From chemokine receptors at Rockefeller to founding Dr. . << Back to podcast list Strategic Partner(s) Yamina Berchiche: Beyond the Lab — From Chemokine Receptors Berchiche spent two decades working on G protein-coupled receptors at the bench — training that spanned chemokine and chemokine receptors that would define her career. multiple chemokines bind multiple receptors.

Chemical biologist Johannes Broichhagen reveals how fluorescent probes transform GPCR imaging, internalization GPCR Podcast, chemical biologist Dr. Why this matters How a chemist with zero biology training became a leader in GPCR probe design. , peptide chemistry, and advanced imaging. His lab integrates synthetic chemistry, theoretical chemistry, cell biology, and imaging to understand

. << Back to podcast list Strategic Partner(s) Custom Molecules, Fluorescent Probes: When Chemists Think At Celtarys, the focus is on enabling fast, customizable development of fluorescent ligands and chemical She began as a medicinal chemist in Italy, but a postdoc opportunity in Santiago de Compostela—and a Pivoting: From Chemistry Company to Discovery Partner Initially focused on tool production, Celtarys “We always start with the problem, then generate the right compound using our chemistry.

Ross Cheloha approaches these questions from a chemical biology perspective - using synthetic peptide His research combines peptide chemistry, chemical biology, and nanobody engineering to build mechanistic Chemistry in Bethesda, MD, where he started in October 2020. Cheloha’s work. Dr. Ross Cheloha on the web NIDDK Cheloha Lab Google Scholar LinkedIn Twitter ResearchGate Dr.

Any scientist working with GPCRs — pharmacologists, medicinal chemists, cell biologists, translational

Chemokine receptors like CXCR1 and CXCR2 share over 75% sequence identity - use the wrong peptide region

For years the field's spotlight drifted to checkpoints and T-cell receptors.

fluorescence-based kinetic binding assays specifically designed to assess the kinetics of unlabelled compounds (and chemical

modulation and biased agonism, and incorporates computational and mathematical modelling, structural and chemical biology, molecular and cellular pharmacology, medicinal chemistry, and preclinical models of behaviour Always check for accuracy.

Fluorescent chemical probes offer one of the most direct approaches for investigating receptor distribution Broichhagen trained in chemistry at the University of Erlangen-Nuremberg, completed his doctorate at His group focuses on the development of chemical tools — including fluorescent ligands and photopharmacological Organizers Celtarys Research Celtarys develops and commercializes fluorescent chemical tools and related and flow cytometry applications Screening services using proprietary probes in living cells Custom chemical

For Comeo, who entered GPCR research without any background in the field and built her PhD around chemistry A trained medicinal chemist and pharmacist, her research focuses on the design and synthesis of fluorescent ligands for adenosine A1 and A2A receptors, with the goal of developing chemical tools capable of interrogating SCIENTIFIC THEMES OF THE CONVERSATION Fluorescent ligands as pharmacological tools - how synthetic chemistry About this episode Eleonora Comeo is a doctoral candidate in Medicinal Chemistry and Drug Discovery in

Always check for accuracy. Yamina’s Podcast Journey and Career Advice Yamina discussed how her podcast on chemokine ligands led Yamina shared her experiences at Rockefeller, where she studied chemical receptors.

Working on chemokine receptor CCR1 in multiple myeloma, free fatty acid receptor FFA2 in type 2 diabetes Her lab studies chemokine receptor CCR1 in multiple myeloma and cancer-to-bone metastasis, free fatty Join me and learn more about Annette’s career, our common love for chemokines, and how you can use your

Sri is a co-founder at Octant and an Associate Professor at UCLA in the Chemistry and Biochemistry Department empirically exploring questions in protein biochemistry, human genetic variation, gene regulation, chemical

produced a light-bulb recognition that reshaped his entire research direction. 21 degrees changed what was chemically He still asks every candidate who wants to join his group one question: do you know, in chemical terms

Preview your site to check that all your elements are displaying content from the right collection fields

Lefkowitz was awarded the Nobel Prize in Chemistry, shared with Brian Kobilka, for studies of G protein-coupled Lefkowitz learned at 5 AM on October 10, 2012, that he had won the Nobel Prize in Chemistry, his first Lefkowitz, M.D., 2012 Nobel Prize in Chemistry, which he shared with Dr. Brian Kobilka . Duke Professor of Medicine and Professor of Biochemistry, Chemistry, and Pathology at the Duke University

Premont obtained his B.S. in Biology and Chemistry at the California Institute of Technology in 1985,

built BitterDB - the first dedicated database of bitter compounds - and has mapped the structural and chemical She was also a key contributor to the GCCR consortium's large-scale chemosensory research during the What makes this finding unusual is the magnitude of the effect relative to the size of the chemical change The Niv lab is also part of the Global Consortium for Chemosensory Research. Masha earned her Bachelor’s degree in chemistry, followed by a direct Ph.D. at the Institute of Chemistry

Bridging computation, chemistry, and pharmacology is key to speeding up drug discovery. when building a research career Who Should Listen GPCR scientists and pharmacologists Computational chemists With a reputation for collaborative science, Jens is a strong advocate for bringing together chemists

Always check for accuracy.

Christel Menet "I did my Ph.D. in Manchester UK with Prof Jonathan Clayden in organic chemistry. After 2 years, I joined Galapagos where I spent almost 11 years and became head of medicinal chemistry

team’s projects are devoted to the activation/function of CXCR4-ACKR3 (CXCR7) receptors of the CXCL12 chemokine recognized for her expertise and pioneering works in the field of biological and pathological functions of chemokines international committees in the field, including the one that reviewed the standard nomenclature for chemokine receptors that are categorized into a large subgroup of G protein–coupled (GPCR) leukocyte chemotactic receptors (including CXCR4), and a smaller subgroup of atypical chemokine receptors (including the CXCR7

moved from a side project nobody believed in to a recognized driver class in oncology, and explains why chemokine include GαQ-driven uveal melanoma, GαS mutations across pancreatic, colon, and appendix cancers, and chemokine pathway Non-canonical GαQ signaling through TRIO, Rho, YAP, and the druggable FAK node CXCR3 and the chemokine CXCL9, CXCL10, and CXCL11 are among the most robust predictive signatures for checkpoint inhibitor response The cancer genomics result that reframed GPCRs as drivers 16:45 Why CXCR3 may decide who responds to checkpoint

modulation and biased agonism, and incorporates computational and mathematical modelling, structural and chemical biology, molecular and cellular pharmacology, medicinal chemistry, and preclinical models of behaviour Always check for accuracy.

(MFI): a reliable, self-sustaining computational chemistry service provider, developing its own software I am now combining my training as a chemist and as an entrepreneur to grow a sustainable service and

Prior to experiences at PerkinElmer and BioTek, Banks was an Assistant Professor in Analytical Chemistry

After spending two years at the Cleveland Institute of Art, he earned degrees in Biochemistry and Chemistry

Caron and his family moved to Durham, NC in 1977, following receipt of his BSc in Chemistry from Laval

He taught himself chemoinformatics as a way to optimize compound selection for screening, and in 1997 switched to computational chemistry full-time.