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Cutting-edge cryo-EM reveals how LYCHOS, a lysosomal protein, senses cholesterol to regulate metabolism cell growth ➡️https://www.ecosystem.drgpcr.com/structural-and-molecular-insights-into-gpcr-function/cryo-em-reveals-cholesterol-binding-in-the-lysosomal-gpcr-like-protein-lychos Cutting-edge cryo-EM reveals how LYCHOS, a lysosomal protein, senses cholesterol to regulate metabolism cell growth ➡️ https:// www.ecosystem.drgpcr.com/structural-and-molecular-insights-into-gpcr-function/cryo-em-reveals-cholesterol-binding-in-the-lysosomal-gpcr-like-protein-lychos

Home → Flash News → insights into g protein coupling preference from cryo em structures of gq bound PTH1R This new Nature Chemical Biology paper reveals cryo-EM structures of Gq-bound PTH1R—highlighting how

Home → Flash News → New cryo-EM insights reveal how extracellular domains communicate with transmembrane conformational-coupling-between-extracellular-and-transmembrane-domains-modulates-holo-adhesion-gpcr-function #gpcr #drgpcr Published on January 7, 2025 Category GPCR Weekly News New cryo-EM

Through Cryo-EM and single-cell experiments, the authors show differences in binding affinity, duration Through Cryo-EM and single-cell experiments, the authors show differences in binding affinity, duration

👅🔬 Researchers have unveiled the cryo-EM structure of TAS2R14, the most promiscuous bitter taste receptor 👅🔬 Researchers have unveiled the cryo-EM structure of TAS2R14 , the most promiscuous bitter taste receptor

New cryo-EM structures from Chen et al. New cryo-EM structures from Chen et al.

New cryo-EM structures of GPR4 and GPR68 reveal how extracellular histidines act as proton sensors-trigger New cryo-EM structures of GPR4 and GPR68 reveal how extracellular histidines act as proton sensors-trigger ago How GPCR Spatial Signaling Sparked a Scientific Journey Michelle hadn’t mapped out a scientific empire

Patrick Sexton " Patrick Sexton is a NHMRC Senior Principal Research Fellow and Director, ARC Centre for Cryo-electron Recently, his team has applied cryo-EM to elucidation of the structure and dynamics of GPCRs. Prof.

mechanism of this family of G protein-coupled receptors using innovative approaches, including biosensors, cryo-EM

Australia Senior Principal Research Fellow, and Director of the Australian Research Council Centre for Cryo-electron More recently, his team has been at the forefront of the application of cryo-EM to elucidate of the structure

Yamina Berchiche emphasizes the importance of diverse voices in the GPCR community: “It’s been a very Allosteric Modulation: The New Frontier of GPCR Drug Discovery Ben reflects on the emerging potential Structural Biology Roadblocks: The Cryo-EM Challenge One bottleneck in Ben’s work is visualizing binding sites of PAMs via cryo-EM , due to low compound potency and membrane-embedded binding pockets. Still, by collaborating with structural biology teams and combining cryo-EM with NMR , his lab is narrowing

Chris also worked on the E. coli multidrug transporter EmrE and obtained both 2D and 3D crystals as well as a 3D structure using cryo-EM. determined by X-ray crystallography of receptors coupled to either mini-Gs or mini-Go, and also by electron cryo-microscopy

G-type receptors (CELSRs) are conserved adhesion G protein-coupled receptors; they are essential for embryogenesis Here, we report the 3.8 Å cryo-EM reconstruction of the CELSR1 ECR which enables unambiguous assignment We employ cellular assays with full-length CELSR1 and truncation constructs to assess the adhesive and

dissecting the three-dimensional architecture and underlying molecular signaling mechanism of GPCR using cryo-electron microscopy (cryo-EM).

has made use of several techniques including various mass spectrometry approaches, single particle cryo-EM Yamina emphasized that the content should be kept in a PG-13 context and be scientifically related to He detailed his initial email contact, the subsequent Skype meeting, and the in-person visit that led The conversation emphasized the importance of diverse backgrounds and skill sets in tackling complex John emphasized that negotiating salary is often not possible due to strict regulations.

Here, we describe the cryo-EM reconstruction of an aGPCR, Latrophilin3/ADGRL3, and reveal that the conserved

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GPCR Ecosystem, where we connect and empower the GPCR community in the United States. Discovery Failures GPCR Flash News ➚ Closing the Gap Between Academia and Industry Our vision is simple: empower Closing the Gap Between Academia and Industry Our vision is simple: empower the GPCR field through shared

breakthrough that didn’t start in a grant proposal December 3, 2025 Read full article It started with a cold email durable innovation hub This is more than a story — it’s a blueprint for GPCR science, biotech R&D, and CRO Irreversible interactions emerge when one simple imbalance tips the scale: inflow outpacing outflow.

that didn’t start in a grant proposal Published on December 3, 2025 Category It started with a cold email

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They also shared their career journeys, emphasizing the value of being open-minded, proactive, and embracing Summary Embracing Cultural Differences and Collaboration Yamina and Jacek shared their experiences with name mispronunciations and variations and discussed the importance of embracing cultural differences His advice was to be ready for changes and to embrace opportunities as they arise. Yamina agreed, emphasizing the importance of mental preparation and embracing different social situations