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- Predicting GPCR Function: Inside the Carlsson Lab’s Modeling Toolbox
Jens Carlsson , Professor of Computational Biochemistry at Uppsala University. For Carlsson, a prediction is only valid if it survives wet-lab testing. Carlsson’s group integrates modeling with mechanistic pharmacology. Carlsson’s group does not aim for perfect predictions. Jens Carlsson breaks down the tools, challenges, and mindset behind building models that don’t just explain—they
- Irreversible Drugs, Real Control: Design for Durable Target Engagement
Over 50% Discount at Checkout Get Yearly Access On-Demand Now — Free 7 Day Trial ➤ DrGPCR Podcast: Jens Carlsson on Predictive Modeling Prediction over explanation—that’s the shift. Jens Carlsson shares how structure-based design, molecular dynamics, and smart collaboration turn models
- From Failed Experiments to Predictive GPCR Models
Jens Carlsson’s path into science was anything but straightforward. A professor highlighted Carlsson’s talent in molecular modeling, a skill he hadn’t yet recognized as Predictive GPCR-Ligand Modeling Carlsson's work quickly shifted from curiosity to impact. For Carlsson, this marked a shift in how his lab approached GPCR research. Hear the full conversation with Jens Carlsson 🎧 Catch the full episode on the Dr.
- GPCR Collaboration: From Models to Medicine
Watch Episode 175 When Jens Carlsson was a PhD student, he thought collaborations slowed science down But Carlsson doesn’t try to do everything under one roof. Carlsson points to a deeper problem: credibility . Carlsson’s lab is a proof point : collaboration is not just a cultural preference. Carlsson mentors the next generation? 🎧 Listen to the full episode on the Dr.
- Assay Volume Control: Your GPCR Drug Discovery Power Lever
Jens Carlsson (Uppsala University) joins Yamina to explore how computational modeling is evolving from
- AlphaFold’s Breakthrough in GPCR Research: Revolutionizing Discovery, Yet Awaiting Experimental Proof
relies on using the known structure of a homologous protein as a template to model the target protein ( Carlsson References: Carlsson, J. et al.
- Decoding GPCR Function: The Role of Mutagenesis in Rational Drug Discovery
For example, Carlsson et al. (2010) utilised structural information and virtual ligand screening to discover Carlsson, J., Yoo, L., Gao, Z. G., Irwin, J. J., Shoichet, B. K., & Jacobson, K. A. (2010).
- Exciting GPCR Events for Next Year! + GPCR Weekly Rocket Launch ⦿ Oct 28 - Nov 3, 2024
: Congrats to: Ya-Tzu Li , our notable contributor, for her superb undergrad paper along with Hao-Jen
- Ode to GPCRs
transduction.[47] The 2000 Nobel Prize in Physiology or Medicine went to Eric Richard Kandel, Arvid Carlsson , and Paul Greengard for research on signal transduction in the nervous system.[48–54] Carlsson won the Arvid Carlsson – Facts - NobelPrize.org. https://www.nobelprize.org/prizes/medicine/2000/carlsson/facts
