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Our CSO, Maria, has recently traveled to the US to attend the ACSMEDI-EFMC Medicinal Chemistry Frontiers 2025 , a conference organized by both the EFMC and the ACSMEDI, in an effort to share the most novel medicinal chemistry advancements in both the US and Europe. Another section was dedicated to Chemistry Tools, highlighting their importance. This Chemistry Tools session was more industry focused than those before, and Maria shared the floor

August 2022 "GPCRs in Medicinal Chemistry Event 8th RSC / SCI symposium on GPCRs in Medicinal Chemistry

October 2022 "Cannabinoid Receptor 2 (CB2) is a G protein-coupled receptor (GPCR) with considerable, though as yet unrealised, therapeutic potential. Promising preclinical data supports the applicability of CB2 activation in autoimmune and inflammatory diseases, pain, neurodegeneration, and osteoporosis. A diverse pharmacopoeia of cannabinoid ligands is available, which has led to considerable advancements in the understanding of CB2 function and extensive preclinical evaluation. However, until recently, most CB2 ligands were highly lipophilic and as such not optimal for clinical application due to unfavourable physicochemical properties. A number of strategies have been applied to develop CB2 ligands to achieve closer to 'drug-like' properties and a few such compounds have now undergone clinical trial. We review the current state of CB2 ligand development and progress in optimising physicochemical properties, understanding advanced molecular pharmacology such as functional selectivity, and clinical evaluation of CB2-targeting compounds." Read more at the source #DrGPCR #GPCR #IndustryNews

August 2022 "Cannabinoid Receptor 2 (CB2) is a G protein-coupled receptor (GPCR) with considerable, though as yet unrealized, therapeutic potential. Promising preclinical data support the applicability of CB2 activation in autoimmune and inflammatory diseases, pain, neurodegeneration, and osteoporosis. A diverse pharmacopeia of cannabinoid ligands is available, which has led to considerable advancements in the understanding of CB2 function and extensive preclinical evaluation. However, until recently, most CB2 ligands were highly lipophilic and as such, not optimal for clinical application due to unfavorable physicochemical properties. A number of strategies have been applied to develop CB2 ligands to achieve closer to 'drug-like' properties and a few such compounds have now undergone clinical trials. We review the current state of CB2 ligand development and progress in optimizing physicochemical properties, understanding advanced molecular pharmacology such as functional selectivity, and clinical evaluation of CB2-targeting compounds." Read more at the source #DrGPCR #GPCR #IndustryNews

leadership wasn’t meticulously planned, it was a bold leap fueled by gut instinct and a deep love for chemistry GPCR Podcast, she shares how her background in medicinal chemistry paved the way to co-founding Celtarys Over time, she developed a fascination with how molecules influence biology and how that chemistry could their company page . _______________ Keyword Cloud:   GPCR drug discovery , GPCR research community , medicinal chemistry , Dr.

GPCRs demanded something different: the integration of modeling, medicinal chemistry, and pharmacology Supporting them is a medicinal chemist who can design and synthesize new scaffolds when commercial libraries Predictions from modeling inform chemistry. Chemistry fuels assays. Medicinal chemists can synthesize molecules, but must choose carefully from infinite possibilities. in mind, chemistry connected to assays, and assay data cycling back to refine predictions.

receptors Septerna Secures $150 Million in Series B Financing to Advance Pipeline of Novel GPCR-targeted Medicines cell-based assays in drug discovery October 2024 | Biologics US 2024 October 2 - 4, 2024 | 9th GPCRs in Medicinal Chemistry October 23 - 25, 2024 | 11th Adhesion GPCR Workshop July 12 - 17, 2026 | 20th World Congress

GPCR University Learner Celtarys Research Recap: Medicinal Chemistry Highlights You May Have Missed The pace of innovation in medicinal chemistry is accelerating—and if you missed this year’s ACSMEDI-EFMC Medicinal Chemistry Frontiers 2025 , you’re already behind.

His lab sits at the crossroads of structure-based modeling, computational chemistry, and drug discovery That medicinal chemistry capacity is unusual for a modeling lab and provides a critical bridge between Notably, this isn’t contract computational chemistry—it’s strategic guidance  on target selection, ligand

the latest in GPCR-targeted drug design, including machine learning, new biophysical techniques, and medicinal chemistry. Chemistry group Call for GPCR Papers Emerging Voices in GPCR Biology in Special Issue of Molecular Chemistry October 17, 2024 | Unprecedented fragment-based screening using Spectral Shift for GPCRs October Postdoc in Molecular Pharmacology - The Hauser Group Senior Scientist/Staff Scientist, Computational Chemistry

With collaborations across medicinal chemistry and neuropathic pain research, Ben is bridging molecule

Explore Terry's Corner From Chemistry Lab to GPCR Partner – New Podcast with Celtarys Dr. Maria Majellaro of Celtarys shares how her team translates medicinal chemistry into practical GPCR assay

December 2021 "Dame Carol Robinson DBE, FRS, FRSC, FMedSci, Oxford University’s first female Professor of Chemistry , former president of the Royal Society of Chemistry and Founder of (and ongoing consultant to) OMass Therapeutics, which is based at Oxford Science Park, has been awarded the 2022 Louis-Jeantet Prize for Medicine

The Early Days: Molecules and Mentors Alessandro began his academic life studying pharmaceutical chemistry Moro , a medicinal chemist who introduced him to the interplay between molecular structure and biological Suddenly, chemistry wasn’t just synthetic—it was strategic. Falling for Computational Chemistry Alessandro’s master’s thesis brought him face to face with his “second academic love”: computational chemistry .

GPCR Podcast, is filled with such moments, from bombing her first high school chemistry test to co-founding She studied pharmacy with a specialization in pharmaceutical chemistry, a degree that allowed her to Maria Majellaro Now, she leads a team of talented chemists at Celtarys, developing fluorescent ligands

GPCR-targeted drug development, incorporating machine learning, innovative biophysical methods, and medicinal chemistry. 2024 | 22nd Discovery on Target October 2024 | Biologics US 2024   October 2 - 4, 2024 | 9th GPCRs in Medicinal Chemistry October 17, 2024 | Unprecedented fragment-based screening using Spectral Shift for GPCRs October function NEW Protein Biochemist/Structural Biologist Senior Scientist/Staff Scientist, Computational Chemistry

Journal of Medicinal Chemistry , 41 (16), 2911-2927. Carlsson, J., Yoo, L., Gao, Z. G., Irwin, J. Journal of Medicinal Chemistry , 53 (9), 3748-3755. Di Roberto, R. B., Chang, B., & Peisajovich, S.

Dive into the exciting world of incorporating machine learning, innovative biophysical methods, and medicinal chemistry to push the boundaries of scientific discovery! 2024 | 22nd Discovery on Target October 2024 | Biologics US 2024   October 2 - 4, 2024 | 9th GPCRs in Medicinal Chemistry October 17, 2024 | Unprecedented fragment-based screening using Spectral Shift for GPCRs October cell function Protein Biochemist/Structural Biologist Senior Scientist/Staff Scientist, Computational Chemistry

This is Lucía from the Celtarys Research chemistry team.  It’s reversible under non-reducing conditions. [ 4]     Other strategies include click chemistry,  more Analysis of Past and Present Synthetic Methodologies on Medicinal Chemistry: Where Have All the New Reactions In Comprehensive Analytical Chemistry ; Verma, S. K., Das, A.

precise GPCR-targeted drugs, including the role of machine learning, new biophysical techniques, and medicinal chemistry approaches in understanding these challenging receptors. 2024 | 22nd Discovery on Target October 2024 | Biologics US 2024   October 2 - 4, 2024 | 9th GPCRs in Medicinal Chemistry October 17, 2024 | Unprecedented fragment-based screening using Spectral Shift for GPCRs October Postdoc in Molecular Pharmacology - The Hauser Group NEW Senior Scientist/Staff Scientist, Computational Chemistry

XXIII GEM Meeting in 2025 April 3 - 6, 2025 | ASPET 2025 April 14 - 17, 2025 | 20th Drug Discovery Chemistry Pharmacologist Scientist - Biology Scientist I Cell Biology - Tectonic Therapeutic Senior Principal Scientist, Medicinal Chemistry PhD fellowship in GPCR mechanosensing Senior Scientist, GPCR Pharmacology Research Associate

cell-based assays in drug discovery October 2024 | Biologics US 2024   October 2 - 4, 2024 | 9th GPCRs in Medicinal Chemistry NEW October 17, 2024 | Unprecedented fragment-based screening using Spectral Shift for GPCRs

25 - 29, 2024 | FENS Forum 2024 October 2024 | Biologics US 2024 October 2 - 4, 2024 | 9th GPCRs in Medicinal Chemistry October 23 - 25, 2024 | 11th Adhesion GPCR Workshop July 12 - 17, 2026 | 20th World Congress

2024 | 22nd Discovery on Target October 2024 | Biologics US 2024   October 2 - 4, 2024 | 9th GPCRs in Medicinal Chemistry October 17, 2024 | Unprecedented fragment-based screening using Spectral Shift for GPCRs October

| Ligand Recognition and Molecular Gating Conference April 1 - 4, 2024 | 19th Annual Drug Discovery Chemistry 25 - 29, 2024 | FENS Forum 2024 October 2024 | Biologics US 2024 October 2 - 4, 2024 | 9th GPCRs in Medicinal Chemistry October 23 - 25, 2024 | 11th Adhesion GPCR Workshop July 12 - 17, 2026 | 20th World Congress Pharmacology 2026 GPCR Jobs Postdoctoral Associate Research Technologist I Senior Scientist- Internal Medicine

Watch Episode 176 She didn’t want to be in the lab. It was supposed to be just a summer project—routine pipetting, repetitive assays, a box to tick before moving on. But something shifted. A single experiment worked. Then another didn’t. And somewhere between the results and the unknown, curiosity turned into obsession. I didn’t expect to love it, says Michelle Halls. But the moment I designed my own experiment, I was hooked. The Accidental Beginning Michelle hadn’t mapped out a scientific empire. She was a student expecting tedium, not inspiration. Yet that summer research placement cracked open a new reality: the thrill of asking questions no one else could answer . Her early work didn’t involve groundbreaking receptor models or million-dollar grants. It involved making sense of messy data and realizing the power of not knowing . This moment—the first taste of scientific ownership—reshaped her trajectory. It wasn’t the result that mattered. It was the fact that it was my  experiment. Many GPCR scientists trace their origin story back to a single unexpected spark. Not a grand plan. A spark. For innovators building tools, platforms, or therapeutics, these origin moments are where tomorrow’s leaders are born. The Moment It Clicked Once the initial spark was lit, Michelle’s curiosity snowballed. Instead of dreading lab time, she found herself chasing questions late into the night. This shift—from passive observer to active investigator—wasn’t about external validation. It was about internal ignition. She moved from “What am I supposed to do?” to “What happens if I try this?” That transition defines every true scientist. It’s not about perfection. It’s about chasing a signal through the noise. For Early-Career Scientists: Your pivotal moment might not feel like fireworks. It might be quiet, subtle—an idea you can’t stop thinking about. Pay attention to that. What began as a quiet obsession soon demanded a bigger stage. Curiosity wasn’t just something Michelle felt — it started steering every decision she made. From Cambridge to Leadership That early curiosity led her to pursue a PhD in Molecular Pharmacology at Monash University, and later to train in single-cell biology at University of Cambridge. She went from reluctant intern to global researcher shaping how we understand GPCR spatial signaling. By 2011, she had established her own group within the Drug Discovery Biology theme at Monash Institute of Pharmaceutical Sciences, exploring how receptors control localised signaling, how disease hijacks these systems, and how to target them for therapeutic gain. Mini Timeline Summer Project  — Unexpected spark PhD at Monash  — From curiosity to expertise Cambridge Fellowship  — Precision meets scale Leadership at MIPS  — Turning questions into impact What Changed After This : Her scientific questions got bigger. Instead of “what happens in this cell,” she began asking “how do cells organize signaling at scale?” This pivot reflects a universal research truth: origin stories evolve—but the spark remains . Luck, Leadership & GPCR Signaling Michelle is clear: luck played a role. But so did choice. She built on chance moments with deliberate moves—grants pursued, labs chosen, collaborations built. She emphasizes leadership not as titles but as creating spaces where science thrives . For her, leadership in GPCR research is about enabling others to find their spark the way she found hers. It’s easy to call it luck. But luck only works if you say yes when the door opens. For innovators and biotech strategists, stories like Michelle’s reveal how scientific leadership emerges. Not from polished plans—but from patterns of curiosity, risk-taking, and mentorship loops. Why GPCR Spatial Signaling Is Changing Drug Discovery Today, Michelle leads the Spatial Organization of Signaling laboratory, asking a deceptively simple question: where  do GPCR signals happen—and how does location change everything? Her work sits at the intersection of fundamental biology and therapeutic strategy. By understanding how signaling is organized in time and space, her team is opening doors to next-generation GPCR drug discovery and precision targeting. Spatial signaling isn’t just a technical detail. It’s a new language for drug discovery. Knowing where  signals occur could unlock new therapeutic strategies, better efficacy, and fewer side effects. Built to Inspire The story of Michelle Halls isn’t just about a career; it’s about a pattern. Curiosity → Ownership → Opportunity → Leadership → Innovation. For young scientists, that summer moment is waiting. For biotech innovators, those sparks are the future workforce and idea engines. For GPCR research, leaders like Michelle are showing what happens when we follow the signal all the way. 🎧 Listen to the full conversation with Michelle Halls on  The Dr. GPCR Podcast 🔓 Want to go deeper? Join   Dr. GPCR Premium  for exclusive tools, deep dives, and expert access.

| Ligand Recognition and Molecular Gating Conference April 1 - 4, 2024 | 19th Annual Drug Discovery Chemistry 25 - 29, 2024 | FENS Forum 2024 October 2024 | Biologics US 2024 October 2 - 4, 2024 | 9th GPCRs in Medicinal Chemistry October 23 - 25, 2024 | 11th Adhesion GPCR Workshop July 12 - 17, 2026 | 20th World Congress Basic and Clinical Pharmacology 2026 GPCR Jobs NEW Research Technologist I Senior Scientist- Internal Medicine

XXIII GEM Meeting in 2025 April 3 - 6, 2025 | ASPET 2025 April 14 - 17, 2025 | 20th Drug Discovery Chemistry Pharmacology GPCR Jobs Scientist I Cell Biology - Tectonic Therapeutic NEW Senior Principal Scientist, Medicinal Chemistry PhD fellowship in GPCR mechanosensing Senior Scientist, GPCR Pharmacology Research Associate cell function Protein Biochemist/Structural Biologist Senior Scientist/Staff Scientist, Computational Chemistry

25 - 29, 2024 | FENS Forum 2024 October 2024 | Biologics US 2024 October 2 - 4, 2024 | 9th GPCRs in Medicinal Chemistry October 23 - 25, 2024 | 11th Adhesion GPCR Workshop July 12 - 17, 2026 | 20th World Congress Technologies Novo Nordisk Postdoctoral Associate Research Technologist I Senior Scientist- Internal Medicine

Research reveals pro-phagocytic function and structural basis of GPR84 signaling Advancements in Precision Medicine : Superluminal Medicines Inc. | Ligand Recognition and Molecular Gating Conference April 1 - 4, 2024 | 19th Annual Drug Discovery Chemistry Conference and Exhibition June 2 - 7, 2024 | Chemotactic Cytokines October 2 - 4, 2024 | 9th GPCRs in Medicinal Chemistry July 12 - 17, 2026 | 20th World Congress of Basic and Clinical Pharmacology 2026 GPCR Jobs