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Following this tremendous experience, he was recruited to be the Principal Investigator of the Receptor Biology National Institutes of Health – National Institute on Aging at the Johns Hopkins University Medical Center the highly-valued Odysseus Program Type I Program Grant to work as both the Adjunct Director of the VIB Stuart’s current research, in the Receptor Biology Lab, focuses on the development of novel GPCR-based Maudsley on the web Maudsley Lab LinkedIn Google Scholar ResearchGate Maudsley Lab on Facebook Receptor Biology

Following this tremendous experience, he was recruited to be the Principal Investigator of the Receptor Biology National Institutes of Health – National Institute on Aging at the Johns Hopkins University Medical Center the highly-valued Odysseus Program Type I Program Grant to work as both the Adjunct Director of the VIB Stuart’s current research, in the Receptor Biology Lab, focuses on the development of novel GPCR-based Maudsley on the web Maudsley Lab LinkedIn Google Scholar ResearchGate Maudsley Lab on Facebook Receptor Biology

Following this tremendous experience, he was recruited to be the Principal Investigator of the Receptor Biology National Institutes of Health – National Institute on Aging at the Johns Hopkins University Medical Center the highly-valued Odysseus Program Type I Program Grant to work as both the Adjunct Director of the VIB Stuart’s current research, in the Receptor Biology Lab, focuses on the development of novel GPCR-based Maudsley on the web Maudsley Lab LinkedIn Google Scholar ResearchGate Maudsley Lab on Facebook Receptor Biology

This conversation covers thermostabilization, cryoEM, and GPCR structural biology. << Back to podcast list Strategic Partner(s) Chris Tate: Thermostabilizing GPCRs for Structural Biology For most of the 1990s and early 2000s, GPCR structural biology was not a biology problem - it was a stability problem biology - that enabled the first high-resolution crystal structures of multiple GPCRs in defined conformational biology alone cannot provide.

Joseph Kim exploring GPCR structural biology, cryo-electron microscopy, opioid receptor pharmacology, Joseph Kim discusses the intersection of structural biology, membrane protein biochemistry, and drug The discussion explores how structural biology technologies—particularly cryo-EM—have transformed the His work combines structural biology, membrane protein biochemistry, and pharmacological insights to His broader scientific interests lie at the interface of structural biology and drug discovery, where

Moro, that he truly saw how molecules could go beyond the bench and interact with biology in powerful The Moment Chemistry Met Biology Nicoli’s turning point came when he realized that molecules weren’t biology. Modeling the Invisible: Olfactory Receptors Nicoli’s work centers on predicting ligand binding and receptor Alessandro Nicoli on the web Leibniz Institute for Food Systems Biology at the Technical University of

Demet Araç "Demet was an undergraduate at Bilkent University in Turkey, where she majored in Molecular Biology independent research career at the University of Chicago within the Department of Biochemistry and Molecular Biology Demet, who had studied various subjects including chemistry, physics, biology, and math, shared his interest Demet shared that his interest in science led him to study biology, genetics, and molecular biophysics biology and signaling assays.

The work connects receptor biology to neuropsychiatric disease: addiction, autism spectrum disorder, frontier, where the biology is catching up to the structural classification. 2. The Structural Bottleneck Cryo-EM has transformed understanding of classical GPCR structure, but adhesion That gap is where the most important biology is happening. 6. Mexico City offered something different: a research territory in adhesion GPCR biology that was entirely

, structural biologists, and drug-discovery veterans — drew on their combined experience to separate Yaroslav Nikolaev is a scientist at InterAx Biotech with a dual background in biology and computation His research combines biomolecular NMR, structural biology, and machine learning to study how GPCRs function University of New Mexico and coordinator of the Illuminating the Druggable Genome Knowledge Management Center The explosion of biomedical data such as in genomics, structural biology, and pharmacology can provide

Her research centers on developing computational pipelines that guide the design of hybrid or chimeric engineering Hybrid and chimeric GPCR constructs Experimental–computational feedback loops in receptor biology GPCR Biology Continues to Produce “Gotcha Moments” Despite decades of research, GPCRs remain complex How do you see the role of computational approaches in GPCR biology? So whether it’s in academia or industry, I hope to continue doing research related to GPCR biology.

systems Interrogating Incretin Receptor Biology Across Biological Complexity GLP-1 and GIP receptors chemical tools — including fluorescent ligands and photopharmacological compounds — to investigate GPCR biology selective fluorescent ligands for GPCRs, supporting researchers working at the interface of chemical biology It provides curated industry intelligence, expert-led masterclasses, and structured engagement opportunities drug discovery trends and developments Expert-led webinars and masterclasses with leading researchers Structured

discovery professionals working on receptor trafficking, spatial signaling, and endocrine receptor biology His work centers on compartmentalized receptor signaling and on rare skeletal and mineral-ion disorders Jansen's metaphyseal chondrodysplasia, integrating cell-based biosensor assays, mouse genetics, and structure-guided His research on disease-informed PTH1R biology directly shapes the focus of this Masterclass, where rare

uveal melanoma, GαS mutations across pancreatic, colon, and appendix cancers, and chemokine receptor biology biology, machine learning, and team science in GPCR pharmacology Key Insights from the Conversation Team science is structural, not decorative. hallway conversation, combining bioinformatics from Europe, high-throughput screens from Japan, and biology biology, machine learning, and the coupling problem 45:31 Two "what the heck" moments that became Nature

Her work spans GPCR structural biology, membrane protein stabilization, allosteric modulation, and the Marshall in the room — a new category of GPCR biology opened, with heterodimers as obligate signaling Years of assumed peptide biology dissolved into a simpler truth hidden in the solvent. An expert in GPCR biology, Fiona published the first description of the cloning and structural requirements Richard Henderson at the Laboratory of Molecular Biology in Cambridge, UK.

podcast list Strategic Partner(s) Gáspár Pándy-Szekeres About Gáspár Pándy-Szekeres " After a BSc in biology branched out to multiple areas of GPCR research such as sequence alignments, generic numbering systems, structure As a developer, and more recently the lead developer of GPCRdb my day-to-day work centers around the

Lukas Grätz "After a BSc in biology and a MSc in bioinformatics, I have been working in David Gloriam's branched out to multiple areas of GPCR research such as sequence alignments, generic numbering systems, structure As a developer, and more recently the lead developer of GPCRdb my day-to-day work centers around the

From virtual screening of billions of molecules to leveraging AlphaFold for structure prediction, Jens biology—and where it still falls short Advice for junior scientists: what really matters when building biologists Early-career researchers exploring drug discovery Biotech leaders and R&D strategists Anyone interested in predictive modeling, AI in biology, or structure-function relationships About Jens Carlsson for collaborative science, Jens is a strong advocate for bringing together chemists, modelers, and biologists

To answer this, his work integrates GPCR molecular pharmacology with computational biology, population His research integrates GPCR molecular pharmacology, computational biology, and pharmacoepidemiology biology, evolutionary data, genetics, and psychiatry - back to a flexible undergraduate program and Alexander has a big interest in the integration of large biomedical data in genomics, structural biology and pharmacoepidemiology with innovative computational methods to gain novel insights into receptor biology

Cardarelli is a drug development leader with extensive experience driving drug discovery teams in bringing biologics She has expertise in cell biology, pharmacology, translational medicine, oncology, immuno-oncology, immunology Previously, she held the position of Vice President of Cell Biology & Pharmacology, at Bristol-Myers She has extensive experience working with Biologics, and Antibody Drug Conjugates as well as experience issued U.S. patents including anti-PD-1 patents, 22 EP patents, and greater than 100 global patents centered

This webinar explains the biological basis of signaling bias, shows how to detect and quantify it using value of comparing pathway outputs quantitatively, rather than relying on potency alone, sit at the center The Biology Behind Bias Ligands produce differential pathway engagement at a single receptor because It provides curated industry intelligence, expert-led masterclasses, and structured engagement opportunities drug discovery trends and developments Expert-led webinars and masterclasses with leading researchers Structured

Gutkind — carrying a personal loss in New York and leading a cancer center building that operated at He walks through the structure his team built: staggered schedules at 10–15% occupancy, written contracts His research spans GPCR signaling in cancer biology, head and neck squamous cell carcinoma, and the molecular A small language correction with structural weight. Dr. J Silvio Gutkind on LinkedIn Gutkind Lab on Twitter UCSD Moores Cancer Center Dr.

medicinal chemistry from the University of Bari in 2018, including research training at the CIQUS Research Center Her work centers on GPCR modulators, synthetic chemistry, and enabling robust biological assays through Turner Professor of Diabetic Medicine at the University of Oxford and a leading expert in metabolic GPCR biology By integrating advanced tools and translational biology, his work directly informs therapeutic strategies Institute for Molecular Pharmacology (FMP) Profile David Hodson Radcliffe Department of Medicine Islet Biology

Bender uses virtual docking to find chemical probes for orphan GPCRs - receptors biology can't study At UCSF, he develops structural models of GPCRs using sparse experimental data - combining restraints biology and receptor pharmacology. He trained as a structural biologist at Vanderbilt University, working with X-ray crystallography, protein They may vary slightly from the final edited version. 00:00 Introduction 01:31 From structural biology

non-psychedelic psychedelic for depression — and why the real bottleneck in GPCR drug discovery is the biology Louis University and trained in pharmacology at NIH and in molecular biology and psychiatry at Stanford It reframes the field's task from finding good targets to understanding the biology well enough to connect Six weeks in, structures are turning over and chemistry is iterating. Louis University in 1983, he subsequently trained in pharmacology (NIH), molecular biology, and psychiatry

Joseph Kim’s curiosity for science led him into GPCR research, drug discovery, and membrane protein biology—plus observed signaling outcomes, providing a bridge between structural biology and pharmacology. Nivedha reflects on how her career in GPCR biology began unexpectedly during her postdoctoral work. I was always interested in biology, especially studying anatomy. At the time, I didn’t realize the full scope of GPCR biology.

A reagent gap that holds back the biology GPCR activity is targeted by one-third of all FDA-approved Part of the gap is biology. Multipass transmembrane proteins are genuinely difficult targets. GeneTex is offering free samples of the recombinant antibodies to GPCR researchers in exchange for structured California School of Medicine and completed internal medicine training at California Pacific Medical Center for specificity screening when feasible Free samples available to GPCR researchers willing to give structured

<< Back to podcast list Strategic Partner(s) Translating computational approaches to GPCR biologists He earned his PhD in Physics at the same university, focusing on in silico structural vaccinology and Now in a tenure-track position, his research spans the development of computational methods such as structure-based Scholar ResearchGate Bysky App : @ riccardocapelli.bsky.social Twitter X : @ ric_capelli Computational Structural Biology Upcoming Live Expert Sessions ➚ 🔒Explore the Full Masterclass ➚ Unlock the Full Dr.

Gloriam on orphan GPCR biology, GPCRDB, biased signaling, and how the data analysis bottleneck is reshaping This conversation explores the intersection of computational biology, cheminformatics, and structural biology. His primary research focus is orphan GPCR biology, with particular emphasis on identifying endogenous for experimentalists, but as the primary constraint to overcome in advancing receptor biology.

Di Pizio — who leads the computational pharmacology group at the Leibniz Institute for Food Systems Biology biology lab in Marburg. Antonella Di Pizio, an independent research group leader at the Leibniz Institute for Food Systems Biology biology. Antonella Di Pizio on the web Leibniz-Institute for Food Systems Biology at the Technical University

Communications, which she joined in April 2020, following three years on the editorial teams of Nature Structural and Molecular Biology and Nature Biotechnology. Katarzyna handles submissions in structural biology, biophysics and biochemistry, with a particular focus