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Alex Serafini  pointed out in his interview, Regulators of G protein Signaling (RGS proteins)  might GPCRs as tangential but inevitable: "I feel like I never was particularly explicitly interested in GPCR signaling Whether working on opioid withdrawal, addiction vulnerability, or chronic pain, GPCR-related signaling repeatedly emerged as the core mediator  — demonstrating the reach of these signaling pathways beyond signaling .

Questions about how opioids impair breathing, why xylazine complicates interventions, and how receptor-level While writing a literature review on opioid and alcohol addiction susceptibility, something shifted. “That was kind of a signal to me that maybe I should start thinking about a PhD,” Catherine recalls. She is especially interested in mu-opioid receptor signaling  and how xylazine, as an alpha-2 adrenergic Instead, she followed the signals that kept her engaged and energized.

October 2022 Coincident Regulation of PLCβ Signaling by Gq-Coupled and μOpioid Receptors Opposes Opioid The primary analgesic target of opioids is the μ-opioid receptor (MOR). Here we investigated a potential mechanism for regulation of PLC signaling downstream of MOR in HEK293 cells and found that MOR alone could not stimulate PLC, but rather required a coincident signal from These data support a model where Gq and Gβγ-dependent signaling cooperatively regulate PLC activation

It turns out that it was signal transduction, and he worked on the signaling cascades involved in heart His encounter and interest in signaling in the context of GPCRs during his postdoctoral training in Dr Today, John and his team focus on understanding how signal transduction cascades downstream of the opioid receptors work, including the unique organization of chaperone protein Hsp90 modulation of opioid signaling Built an Innovation Engine From Pipettes to Platforms: The Evolution of GPCR Research How GPCR Spatial Signaling

Committee Sponsors GPCR Retreat Program < Back to schedule Regulation and role of mitochondria delta opioid pharmacology and has published seminal papers where he used various approaches to describe the role of opioid pain and anagesia as well as to study the mechanisms involved in the cellular trafficking of the delta opioid

Paul Clarck , where she studied opioid receptors. She then returned to academia and worked on opioids as a postdoctoral trainee with Dr. Brigitte Kieffer , where she studied ligand-directed signaling at the delta-opioid receptor. Amynah studied how arrestins regulate ligand-directed signaling at delta-opioid receptors, and it is Built an Innovation Engine From Pipettes to Platforms: The Evolution of GPCR Research How GPCR Spatial Signaling