📰 GPCR Weekly News, June 19 to 25, 2023

Welcome, GPCR buffs! Join us for our weekly round-up of GPCR News.

Congratulations to our Dr. GPCR Partner, GPCR Therapeutics, for passing the Technology Evaluation process for listing on the KOSDAQ market.

Before we dive into the latest news, mark your calendars for July 21st for our next Dr. GPCR Symposium on Structural and Molecular Insights on GPCR Activation. As we approach the event, we have some news to share:

• We’ve decided to make this event a trainee day event!

• We will be hosting a career panel (more on our panelists soon)!

• We are looking for poster presenters; please fill out the poster submission form. Everyone is welcome to present their work. Please note that you will have to submit a 1-minute abstract video.

• Stay up-to-date as the program develops by subscribing to our monthly Dr. GPCR Newsletter.

Let's review the weekly Classified GPCR News from June 19th to June 25th, 2023.

GPCR Activation and Signaling

• Stimulation of ectopically expressed muscarinic receptors induces IFN-γ but suppresses IL-2 production by inhibiting activation of pAKT pathways in primary T cells.

• Serotonin 5-HT7 receptor slows down the Gs protein: a single molecule perspective.

• Striatal mGlu5-mediated synaptic plasticity is independently regulated by location-specific receptor pools and divergent signaling pathways.

GPCR Binders, Drugs, and more

• Molecular Characterization of Two Wamide Neuropeptide Signaling Systems in Mollusk Aplysia.

• Discovery and in vitro Characterization of BAY 2686013, an Allosteric Small Molecule Antagonist of the Human PAC1 Receptor.

• PTK7 is a positive allosteric modulator of GPR133 signaling in glioblastoma.

GPCRs in Neuroscience

• Whole genome sequencing across clinical trials identifies rare coding variants in GPR68 associated with chemotherapy-induced peripheral neuropathy.

Methods & Updates in GPCR Research

• A coiled-coil-based design strategy for the thermostabilization of G-protein-coupled receptors.

Reviews, GPCRs, and more

• 7TM domain structures of adhesion GPCRs: what's new and what's missing?

• Specialized Pro-resolving Lipid Mediators and Resolution of Viral Diseases.

Structural and Molecular Insights into GPCR Function

• Structure-Activity Relationship Study of the High-Affinity Neuropeptide Y4 Receptor Positive Allosteric Modulator VU0506013.

Industry News

• Data shows nearly 19% weight loss in people with overweight or obesity in Boehringer Ingelheim and Zealand Pharma Phase II trial with survodutide (BI 456906).

• Sanofi Goes All-In On AI.

• Inversago Pharma Presents Data from Phase 1b Trial of INV-202, a Peripheral CB1r Blocker for Metabolic Syndrome, at the 83rd American Diabetes Association Scientific Sessions.

• Octopus 3.0 - Next-Day Turnaround Of Full Plasmid Sequencing Directly From Colonies

• Indivior to Commence Trading on Nasdaq.

• GPCR Therapeutics passes the Technology Evaluation process for listing on KOSDAQ.

GPCR Events, Meetings, and Webinars

• Training School on “Cell-based assays to study Adhesion GPCR function" (June 28 - 30, 2023)

• FREE Seminar Antibodies targeting Membrane Proteins - From Antigen to New Therapeutics (June 30, 2023)

• FREE 11th Adrenoceptor Symposium: Adrenoceptors and GPCR Signalling (June 30 - July 1, 2023)

• 19th World Congress of Basic & Clinical Pharmacology 2023. (July 2 - 7, 2023).

• ONCORNET2.0 Final Symposium (August 31 - September 1, 2023) Registration ends Tomorrow!

• 3rd Annual Meeting IRN I-GPCRNet (October 25 - 27, 2023)

• GPCR Retreat (November 2 - 4, 2023) Registration is now open!

• Structure, Mechanism, and Drug Interactions of GPCRs, Ion Channels, and Transport Proteins (March 24 - 29, 2024)

GPCR Jobs

• Professor in Cardiovascular Pharmacology

• Scientist I / Scientist II DOE (Native Mass Spectrometry)

• Senior Vice President of Global Medical Affairs

• Postdoctoral Position in the Gliovascular Unit of Glioblastoma

• Associate Director / Director, Clinical Operations

• Postdoctoral Research Associate

Explore Dr. GPCR Ecosystem