Search Results

how a headache neurologist redirected two decades of work Key Insights from the Conversation The yin-yang

GPCR Retreat is an annual joint meeting with the Club des récepteurs à Sept Domaines Transmembranaires du Retreat partnered with the annual symposium of the Club des Récepteurs à Sept Domains Transmembranaires du Protein-Coupled Receptor Retreat held jointly with the Club des Récepteurs à Sept Domaines Transmembranaires du

In 2006, Bianca obtained a Doctoral Scholarship from the Fonds de Recherche du Québec en Santé.

That training, initially set aside during postdoctoral work on biased agonism at Monash, is now being computational pharmacologists, and receptor scientists working across GPCR classes gave her the methodological range run in the mountains, play with Tilly (a 9-year old retired greyhound), collecting mini shoes, and hang

advanced fluorescent probes developed specifically for working with endogenous GLP-1R and GIPR across a range Available across multiple spectral ranges for confocal, super-resolution, and intravital imaging. daLUXendin Family Fluorescent dual agonists for both GLP-1R and GIPR (daLUXendin544+ and daLUXendin660+), structurally

Mikel Garcia-Marcos "I was trained as a biochemist and molecular biologist during my Ph.D (2005) in Spain and Belgium, and subsequently as a cell biologist during my postdoc (2006-2011) with Dr. To achieve this goal, we use a wide range of established approaches (biochemistry, cell biology, genetics

This dual functionality—environmental sensing and compartment-specific signaling—offers a new layer of titles, with Yamina suggesting "Ancient Greek Chemistry and GPCRs"—a nod to Ian’s heritage and the wide-ranging

biochemistry from Leipzig University (Germany) being already fascinated by G protein-coupled receptors (GPCRs) due During my Ph.D. at the International Max Planck Research School “The Leipzig School of Human Origins” Quick recap Yamina and Claudia had a wide-ranging discussion about Claudia's work on metabolites and interest in attending a meeting about GPCRs and metabolism in the UK, but was unsure if she could make it due

A stalled labeling project on the NPY2 receptor during his PhD at Vanderbilt redirected his entire trajectory crystallography, protein NMR, and electron paramagnetic resonance before transitioning to computation during That period of laborious, close-range data inspection became the conceptual foundation of his pan-GPCR

The discussion ranges across four decades of receptor pharmacology — from the era when the field debated sealed it: receptors 06:30 When the field debated whether opioid receptors were even proteins 11:31 The "dumb

active consent and recruit selected populations that do not represent a country's full demographic range 14 - What a computational GPCR scientist actually does across a typical week 20:51 - Having children during During his Ph.D. with David Gloriam at the Department of Drug Design and Pharmacology in Copenhagen,

subtypes, A1, A2A, A2B, and A3, are expressed across virtually every tissue and implicated in conditions ranging Dual A2A/A2B antagonists are now in clinical trials specifically to interrupt this mechanism. During the conversation, an unresolved question surfaced: when a tagged receptor is transfected into

particular emphasis on identifying endogenous ligands and physiological roles for receptors discovered during THE CONVERSATION The Human Genome as a Discovery Platform When Gloriam joined a bioinformatics group during identified physiological hormones of such under characterized ‘orphan’ receptors and functional probes for a range

His dual perspective - having depended on antibodies as a bench scientist and now helping produce them Her own experience with GPCR antibody failures during knockout mouse experiments - purchasing commercial Inside a company, you understand the full range of decisions - immunogen design, host selection, production

During these four sessions, you'll dive into: Advanced pharmacokinetic modeling The Druglike Quality calcium mobilization: Cell type-dependent involvement of Gi, Gq, Gs proteins and protein kinase C Qin Wang

end, her lab uses several computational structural biology tools and rational drug design approaches, ranging

learning, with a particular focus on how chronic alcohol exposure disrupts those mechanisms across levels ranging circuits - and that has the potential to impact our understanding of how they influence a really wide range

In this wide-ranging conversation, he reflects on the mentors, failures, and bold questions that shaped

They are involved in several pathologies, ranging from neurological, oncological, degenerative, metabolic

to translate scientific training into career options that are often invisible to bench scientists, ranging

subfamilies in the GPCR superfamily - just 15 receptor genes - yet they govern a disproportionately wide range

David Hodson Topics Covered: LUXendin probes for GLP-1R labeling across imaging modalities daLUXendin dual

publishing negative results; pressure on PhD timelines 40:54 - Upcoming GPCR conferences in Leipzig and Dusseldorf

What happens during the live discussion?

Duke Distinguished Professor of Medicine and Biochemistry at Duke University, where he has led his laboratory Kobilka had applied to Duke without ever meeting him, had joined the lab without an interview, and had Duke Professor of Medicine and Professor of Biochemistry, Chemistry, and Pathology at the Duke University Thing Happened on the Way to Stockholm: The Adrenaline-Fueled Adventures of an Accidental Scientist Duke

was awarded a Howard Hughes Medical Institute Fellowship to train with Professor Robert Lefkowitz at Duke

carrying a personal loss in New York and leading a cancer center building that operated at 93% capacity during That dual lineage — extramural academic and intramural NIH — shapes how he thinks about research infrastructure architecture of a research lab under constraint The contract between scientific leadership and trainees during Gutkind describes operating his cancer research building at 93–94% capacity during the early pandemic Gutkind argues the scientific community grew closer during the pandemic, not further apart — the physical

A Forgotten Sample, a First Paper During his graduate studies, Boucard left an enzymatic reaction on you're there for a short time or for the rest of your life, you'll have the best time of your life during

During dinner with colleagues and Alfred Gillman , co-recipient of the 1994 Nobel Prize in Physiology

Caron and his family moved to Durham, NC in 1977, following receipt of his BSc in Chemistry from Laval He joined the faculty of Laval University School of Medicine in 1975 and then returned to join Duke’s Duke Professor until his death.