Electron cryo-microscopy (cryo-EM) is a powerful technique for the structural characterization of biological In recent years, pharmaceutical companies have begun to utilize cryo-EM for structure-based drug design As a result, cryo-EM has begun to make major impacts in bringing critical therapeutics to market. In this review, we discuss recent instructive examples of impacts from cryo-EM in therapeutics design We also discuss the opportunities afforded by emerging technological advances in cryo-EM, and the prospects

August 2022 "Single particle cryogenic-electron microscopy (cryo-EM) is used extensively to determine Although a similar strategy has the potential to broadly facilitate cryo-EM structure determination of The fusion strategies explored here are likely applicable to cryo-EM interrogation of other GPCRs and

Here, we report the cryo-EM structures of an EBI2-Gi signaling complex with its endogenous agonist 7α

mechanism of this family of G protein-coupled receptors using innovative approaches, including biosensors, cryo-EM

mechanism of this family of G protein-coupled receptors using innovative approaches, including biosensors, cryo-EM

Patrick Sexton " Patrick Sexton is a NHMRC Senior Principal Research Fellow and Director, ARC Centre for Cryo-electron Recently, his team has applied cryo-EM to elucidation of the structure and dynamics of GPCRs. Prof.