. << Back to podcast list Strategic Partner(s) Custom Molecules, Fluorescent Probes: When Chemists Think At Celtarys, the focus is on enabling fast, customizable development of fluorescent ligands and chemical She began as a medicinal chemist in Italy, but a postdoc opportunity in Santiago de Compostela—and a Pivoting: From Chemistry Company to Discovery Partner Initially focused on tool production, Celtarys “We always start with the problem, then generate the right compound using our chemistry.

Chemical biologist Johannes Broichhagen reveals how fluorescent probes transform GPCR imaging, internalization GPCR Podcast, chemical biologist Dr. Why this matters How a chemist with zero biology training became a leader in GPCR probe design. , peptide chemistry, and advanced imaging. His lab integrates synthetic chemistry, theoretical chemistry, cell biology, and imaging to understand

From chemokine receptors at Rockefeller to founding Dr. . << Back to podcast list Strategic Partner(s) Yamina Berchiche: Beyond the Lab — From Chemokine Receptors Berchiche spent two decades working on G protein-coupled receptors at the bench — training that spanned chemokine and chemokine receptors that would define her career. multiple chemokines bind multiple receptors.

Ross Cheloha approaches these questions from a chemical biology perspective - using synthetic peptide His research combines peptide chemistry, chemical biology, and nanobody engineering to build mechanistic Chemistry in Bethesda, MD, where he started in October 2020. Cheloha’s work. Dr. Ross Cheloha on the web NIDDK Cheloha Lab Google Scholar LinkedIn Twitter ResearchGate Dr.

Purpose-built GPCR panels Run in agonist formats for profiling, selectivity, and promiscuity gpcrMAX orphanMAX Chemokine on the same platform as our services View the DiscoverX page Additional services Eurofins Discovery Chemistry

ABOUT RANDY Randy Hall is Professor of Pharmacology and Chemical Biology at Emory University School of agonist model - 39:38 Are adhesion GPCRs druggable, and what GPR97 changed - 46:46 In silico screening, chess

Trained first as a chemist in Edmonton and then as a pharmacologist, Kenakin spent more than thirty years GlaxoWellcome, and GlaxoSmithKline, where he led a CCR5 entry inhibitor program for HIV and worked on chemokine Redundancy in the chemokine system turned out to be resolution. Twenty some receptors and roughly fifty chemokines were long read as a fail safe arrangement. EPISODE TIMELINE Timestamps were generated using AI for readability. - 00:00 Introduction - 02:19 Chemistry

Any scientist working with GPCRs — pharmacologists, medicinal chemists, cell biologists, translational

Caron and his family moved to Durham, NC in 1977, following receipt of his BSc in Chemistry from Laval

Premont obtained his B.S. in Biology and Chemistry at the California Institute of Technology in 1985,

Kaavya Krishna Kumar on the web Journal of Biology Chemistry Stanford University Google Scholar LinkedIn

inversion - question first, receptor second - shaped a body of work that spans adrenergic receptors, chemokine spontaneous activity of a constitutively active receptor - to a mixed audience of pharmacologists and chemists The chemists called it allosteric regulation and asked what was new. final edited audio before publishing. 00:00 Introduction 02:23 Scientific origin - the high school chemistry "The pharmacologists were ready to burn me for heresy, the chemists were saying, what's new, Pussycat

built BitterDB - the first dedicated database of bitter compounds - and has mapped the structural and chemical She was also a key contributor to the GCCR consortium's large-scale chemosensory research during the What makes this finding unusual is the magnitude of the effect relative to the size of the chemical change The Niv lab is also part of the Global Consortium for Chemosensory Research. Masha earned her Bachelor’s degree in chemistry, followed by a direct Ph.D. at the Institute of Chemistry

Strategic Partner(s) Antonella Di Pizio: Computational Pharmacology of Taste and Olfactory Receptors Chemosensory medicinal chemistry before spending a formative period in Gerhard Klebe's structural biology lab in Scientific Themes of the Conversation Chemosensory receptors as a frontier for GPCR drug discovery Trace TAARs look more classical than most chemosensory GPCRs — and that matters for modeling. Antonella trained as a medicinal chemist in Italy, followed by a Ph.D. in computational medicinal chemistry

Caron and his family moved to Durham, NC in 1977, following receipt of his BSc in Chemistry from Laval

Structural snapshots of receptor-ligand complexes can validate docking predictions and guide medicinal chemistry

team’s projects are devoted to the activation/function of CXCR4-ACKR3 (CXCR7) receptors of the CXCL12 chemokine recognized for her expertise and pioneering works in the field of biological and pathological functions of chemokines international committees in the field, including the one that reviewed the standard nomenclature for chemokine receptors that are categorized into a large subgroup of G protein–coupled (GPCR) leukocyte chemotactic receptors (including CXCR4), and a smaller subgroup of atypical chemokine receptors (including the CXCR7

Always check for accuracy. Aurelien Rizk and Yamina Berchiche had a detailed conversation about the intricacies of cell signaling and chemokine which includes mathematics, signaling pathways, a wet lab for data generation, and AI and computational chemistry They validated their technology and made collaborations for expertise on chemokine receptors.

Christel Menet "I did my Ph.D. in Manchester UK with Prof Jonathan Clayden in organic chemistry. After 2 years, I joined Galapagos where I spent almost 11 years and became head of medicinal chemistry

With a career spanning two decades at the intersection of fluorescence chemistry, functional assays, How collaborations with David Parker and Jean-Philippe Pin accelerated both probe chemistry and biological Originally trained as a physicist with a strong interest in photophysics and fluorescence chemistry, His passion lies in turning cutting-edge probe chemistry into robust, scalable tools for drug discovery

Prashen Chelikani .

.” – Alessandro Nicoli He studied pharmaceutical chemistry in Padua, where his fascination with molecular The Moment Chemistry Met Biology Nicoli’s turning point came when he realized that molecules weren’t For Nicoli, chemistry became more than reactions—it became a bridge to biological insight. Nicoli dove into computational chemistry. “We’re living in a golden era for computational chemistry… the tools are out there.

Sri is a co-founder at Octant and an Associate Professor at UCLA in the Chemistry and Biochemistry Department empirically exploring questions in protein biochemistry, human genetic variation, gene regulation, chemical

he completed a PhD in protein engineering (Cambridge, UK) with Sir Gregory Winter (Nobel Prize for Chemistry

Ilana uses chemical biology-based methods to study the regulation and protein-protein interactions of Ilana graduated Summa cum laude from Cornell University, where she studied Chemistry and Chemical Biology

Matthew Eddy Matthew Eddy earned his BA in Chemistry from Oberlin College, where he trained with solid-state He then earned his Ph.D. in physical chemistry from the Massachusetts Institute of Technology, training

wraps with a playful exchange about possible podcast titles, with Yamina suggesting "Ancient Greek Chemistry

Panelists from InterAx Biotech, Rockefeller University, and the University of New Mexico — computational chemists homology modeling, coarse-grained molecular dynamics, and genetic code expansion for site-specific chemistry in ligand design The true-negatives problem and how it distorts biological models The hybrid future: chemical Chemical intuition has no AI equivalent yet — and won't soon. The experience of a seasoned medicinal chemist mentally docking a molecule from a 2D structure is not

Her work focused on chemokine receptors, members of the GPCR family that control cell movement in the

This conversation explores the intersection of computational biology, cheminformatics, and structural