work has produced structural data at the extracellular domain level and, more recently, full-length cryo-EM Her work employs X-ray crystallography, single-particle cryo-EM, mutagenesis, and mass spectrometry, same year, established inactive, active, and intermediate conformational states of this receptor using cryo-EM inside the transmembrane bundle: a discovery nobody expected When Fan's team solved the full-length cryo-EM The field has moved from not knowing the subunit composition of GABA-B to holding cryo-EM structures

Yamina Berchiche emphasizes the importance of diverse voices in the GPCR community: “It’s been a very Allosteric Modulation: The New Frontier of GPCR Drug Discovery Ben reflects on the emerging potential Structural Biology Roadblocks: The Cryo-EM Challenge One bottleneck in Ben’s work is visualizing binding sites of PAMs via cryo-EM , due to low compound potency and membrane-embedded binding pockets. Still, by collaborating with structural biology teams and combining cryo-EM with NMR , his lab is narrowing

mechanism of this family of G protein-coupled receptors using innovative approaches, including biosensors, cryo-EM

Joseph Kim exploring GPCR structural biology, cryo-electron microscopy, opioid receptor pharmacology, The discussion explores how structural biology technologies—particularly cryo-EM—have transformed the Structural Biology Reveals the Molecular Logic of Drug Action Through cryo-EM studies of the μ- and κ-opioid New Tools Enable Re-exploring Old Questions Advances in cryo-EM, computational modeling, and machine microscopy Graduate training in cryo-EM and early exposure to membrane protein structural biology. 10

Australia Senior Principal Research Fellow, and Director of the Australian Research Council Centre for Cryo-electron More recently, his team has been at the forefront of the application of cryo-EM to elucidate of the structure

biology — addiction, autism spectrum disorder, schizophrenia, and cancer The structural bottleneck: what cryo-EM Adhesion GPCRs Open a Pandora's Box Adhesion GPCRs appear across nearly every biological process — from embryonic The Structural Bottleneck Cryo-EM has transformed understanding of classical GPCR structure, but adhesion The deeper issue, Boucard argues, is not just the quantity of structures but their nature: every cryo-EM teaches about choice 31:33 The underground restaurant in San Francisco, born out of an immigration emergency

pharmacology — from the era when the field debated whether opioid receptors were even proteins, to the cryo-EM-driven receptor and the pursuit of a non-psychedelic psychedelic Structure-guided GPCR drug discovery in the cryo-EM internet seller who supplied the compound disagreed, took naloxone, smoked salvia to disprove it, and emailed

Institute of Technology, Kanpur attacks this question from multiple angles: structural snapshots by cryo-EM research focuses on the structural and functional basis of GPCR–beta-arrestin interactions, combining cryo-electron What a one-line email to Bob Lefkowitz can do Toward the end of his PhD in Frankfurt, Dr. I wrote an email to him. No formal interview, nothing of that sort. Gill Chair Professor, Intermediate Fellow, Wellcome Trust DBT India Alliance Swarnajayanti Fellow & EMBO

his research focuses on the structural and biochemical study of membrane proteins, with particular emphasis Chris also worked on the E. coli multidrug transporter EmrE and obtained both 2D and 3D crystals as well as a 3D structure using cryo-EM. determined by X-ray crystallography of receptors coupled to either mini-Gs or mini-Go, and also by electron cryo-microscopy

has made use of several techniques including various mass spectrometry approaches, single particle cryo-EM Yamina emphasized that the content should be kept in a PG-13 context and be scientifically related to He detailed his initial email contact, the subsequent Skype meeting, and the in-person visit that led The conversation emphasized the importance of diverse backgrounds and skill sets in tackling complex John emphasized that negotiating salary is often not possible due to strict regulations.

ABOUT RANDY Randy Hall is Professor of Pharmacology and Chemical Biology at Emory University School of Screening work has since produced agonists and antagonists, and the first cryo EM structure of an adhesion

Access expert CRO advisory services through the Dr. GPCR Ecosystem. Home About Services News Get in Touch Welcome CRO & Vendor Advisory Your Science Is Strong. I help CRO teams bring structure to collaboration—so your data gets acted on, not overlooked. How I Help CROs Deliver High-Impact Science That Biotech Teams Trust Biotech Clients Stay in Sync With Power My Discovery Send me a message First name* Last name Company name* Email* How Can I Help?

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<< Back to podcast list Strategic Partner(s) Empowering Drug Discovery for the GPCR Community with Dr

GPCR Affiliate Program Earn by Empowering the GPCR Ecosystem Help us connect scientists, founders, and

biased agonism, assay design, drug discovery workflows, translational challenges, and the science behind emerging

Sessions focus on research questions, experimental interpretation, and emerging challenges in GPCR science

monoclonal antibody facility has produced reagents paired with enhanced validation protocols and a strong emphasis

His primary research focus is orphan GPCR biology, with particular emphasis on identifying endogenous He completed two postdocs in the UK at the EMBL-European Bioinformatics Institute and GlaxoSmithKline

Mentorship under isolation — The practical and emotional work of keeping graduate students — especially

Biased agonism, endosomal signaling, and what remains 47:13 Three aha moments: first data, an email from

Bengtsson emphasizes the dominant role of skeletal muscle in metabolic regulation.

Finding the Right Mentor and Lab A birthday email changed everything. “Let’s embrace the challenge to study all of them… they’re unique in how they bind ligands, how selective they are.” – Alessandro Nicoli He emphasized that olfactory receptors , while underexplored, present receptors move in physiological conditions, with water, membranes, ligands.” – Alessandro Nicoli He emphasized

Our ongoing efforts have direct implications in cancer, embryonic development defects, and neurological The conversation further delves into the dynamics of managing a diverse team, emphasizing the role of

systems Interrogating Incretin Receptor Biology Across Biological Complexity GLP-1 and GIP receptors have emerged

studies opioid receptor biology in the context of headache disorders, chronic pain, and their comorbid emotional Ligand-directed signaling and receptor trafficking — how internalization shapes tolerance and adverse effects The emotional would be non-internalizing, brain-penetrant, long-half-life, and directed at forebrain circuits where emotional Pradhan argues that migraine — with its emotional comorbidity, its anatomical overlap with delta receptor — tolerance, internalization, downregulation 14:17 Designing the delta agonist she wants 17:30 The emotional

Yamina emphasized the potential of multiplexing assays in expanding the scope of scientific exploration Lastly, Badr emphasized the importance of choosing a city one would like to live in for several years Fluctuations Badr shared his journey of overcoming fluctuating confidence levels during his PhD journey, emphasizing She emphasized preparation and understanding guests’ backgrounds for engaging interviews.

Lastly, they touched upon the global challenges of healthcare workforce growth, climate change, and emerging Arthur and Yamina from Monash University discussed their collaborative approach to scientific research, emphasizing Lastly, they discussed the global challenges of healthcare workforce growth, climate change, and emerging They also emphasized the significance of fundamental discoveries, the role of biotech, and the need for Hiring Process, Collaboration, and Education-Focused Initiatives Arthur emphasized the importance of

Crauwels emphasizes the critical role of well-annotated experimental data for training predictive models Charlotte Crauwels emphasizes that predictive models are only as reliable as the datasets used to train

They emphasized the significance of mathematical models in systems biology and pharmacology and the challenges Yamina shared her research experience, emphasizing the fascination of understanding how cells respond They emphasized the need to quantify the dynamics of the pathways and the residence time of the receptor Towards the end, Aurelien Rizk shared his top three 'aha' moments as a scientist, emphasizing the importance at Interax Biotech, with Aurelien Rizk and Yamina clarifying that job openings are communicated via email