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Discover the Dr. GPCR Ecosystem, where we connect and empower the GPCR community in the United States. Home: About Accelerating GPCR Drug Discovery, Together Dr. GPCR is the global hub where academia and industry meet to advance GPCR research, accelerate drug discovery, and foster collaboration across the entire ecosystem. 👉 Join Free Today 🔒 Go Premium Strategic Partners Your Path to GPCR Mastery Flexible, career-ready courses designed by scientists for scientists. GPCR Courses ➚ GPCR Weekly News ➚ Dr. GPCR Podcast ➚ Articles from the Ecosystem ➚ How Collaboration Sparked a GPCR Imaging Breakthrough in Chemical Biology How System-Level GPCR Thinking Prevents Discovery Failures How to Avoid the Most Common Gaps in Your Biotech Pitch GPCR Pharmacology Insights That Prevent Real Drug Discovery Failures GPCR Flash News ➚ Closing the Gap Between Academia and Industry Our vision is simple: empower the GPCR field through shared knowledge, collaboration, and open access to tools that accelerate drug discovery. 🤝 Support the Mission Home: Premium $ 249.99 Every year 🚀 Everything you need to master GPCR science — in one membership. Valid until canceled Select 🎓 Full GPCR University + 🔬 200+ expert talks 🗞️ Weekly research, careers & event intelligence 🤝 Members-only networking, AMAs & matchmaking 💡 Support open resources for the global GPCR field 🧠 Designed for researchers at every career stage 🚀 Don’t just keep up — lead the way. 🔒 Grandfather Guarantee, your rate never increases Everything You Need to Master GPCR Science in One Membership Join the most complete GPCR learning & collaboration hub. Closing the Gap Between Academia and Industry Our vision is simple: empower the GPCR field through shared knowledge, collaboration, and open access to tools that accelerate drug discovery. 🤝 Support the Mission

Your go-to hub for everything GPCR! Stay ahead with the latest research breakthroughs, industry updates, job opportunities, and upcoming events—all in one place. GPCR Weekly News - Your Hub for GPCR Research, Industry Updates, Jobs & Events Delivered straight to your inbox every week Become a Premium Member Welcome to GPCR Weekly News! Whether you're a GPCR scientist, biotech innovator, or industry professional, GPCR Weekly News keeps you connected to the discoveries and opportunities that matter most. Latest Research Breakthrough discoveries, new publications, and cutting-edge GPCR research insights. Industry Events Upcoming conferences, workshops, webinars, and networking events worldwide. Career Opportunities GPCR job listings, career tips, and networking opportunities in the field. Read the Free Edition Here's a preview of what you'll find in our latest newsletter How System-Level GPCR Thinking Prevents Discovery Failures Most GPCR programs don’t fail because of weak molecules—they fail because biology behaves differently than the assay implied. This week’s feature goes straight to the foundation: how system-level GPCR thinking protects discovery teams from the costly misinterpretations that derail programs. If your work touches GPCR pharmacology, these insights aren’t optional—they’re essential. Dr. GPCR News 3 min read Get Premium for Full Access Latest Issues How System-Level GPCR Insights Strengthen Every Discovery Decision Read Full Issue November 21 - December 4, 2025 Schild Truths & Incretin Insights — This Week in GPCRs Read Full Issue November 14 - 20, 2025 Crafting Chemical Keys for GPCR Drug Discovery Read Full Issue November 7 - 13, 2025 A Note from Yamina — The Next Chapter of Dr. GPCR Read Full Issue Oct 24 - Nov 6, 2025 The Power and Peril of Irreversible Drugs Read Full Issue Oct 17 - 23, 2025 Enzyme Insight, Real-World Impact Read Full Issue Oct 10 - 16, 2025 1 2 3 4 5 1 ... 1 2 3 4 5 6 7 8 ... 8 About GPCR Weekly News GPCR Weekly News was launched in 2020 as part of the Dr. GPCR initiative. Our mission is to provide timely, relevant, and accessible information to scientists and industry professionals working in GPCR research and drug discovery. Every week, our team curates the most important developments so you never miss a breakthrough, opportunity, or event that could impact your work. Learn More about DrGPCR Unlock Premium 🔥 Upgrade to Premium Premium Yearly $249.99 $ 249.99 Every year 🚀 Everything you need to master GPCR science — in one membership. Valid until canceled Join Premium Now 🎓 Full GPCR University + 🔬 200+ expert talks 🗞️ Weekly research, careers & event intelligence 🤝 Members-only networking, AMAs & matchmaking 💡 Support open resources for the global GPCR field 🧠 Designed for researchers at every career stage 🚀 Don’t just keep up — lead the way. 🔒 Grandfather Guarantee, your rate never increases Ready to Stay Ahead in GPCR Research? Join scientists worldwide who rely on GPCR Weekly News for the latest insights and opportunities.

Explore the scientific conference program at DrGPCR for cutting-edge insights in GPCR research. Stay updated with our program today! Welcome to Flash News—your fastest track to the latest updates in GPCR research, pharmacology, and biotechnology. Stay informed with breaking news, announcements, and key industry trends—all published here before they appear on social media. 🚀 Want full access? Become Premium! Unlock exclusive resources like the University Vault, in-depth courses, and weekly insights that go beyond the headlines. 👉 Become Premium Strategic Partners A GPCR imaging breakthrough that didn’t start in a grant proposal December 3, 2025 Read full article It started with a cold email. A young chemist, Dr. Johannes Broichhagen, was asked if he could synthesize a molecule “when you’re back in Munich.” That small moment pulled him into islet biology, confocal imaging, and a collaboration that would reshape how GLP-1R is visualized in real tissue. The new blog takes you behind the scenes — the London trip, the early confocal experiments, the pivot to chemical probes, and the trust-driven partnership that sparked a new era in GPCR imaging. If you care about chemical biology, receptor visualization, or building tools that actually work in complex systems, this one is worth reading. 🔗 Read the full story : https://www.ecosystem.drgpcr.com/post/how-collaboration-sparked-a-gpcr-imaging-breakthrough-in-chemical-biology Visualizing GPCRs in their native environment changes everything December 2, 2025 Read full article This week on The Dr. GPCR Podcast , we bring you Episode 2 of our three-part series with Celtarys Research — featuring chemist Dr. Johannes Broichhagen , whose work is redefining how we image GPCRs in real tissue. His team’s chemical probes enabled high-resolution GLP-1R visualization across systems — from pancreatic islets to in vivo two-photon imaging. Inside the episode: Chemical probes vs antibodies: specificity, stability, and live-cell performance Mapping GPCR surface pools with precision Tissue-level insights reshaping metabolic disease research What’s next: multiplex receptor labeling + AI-designed tools If GLP-1R biology, receptor trafficking, or advanced imaging are part of your work, this conversation belongs on your radar. 🎧 Listen to Episode 2 → https://www.ecosystem.drgpcr.com/dr-gpcr-podcast/chemical-probes-for-gpcr-imaging-and-internalization And stay tuned for Episode 3 with Celtarys. #GPCR #DrGPCR #metabolism #GLP1R #receptorbiology #fluorescenceimaging #drugdiscovery How GPCR Collaboration Built an Innovation Engine November 16, 2025 Dr. GPCR Podcast Read full article Collaboration isn’t a soft skill — it’s an innovation strategy. At Monash Institute of Pharmaceutical Sciences, a quiet experiment challenged the traditional PI-silo model: no private labs, shared infrastructure, pooled funding, and student rotations. The result? An ecosystem where GPCR innovation accelerated — not because of a single star scientist, but because the system itself made collaboration unavoidable. “No one had their own lab. That meant no one could build a fiefdom — and everyone had to talk.” — Michelle Halls This structure: Multiplied research capacity Attracted talent and funding Created a durable innovation hub This is more than a story — it’s a blueprint for GPCR science, biotech R&D, and CRO partnerships. 🎧 Listen to the full episode: Leadership, Luck, and GPCR Signaling 🔓 Learn more: Dr. GPCR Premium #GPCR #DrGPCR #DrugDiscovery #Innovation #ScienceLeadership #Collaboration Scientific careers aren’t just built on brilliance November 14, 2025 Dr.GPCR Podcast Read full article Scientific careers aren’t just built on brilliance—they’re shaped by curiosity, timing, and paying close attention. In this conversation, Michelle Halls reminds us of something every scientist eventually learns: hard work is essential, but noticing the unexpected often defines your biggest breakthroughs. She also names a truth we rarely acknowledge out loud—luck and timing matter. Many talented scientists leave the field not because they lacked skill, but because the right opportunity didn’t land at the right time. And that’s why attention to detail, persistence, and a bit of serendipity can change the trajectory of a research career. 🎧 Watch this moment — then catch the full episode: https://www.ecosystem.drgpcr.com/dr-gpcr-podcast/leadership-luck-and-gpcr-signaling #GPCR #DrGPCR Why does it matter where signaling happens inside a cell? November 13, 2025 Dr.GPCR Podcast Read full article Why does it matter where signaling happens inside a cell? This moment cuts straight to the heart of how many of us fell in love with GPCR biology — that realization that signaling isn’t random. It’s structured, organized, and spatially constrained. Michelle describes how reading those early papers on lipid-rich domains and GPCR–G protein compartmentalization reframed her view of receptor pharmacology. This shift — from thinking about “pathways” to understanding localized signaling architecture — is what drove her to build a research career around spatial control of GPCR signaling. This isn’t just academic. The way signals are organized defines specificity, drug response, and potential for targeted therapies. If you work with GPCRs, this perspective changes how you design experiments and interpret data. 🎧 Watch this insight — or listen to the full conversation with Michelle.🔗 Full episode: https://www.ecosystem.drgpcr.com/dr-gpcr-podcast/leadership-luck-and-gpcr-signaling ✨ Join Premium: https://www.ecosystem.drgpcr.com/gpcr-university-pricing #GPCR #DrGPCR From Pipettes to Platforms: The Evolution of GPCR Research November 13, 2025 Dr. GPCR Podcast Read full article Back when GPCR assays were performed with single channel pipettes, failure wasn’t cheap. Michelle Halls still remembers pipetting one sample at a time, holding her breath to keep the assay alive. Today, automation and high-throughput platforms make it easy to forget how fragile discovery used to be. But that history matters. It shaped how we design experiments, make decisions, and lead teams. In this week’s Dr. GPCR Podcast blog, we unpack: How the manual era shaped experimental discipline Why technology changed what we ask, not just how we ask How scientists grow from technicians to strategic leaders 🎧 Read the full story and listen to the episode: https://www.ecosystem.drgpcr.com/post/from-pipettes-to-platforms-the-evolution-of-gpcr-research 🔓 Join Dr. GPCR Premium for deeper tools and insights: https://www.ecosystem.drgpcr.com/gpcr-university-pricing #GPCR #DrGPCR #DrugDiscovery #Pharmacology #Biotech How GPCR Spatial Signaling Sparked a Scientific Journey November 12, 2025 Dr. GPCR Podcast Read full article When boredom met obsession. It started as a summer project.A reluctant student pipetting through the day, expecting nothing more than routine lab work. But for Michelle Halls, that first experiment flipped everything. One spark led to a PhD at Monash University, a fellowship at University of Cambridge, and eventually a leadership role at the forefront of GPCR spatial signaling — a field reshaping how we understand receptor biology and drug discovery. Michelle’s story isn’t just about science.It’s about what happens when curiosity takes over. From reluctant intern to scientific leader From local signaling to spatial pharmacology From spark to strategy Read the full story here🔗 https://www.ecosystem.drgpcr.com/post/how-gpcr-spatial-signaling-sparked-a-scientific-journey 🔓 Want deeper GPCR insights? Join Dr. GPCR Premium for exclusive content, expert access, and community. #GPCR #DrGPCR #SpatialSignaling #Pharmacology #DrugDiscovery #ScientificLeadership #Biotech Every receptor tells a story November 11, 2025 Dr.GPCR Podcast Read full article Every receptor tells a story — but GPCRs speak a language of organization. Dr. Michelle Halls unpacks how GPCR signaling isn’t just about ligand–receptor interaction. It’s about where and how signaling happens — spatially confined microdomains, scaffolding proteins, and preassembled complexes that fine-tune the cell’s response. This level of organization defines specificity in signaling, and understanding it changes how we think about drug targeting and disease mechanisms. It’s a moment that reframes GPCR biology from static pathways to dynamic, organized systems — where complexity is the key to precision. 🎧 Watch this moment from our conversation, then listen to the full episode on leadership, luck, and GPCR signaling: 👉 https://www.ecosystem.drgpcr.com/dr-gpcr-podcast/leadership-luck-and-gpcr-signaling #GPCR #DrGPCR How sensitive can a GPCR really be? November 9, 2025 Dr. GPCR Podcast Read full article Think femtomolar. That’s the scale we’re talking about. This week on the Dr. GPCR Podcast , we sit down with Michelle Halls , leader of the Spatial Organisation of Signalling lab at Monash University. Her team is redefining how we understand GPCR signaling — not just at the cell surface, but in space, time, and disease context. In this episode, you’ll learn: How GPCR pre-assembly enables femto-level signal detection. Why receptor location matters as much as receptor type. How disease can hijack signaling organization — and what that means for drug discovery. Michelle’s work bridges elegant mechanistic biology with translational impact — giving us new ways to think about receptor pharmacology, biased agonism, and therapeutic precision. 🔗 Listen here → https://www.ecosystem.drgpcr.com/dr-gpcr-podcast/leadership-luck-and-gpcr-signaling 🎓 Explore Dr. GPCR Premium → https://www.ecosystem.drgpcr.com/gpcr-university #GPCR #DrGPCR #pharmacology #drugdiscovery #receptors #biotech #signaltransduction AI is changing how we think about structure, function, and discovery November 4, 2025 Dr. GPCR Podcast Read full article AI is changing how we think about structure, function, and discovery — but Jens Carlsson reminds us: the real test isn’t whether we can explain today’s data, it’s whether we can predict tomorrow’s results . In this clip, Jens unpacks a mindset shift that every computational scientist should hear. For decades, molecular modeling focused on explaining — rationalizing why a ligand binds, why a mutation shifts signaling, why a simulation behaves a certain way. But explaining is retrospective. Prediction is transformative. With tools like AlphaFold , his lab can now model receptor–peptide complexes in seconds — an achievement that once took months. Yet Jens’s caution stands: prediction must be proven. A good model doesn’t just match published structures; it forecasts new biology, new ligands, and new function. That’s where the future of GPCR research lies — not in describing the past, but in anticipating it. Whether you’re running simulations, screening compounds, or designing next-gen molecules, this insight reframes what “success” in computational pharmacology really means. 👉 Watch the full episode: model predict discover #GPCR #DrGPCR If your model can’t change an experiment, what’s the point? October 31, 2025 Dr. GPCR Podcast Read full article If your model can’t change an experiment, what’s the point? That’s the standard Dr. Jens Carlsson sets in his lab at Uppsala University. For him, modeling isn’t just about elegant simulations; it’s about impact . The kind of impact that shows up in how experiments are designed, which compounds get prioritized, and what gets synthesized next. Carlsson’s lab doesn’t work in isolation. They collaborate deeply with medicinal chemists, pharmacologists, and biotech partners to create workflows that connect virtual screening to synthesis and bioassay. Every step has a purpose. Every prediction feeds into a testable hypothesis. But the real differentiator? The way they collaborate: strategically, transparently, and without ego. His team is clear about the capabilities and limitations of their models, an honesty that builds long-term trust across disciplines. In GPCR drug discovery, where complexity is the rule and timelines are tight, this kind of cross-functional fluency is no longer optional. It’s the catalyst for turning insight into innovation. 🎧 Learn how Carlsson turns models into translational outcomes in this episode of the Dr. GPCR Podcast: model predict discover #DrGPCR #GPCR #CollaborationInScience #ComputationalChemistry #Pharmacology #DrugDesign “Technologies come and go. If that’s all you know, you’ll be out of the game fast.” October 30, 2025 Terry's Corner Read full article “Technologies come and go. If that’s all you know, you’ll be out of the game fast.” In our AMA, Terry Kenakin shared timeless career advice for young pharmacologists navigating a fast-changing field: “Try to keep a finger on the pulse of as much as you can… that was one of the main reasons for doing Terry’s Corner. New ideas come up, and if we can encapsulate them and expose them, you can just hit a button, hear about it, and pursue it.” To stay relevant in the next decade, it’s not about chasing the latest assay or tool. It’s about building adaptive thinking—knowing where the field is moving and being ready to pivot with it. That’s what Terry’s Corner was built for: a space to turn decades of industry experience into short, targeted insights that keep you ahead of the curve. 🟢 Join Terry’s Corner → https://www.ecosystem.drgpcr.com/terry-corner ✳️ Next AMA Session: ⚠️ Today, Oct 30 | 12–1 PM EST #GPCR #DrGPCR #Pharmacology #DrugDiscovery #CareerDevelopment #Biotech #Mentorship #EarlyDiscovery #ScientificLeadership What happens when 40+ years of discovery experience get distilled into one conversation? October 29, 2025 Terry's Corner Read full article What happens when 40+ years of discovery experience get distilled into one conversation? That’s exactly what our first-ever AMA session with Terry Kenakin set out to do. Terry’s Corner was built to make advanced pharmacology practical: a space where scientists don’t just learn passively—they shape the curriculum and bring their toughest questions forward. As Terry shared during the AMA: “This is a labor of love. Pharmacologists are almost always working in systems they don’t fully understand. The more we can see, the better choices we make.” Through live Q&A, targeted modules, and short, focused lessons, Terry’s Corner gives discovery teams the frameworks to: Decode complex GPCR signaling. Rethink outdated models. Translate early data into better decisions. This is more than another course. It’s an open vault of knowledge. 🟢 Read More → https://www.ecosystem.drgpcr.com/post/accelerating-gpcr-drug-discovery-what-40-years-of-pharmacology-reveal ✳️ Next AMA Session: October 30 | 12–1 PM EST #GPCR #DrGPCR #Pharmacology #DrugDiscovery #AllostericModulation #Kinetics #AssayDevelopment #EarlyDiscovery #PharmaR&D #BiotechInnovation Ask-Me-Anything Session - Sept 18 - Trailer October 28, 2025 Terry's Corner Read full article Pharmacology doesn’t stand still—and neither should your toolkit. In the discovery phase, one overlooked kinetic parameter or a misjudged model can set your team back months . Precision in early decisions determines whether your molecule moves forward or stalls. That’s why we’ve built a dedicated space inside Terry’s Corner to get clear, evidence-based answers to the questions that shape your experiments and strategy. In this AMA session, you’ll learn how to: Decode GPCR signaling complexity using functional assay strategies Identify allosteric modulators before they derail downstream decisions Integrate kinetics early—before your program locks into costly pathways Rethink legacy screening frameworks through modern pharmacology This isn’t theory. It’s 45+ years of applied discovery experience from Terry Kenakin distilled into practical, modular lessons designed for scientists who need clarity fast. 🟢 Join Terry’s Corner → Terry's Corner | Dr. GPCR Ecosystem ✳️ BONUS — Live AMA Session: Get direct, unfiltered access to Terry. Bring your most challenging questions to our next Ask Me Anything session on October 30, 12–1 PM EST . ⚠️ Seats are limited. Don’t fall behind on what will shape the next decade of discovery. #GPCR #DrGPCR #Pharmacology #DrugDiscovery #Biotech #AllostericModulation #Kinetics #AssayDevelopment #EarlyDiscovery #PharmaR&D #BiotechInnovation Irreversible kinetics = strategic lever in drug design. October 27, 2025 Terry's Corner Read full article Receptor pharmacology has evolved. Irreversible interactions are no longer niche curiosities — they’re strategic levers that shape how molecules behave in vivo and whether candidates advance or stall in discovery. Inside Terry’s Corner, you’ll gain access to focused, high-impact modules built for teams who need to engineer binding kinetics, not just potency . These lessons bridge molecular pharmacology with real-world design strategy, giving discovery teams the tools to make smarter decisions earlier in the pipeline. Here’s what’s covered in this week’s lesson: Target depletion vs. replenishment dynamics — how offset rates control exposure windows, shape therapeutic durability, and influence dosing intervals. Structured tissue penetration challenges — why high-affinity molecules stall at the periphery and how to optimize kinetic profiles for deeper reach. Quantifying irreversible activity (K_inact / K_I) — turning persistent binding into measurable design parameters that guide candidate optimization. Join to learn the same principles guiding successful drug programs today. 🟢 Browse the full video vault and stay ahead of the curve: ✳️ Courses by Terry | Dr. GPCR Ecosystem #GPCR #DrGPCR #Pharmacology #DrugDiscovery #Kinetics #ReceptorPharmacology #MedicinalChemistry #PKPD #DrugDevelopment Can your model actually predict the outcome of a GPCR experiment? October 27, 2025 Dr. GPCR Podcast Read full article “Explain” is no longer enough. Can your model actually predict the outcome of a GPCR experiment? At Uppsala University, Dr. Jens Carlsson and his team are redefining what computational modeling means in drug discovery. Their lab doesn’t just simulate receptor-ligand interactions after the fact; they aim to forecast receptor behavior before the first assay is run. By integrating molecular docking, molecular dynamics, and machine learning, they design ligands with the goal to anticipate biological outcomes. This kind of predictive modeling challenges the traditional role of computation in pharmacology, where models have too often served as post hoc rationalizations. But Carlsson’s lab stands out for another reason: knowing when not to predict. His team is candid about the limits of their models. If the resolution isn't good enough, or if the data is too uncertain, they’re not afraid to say, “We don’t know.” That scientific humility (combined with deep collaborations with medicinal chemists and pharmacologists) is exactly what makes their predictions so useful. This episode is essential listening for anyone thinking seriously about translational pharmacology and the future of GPCR drug discovery. 🎧 Explore how predictive modeling is reshaping GPCR science in this Dr. GPCR Podcast episode: model predict discover #DrGPCR #GPCR #MolecularModeling #PredictivePharmacology #DrugDiscovery Persistent binding ≠ just covalent. October 24, 2025 Terry's Corner Read full article Why do some inhibitors act long after the drug itself is gone? It’s not always about covalent chemistry — often, it’s about kinetics. Irreversible interactions emerge when one simple imbalance tips the scale: inflow outpacing outflow. That’s why a compound like phenoxybenzamine can knock down receptor populations after just a brief exposure. And why slow-dissociating allosteric inhibitors can reshape signaling curves for hours — or even days — after dosing stops. When persistent binding meets structured tissues, this effect can amplify or collapse. High-affinity molecules can get trapped at the periphery of a tumor, never reaching the core. The result: inconsistent exposure, patchy activity, and sometimes, outright therapeutic failure. This isn’t a subtle nuance. Binding kinetics are a design variable, as critical as potency or clearance. Get it wrong, and the best molecule on paper stalls in development. Get it right, and you unlock durable efficacy with leaner dosing strategies. If your discovery strategy still treats kinetics as an afterthought, you’re already behind. ✳️ Read More: https://www.ecosystem.drgpcr.com/post/beyond-clearance-the-strategic-power-of-irreversible-drug-binding #GPCR #DrGPCR #Pharmacology #DrugDiscovery #BindingKinetics #ReceptorPharmacology #MedicinalChemistry #PKPD #DrugDesign Dr. GPCR Weekly News - Oct 23 - The Power and Peril of Irreversible Drugs October 23, 2025 GPCR Weekly News Read full article This week’s Weekly News breaks down how to control target engagement—so duration, penetration, and PK/PD separation serve your program, not sink it. Premium sneak peek inside. 🔹 Terry’s Corner: A practical framework for irreversible drugs—defining “irreversible” in real systems, anticipating PK/PD decoupling, and using k_inact/K_I when Ki falls short. 🔹 Podcast Spotlight: Dr. Jens Carlsson on predictive modeling—where structure-based design and MD guide experiments (and where AlphaFold still needs a chaperone). If you’re advancing covalent or tight-binding candidates—or building models meant to predict, not narrate —this edition is built to shorten cycles and reduce surprises. Read the full Weekly News ➤ https://bit.ly/3KVlL4m If it helps your team, share it forward. #DrGPCR #GPCR Model. Predict. Discover. – Podcast Episode Release October 22, 2025 Dr. GPCR Podcast Read full article What if a failed experiment became the best thing that ever happened to your career? Dr. Jens Carlsson started his journey aiming to be a biotech engineer. But during a summer internship in protein purification, he faced a harsh reality: lab work wasn’t his strength. The experiments didn’t work, the data didn’t flow, and it was frustrating. But in the quiet hours, he found himself drawn to the structures, to the models, to figuring out why things weren’t working. A professor noticed and called it out in a recommendation letter. That unexpected moment of clarity redirected his path. Today, Jens is a Professor of Computational Biochemistry at Uppsala University , where his lab uses structure-based modeling to predict GPCR-ligand interactions, before they’re ever tested in the lab. The mindset shift? Stop explaining experiments after they happen. Start designing them to happen. His journey is a powerful reminder that the right career often reveals itself through “failure.” Follow what lights you up. Notice where your mind naturally goes. And don’t ignore the signs, it might be your real path calling. 🎧 Listen to Jens’ full story on the Dr. GPCR Podcast : https://www.ecosystem.drgpcr.com/dr-gpcr-podcast/model-predict-discover #DrGPCR #GPCR #CareerInScience #ComputationalBiology #DrugDiscovery #PhDLife Irreversible Drugs – Trailer October 21, 2025 Terry's Corner Read full article Irreversible drugs change the rules of engagement. Unlike reversible ligands, their impact can persist long after the compound is gone — creating durable pharmacological effects that reshape how pharmacokinetics and pharmacodynamics intersect. In modern discovery programs, that’s a decisive advantage (or a hidden liability) in candidate selection. In this week’s lesson, you’ll unpack: Why low offset rates can mimic covalent effects without forming actual bonds. How target depletion and replenishment kinetics define the therapeutic window. How persistent binding alters structured tissue penetration — and why that matters for tumor targeting and beyond. These tactical frameworks are used to optimize molecules, sharpen PK/PD strategy, and mitigate downstream safety surprises before they appear in IND-enabling studies. Understanding irreversible interactions can mean the difference between a stalled program and a strategic breakthrough. Those who master kinetic pharmacology set the pace. 🟢 Join Terry’s Corner and sharpen your pharmacology toolkit. ✳️ Terry's Corner | Dr. GPCR Ecosystem #GPCR #DrGPCR #Pharmacology #DrugDiscovery #MedicinalChemistry #PKPD #ReceptorKinetics #DrugDevelopment 1 2 3 4 5 1 ... 1 2 3 4 5 6 7 ... 7 🔔 Don’t Just Stay Updated—Stay Ahead Flash News gives you a glance at what’s happening right now in the GPCR world. But to go deeper—with full presentations, expert courses, and exclusive resources—you’ll need more than just a headline. 🎓 Go Premium and unlock: 200+ expert presentations in the University Vault Weekly News with in-depth insights Exclusive courses and masterclasses 👉 Upgrade to Premium Today

A collaboration between chemistry and biology sparked a GPCR imaging breakthrough, leading to new chemical probes for GLP-1R visualization in real tissue. Home → Flash News → A GPCR imaging breakthrough that didn’t start in a grant proposal A GPCR imaging breakthrough that didn’t start in a grant proposal Published on December 3, 2025 Category It started with a cold email. A young chemist, Dr. Johannes Broichhagen, was asked if he could synthesize a molecule “when you’re back in Munich.” That small moment pulled him into islet biology, confocal imaging, and a collaboration that would reshape how GLP-1R is visualized in real tissue. The new blog takes you behind the scenes — the London trip, the early confocal experiments, the pivot to chemical probes, and the trust-driven partnership that sparked a new era in GPCR imaging. If you care about chemical biology, receptor visualization, or building tools that actually work in complex systems, this one is worth reading. 🔗 Read the full story : https://www.ecosystem.drgpcr.com/post/how-collaboration-sparked-a-gpcr-imaging-breakthrough-in-chemical-biology Previous Next Recent Articles

Explore how chemical probes enable real-time GLP-1R visualization in cells and tissues. Episode 2 reveals new GPCR imaging strategies and tool design insights. Home → Flash News → Visualizing GPCRs in their native environment changes everything Visualizing GPCRs in their native environment changes everything Published on December 2, 2025 Category This week on The Dr. GPCR Podcast , we bring you Episode 2 of our three-part series with Celtarys Research — featuring chemist Dr. Johannes Broichhagen , whose work is redefining how we image GPCRs in real tissue. His team’s chemical probes enabled high-resolution GLP-1R visualization across systems — from pancreatic islets to in vivo two-photon imaging. Inside the episode: Chemical probes vs antibodies: specificity, stability, and live-cell performance Mapping GPCR surface pools with precision Tissue-level insights reshaping metabolic disease research What’s next: multiplex receptor labeling + AI-designed tools If GLP-1R biology, receptor trafficking, or advanced imaging are part of your work, this conversation belongs on your radar. 🎧 Listen to Episode 2 → https://www.ecosystem.drgpcr.com/dr-gpcr-podcast/chemical-probes-for-gpcr-imaging-and-internalization And stay tuned for Episode 3 with Celtarys. #GPCR #DrGPCR #metabolism #GLP1R #receptorbiology #fluorescenceimaging #drugdiscovery Previous Next Recent Articles

Dr. GPCR Podcast - The Voice of the Community Whether you’re a scientist, student, or just curious, you’ll hear about discoveries, career stories, and the latest GPCR news. Jump in and get inspired! Strategic Partners Latest Podcast Episodes 2025-12-03 2025-10-22 2025-08-19 2025-07-08 2025-05-13 2025-11-19 2025-09-22 2025-08-05 2025-06-11 2025-04-29 2025-09-02 2025-07-22 2025-05-27 1 2 3 4 5 1 ... 1 2 3 4 5 6 7 8 ... 8 Enjoying the Dr. GPCR Podcast? Leave a Review. Leave a quick review to help more scientists find the show—and help us keep improving every episode. It takes <60 seconds and makes a big difference. ★ Review on Apple Podcasts ★ Rate on Spotify ✉️ Send feedback to the team Thanks for listening to this podcast episode Follow us on your favorite Podcast Player Listen and subscribe where you get your podcasts

Chemical biologist Johannes Broichhagen reveals how fluorescent probes transform GPCR imaging, internalization studies, and assay development in live cells and tissues. << Back to podcast list Dr. GPCR Podcast Strategic Partners Chemical Probes for GPCR Imaging and Internalization with Dr. Johannes Broichhagen In this episode of The Dr. GPCR Podcast, chemical biologist Dr. Johannes Broichhagen shares how his lab builds next-generation fluorescent probes to visualize GPCRs with precision. From the early days of ion channel chemistry to pioneering peptide–fluorophore conjugates for the GLP-1 receptor, JB breaks down the strategic decisions that shaped these tools—and why reliable chemical probes are transforming GPCR drug discovery . He explains what chemical design can solve that antibodies can’t, how to validate functional assay systems, and why fluorescence-based assays paired with careful synthetic planning open doors for both high-resolution imaging and high-throughput screening . You will walk away with a deeper understanding of GPCR internalization, probe specificity, and the cross-disciplinary habits that make collaborations actually work. Why this matters How a chemist with zero biology training became a leader in GPCR probe design. Why peptide-based fluorescent ligands succeeded where antibodies repeatedly failed. What actually happened the moment JB and collaborators imaged an entire pancreatic islet in one shot. How parallel synthesis and side-by-side functional assays accelerate probe optimization and reduce false leads. Why targeting the pharmacologically relevant surface-exposed receptor pool changes the way scientists interpret GPCR trafficking. The moment when super-resolution imaging revealed nanoscale receptor domains that conventional tools completely missed. Who should listen If you’ve ever: Navigated a project where the biology refused to match the textbook mechanism. Balanced creativity in tool development with the pressure for reproducible, publication-grade data. Tried to build assays that behave in living cells—not just on paper. Collaborated across chemistry and biology and felt the translation gap firsthand… …this episode will resonate. About Johannes Broichhagen Dr. Johannes Broichhagen is a chemical biologist whose work sits at the intersection of organic synthesis, peptide chemistry, and advanced imaging. Born in 1984, he studied chemistry at the University of Erlangen-Nuremberg (2004–2010) and completed his doctorate at LMU Munich in 2014 . His postdoctoral training included research at the École Polytechnique Fédérale de Lausanne (2015–2016) and later at the Max Planck Institute for Medical Research in Heidelberg, where he served as both postdoc and departmental group leader (2017–2020). These years shaped his interest in ion channels, GPCR pharmacology, and the chemical strategies needed to probe complex biology. Since 2020, JB has led his research group at the Leibniz Research Institute for Molecular Pharmacology (FMP) in Berlin, focusing on developing fluorescent chemical tools to visualize GPCRs and other cell-surface proteins with high specificity. His lab integrates synthetic chemistry, theoretical chemistry, cell biology, and imaging to understand receptor organization and dynamics across cells, tissues, and intact organisms. Curiosity, collaboration, and a love of translating chemical concepts into biological insight drive his scientific mission. Johannes Broichhagen on the Web LinkedIn Google Scholar Lab Website Leibniz Research Institute for Molecular Pharmacology (FMP) Profile Enjoying the Dr. GPCR Podcast? Leave a Review. Leave a quick review to help more scientists find the show—and help us keep improving every episode. It takes <60 seconds and makes a big difference. ★ Review on Apple Podcasts ★ Rate on Spotify ✉️ Send feedback to the team Recent Podcast Articles How Collaboration Drives GPCR Discoveries How a Failed Experiment Created a Powerful GPCR Imaging Tool From Farm Fields to GPCR Discovery, GLP-1 and GIP Thanks for listening to this podcast episode Follow us on your favorite Podcast Player << Previous Podcast Episode Next Podcast Episode >>

Explore the world of GPCRs with Dr. GPCR Podcast! Join industry leaders as they share insights, stories, and groundbreaking discoveries, enriching our understanding of GPCRs. Delve into the science behind these vital components shaping our collective knowledge. Welcome to the Dr. GPCR Podcast - The Voice of the Community Conversations with the world’s leading GPCR scientists. Exploring discoveries, careers, and ideas shaping human health. In each episode, we sit down with leading experts to explore their career journeys, groundbreaking discoveries, and the impact of their research on our shared understanding of GPCR biology. Launched at the height of the pandemic, the Dr. GPCR Podcast was created with three goals: Share discoveries – Highlight the latest advances in the GPCR field. Amplify voices – Provide scientists a platform to showcase their work. Inspire the future – Motivate the next generation to pursue GPCR research. At its core, Dr. GPCR’s mission is simple yet ambitious: to bring the GPCR community together - across borders and disciplines - to connect, exchange, and collaborate in order to improve human health through a deeper understanding of GPCR biology. Latest Podcast Episodes More podcast episodes Dr. GPCR Podcast Audience Survey We are currently planning our next season and need your help. This short survey will help us understand your needs to bring you exciting and informative content. We also know that you are busy, which is why we designed this short survey that should take you 5 minutes. Fill out this form Be our Guest In each episode, we chat with an expert about their career trajectory, discoveries, and how their research contributed to the shared pool of knowledge about GPCR biology. We’d love to have you on our podcast. To be a guest, fill out the form below, and we’ll be in touch in 48 hours. Fill out this form What others are saying about this podcast Really enjoyable science podcast! Dr. Yamina Berchiche interviews leading GPCR scientists on this vibrant, entertaining podcast. I really appreciate the way the podcast educates and mentors, particularly towards junior scientists but also to the community as a wholen Yamina is a great interviewer, getting insight and personal history from her guests. Am very grateful for Dr GPCR livening up the week in these difficult times! Sam @Pharmamechanic I enjoy the breadth of questioning that goes beyond just the science, and reveals a bit about the scientists as individuals/mentors/people. Anonymous Great initiative, thanks. Carrier paths, choosing research topics, switching fields, late start, failures and successes. Anonymous This came at just the most perfect time. I hadn't heard a scientific talk outside my lab since February and was starved to hear someone else talk passionately about GPCRs. I've listened to the episodes multiple times and it's just like being at a conference getting new ideas. I just couldn't be happier y'all created this podcast. Anonymous I think it's really well done. I'm genuinely interested to see how it evolves and grows over time, as I feel it has the potential to develop into something even more impactful. Anonymous Listen and subscribe where you get your podcasts

Home Courses Articles About Log In / Sign Up Terry's Pharmacology Corner Lost in GPCR Complexity? Step Into Terry’s Corner Finally, See the Signal 🔥 Watch the AMA Session | Dec 2, 2025 🔥 Watch course | Nov 18, 2025 🔥 Watch course | Nov 11, 2025 🔥 Watch the AMA Session | Sept 18, 2025 🔥 Watch course | Oct 21, 2025 🔥 Watch course | Oct 14, 2025 🔥 Watch course | Oct 7, 2025 🔥 Watch course | Sept 30, 2025 🔥 Watch course | Sept 23, 2025 🔥 Watch course | Sept 16, 2025 🔥 Watch course | Sept 9, 2025 🔥 Watch course | Sept 2, 2025 🔥 Watch course | Aug 26, 2025 🔥 Watch course | Aug 19, 2025 🔥 Watch course | Aug 12, 2025 🔥 Watch course | Aug 5, 2025 🔥 Watch course | July 29, 2025 🔥 Watch course | July 22, 2025 🔥 Watch course | July 15, 2025 🔥 Watch course | July 8, 2025 🔥 Watch course | July 1, 2025 🔥 Watch course | July 1, 2025 🔥 Watch course | July 1, 2025 🔥 Watch course | July 1, 2025 🔥 Watch course | July 1, 2025 🔥 Watch course | July 1, 2025 🔥 Watch course | July 1, 2025 🔥 Watch course | July 1, 2025 🔥 Watch course | July 1, 2025 🔥 Watch course | July 1, 2025 TCBuyCourse Start Learning with Terry Best Value Terry’s Corner $2,999 $ 2,999 Every year Only Founders Get Discounted Full Vault Access —Then It’s Gone 40 years. One corner. One-time pricing. Valid until canceled 7 day free trial Select Watch 4 New Courses Each Month Connect in a Private Drug Hunter Hub Skip The Fluff, Learn What Matters Join Monthly AMAs with Terry Unlock 40+ Years of Expertise Master GPCRs with Precision Terry’s Pharmacology Corner — Created by Dr. Terry Kenakin , powered by Dr. GPCR . Stay connected on LinkedIn and YouTube . Explore : Foundational Lessons — Build Your Pharmacology Core Emerging Drug Hunter — Expand Your Edge Expert-Level Mastery — Advanced Pharmacology Live AMA Sessions with Terry

Discover the incredible benefits of the Dr. GPCR University. ​All these benefits are designed to enhance your research experience and keep you informed about the latest developments in GPCR science.​ Accelerate Your GPCR Research Join a global community of scientists transforming how GPCR discoveries happen — through shared learning, collaboration, and expert insight. Access the tools, knowledge, and network that empower you to go further, faster. 🔥 Unlock Premium Now! ⏰ Next year’s rate increase is coming. Upgrade today and keep the current price permanently. Premium Membership Benefits Everything you need to stay at the forefront of GPCR research and advance your career. Expert-Led GPCR Courses 200+ Expert Talks Events & Jobs Board Complete GPCR Coverage Community Tools Career Matchmaker Why is it Worth It? Common concerns and why Premium delivers exceptional value "It's too expensive." At less than $1 a day, Premium gives you access to 20+ on-demand GPCR courses, 200+ expert talks, and global networking tools. One insight, one connection, one ‘aha’ moment — can save months of research time. "I already get what I need from papers." Papers inform. DrGPCR helps you understand and apply that knowledge — through structured training, expert context, and real interaction with peers from academia and industry. "I'm not sure I'll use it often." Even one course or one new collaboration can make a difference. Members often find value in ways they didn’t expect — from expert feedback to career-changing introductions. "Will this really help my career?" Yes. Members grow visibility, confidence, and connections that open doors. It’s not just about learning — it’s about being seen, supported, and part of something bigger . Choose a package that works for you $0 Free Stay in the loop! 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How much does Premium cost? $249.99/year for individuals $212.49/year for teams (minimum 3 members) $24.99/year for developing countries Is there a monthly payment option? Currently, the membership is billed annually for maximum savings and uninterrupted access. Are the courses self-paced? Yes. All courses and talks are available on-demand so you can learn anytime. Can I register my entire team for Premium? Yes. The Team plan offers discounted rates for groups of 5 or more. Do you offer discounts for students or developing countries? Yes. Members from developing countries can join for $24.99/year. Students please reach out to hello@drgpcr.org What happens after I join? You’ll receive instant access to all Premium resources, your member dashboard, and exclusive community tools to start networking and learning right away. Ready to Advance Your GPCR Research? Join thousands of researchers who trust DrGPCR for cutting-edge insights and resources. Start Your Premium Journey Try Free First

Advance your GPCR research career with Dr. GPCR University. Access 20+ on-demand GPCR courses, 200+ expert talks, weekly news, and a global scientist network. Join Premium today. Dr. GPCR University A nonprofit created by scientists, for scientists—bringing the global GPCR community together to advance biology and therapeutics. 📚 Learn faster. 🤝 Connect deeper. 🔬 Drive discoveries. Join the trusted home for GPCR scientists worldwide, where collaboration fuels innovation and every voice helps shape the future of discovery. Become a Premium Member Strategic Partners Why Join? Learn from leading GPCR experts — anytime, anywhere Access trusted, on-demand courses designed to help you grow your knowledge and confidence. Stay ahead with complete GPCR coverage News, papers, jobs, and industry insights — all curated for scientists who care about what’s next. Get the latest GPCR news delivered to your inbox every week Stay informed and inspired — without the noise. Explore 200+ expert talks that bring GPCR discoveries to life From structural biology to therapeutics — hear directly from the scientists shaping the field. Connect with peers who speak your scientific language Build meaningful collaborations and friendships within a global community of GPCR experts. Find your perfect fit Through personalized matchmaking, discover new roles, partners, or team members who align with your goals. Explore the Masterclass Pharmacology Foundations Build the essential lens every scientist needs to see pharmacology clearly, from core principles to the hidden variables of drug disposition. Advanced Quantitative Approaches Sharpen your toolkit with rigorous quantitative methods that bring clarity to bias, binding, and response analysis. Agonists, Antagonists & Core Mechanisms Master the classic players in GPCR pharmacology and learn how agonists and antagonists shape efficacy, signaling, and therapeutic potential. Innovation & Strategic Application Translate science into impact by exploring unconventional ligands, unique GPCR behaviors, and the strategies to drive successful drug discovery projects. Allosteric Modulation & Kinetics Step beyond orthosteric drugs and uncover the power of allosteric modulators and kinetic insights to unlock new therapeutic dimensions. Explore Premium Package 🔥 Upgrade to Premium Premium Yearly $249.99 $ 249.99 Every year 🚀 Everything you need to master GPCR science — in one membership. Valid until canceled Join Premium Today! 🎓 Full GPCR University + 🔬 200+ expert talks 🗞️ Weekly research, careers & event intelligence 🤝 Members-only networking, AMAs & matchmaking 💡 Support open resources for the global GPCR field 🧠 Designed for researchers at every career stage 🚀 Don’t just keep up — lead the way. 🔒 Grandfather Guarantee, your rate never increases See all Discount Options Why is it Worth It? Common concerns and why Premium delivers exceptional value "It's too expensive." At less than $1 a day, Premium gives you access to 20+ on-demand GPCR courses, 200+ expert talks, and global networking tools. One insight, one connection, one ‘aha’ moment — can save months of research time. "I'm not sure I'll use it often." Even one course or one new collaboration can make a difference. Members often find value in ways they didn’t expect — from expert feedback to career-changing introductions. "I already get what I need from papers." Papers inform. DrGPCR helps you understand and apply that knowledge — through structured training, expert context, and real interaction with peers from academia and industry. "Will this really help my career?" Yes. Members grow visibility, confidence, and connections that open doors. It’s not just about learning — it’s about being seen, supported, and part of something bigger . Frequently asked questions What is Dr. GPCR University? Dr. GPCR University is an educational platform that provides in-depth learning and training resources on G protein-coupled receptors (GPCRs). At Dr.GPCR University, you’ll find: Courses: Dive deep into curated educational content designed by experts in GPCR research. Our courses provide comprehensive, on-demand learning to help you expand your knowledge and stay current in the field. Symposia Engage with leading scientists through our symposia, featuring in-depth discussions on cutting-edge research and breakthroughs in GPCR science. Each session brings together a community of experts to share insights and advancements. Summit A global gathering of researchers and professionals showcasing the latest developments in GPCR research. Participate in presentations, networking opportunities, and collaborative sessions. Virtual Café Listen to casual, interactive discussions with experts in the field. How do I register for Dr. GPCR University Masterclasses? To register for any course, you must have a FREE Ecosystem member account . We carefully screen anyone signing up to ensure they are real humans working on GPCRs, so you might not receive confirmation immediately. When signing up for the first time, try to complete as much information as possible about yourself. Who are the Dr. GPCR University Masterclasses designed for? The classes are designed for researchers, students, and professionals in biology, pharmacology, and biochemistry, but anyone interested in GPCR research is welcome to join. What topics are covered in the masterclasses? Masterclasses cover a variety of track including but not limited to p harmacology foundations, agonists, antagonists & core mechanisms , allosteric modulation & kinetics, advanced quantitative approaches and innovation & strategic application Can I register my team for a Dr. GPCR University Masterclasses? To register as a team, one of you must be a Premium Member . This person must email hello@drgpcr.o rg indicating how many people will register for the course, the names of the participants, and their emails. We will contact each person individually to help them set up a FREE Ecosystem Membership . They will be asked to join a private group to keep updated with the latest announcements about the course. Are the masterclasses on-demand or live? Dr. GPCR University offers both on-demand and live classes led by experts in the field. On-demand classes are only available for Premium Members . Do I need prior knowledge of GPCRs to join the masterclasses? Some classes may require basic knowledge of GPCRs, but many are designed to accommodate beginners as well as advanced learners. What kind of certification will I receive upon completing a masterclass? Participants will receive a certificate of completion from Dr. GPCR University, which can be used to showcase your expertise and enhance your professional credentials. 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Get one year of free Dr. GPCR Premium access for your entire academic lab. Teach a course at Dr. GPCR University and unlock expert resources, training, and tools. Academic Team Access Program One Year of Dr. GPCR Premium — Free for Your Entire Lab Empowering academic discoveries with industry-grade GPCR resources. Why We Created This Program? Your research group plays a critical role in advancing GPCR science. We want to support academic labs with the same high-quality tools, courses, and insights used by leading biotech teams—without financial barriers. The Dr. GPCR Academic Team Access Program gives your entire lab one year of Premium membership at no cost, in exchange for contributing to the community’s shared knowledge base through teaching . How does it work? No Cost, No Hidden Requirements The program is 100% free for academic labs who contribute as instructors. No recurring charges. No credit card required. Your Whole Lab Gets One Year of Premium Access Once approved, every member of your team receives free Premium access for 12 months, including: Full access to Dr. GPCR Masterclasses & University Vault Weekly News extended editions Exclusive event recordings, slides, and community decks Premium research insights and ecosystem reports Priority access to certain events and AMAs A Member of Your Lab Teaches at Dr. GPCR University Contribute your expertise by teaching a topic, workshop, or course within the Dr. GPCR University. Format is flexible — we work with your availability. Become part of the Dr. GPCR University Instructor community Learn More & Join the Program To keep things simple, we created a single guide that covers: Eligibility guidelines Teaching formats & examples Instructor expectations Course creation support Application steps Timeline & onboarding What your team receives Renewal options 👉 Everything is explained here *This link takes you to a dedicated page with all the details. Book Ready to Unlock Premium for Your Entire Lab—At No Cost? 👉 Learn More & Get Started Meet directly with Dr. Yamina Berchiche for a focused strategy conversation to align your goals, uncover opportunities, and map your next steps.

Discover special university group pricing for Dr. GPCR courses. Save with discounted packages and provide your students or faculty access to premium GPCR learning resources. Empower Your Team with Dr. GPCR Premium Give your team the tools to grow together and stay at the forefront of GPCR science. Save 15% on annual Premium Memberships when you enroll five or more members. Access expert-led courses, 200+ talks, community tools, and curated insights designed to keep your team connected, informed, and inspired. Important Information To qualify for the team discount, your group must include at least five members. If fewer than five members are submitted: • Memberships won’t be activated. • You’ll receive a 50% refund to cover processing costs. 👉 Please double-check your team list before submitting to avoid delays. Questions? We’re here to help: Hello@DrGPCR.org . How It Works? 1️⃣ Get Your Team Ready Gather at least 5 team members who’ll join under your group plan. Make sure each person has (or creates) an account on the Dr. GPCR Ecosystem . 3️⃣ Confirm and Pay Securely After submitting, review your details and finalize your team payment. You’ll automatically receive a confirmation email once your submission is received. 2️⃣ Submit the Team Form Complete the short form with your team names, emails, and organization details. This ensures every member gets full Premium access and personalized onboarding. 4️⃣ Membership Activation Our team will manually review and activate your group’s memberships. Activation takes 3–5 business days , and we’ll notify you once your access is live. 💡 Need to add someone later? No problem — we’ll help you update your team anytime. Apply for Your Team Discount 👇 📢 Limited-time offer – don’t miss out! First name* Last name* Email* Company name* Company Website* Names & Emails of Each Team Member (minimum 5)* Team Size* Premium Team Yearly (Minimun 5 Seats) $212.49 Order Now 💡 Have questions? Contact us at Hello@DGPCR.org Book Plan Your Next Move in GPCR Discovery Meet directly with Dr. Yamina Berchiche for a focused strategy conversation to align your goals, uncover opportunities, and map your next steps.

Discover Media Partner Packages with Dr. GPCR Ecosystem. Amplify your brand, reach a targeted scientific audience, and showcase your organization in the GPCR community. Elevate Your GPCR Focused Company Visibility Reach 1300+ GPCR researchers. Build visibility, trust, and partnerships that matter. Only 12 partners are accepted per year. Partner with us Today! ⚠️ Next year’s rate increase is coming. Join today and keep the current price permanently. Connect With The GPCR Community You've built incredible tools, services, or platforms for GPCR researchers. But are the right scientists discovering them? Dr. GPCR is the world's largest nonprofit community focused on GPCRs. As a media partner, you'll gain trusted access to an engaged audience of academic researchers, biotech teams, and drug discovery innovators—without having to fight for attention. We only accept 12 media partners per year. Each one receives personalized support, targeted visibility, and a seat at the table in the GPCR ecosystem. Ready to share your company with the GPCR world? With only 10 media partner seats available each year, every partner gets intentional placement, dedicated support, and real visibility. No noise. No clutter. Only connections. Why Partner with Dr. GPCR? As a media partner, you'll be featured across our nonprofit platform, trusted by thousands of GPCR scientists and biotech professionals. 🎯 Reach Qualified Researchers Connect with scientists who are actively looking for tools like yours, without the noise of general platforms. 🤝 Build Trust Develop content that speaks their language and establishes your credibility in the GPCR research community. 🌐 Join a Curated Ecosystem Become part of a collaborative, curated ecosystem—not just another name on a crowded vendor list. With only 8 seats remaining in 2025, we're focused on quality over quantity - and on partnerships that deliver long-term value to the field. 12 Partners Accepted Per Year 1300+ GPCR Scientists Reached 8 Spots Remaining for 2025 What You Get as Media Partner Becoming a Dr. GPCR media partner means more than visibility. It means integration into a trusted scientific ecosystem that's built to elevate your story. 🎙️ Featured Podcast Episode ✓ Be the guest on a dedicated episode of the Dr. GPCR Podcast ✓ Feature up to 3 team members to share your story ✓ Distributed across podcast platforms and social media 📄 Custom Company Page ✓ Permanent company profile on the Dr. GPCR Ecosystem ✓ Logo, branding, and description of your mission ✓ Contact links and key highlights 🧰 Product or Service Pages ✓ Individual pages for each product or service ✓ Educate researchers and showcase technical value ✓ Provide downloadable resources or use cases 📬 Newsletter Visibility ✓ Featured in our highly read weekly newsletter ✓ Tell your story with context, clarity, and purpose ✓ Bonus: Mentioned in podcast intros/outros 📣 Social Media Promotion ✓ Engaging posts about your organization ✓ Targeted to GPCR researchers and biotech professionals ✓ Shared on LinkedIn and X (Twitter) 👩🔬 Premium Licenses ✓ 10 Scientists Premium Accounts ✓ 3 Non-Scientists Premium Accounts ✓ Shared on LinkedIn and X (Twitter) 📝 Blog Contributions ✓ Contribute to blog posts on the Dr. GPCR platform as a valued partner ✓ Share insights on product launches, scientific discoveries, or customer stories ✓ Reach a targeted scientific audience with your contributions. 🎤 Co-Branded Events & Training ✓ Collaborate on webinars and virtual training sessions to showcase your expertise ✓ Host educational events that focus on GPCR research ✓ Engage directly with the GPCR research community through these initiatives Present & Previous Partners Join these leading organizations in the GPCR research ecosystem Book Book a 30-minute Strategy Call with Yamina Ready to Connect with the GPCR Community? With only 11 spots remaining for 2025... Secure your place in our exclusive media partner program today.

A conversation with Prof. David Hodson on visualizing GLP-1 and GIP receptors in pancreatic islets and brain circuits to advance GPCR-targeted therapies for diabetes and obesity. << Back to podcast list Dr. GPCR Podcast Strategic Partners Visualizing GLP-1 & GIP Receptors in Islets and Brain In this episode, Professor David Hodson discusses how GLP-1 and GIP receptors regulate metabolism across the pancreas and brain, and why visualizing receptor localization and signaling in real tissues is essential for advancing GPCR drug discovery . His team develops fluorescence-based and chemically engineered tools to study gpcr internalization and ligand engagement in intact islets and neuronal circuits — insights that inform next-generation functional assay development and translational therapeutic design. The conversation also highlights the role of interdisciplinary collaboration in accelerating innovation in diabetes and obesity research. Why this matters How receptor distribution in islets and brain circuits shapes incretin hormone drug effects Why visualization tools changed our understanding of GPCR signaling in metabolic tissues What collaborative chemistry enabled in designing receptor-targeted fluorescent ligands The moment when structural and imaging evidence clarified unexpected glucagon-derived peptide behavior How future metabolic therapies may evolve based on receptor cross-talk and tissue-specific engagement Who should listen Navigated complex datasets where interpretation depended on biological context Balanced innovation with the need for reproducible, well-controlled functional assays Worked across disciplines where chemistry, pharmacology, and physiology converge Questioned how drug action differs in real tissues vs. recombinant cell lines …this episode will resonate. About David Hodson Prof. David Hodson is the Robert Turner Professor of Diabetic Medicine at the University of Oxford , working within the Oxford Centre for Diabetes, Endocrinology and Metabolism. Originally trained as a Veterinary Surgeon , he completed postdoctoral research at the CNRS in Montpellier before establishing his independent laboratory at Imperial College London as a Diabetes UK RD Lawrence Fellow. He later served as Professor of Cellular Metabolism and Institute Deputy Director at the University of Birmingham. His group develops imaging and chemical biology tools to reveal how GLP-1 and GIP receptors operate within complex tissues, with direct relevance to type 2 diabetes and obesity therapy . David Hodson on the Web Radcliffe Department of Medicine Islet Biology Lab University of Birmingham Enjoying the Dr. GPCR Podcast? Leave a Review. Leave a quick review to help more scientists find the show—and help us keep improving every episode. It takes <60 seconds and makes a big difference. ★ Review on Apple Podcasts ★ Rate on Spotify ✉️ Send feedback to the team Recent Podcast Articles How GPCR Collaboration Built an Innovation Engine From Pipettes to Platforms: The Evolution of GPCR Research How GPCR Spatial Signaling Sparked a Scientific Journey Thanks for listening to this podcast episode Follow us on your favorite Podcast Player << Previous Podcast Episode Next Podcast Episode >>

Expert support, trusted CROs, and ready-to-use tools to accelerate GPCR drug discovery, reduce risk, and advance your discovery-stage projects. Dr. GPCR Foundry: Accelerate GPCR Drug Discovery Move from idea to insight—faster, smarter, and with confidence. Partner with our nonprofit team for expert guidance, trusted CRO collaborations, and field-tested tools that de-risk your GPCR programs and keep momentum strong. 👉 Book a Free 30-min Strategy Call What Is the Dr. GPCR Foundry? In short: The Foundry gives you the right people, tools, and insight to move your GPCR programs forward — faster and with confidence. What Is the Dr. GPCR Foundry? The Dr. GPCR Foundry is a nonprofit platform designed to help biotech leaders accelerate GPCR drug discovery with precision, credibility, and speed. Here’s how we add value: Bridge early discovery to development: transform receptor concepts into validated, investment-ready programs. Leverage a trusted GPCR partner network: access curated CROs, consultants, and collaborators with proven track records. De-risk decisions: gain expert strategic guidance on study design, timelines, and partner selection before execution. Scale internal expertise: upskill teams through specialized GPCR programs and leadership-level insights. Partner through purpose: as a nonprofit, we align with your mission—accelerating breakthroughs, not billing hours. Why Biotechs choose Dr. GPCR Foundry? The Foundry is built for GPCR biotech companies at the discovery stage . 🔬 Validate your first target with confidence ⏱️ Scale programs faster with proven timelines 🤝 Access credible GPCR CROs and expert consultants 📚 Train and upskill your team with specialized programs 📢 Gain visibility through trusted media partnerships We connect you to: Specialized Consultants & KOLs Trusted GPCR CROs Learning Resources Media Visibility Opportunities Who is the Foundry for? The Dr. GPCR Foundry supports biotech teams working on discovery-stage GPCR programs who need expert guidance, trusted partners, or a clearer path forward. Wherever you are in your journey — from first target to scale-up — we’re here to help you move faster, smarter, and with confidence. You’ll benefit most if you’re: ✔ A GPCR biotech startup validating your first target ✔ An established biotech ready to expand or optimize discovery programs ✔ Looking for credible GPCR CROs and consultants to advance your work Explore Resources Expert Guidance — Built for GPCR Biotechs Get strategic clarity on your next discovery move — from target validation to translational strategy. Avoid costly missteps with data-driven, expert-backed recommendations. Gain confidence and direction with a customized roadmap aligned to your biotech’s goals and timeline → Book Your Free Strategy Call Specialized Training — Build GPCR Expertise Within Your Team Strengthen your team’s GPCR knowledge with structured, science-driven training . Learn proven experimental and analytical methods that accelerate discovery outcomes. Stay ahead of the curve with expert-led programs designed for real-world biotech challenges. → Explore the Dr. GPCR University GPCR Insights in Action Transform complex pharmacology into clear, practical understanding that drives discovery. Learn how to apply GPCR concepts and data to real-world research and development. Build confidence through expert-led lessons, case studies, and proven experimental strategies. → Explore Terry's Corner Visibility & Reputation — Amplify Your Scientific Voice Showcase your expertise and achievements within a trusted global GPCR network. Build credibility and visibility among scientists, biotechs, and CRO partners worldwide. Strengthen your organization’s presence through authentic storytelling and mission-aligned collaborations. → Email Hello@DrGPCR.org to learn more or Book a call below Team Advantage — Grow Together, Discover Faster Unite your scientists under one trusted GPCR learning hub. Give every team member access to the same expert-led, science-driven resources. Build collective expertise and alignment that accelerates discovery outcomes. → Explore Dr. GPCR University Team Membership Biotech Growth Workshops — Scale With Strategy Replace trial-and-error with structured frameworks tailored for biotech growth. Learn to scale confidently through data-driven, real-world case studies. Gain clarity and direction to move your biotech forward—faster and smarter. → Explore Timeline Strategy Help Your GPCR Discovery Program Succeed Work with the Dr. GPCR Foundry to accelerate your discovery programs with clarity, confidence, and trusted partnerships. Our core support areas: Discovery Consulting & Strategy Expert guidance to de-risk projects, refine strategy, and drive scientific progress. Visibility for GPCR Solution Providers Strategic media partnerships that connect your company with biotech innovators and showcase your expertise Training & Upskilling Specialized, insight-packed courses designed for discovery-phase GPCR teams. Tools & Templates Ready-to-use frameworks and resources tailored to the realities of discovery-stage GPCR work ✉ Contact Us Our Partners Join these innovative organizations already benefiting from the DrGPCR Foundry. Book Plan Your Next Move in GPCR Discovery Meet directly with Dr. Yamina Berchiche for a focused strategy conversation to align your goals, uncover opportunities, and map your next steps. Let's move your GPCR discovery program forward. Wherever you are in your discovery journey, the Foundry helps GPCR biotech companies move faster and reduce risk. Let's discuss your next step.

<< Back to podcast list Dr. GPCR Podcast Strategic Partners Jacob Lee & Jin Choe About this episode In this special episode of the Dr.GPCR podcast , I sat down with the co-founders of Genemod . Jacob Lee and Jin Choe met in ninth grade in English class and have been friends since. Although both went to the same college, Jacob and Jin choose different career paths. One day as they were catching up, Jacob shared his struggles of managing samples and an incredible amount of data and projects in the lab with Jin. Our of this need Genemod was born. Today, Genemod has built a freezer management tool and a project management tool where scientists can manage their reagents, samples, and projects on one intuitive platform. The team is planning on building even more tools that will make Genemod the go-to platform for all research scientists to make research more efficient. Genemode on the web Website Jacob Lee on LinkedIn Jacob Lee on Dr. GPCR Ecosystem Jin Choe on LinkedIn Jin Choe on Dr. GPCR Ecosystem Enjoying the Dr. GPCR Podcast? Leave a Review. Leave a quick review to help more scientists find the show—and help us keep improving every episode. It takes <60 seconds and makes a big difference. ★ Review on Apple Podcasts ★ Rate on Spotify ✉️ Send feedback to the team Recent Podcast Articles How GPCR Collaboration Built an Innovation Engine From Pipettes to Platforms: The Evolution of GPCR Research How GPCR Spatial Signaling Sparked a Scientific Journey Thanks for listening to this podcast episode Follow us on your favorite Podcast Player << Previous Podcast Episode Next Podcast Episode >>

Retreat 2023 About Program Registration Logo Contest Committee Sponsors GPCR Retreat Program < Back to schedule Atypical Structure and Function of Typical Chemokine Receptors Date & Time Saturday, November 4th / 11:00 AM Abstract Coming Soon About Amy Ramsey "One of the principal efforts of our laboratory is to understand the physiological consequences of NMDA receptor deficiency using genetic mouse models. The NMDA receptor is a subtype of glutamate neurotransmitter receptor that regulates the formation and maintenance of synaptic connections between neurons. It plays an important role in the way that neurons wire together and change the strength of synaptic connections with experience. Our laboratory is interested in the role of NMDA receptors not only on neurons, but also on other cells of the brain such as astrocytes, oligodendrocytes, and endothelial cells. NMDA receptors are implicated in a number of brain disorders including schizophrenia, autism, and epilepsy. Our laboratory has a long-standing interest in the way that NMDA receptors contribute to the symptoms of schizophrenia. Recently, we have focused our efforts on GRIN disorder. This is a rare neurodevelopmental disorder caused by de novo mutations in the GRIN genes that encode NMDA receptors. Although symptoms of GRIN disorder appear very early in childhood, it can take years to reach the right diagnosis through genetic tests. Children with GRIN disorder experience developmental delays, intellectual impairment, visual impairments, and difficulties with daily tasks like talking and walking, feeding and toileting. Many children experience seizures that can be life-threatening. Our laboratory is working to help patients by developing genetically-modified mice that have disease-causing variants in their Grin1 gene. These mice can then be used to test dietary regimens, drugs, and adenoviral gene therapies for their ability to improve specific symptoms. The Ramsey lab uses a combination of biochemical and behavioural approaches to understand the many roles of NMDA receptors and to find treatments for debilitating brain disorders." The Ramsey Lab Amy Ramsey on the web University of Toronto Pubmed Google Scholar LinkedIn Twitter Dr. GPCR Previous Event Next Event Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires du Québec Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires du Québec 22nd GPCR Retreat Sponsored by

<< Back to podcast list Dr. GPCR Podcast Strategic Partners Dr. Sudha Shenoy About Dr. Sudha Shenoy Dr. Sudha Shenoy is currently an Associate Professor in Medicine & Cell Biology in the Division of Cardiovascular Medicine, Duke University Medical Center. She received her Ph.D. from Oklahoma State University and completed her postdoctoral training with Dr. Robert J. Lefkowitz (Nobel Laureate, 2012) at Duke University. Dr. Shenoy’s postdoctoral research discovered that ubiquitination of mammalian G protein-coupled receptors is a tag for lysosomal degradation, whereas ubiquitination of the adaptor protein, β-arrestin, is a tag for receptor internalization and formation of signaling endosomes. Her laboratory has continued to work on identifying the molecular mechanisms that ascribe ubiquitin code on GPCRs and β-arrestins. Current efforts aim to understand the regulation of GPCR and beta-arrestin signaling in the heart and vascular endothelium by the deubiquitinating enzymes USP20 and USP33. Dr. Sudha Shenoy on the web Duke University Personal Reflections and Words of Wisdom: Story From Dr. Sudha Shenoy LinkedIn Pubmed Dr. GPCR Ecosystem Enjoying the Dr. GPCR Podcast? Leave a Review. Leave a quick review to help more scientists find the show—and help us keep improving every episode. It takes <60 seconds and makes a big difference. ★ Review on Apple Podcasts ★ Rate on Spotify ✉️ Send feedback to the team Recent Podcast Articles How GPCR Collaboration Built an Innovation Engine From Pipettes to Platforms: The Evolution of GPCR Research How GPCR Spatial Signaling Sparked a Scientific Journey Thanks for listening to this podcast episode Follow us on your favorite Podcast Player << Previous Podcast Episode Next Podcast Episode >>

Retreat 2023 About Program Registration Logo Contest Committee Sponsors GPCR Retreat Program < Back to schedule Registration Date & Time Thursday, November 2nd / 11:00 AM - 1:30 PM Previous Event Next Event Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires du Québec Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires du Québec 22nd GPCR Retreat Sponsored by

Retreat 2023 About Program Registration Logo Contest Committee Sponsors GPCR Retreat Program < Back to schedule Dinner 1 Date & Time Thursday, November 2nd / 8:00 PM Previous Event Next Event Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires du Québec Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires du Québec 22nd GPCR Retreat Sponsored by

<< Back to podcast list Dr. GPCR Podcast Strategic Partners Dr. Nicolas Gilles About Dr. Nicolas Gilles "Dr. Nicolas Gilles is an expert in the study of animal toxins. He is pioneering the investigation of animal toxins acting on GPCRs, the largest therapeutic target class. His strongest expertise lies in therapeutic target identification and all the steps from venom manipulations, to in vivo validation. When the pharmacological properties of these new ligands are deemed exceptional, a lead optimization is realized and its therapeutic development initiates through a dedicated start-up." Dr. Nicolas Gilles on the web Google Scholar LinkedIn Dr. GPCR Enjoying the Dr. GPCR Podcast? Leave a Review. Leave a quick review to help more scientists find the show—and help us keep improving every episode. It takes <60 seconds and makes a big difference. ★ Review on Apple Podcasts ★ Rate on Spotify ✉️ Send feedback to the team Recent Podcast Articles How GPCR Collaboration Built an Innovation Engine From Pipettes to Platforms: The Evolution of GPCR Research How GPCR Spatial Signaling Sparked a Scientific Journey Thanks for listening to this podcast episode Follow us on your favorite Podcast Player << Previous Podcast Episode Next Podcast Episode >>

<< Back to podcast list Dr. GPCR Podcast Strategic Partners Dr. Yamina Berchiche About Dr. Yamina Berchiche Dr. Yamina A. Berchiche is the founder of Dr. GPCR, an ecosystem designed to bring together stakeholders interested in using G-Protein Coupled Receptors (GPCRs) that control virtually everything in the body as drug targets. The mission of Dr. GPCR is to accelerate GPCR drug discovery by sharing the latest research and technology advances in the field and providing exposure to scientists through the Dr. GPCR podcast. Dr. Berchiche obtained her Master’s and Ph.D. in Biochemistry at the University of Montreal in Canada before training at Rockefeller University in New York and the National Institutes of Health in Bethesda, Maryland. She developed expertise over the past two decades studying structure/function relationships of GPCRs using live-cell bioluminescence resonance energy transfer (BRET). Her work focused on chemokine receptors, members of the GPCR family that control cell movement in the body. Dr. Yamina Berchiche on the web Website LinkedIn Facebook Twitter ResearchGate PubMed Google Scholar Dr. GPCR Ecosystem Enjoying the Dr. GPCR Podcast? Leave a Review. Leave a quick review to help more scientists find the show—and help us keep improving every episode. It takes <60 seconds and makes a big difference. ★ Review on Apple Podcasts ★ Rate on Spotify ✉️ Send feedback to the team Recent Podcast Articles How GPCR Collaboration Built an Innovation Engine From Pipettes to Platforms: The Evolution of GPCR Research How GPCR Spatial Signaling Sparked a Scientific Journey Thanks for listening to this podcast episode Follow us on your favorite Podcast Player << Previous Podcast Episode Next Podcast Episode >>

Home → Flash News → 10 GPCR pharmacology lessons. Zero fluff. Launching July 1, Terry’s Corner gives you the clarity and confidence to make better decisions—starting with: • The role of pharmacology in discovery strategy • Black & Leff’s operational model—finally made practical • Binding curves, orthosteric vs allosteric function, and real vs apparent affinity • Molecular dynamics and how they guide ligand design • Why Terry built this—and how it sharpens your next move 📅 Learn anytime. New course every week. 📬 Subscribe to The Kenakin Brief → https://www.terrykenakin.com #GPCRscience #drugdiscovery #TerrysCorner #GPCRpharmacology #ligandbinding Published on June 30, 2025 Category Terry's Corner 10 GPCR pharmacology lessons. Zero fluff. Launching July 1, Terry’s Corner gives you the clarity and confidence to make better decisions—starting with: 🟢 The role of pharmacology in discovery strategy 🟢 Black & Leff’s operational model—finally made practical 🟢 Binding curves, orthosteric vs allosteric function, and real vs apparent affinity 🟢 Molecular dynamics and how they guide ligand design 🟢 Why Terry built this—and how it sharpens your next move 📅 Learn anytime. New course every week. 📬 Subscribe to The Kenakin Brief → https://www.terrykenakin.com #GPCRscience #drugdiscovery #TerrysCorner #GPCRpharmacology #ligandbindingv Previous Next Recent Articles

<< Back to podcast list Dr. GPCR Podcast Strategic Partners Dr. Katarina Nemec About Dr. Katarina Nemec " I am a pharmacist with an interest in systems pharmacology and precision medicine. Since my undergraduate studies, I have been engaged in researching molecular mechanisms that govern human (patho-)physiology and their interplay with drugs. I aim to discover new therapeutic approaches, and druggable molecules or refine canonical drug targets to create drugs with fewer adverse effects. I studied Pharmacy at the University in Ljubljana, Slovenia, and at the University of Bonn, Germany, working initially on the role of prostaglandin receptor EP4 in chronic lymphocytic leukemia. During my PhD studies in Martin Lohse lab at the Max Delbrueck Center in Berlin, I consolidated my knowledge of GPCRs pharmacology while performing various cell-based experiments to understand the binding, activation, and signaling of therapeutically relevant GPCRs. In addition, I generated various optical biosensors based on fluorescence or bioluminescence resonance energy transfer technologies (FRET, BRET) that were used for functional screens with state-of-the-art microscopy and high throughput screening to explain novel ways of GPCR modulation. I am continuing with the development of advanced screening approaches in the Madan Babu lab to progress in the understanding of spatiotemporal regulation of biased GPCR activation and signaling. I want to combine experimental approaches with data-driven discovery and adopt data science methodology to tackle relevant scientific questions on the systems pharmacology level. " Dr. Katarina Nemec on the web Babu Lab ResearchGate Google Scholar ORCID LinkedIn Twitter Dr. GPCR Enjoying the Dr. GPCR Podcast? Leave a Review. Leave a quick review to help more scientists find the show—and help us keep improving every episode. It takes <60 seconds and makes a big difference. ★ Review on Apple Podcasts ★ Rate on Spotify ✉️ Send feedback to the team Recent Podcast Articles How GPCR Collaboration Built an Innovation Engine From Pipettes to Platforms: The Evolution of GPCR Research How GPCR Spatial Signaling Sparked a Scientific Journey Thanks for listening to this podcast episode Follow us on your favorite Podcast Player << Previous Podcast Episode Next Podcast Episode >>

<< Back to podcast list Dr. GPCR Podcast Strategic Partners Exploring Career Paths in GPCR Research with Dr. Jacek Mokrosiński About Dr. Jacek Mokrosiński "Jacek is a Senior Scientist at Novo Nordisk specializing in molecular pharmacology and cell-based screening technologies. He works in a multidisciplinary Chemical Biology team based at the recently established US R&D hub in Lexington, MA. Originally from Łódź, Poland, Jacek completed his Master's degree in Biology, specializing in Biochemistry at the University of Łódź. He then moved to Denmark, where he trained at the University of Copenhagen under supervision of Professor Thue W. Schwartz, and worked closely with Dr Birgitte Holst studying structural and mechanistic properties of ghrelin receptor and GPCRs involved in regulation of metabolism. After completing his Ph.D., he pursued research in genetics of metabolic regulation at the Institute of Metabolic Science - Metabolic Research Laboratories at the University of Cambridge in the team led by Professor I. Sadaf Farooqi. His research aimed at understanding molecular mechanism through which rare genetic variation may lead to or protecting from excessive body weight gain. As part of Farooqi's team, he characterized a series of novel human genetic variants identified in several GPCRs associated with obesity and other metabolic diseases, including GPR10, Melanocortin 4, Serotonin 2C and TRH receptors. Since 2021, Jacek has been working at Novo Nordisk at its research sites in the UK (Oxford) and the US (Indianapolis, Indiana and most recently Lexington, Massachusetts). He is passionate about cell-based in vitro technologies to study mechanistic properties of GPCRs and understanding the dynamics of receptor signalling. He is an avid proponent of close collaboration between industry and academia." Dr. Jacek Mokrosiński on the web ORCID ResearchGate LinkedIn Twitter Dr. GPCR AI Summary AI-generated content may be inaccurate or misleading. Always check for accuracy. Quick Recap Yamina and Jacek discussed their experiences with name mispronunciations, cultural differences, and the importance of a multidisciplinary approach in drug development. They also shared their career journeys, emphasizing the value of being open-minded, proactive, and embracing new opportunities. Lastly, they discussed their research interests, particularly in the field of GPCR, and the importance of method development, integrity, and honesty in scientific research. Next Steps Jacek will collaborate with Alex Romeo on a podcast about transitioning to the industry. In future talks and interviews, Jacek will share his stories and advice about GPCRs. Yamina will schedule a future talk with Jacek about GPCRs as therapeutic modalities. Summary Embracing Cultural Differences and Collaboration Yamina and Jacek shared their experiences with name mispronunciations and variations and discussed the importance of embracing cultural differences. They also discussed their professional backgrounds, highlighting the benefits of a multidisciplinary approach in drug development and the importance of collaboration between academia and industry. They talked about their shared passion for advancing science and improving patient outcomes, and their early interests in science and chemistry. They also shared their appreciation for documentaries showcasing manufacturing processes and the value of true experimentation in scientific research. Jacek's Career Journey and Advice Jacek and Yamina discussed Jacek's career journey, focusing on his experiences, challenges, and lessons learned. Jacek highlighted the importance of being open-minded and proactive, emphasizing that he learned by doing rather than taking specific courses. He also underscored the role of the people around him, expressing gratitude for their guidance and support. His advice was to be ready for changes and to embrace opportunities as they arise. Jacek's career path, which led him from Poland to Denmark and then to the US, exemplified his advice in action. Passion for Science and Career Journeys Yamina and Jacek discussed their passion for science and how it led them to their current careers. Jacek shared his experience of working with Piketa and how he found a job in Seda's lab at Cambridge, where he could immediately contribute due to his technical skills. Yamina agreed with Jacek's sentiments and spoke about her own journey, expressing her happiness in discussing science and reading papers. They emphasized the importance of finding a job that aligns with one's interests and strengths and being open to opportunities. They also highlighted the need for a work-life balance and the joy of a well-done job. Embracing Networking for Professional Growth Jacek and Yamina discussed the importance of building a network and being open to new opportunities. Jacek realized that being introverted doesn't mean he can't benefit from networking and interaction with others. He also highlighted the benefits of attending conferences and engaging with colleagues, sharing examples of how such interactions led to collaborations and new opportunities. Yamina agreed, emphasizing the importance of mental preparation and embracing different social situations, both virtual and in-person. They underscored the value of these interactions for professional growth and encouraged others to adopt a proactive approach to networking. Building Professional Connections Strategies Yamina and Jacek discussed the importance of building professional connections and strategies for introducing oneself to potential contacts. They emphasized the need to be mindful of the other person's time, provide clear explanations for the purpose of the connection, and offer something of value in return. They also highlighted the advantages of using LinkedIn as a tool for networking and the significance of personalizing messages to make a lasting impression. GPCR Research Interests and Collaborations Yamina and Jacek had a deep and engaging discussion about their research interests and achievements, particularly in the field of GPCR. Jacek shared his fascination with the growth hormone secretion receptor and the melanocortin 4 receptor, and their roles in regulating body weight and growth. Yamina, in turn, talked about her work on melanocortin receptors and an upcoming collaboration with a postdoc scientist. They also highlighted the importance of method development, integrity, and honesty in scientific research. The discussion revealed their interest in GPCRs as therapeutic modalities and possible future collaborations. Enjoying the Dr. GPCR Podcast? Leave a Review. Leave a quick review to help more scientists find the show—and help us keep improving every episode. It takes <60 seconds and makes a big difference. ★ Review on Apple Podcasts ★ Rate on Spotify ✉️ Send feedback to the team Recent Podcast Articles How GPCR Collaboration Built an Innovation Engine From Pipettes to Platforms: The Evolution of GPCR Research How GPCR Spatial Signaling Sparked a Scientific Journey Thanks for listening to this podcast episode Follow us on your favorite Podcast Player << Previous Podcast Episode Next Podcast Episode >>

<< Back to podcast list Dr. GPCR Podcast Strategic Partners Dr. Graham Ladds About Dr. Graham Ladds Graham studied Biochemistry at the University of Birmingham before completing a Ph.D. in yeast pheromone signaling at Warwick. He continued to work at Warwick as a post-doc studying pro-hormone convertases before securing a 5-year independent fellowship funded through the NHS. This project enabled him to return to his interest in GPCRs. He progressed through the ranks at Warwick to become an Associate Professor before leaving in 2015 to join the Department of Pharmacology at Cambridge, where he is also a Fellow of St John’s College. In 2020, he was promoted to a Readership/Professor in Receptor Pharmacology and was elected a Fellow of the British Pharmacological Society. His research group uses a combination of pharmacological investigations and mathematical modeling to study factors that control agonist bias at GPCRs. These investigations have enabled him to foster strong collaborations with the pharmaceutical industry (GSK, Takada, and Firmenich) which have recently been enhanced through him being awarded a Royal Society Industry Fellowship to collaborate with AstraZeneca . Dr. Graham Ladds on the web Twitter ResearchGate LinkedIn Google Scholar PubMed Dr. GPCR Ecosystem Enjoying the Dr. GPCR Podcast? Leave a Review. Leave a quick review to help more scientists find the show—and help us keep improving every episode. It takes <60 seconds and makes a big difference. ★ Review on Apple Podcasts ★ Rate on Spotify ✉️ Send feedback to the team Recent Podcast Articles How GPCR Collaboration Built an Innovation Engine From Pipettes to Platforms: The Evolution of GPCR Research How GPCR Spatial Signaling Sparked a Scientific Journey Thanks for listening to this podcast episode Follow us on your favorite Podcast Player << Previous Podcast Episode Next Podcast Episode >>

<< Back to podcast list Dr. GPCR Podcast Strategic Partners Dr. Caron Tribute Part 1 About Marc Caron Dr. Caron and his family moved to Durham, NC in 1977, following receipt of his BSc in Chemistry from Laval University and his Ph.D. from the University of Miami. He joined the faculty of Laval University School of Medicine in 1975 and then returned to join Duke’s faculty, where he remained as a James B. Duke Professor until his death. He and his laboratory members studied the mechanisms of action and regulation of hormones and neurotransmitters and how they might underlie brain and behavior disorders such as schizophrenia, Parkinson's disease, attention-deficit hyperactivity disorder, mood disorders, and addiction. Among his many honors, Dr. Caron was an investigator of the Howard Hughes Medical Institute from 1992 to 2004, a member of the American Academy of Arts & Sciences, a fellow of the American Association for the Advancement of Science, and a recipient of the Julius Axelrod Award. An authoritative and prolific scientist, with over 650 scientific publications, he is most beloved as a mentor and his relentless encouragement that shaped the careers of hundreds of scientists worldwide. About our panelists in alphabetical order and the year they first met Dr. Caron Dr. Jeffrey Benovic (1985) Dr. Michel Bouvier (1985) Dr. Kathleen Caron - Co-host- (1970) Dr. Richard Cerione (1985) Dr. Brian Kolbilka (1987) Dr. Frederik Leeb-Lundberg (1984) Dr. Robert Lefkowitz (1973) Dr. Lee Limbird (1973) Dr. David Sibley (1988) Memories our panelists shared with us Enjoying the Dr. GPCR Podcast? Leave a Review. Leave a quick review to help more scientists find the show—and help us keep improving every episode. It takes <60 seconds and makes a big difference. ★ Review on Apple Podcasts ★ Rate on Spotify ✉️ Send feedback to the team Recent Podcast Articles How GPCR Collaboration Built an Innovation Engine From Pipettes to Platforms: The Evolution of GPCR Research How GPCR Spatial Signaling Sparked a Scientific Journey Thanks for listening to this podcast episode Follow us on your favorite Podcast Player << Previous Podcast Episode Next Podcast Episode >>

Home → Flash News → New biosensor technologies are shedding light on GPCR dynamics directly in cells, offering exciting possibilities for multiplexing and miniaturization! Curious about how these advances could impact drug discovery? Check out the latest review on GPCR biosensors. Check out the latest GPCR news in the Ecosystem today! You’ll need to register but don’t worry, it’s Free! Published on October 24, 2024 Category GPCR Weekly News New biosensor technologies are shedding light on GPCR dynamics directly in cells, offering exciting possibilities for multiplexing and miniaturization! Curious about how these advances could impact drug discovery? Check out the latest review on GPCR biosensors. Check out the latest GPCR news in the Ecosystem today! You’ll need to register but don’t worry, it’s Free! ➡️ https:// www.ecosystem.drgpcr.com/reviews/gpcr-biosensors-to-study-conformational-dynamics-and-signaling-in-drug-discovery #GPCR #DrGPCR #biosensor Previous Next Recent Articles

Home → Flash News → 🚀 New Workshop: Practical Quantification of Allosteric Modulation Join Dr. Terry Kenakin on May 1st, 2025, for an advanced live workshop on allosteric modulators in GPCR drug discovery. Learn how to: ✔️ Identify, measure, and quantify allosteric properties ✔️ Apply functional allosteric models to determine mechanisms of action ✔️ Confirm allostery through kinetic analysis 📅 Date: May 1st, 2025 ⏳ Registration deadline: April 18th 📍 Live on Google Meet 🔗 Register now: https://www.ecosystem.drgpcr.com/event-details-registration/practical-quantification-of-allosteric-modulation #GPCR #Allostery #DrugDiscovery #Pharmacology Published on March 3, 2025 Category GPCR University 🚀 New Workshop: Practical Quantification of Allosteric Modulation Join Dr. Terry Kenakin on May 1st, 2025 , for an advanced live workshop on allosteric modulators in GPCR drug discovery. Learn how to: ✔️ Identify, measure, and quantify allosteric properties✔️ Apply functional allosteric models to determine mechanisms of action✔️ Confirm allostery through kinetic analysis 📅 Date: May 1st, 2025⏳ Registration deadline: April 18th📍 Live on Google Meet 🔗 Register now: https://www.ecosystem.drgpcr.com/event-details-registration/practical-quantification-of-allosteric-modulation #GPCR #Allostery #DrugDiscovery #Pharmacology Previous Next Recent Articles