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A Final Aha Moment: Try the Crazy Idea When a collaborator offered a neuroma model (one where opioids _____ Keyword Cloud: GPCR online course, early-career scientists, imposter syndrome, GPCR podcast, neuroma model

“We’ve seen these modulators rescue opioid function where it completely fails in neuroma models. .” – Ben Clements By combining chronic pain models with receptor-level pharmacology, Ben is bridging molecule to model, and model to patient. Neuropathic conditions like neuromas often resist standard opioid treatments. collaborations across medicinal chemistry and neuropathic pain research, Ben is bridging molecule to model

Terry Kenakin’s newest foundational lesson in Terry's Corner  cuts straight to it:   Why models are vital for translating lab data into clinical forecasts The 4 types of pharmacologic models (and when to use each) The truth about linear models: useful or misleading? How the Mass Action Law underpins nearly every model Future of Receptor Theory: Linkage vs. Unlock "Pharmacologic Models" now

He is particularly excited by the novel application of PAMs in chronic and neuropathic pain models , including the neuroma model , which is typically opioid-insensitive. 4. Discovering breakthrough results in neuroma pain models via a spontaneous collaboration. This project involves molecular pharmacology in cell models to determine binding sites and mechanisms of allostery, as well as efficacy studies in mouse and rat models of acute and chronic pain.

From neuromas to novel modulators, this episode is full of breakthroughs that matter for patients. 📲 From neuromas to novel modulators, this episode is full of breakthroughs that matter for patients. 📲

Home → Flash News → terrys corner model drug response Published on July 10, 2025 Category Terry's Corner In Terry’s Corner latest lesson, discover how pharmacologic models do just that. From historical linkage theory to dynamic probability models, the comparison of data to theory will be