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assay and Kd= 42nM in Tag-lite®). Competition experiments of binding of fluorescent ligand CELT-335 to living HEK-293 T cells expressing W.; Wu, Y.; Zhao, S.; Shui, W.; Li, S.; Korde, A.; Laprairie, R. B.; Stahl, E. L.; Ho, J. Cell   2016 , 167  (3), 750-762.e14. https://doi.org/10.1016/j.cell.2016.10.004 . (5)         Li, X.; A Fluorescent Ligand-Binding Alternative Using Tag-Lite® Technology.

GPCR-focused programs, the ability to visualize receptor localization, internalization kinetics, and ligand Yet, despite remarkable progress, HCS workflows remain vulnerable to several performance-limiting factors How Fluorescent Ligands Strengthen HCS Assays: The Case of CELT-331 Fluorescent ligands are now considered Their ability to visualize ligand–receptor interactions directly in living cells produces data that are information that clarifies receptor behavior under different ligand conditions.

The donors used in this technique have longer half-lives  than other fluorophores (between 300μs–1 ms The donors act as light-harvesting antennas, capturing light from all directions, unlike the dipole-dipole This also improves detection of low affinity or slow binding ligands. A Robust and Efficient FRET-Based Assay for Cannabinoid Receptor Ligands Discovery. A Robust and Efficient FRET-Based Assay for Cannabinoid Receptor Ligands Discovery.

2,3,*, Analisa Thompson Gray 2, Feyisayo Adegboye 2, Ainsley McDonald-Boyer 3, Fubiao Shi 1, Dianxin Liu 1, Jose Maldonado 5, Jiesi Feng 4, Yulong Li 4, Simon Alford 5, Julio E. The Department’s strengths lie in GPCR signal transduction and neuroscience, and she has expanded it She gave the Fritz Lipmann Lecture at ASBMB in 2001. " Heidi Hamm on the web The Hamm Lab Vanderbilt School of Medicine Pubmed Google Scholar LinkedIn Twitter Dr.

<< Back to podcast list Dr. GPCR Podcast Strategic Partners Dr. Nicolas Gilles About Dr. His strongest expertise lies in therapeutic target identification and all the steps from venom manipulations When the pharmacological properties of these new ligands are deemed exceptional, a lead optimization Nicolas Gilles on the web Google Scholar LinkedIn Dr. GPCR Enjoying the Dr. GPCR Podcast? : The Evolution of GPCR Research How GPCR Spatial Signaling Sparked a Scientific Journey Thanks for listening

Home → Flash News → Terry's Corner is Officially LIVE! TerrysCorner #DrugDiscovery Published on July 2, 2025 Category Terry's Corner Terry's Corner is Officially LIVE But what if the real opportunity lies in the chemical matter we throw at them?