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journey highlights the transition from general drug development to a deep dive into G protein-coupled receptors on positive allosteric modulators (PAMs) targeting opioid receptors. from the University of Minnesota in 2022, studying the pharmacokinetics and pharmacodynamics of NMDA receptor focuses on determining the mechanisms of action of a series of positive allosteric modulators of the mu-opioid receptor.

Fast, clear, live-cell receptor trafficking detection. This technology supports robust analysis even at low endogenous receptor expression levels. Internalization into acidic compartments = signal activation: Upon receptor-mediated endocytosis, the View Product pHSense Eu SNAP Labeling Reagent Can be used to label receptors and membrane proteins carrying All four formats are validated in well-established models like GLP1R and Mu opioid receptor (MOR), and

Committee Sponsors GPCR Retreat Program < Back to schedule Regulation and role of mitochondria delta opioid receptors Date & Time Friday, November 3rd / 10:40 AM Abstract Coming Soon About Louis Gendron "Dr Louis pharmacology and has published seminal papers where he used various approaches to describe the role of opioid receptors in pain and anagesia as well as to study the mechanisms involved in the cellular trafficking of the delta opioid receptor.

Paul Clarck , where she studied opioid receptors. AstraZeneca as a postdoctoral trainee, where she studied animal models of pain and sensory neuron sensitive-receptor Brigitte Kieffer , where she studied ligand-directed signaling at the delta-opioid receptor. Amynah studied how arrestins regulate ligand-directed signaling at delta-opioid receptors, and it is Andrew Charles that who specialized in animal models of migraine and delta-opioid receptors as a therapeutic

Ph.D. from Department of Pharmacology, University of Washington (1992, mentor Charley Chavkin , sigma receptors Postdoc with Graeme Henderson (Bristol, opioids and Ca signaling) and Mac Christie (Sydney, opioids in Grant-funded independent research positions from 2001 at University of Sydney (opioids and sensory neurons visiting scientist with Ed McCleskey, sensory neuron properties); Pain Management Research Institute (more opioids Focus on study of drugs and toxins on GPCR (opioid, cannabinoid receptor) and ion channel (K, Ca, TRP

Catherine Demery shares how she found clarity and purpose in academic opioid research. , receptors. investigates how fentanyl and xylazine shut down breathing through different mechanisms—work that blends receptor Listen now and see how one scientist is turning molecules into a mission, bridging the gap between receptor pharmacology and the urgent fight to save lives in the opioid epidemic.

Today, John and his team focus on understanding how signal transduction cascades downstream of the opioid receptors work, including the unique organization of chaperone protein Hsp90 modulation of opioid signaling

the regulation of axonal transport by tricyclic antidepressants (M.Sc.) and molecular pharmacology of opioid receptors (Ph.D.) in the Department of Pharmacology at the Université de Montréal under the mentorship Marc Caron, where I cloned the dopamine D5 receptor gene and investigated the regulation of dopaminergic and adrenergic receptors. pursues the study of the molecular, structural, pharmacological and signaling features of dopamine (DA) receptors

Graciela Pineyro’s love for GPCR pharmacology started in Uruguay where she first worked on the serotonin receptors Graciela has done extensive work on the molecular pharmacology of opioid receptors, exploring their signaling

John Traynor , Kathryn worked to develop and understand first-in-class allosteric modulators of opioid receptors. There she researched the beta-2 adrenergic receptor and developed assays to investigate real-time activity

She has done extensive work on the molecular pharmacology of opioid receptors and is currently focusing

GPCR Title: Characterization of Novel Opioid-Neurotensin Bifunctional Ligands Designed to Target Pain During his graduate studies, Emile is interested in characterizing novel G protein-coupled receptors Title: Synapse-Associated Protein 102 and Post-Synaptic Density 95 Differentially Shape Dopamine D1 Receptor Signaling About Bassam Albraidy "My thesis focus on studying the interaction of dopamine D1 receptors

Slosky’s research is focused on understanding how neuropeptide G protein-coupled receptors (GPCRs) regulate motivated behavior and how these receptors can be targeted for therapeutic benefit. These ligands stimulate receptor β-arrestin recruitment without activating canonical G protein signaling Because BAMs engage less well-conserved allosteric sites and exert pathway-specific effects on receptor selectivity can be leveraged in the development of safe and effective treatments for stimulant and opioid

easy filters Select Category Select Event Select Format Activation Mechanism of Metabotropic Glutamate Receptor Michel Bouvier Structural basis of the regulation of human chemokine receptor and HIV-1 co-receptor CCR5 Cesare Orlandi Accurate Mechanistic Calculation of μ Opioid Receptor Signaling Efficacy - Poster Presentation

With respect to GPCRs, I'm particularly interested in peptide/small protein receptors and the mechanisms With a special emphasis on G protein coupled receptors and receptor activity modifying proteins in vascular motivated behavior and how these receptors can be targeted for therapeutic benefit. Because BAMs engage less well-conserved allosteric sites and exert pathway-specific effects on receptor selectivity can be leveraged in the development of safe and effective treatments for stimulant and opioid

Neuroscience at the University of Ottawa as a Postdoctoral Fellow to explore novel G protein-coupled receptor at The Rockefeller University, where she study’s the signaling and degradation of G protein-coupled receptors lab where she helped to investigate the role of various ATP-sensitive potassium channels in pain and opioid to understand the mechanism by which a new class of biased allosteric modulators for the neurotensin receptor

A combined in silico approach to design peptide ligands with increased receptor-subtype selectivity Adam A2B adenosine receptor-triggered intracellular calcium mobilization: Cell type-dependent involvement selectivity Ligand-Independent Spontaneous Activation of Purinergic P2Y6 Receptor Under Cell Culture Soft Substrate 🔎 GPCR KEYWORDS Class-A G protein-coupled receptors , Lophotrochozoa , echinoderms , nerve injury , neuropathic pain , spinal cord dorsal horn , OPN3 , cAMP signalin g , MC4R , docking , opioid

Holo-Adhesion GPCR Demet Araç Heterogeneity of Tethered Agonist Signaling in Adhesion G Protein-Coupled Receptors It has been suggested that the TA can regulate receptor signaling without coming out of the GAIN domain activation, suggesting that non-release or partial release of the TA is unlikely to activate the receptor As an undergraduate, he studied opioid receptor trafficking and G protein conformational dynamics in We utilize several genetically modified mouse models to investigate requirements for receptor activator

/PhD, a rejection letter pivoted him into a PhD program at the University of Iowa, where he studied opioid Driven by the opioid crisis and the lack of non-addictive pain treatments, Ajay co-founded Blue Therapeutics

Sponsors GPCR Retreat Program < Back to schedule Atypical Structure and Function of Typical Chemokine Receptors of the principal efforts of our laboratory is to understand the physiological consequences of NMDA receptor The NMDA receptor is a subtype of glutamate neurotransmitter receptor that regulates the formation and Our laboratory is interested in the role of NMDA receptors not only on neurons, but also on other cells Our laboratory has a long-standing interest in the way that NMDA receptors contribute to the symptoms

Logo Contest Committee Sponsors GPCR Retreat Program < Back to schedule Complex Allosteric Cannabinoid Receptor

Registration Logo Contest Committee Sponsors GPCR Retreat Program < Back to schedule Interrogating Multiscale Receptors for Beta-arrestin signaling in the brain in vivo and has established its importance in D2 dopamine receptors These receptors belong to the super-family of G-protein coupled receptors (GPCR), the major molecular (e.g. lithium) used for bipolar disorder therapy target signaling mechanisms regulated by dopamine receptors

David Hodson on visualizing GLP-1 and GIP receptors in pancreatic islets and brain circuits to advance therapies for diabetes and obesity. << Back to podcast list Strategic Partner(s) Visualizing GLP-1 & GIP Receptors in Islets and Brain In this episode, Professor David Hodson discusses how GLP-1 and GIP receptors regulate metabolism across the pancreas and brain, and why visualizing receptor localization and signaling in Why this matters How receptor distribution in islets and brain circuits shapes incretin hormone drug

Specifically, I am interested in understanding dysregulated G-protein coupled receptor (GPCR) signaling During my post-doctoral research, I was part of a study that identified the receptors of a novel human In this study, I discovered adrenergic receptors (α2A, α2B, and β2-adrenergic receptors) that serve as the gut microbial metabolite (PAG) receptor and characterized the receptor-metabolite interaction. My long-term plan is to conduct research in the field of receptor biology, with a focus on GPCRs.

The team’s projects are devoted to the activation/function of CXCR4-ACKR3 (CXCR7) receptors of the CXCL12 In particular, FB contributed to the discovery that CXCL12 is the ligand for the CXCR4 receptor and can FB’ team has identified the orphan CXCR7/ACKR3 receptor as being the 2nd receptor for CXCL12, which behaves that are categorized into a large subgroup of G protein–coupled (GPCR) leukocyte chemotactic receptors (including CXCR4), and a smaller subgroup of atypical chemokine receptors (including the CXCR7/ACKR3

Plenary Lecture Identification and Functional Characterization of Adhesion GPCRs As Steroid Hormone Receptors and Hearing and Balance Receptors Abstract Only Available for AGPCR24 Attendees About Jin-Peng Sun " Since starting my laboratory in 2011, I has focused on G protein coupled receptors, in particular, the We have identified the receptor subfamily to sense the steroid hormones. progesterone and 17-hydroxyprogesterone membrane receptor are GPR126.

Explore GPCR lipid rafts, bitter taste receptor pharmacology, and data integration in this expert interview construction of an open-access GPCR-lipid raft database and reviews key findings from his research on D1 receptor When you’re mapping receptor localization and need to understand the mechanistic role of microdomains There, under Professor Mario Tiberi, he focused on G protein-coupled receptors and D1 receptor regulation—work that sparked his ongoing engagement with receptor signaling and microdomain biology.

Gunnar Schulte Gunnar Schulte is a Professor in receptor pharmacology and research group leader for the section Receptor Biology and Signaling at the Department of Physiology and Pharmacology. University, Melbourne Australia, GPCR pharmacology; 2006) before starting his independent research team "Receptor Most importantly my research team tries to understand underlying mechanisms of WNT-receptor interaction , the relevance of receptor dynamics, and receptor complex composition for signal initiation and specification

🚀 This workshop will explore how different ligands (compounds) can stabilize unique receptor conformations , leading to distinct signaling outcomes—even when binding to the same receptor. 🧬 Receptor Flexibility : Ligands stabilize different receptor states, creating unique signaling pathways are Dynamic Players 🔹 Different ligands trigger unique receptor states, meaning the same receptor can This allows for a side-by-side comparison of how different compounds influence receptor signaling. 📌

contributed to multiple projects exploring the underlying mechanisms of biased signaling at chemokine receptor signaling profile of CXCR3’s three endogenous biased ligands, elucidating the role of site-specific receptor biased agonists, and demonstrating the ligand specificity behind GRK recruitment to endosomes upon receptor identifying the non-canonical signaling effectors involved in the activation of Atypical Chemokine Receptor 3 (ACKR3), a receptor which does not couple to G protein and has been shown to maintain its activation