reported intracellular CCR2 antagonists, several tetramethylrhodamine (TAMRA)-labeled CCR2 ligands were designed

GPCR that may provide a new venue for highly specific modulation of GPCR function and advanced drug design

, which clarifies the receptor subtype selectivity and provides a template for structure-based drug design

the Next Stage of its Evolution "New team focused on expanding its GPCR-focused structure-based drug design

aGPCRs via post-translational modifications of the Go protein, and offers guidance for future drug design

We designed an integrative approach to improve comparative modeling of TAS2Rs.

Group Corporation (“the Company”; TSE: 4565), the world leader in GPCR-focused structure-based drug design

pharmacological properties and functions of PxOctβ3 in P. xylostella, thus, providing a theoretical basis for the design

that our results could have potential implications in structural biological advancements of GPCRs and design

Insights into GPCR Function Structural and signaling mechanisms of TAAR1 enabled preferential agonist design Showcases Innovative AI-Driven Drug Design at BRIC AI 2023 Workshop Salipro Biotech AB Celebrates Milestones

role, she will focus on the application of artificial intelligence (AI), machine learning, and the design

We designed and synthetized peptides that interfered with integrin αIIb binding (pCIB and pCIBm) or mimicked

The pharmacological profiles and mechanistic insights of our study provide clues for the future design

MQ1-K39A represents the first step in the improvement of the MQ1 design from a medicinal perspective.

restoration of tension in epithelial cells GPCR Binders, Drugs, and more Advances in structure-based drug design copolymers and SMALPs as a platform for investigating GPCRs Reviews, GPCRs, and more Fragment-Based Design

receptor, which could participate in the recognition of MT1-selective ligands and may be exploited in the design

The process of designing and evaluating biased ligands for GPCRs is complex but essential for understanding Advances in understanding the structural and mechanistic aspects of biased GPCR signaling are crucial for designing

Methods: To address this question, we studied mice that express a Gs-coupled designer G protein-coupled

GPCR Binders, Drugs, and more Rational design of highly stabilized and selective adrenomedullin analogs

The mouse CMV (MCMV) GPCR homolog, designated M33, is important for cell-associated virus spread and

Methods & Updates in GPCR Research A coiled-coil-based design strategy for the thermostabilization of

Design, synthesis, and evaluation of substituted alkylindoles that activate G protein-coupled receptors

is of great importance in GPCRs field as it supports the development of alternatives to improve drug design

GPCR Binders, Drugs, and more Design of Drug Efficacy Guided by Free Energy Simulations of the β2 -Adrenoceptor

Modelling altered signalling of G-protein coupled receptors in inflamed environment to advance drug design

protein-coupled receptor C3aR1 reveals ligand-mediated biased agonism GPCR Binders, Drugs, and more Design

Specialist - Natural Sciences - Surgery Senior Scientist- Membrane Technologies Computational Protein Design

Novel Xanomeline-Containing Bitopic Ligands of Muscarinic Acetylcholine Receptors: Design, Synthesis