe Hicks About Chloe Hicks Chloe Hicks will graduate previous endeavors involved exploring the effect of subcellular location on the signaling profile of CXCR3’s involved in the activation of Atypical Chemokine Receptor 3 (ACKR3), a receptor which does not couple to G

<< Back to podcast list Strategic Partner(s) Re-cap of Endocrine Metabolic GPCR 2024 with the Organizers Francisco with Professor Mark von Zastrow where she identified novel core cellular machinery critical for G continued to undertake postdoctoral research in Oxford, investigating the signalling and trafficking of the G

<< Back to podcast list Strategic Partner(s) Dr. Evi Kostenis About Dr. Research interests: Signaling mechanisms involving GPCRs and heterotrimeric G proteins" Dr.

<< Back to podcast list Strategic Partner(s) Dylan Eiger About Dylan Eiger Dylan Eiger is currently an Stephen Craig and studied polymer chemistry and material science.