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Discover the Dr. GPCR Ecosystem – the ultimate hub for GPCR professionals to connect, collaborate, and advance drug discovery. Home: About Accelerating GPCR Drug Discovery, Together Dr. GPCR is the global hub where academia and industry meet to advance GPCR research, accelerate drug discovery, and foster collaboration across the entire ecosystem. 👉 Join Free Today 🔒 Go Premium Strategic Partner(s) Your Path to GPCR Mastery Flexible, career-ready courses designed by scientists for scientists. GPCR Courses ➚ Terry's Corner GPCR Weekly News ➚ Dr. GPCR Podcast ➚ Articles from the Ecosystem ➚ How Early Strategic Decision Making Creates Alignment and Better Results Early Stage Biotech Hiring: What Really Holds a Team Together When the Science Starts to Drift The One Reason Why Biotech Startups Fail More Often Than They Should Why Biotech Fundraising Fails Due to Intellectual Property Gaps Closing the Gap Between Academia and Industry Our vision is simple: empower the GPCR field through shared knowledge, collaboration, and open access to tools that accelerate drug discovery. 🤝 Support the Mission Home: Premium Premium Yearly $499 $ 499 Every year 🚀 Everything you need to master GPCR science — in one membership. Valid until canceled Select 🎓 Full GPCR University + 🔬 200+ expert talks 🗞️ Weekly research, careers & event intelligence 🤝 Members-only networking, AMAs & matchmaking 💡 Support open resources for the global GPCR field 🧠 Designed for researchers at every career stage 🚀 Don’t just keep up — lead the way. 🔒 Grandfather Guarantee, your rate never increases Everything You Need to Master GPCR Science in One Membership Join the most complete GPCR learning & collaboration hub. Explore the packages and choose one that works for you Advancing GPCR Science Through Collective Intelligence Dr. GPCR is a living ecosystem where global minds converge to share knowledge, spark collaboration, and shape the future of GPCR-driven discovery. 🤝 Support the Mission

Dr. GPCR Podcast - The Voice of the Community Whether you’re a scientist, student, or just curious, you’ll hear about discoveries, career stories, and the latest GPCR news. Jump in and get inspired! Strategic Partners Latest Podcast Episodes 2025-12-17 2025-11-05 2025-09-02 2025-07-22 2025-05-27 2025-12-03 2025-10-22 2025-08-19 2025-07-08 2025-05-13 2025-11-19 2025-09-22 2025-08-05 2025-06-11 2025-04-29 1 2 3 4 5 1 ... 1 2 3 4 5 6 7 8 ... 8 Enjoying the Dr. GPCR Podcast? Leave a Review. Leave a quick review to help more scientists find the show—and help us keep improving every episode. It takes <60 seconds and makes a big difference. ★ Review on Apple Podcasts ★ Rate on Spotify ✉️ Send feedback to the team Thanks for listening to this podcast episode Follow us on your favorite Podcast Player Listen and subscribe where you get your podcasts

Explore the world of GPCRs with Dr. GPCR Podcast! Join industry leaders as they share insights, stories, and groundbreaking discoveries, enriching our understanding of GPCRs. Delve into the science behind these vital components shaping our collective knowledge. Welcome to the Dr. GPCR Podcast - The Voice of the Community Conversations with the world’s leading GPCR scientists. Exploring discoveries, careers, and ideas shaping human health. In each episode, we sit down with leading experts to explore their career journeys, groundbreaking discoveries, and the impact of their research on our shared understanding of GPCR biology. Launched at the height of the pandemic, the Dr. GPCR Podcast was created with three goals: Share discoveries – Highlight the latest advances in the GPCR field. Amplify voices – Provide scientists a platform to showcase their work. Inspire the future – Motivate the next generation to pursue GPCR research. At its core, Dr. GPCR’s mission is simple yet ambitious: to bring the GPCR community together - across borders and disciplines - to connect, exchange, and collaborate in order to improve human health through a deeper understanding of GPCR biology. Latest Podcast Episodes More podcast episodes Dr. GPCR Podcast Audience Survey We are currently planning our next season and need your help. This short survey will help us understand your needs to bring you exciting and informative content. We also know that you are busy, which is why we designed this short survey that should take you 5 minutes. Fill out this form Be our Guest In each episode, we chat with an expert about their career trajectory, discoveries, and how their research contributed to the shared pool of knowledge about GPCR biology. We’d love to have you on our podcast. To be a guest, fill out the form below, and we’ll be in touch in 48 hours. Fill out this form What others are saying about this podcast Really enjoyable science podcast! Dr. Yamina Berchiche interviews leading GPCR scientists on this vibrant, entertaining podcast. I really appreciate the way the podcast educates and mentors, particularly towards junior scientists but also to the community as a wholen Yamina is a great interviewer, getting insight and personal history from her guests. Am very grateful for Dr GPCR livening up the week in these difficult times! Sam @Pharmamechanic I enjoy the breadth of questioning that goes beyond just the science, and reveals a bit about the scientists as individuals/mentors/people. Anonymous Great initiative, thanks. Carrier paths, choosing research topics, switching fields, late start, failures and successes. Anonymous This came at just the most perfect time. I hadn't heard a scientific talk outside my lab since February and was starved to hear someone else talk passionately about GPCRs. I've listened to the episodes multiple times and it's just like being at a conference getting new ideas. I just couldn't be happier y'all created this podcast. Anonymous I think it's really well done. I'm genuinely interested to see how it evolves and grows over time, as I feel it has the potential to develop into something even more impactful. Anonymous Listen and subscribe where you get your podcasts

Learn about Celtarys Research through the Dr. GPCR Ecosystem. Explore their innovative GPCR projects, collaborations, and contributions to cutting-edge drug discovery. Partnership Dr. GPCR x Celtarys Reseach Empowering medicinal biochemists Celtarys empowers medicinal biochemists by providing innovative fluorescent probes that de-risk the pre-clinical drug discovery phase. Our proprietary conjugation technology and unparalleled scientific expertise ensure researchers can confidently advance their projects with greater precision and reliability. Visit Website About Celtarys Research Celtarys Research develops and commercializes new chemical tools to spread the use of fluorescence-based methods in the pre-clinical phase of drug discovery. Our proprietary chemical conjugation technology allows us to grow, in a competitive manner and in a short time (<3 months), customized fluorescent ligands with optimal pharmacological and photophysical properties for any druggable target. We have a catalogue of over 30 fluorescent ligands for different families of GPCRs, including adenosine, dopamine, serotonin, cannabinoid and muscarinic receptors. We also offer our expertise in the form of custom development services, where we tackle challenging targets and synthesize probes with the most suitable properties for your needs. Meet the Celtarys Team Wilson Gomes CEO Wilson Gomes holds a Mechanical Engineering degree, an MBA from the University of North Carolina, and completed the General Management Program at Harvard Business School. He has over 20 years of experience in the medtech and diagnostics industries, having held senior roles at Johnson & Johnson and Danaher across the EMEA region in sales, marketing, and general management. He joined Celtarys as CEO in 2024, where he is responsible for driving strategy and growth. His focus is on expanding commercial reach and accelerating the adoption of the company’s GPCR assay technologies. Maria Majellaro Co-Funder and CSO Dr. Maria Majellaro earned her degree in Pharmaceutical Chemistry and Technology from the University of Bari and completed her PhD in Biomolecular Sciences in Pharmacology and Medicine as “Doctor Europeus” in 2018. She then joined the University of Santiago de Compostela as a postdoctoral researcher in Prof. Eddy Sotelo’s group, contributing to the IGNICIA tech transfer project and the validation of Celtarys’ core technology. In 2021, she co-founded Celtarys and now leads the company’s scientific direction. Her work focuses on organic synthesis, medicinal chemistry, and the development of GPCR-targeted tools for pharma, biotech, and academic partners. Podcast Episode Baking Molecules, Building Probes: When Chemists Think Like Biologists Episode #168 • Dr. GPCR Talks with Dr. Maria Majellaro "We always start with the problem, then generate the right compound using our chemistry. It’s about enabling biology.” Celtarys News & Updates Using Live-cell High-Content Screening to Characterize CB2 Ligands: Insights From 16 Synthetic Cannabinoids Live-cell high-content screening (HCS) offers an increasingly valuable alternative. By quantifying ligand–receptor interactions directly in intact cells, HCS allows researchers to observe binding events under near-physiological conditions while simultaneously generating image-based evidence to support numerical affinity estimates. For targets such as CB2, where nuanced shifts in receptor conformation affect signaling outcomes, a whole-cell environment can strengthen early-sta Lucía from Celtarys Research Dec 9, 2025 5 min read High-Content Screening for GPCR Programs: Overcoming Assay Limitations with Fluorescent Ligands High-content screening (HCS) has become a cornerstone in GPCR and phenotypic drug discovery, enabling researchers to quantify cellular responses with spatial, temporal, and mechanistic depth. For GPCR-focused programs, the ability to visualize receptor localization, internalization kinetics, and ligand interactions in intact cells offers advantages that extend far beyond traditional biochemical or radioligand assays. Yet, despite remarkable progress, HCS workflows rema Lucía from Celtarys Research Nov 25, 2025 5 min read 1 2 3 4 5 Our Partnership Dr. GPCR and Celtarys Research Join Forces to Expand Access to Innovative GPCR Tools Boston, MA and Santiago de Compostela, Spain — June 3rd, 2025 — Dr. GPCR, the global knowledge hub for G protein-coupled receptor (GPCR) research and education, is proud to welcome Celtarys Research to its partner ecosystem. This collaboration aims to amplify the visibility and adoption of Celtarys’ cutting-edge fluorescent ligand technology and accelerate the development of GPCR-targeted therapeutics. Celtarys Research develops high-quality, fluorescently labeled ligands and innovative chemical biology tools to support real-time, non-radioactive GPCR assays. These tools enable high-resolution binding studies, kinetic analysis, and live-cell imaging, empowering both academic and industrial scientists to uncover GPCR biology with greater precision and speed. “We’re thrilled to partner with Celtarys and introduce their high-performance fluorescent ligands to our global GPCR community,” said Dr. Yamina Berchiche, Founder and CEO of Dr. GPCR. “These tools can dramatically improve how scientists measure ligand-receptor interactions, visualize binding in live cells, and design better experiments, core to advancing GPCR-targeted discovery.” “Dr. GPCR provides a unique platform to reach scientists at every stage of GPCR research,” said Wilson Gomes, CEO of Celtarys Research. “This partnership will help accelerate the adoption of our chemical tools and foster collaborations that turn receptor biology into therapeutic breakthroughs.” “We’re excited to support the GPCR community with tools that deliver clarity, sensitivity, and speed,” added Dr. Maria Majellaro, CSO of Celtarys. “Working with Dr. GPCR allows us to engage with researchers worldwide who are shaping the future of receptor-targeted therapies.” To explore Celtarys Research’s catalog and learn more about their GPCR tools, visit https://www.ecosystem.drgpcr.com/celtarys-research Services & Expertise NEW! High Content Screening Service Live‑cell HCS imaging in HEK‑293T–hCB2R with fluorescent ligand CELT-331; confocal capture on Operetta CLS. GPCR Expertise Specialized knowledge in adenosine, dopamine, serotonin, cannabinoid and muscarinic receptors for advanced research. Fluorescent Probes Innovative fluorescent probes that de-risk the pre-clinical drug discovery phase with optimal pharmacological properties. Custom Development Customized fluorescent ligands developed in less than 3 months with optimal properties for any druggable target. Product Catalog GPCR Ligands Our GPCR fluorescent ligands are the ideal solution for your High Throughput Screening (HTS) needs. GPCR Functional Assay Fluorescent GTPγS enables sensitive, non-radioactive GPCR activity assays for drug discovery. Custom Development Tailored fluorescent probes designed for unique research requirements. Contact Celtarys Research First name* Last name Email* Write a message Submit Get in Touch Address Avda. Mestre Mateo 2, Santiago de Compostela, 15706, Spain Email Website LinkedIn

Equip your research team with expert-led GPCR pharmacology training. Get 25% off Annual Premium Memberships for teams of five or more. Activate in days. Home Courses Articles About Log In / Sign Up Equip Your Team with Terry Kenakin’s Pharmacology Expertise Shared depth in GPCR pharmacology—built for scientific teams One team membership. Shared pharmacology expertise. Faster, better decisions. Train 5+ team members and receive 25% off annual access. Access monthly courses, live AMAs, and hard-won insight from 40+ years shaping GPCR pharmacology. Activate Team Membership What Your Team Gets? Proven frameworks for drug discovery Learn anytime, anywhere — flexible for busy discovery scientists Shape the curriculum — submit topics you and your team want covered next Weekly new courses — stay ahead of the science Designed for biotech, pharma & academic researchers Live monthly AMA with Dr. Kenakin — get expert answers How It Works? 1️⃣ Prepare Your Team Gather at least 5 team members . Each person must have or create a Dr. GPCR Ecosystem account. 3️⃣ Confirm and Pay Securely Review your submission and complete payment. You’ll receive a confirmation email immediately. 2️⃣ Submit the Team Form Provide names, emails, and organization details. This ensures proper access and personalized onboarding. 4️⃣ Membership Activation Our team manually reviews and activates all seats. Activation takes 3–10 business days . You’ll be notified once access is live. 💡 Need to add members later? We’ll help you update your team anytime. Apply for Your Team Discount 👇 📢 Limited-time offer – don’t miss out! First name* Last name* Email* Company name* Company Website* Names & Emails of Each Team Member (minimum 5)* Team Size* Annual Premium Team access. Minimum five seats. Priced per person per year. $2,249.25 Order Now 💡 Have questions? Contact us at Hello@DGPCR.org Terry’s Pharmacology Corner — Created by Dr. Terry Kenakin , powered by Dr. GPCR . Stay connected on LinkedIn and YouTube . Explore : Foundational Lessons — Build Your Pharmacology Core Emerging Drug Hunter — Expand Your Edge Expert-Level Mastery — Advanced Pharmacology Live AMA Sessions with Terry

Home → Flash News → From aspiring doctor to GPCR scientist! 🔬In this episode, Ian Chronis shares his journey from med school dreams to a PhD in pharmacology, diving into the fascinating world of receptor signaling. Can you guess what’s his favorite GPCR? ✅ Hear his response: Ep 164 with Dr. Ian Chronis #SciencePodcast #GPCR #PhDLife #DrGPCR Published on April 17, 2025 Category Dr. GPCR Podcast From aspiring doctor to GPCR scientist! 🔬In this episode, Ian Chronis shares his journey from med school dreams to a PhD in pharmacology, diving into the fascinating world of receptor signaling. Can you guess what’s his favorite GPCR? ✅ Hear his response: Ep 164 with Dr. Ian Chronis #SciencePodcast #GPCR #PhDLife #DrGPCR Previous Next Recent Articles

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Home Registration Full Agenda Venue Travel Tips Sponsors Special Issue on Adhesion GPCRs CINVESTAV, Mexico City, Mexico October 23-25 Full Agenda Adhesion GPCR workshop 2024 CINVESTAV, Mexico City, Mexico October 23-25 Download PDF Program HERE Oct 23 - 9:00 AM Registration & Coffee with light breakfast Read More 9:50 AM Welcoming Remarks Read More 10:00 AM Student Flash Presentations Health and Disease, Metabolism, Nervous System, Proteomics and Transcriptomics, Receptor Structure, Signaling and Activation Mechanism Abhishek Kumar Singh · Alex Torrelli-Diljohn · Emmanouil Kyrloglou · Vasiliki Karagiannakou · Lara-Sophie Brodmerkel · Rashed Rezwan Parag · Hailey Steichen · Tyler Bernadyn · Jesse Stillwell Read More 12:00 PM Coffee Break with lights snacks Read More 12:30 PM State of the Art Talk Adhesion GPCR in Mechanobiology Tobias Langenhan Read More 1:00 PM Plenary Lecture Identification and Functional Characterization of Adhesion GPCRs As Steroid Hormone Receptors and Hearing and Balance Receptors Jinpeng Sun Read More 2:00 PM Complimentary Lunch Read More 3:00 PM Session I Tethered agonist - dependent/independent activation mechanism in AGPCRs Signe Mathiasen · Demet Araç · Andrew Dates · Frank Kwarcinski · Peng Xiao Read More 4:30 PM Leaving for City Center Read More 5:00 PM Mexico City Nocturnal Tour, Food and drinks Read More Oct 24 - 9:00 AM Session II AGPCR signaling pathways and trafficking Yuling Feng · Monserrat Avila Zozaya · Erwin G. Van Meir · Pal Kasturi Read More 10:30 AM Coffee Break with lights snacks Read More 11:00 AM Session III Molecular tools and biosensors directed at AGPCR signaling and function Stephanie Häfner · Laurent Sabbagh · Ana Lilia Moreno Salinas Read More 12:00 PM Session IV AGPCRs signaling in the nervous system Joseph Duman · Simeon R. Mihaylov · Anne Bormann Read More 1:00 PM Complimentary Lunch Read More 2:00 PM Posters Caroline Formstone · Jianxiang Xue · Virginea de Araujo Farias · Szymon P. Kordon · Tingzhen Shen · Bill Huang · Júlia Rosell · Sheila Ribalta-Mena · Mariam Melkumyan Read More 3:00 PM Session V Structural mechanisms of AGPCR signaling and function Fabian Pohl · Sumit Bandekar · Florian Seufert Read More 4:00 PM Board meeting/General assembly Welcome to Join Read More 5:00 PM Leave for dinner reception Read More 5:30 PM Complimentary Reception dinner Read More Oct 25 - 9:00 AM Session VI AGPCRs shaping the nervous system Yimin Zou · Dimitris Placantonakis · Nicole Perry-Hauser Read More 10:00 AM Coffee Break with lights snacks Read More 10:30 AM Session VII Physiological and pathological roles of AGPCRs in the nervous system Beatriz Blanco Redondo · Willem Berend Post Read More 11:10 AM Dr. GPCR Community Presentation Monserrat Avila Zozaya Read More 11:30 AM Session VIII Physiological and pathological roles of AGPCRs in the periphery Cheng-Chih Hsiao · Anastasia Georgiadi · Douglas Tilley Read More 12:30 PM Complimentary Lunch Read More 1:30 PM Session VIII * Physiological and pathological roles of AGPCRs in the periphery Tobias Langenhan · Anastasia Georgiadi · Douglas Tilley · Hee-Yong Kim · Alain Garcia De Las Bayonas · Gabriela Aust Read More 2:50 PM Session IX / Technology capsule: Light on aGPCR signaling and function NovoiSMART - A new platform for GPCR antibody drug discovery Gavin Zhang Read More 3:20 PM Coffee Break with pastries announcement of the aGEM award Read More 4:00 PM Closing remarks Read More Jinpeng Sun Identification and Functional Characterization of Adhesion GPCRs As Steroid Hormone Receptors and Hearing and Balance Receptors Bill Huang Self-Cleavage of GPR110 SEA Domain and Its Impact on GAIN Domain Autoproteolysis Andrew Dates Heterogeneity of Tethered Agonist Signaling in Adhesion G Protein-Coupled Receptors Pal Kasturi Site Specific N-Glycosylation Of The N-Terminal Fragment Of ADGRG6 Drives Proteolytic Processing, Trafficking And Signalling Ana Lilia Moreno Salinas Characterizing hADGRE5/CD97 Activation and Signaling: A Mechanical Stimulation BRET-Based Approach (MS-BRET) Florian Seufert Unveiling the GPS Cleavage Mechanism in ADGRL1 with QM/MM Willem Berend Post The Adhesion GPCR Latrophilin Interacts With The Notch Pathway To Control Germ Cell Proliferation Tobias Langenhan The CELSR/ADGRC Homolog Flamingo Is Not Autoproteolytically Processed By The GAIN Domain Rashed Rezwan Parag Novel isoforms of adhesion G protein coupled receptor B1 (ADGRB1/BAI1) generated from an alternative promoter in intron 17 Emmanouil Kyrloglou GPR124 Mediates Adhesion Of Leukemic Stem Cells To Their Niche And Leads To Myeloid Skewing Virginea de Araujo Farias Anti-Tumorigenic Role of Brain Angiogenesis Inhibitor 3 (BAI3) in WNT-Activated Medulloblastomas Szymon P. Kordon Conformational And Functional Coupling Between Extracellular and Transmembrane Regions of a Holo-Adhesion GPCR Frank Kwarcinski Discriminating between the extracellular scaffolding and G protein signaling roles of GPR56/ADGRG1 via the characterization of a non-cleavable point mutant knock-in mouse, H381S Erwin G. Van Meir Adhesion GPCR BAI1/ADGRB1 can block IGF1R-mediated growth signalling, increase radiosensitivity and augment survival in medulloblastoma. Laurent Sabbagh bioSens-All: A Multiparametric BRET-Based Platform for Comprehensive Profiling of adhesion GPCR Signaling and Pharmacology-Enabling Drug Discovery Fabian Pohl Structural Determinants Of GAIN Domain Autoproteolysis And Cleavage Resistance Of Adhesion G Protein-Coupled Receptors Beatriz Blanco Redondo Uncovering the signaling pathway of the ADGRA homolog Remoulade in Drosophila Douglas Tilley ADGRF5-mediated regulation of cardiac health and disease Abhishek Kumar Singh Adgrg6/Gpr126 is Required for Myocardial Notch Activity and N-cadherin Localization to Attain Trabecular Identity Lara-Sophie Brodmerkel GAIN Domain Dynamics And Its Relevance For Adhesion GPCR Signaling In Vivo Caroline Formstone Interrogating The Role Of CELSR1 (ADGRC1) In Breast Cancer Mariam Melkumyan GPR110 modulates anxiety-like behaviors and memory function in mice potentially through neuronal and neuroimmune alterations during neurodevelopment Signe Mathiasen Signaling Properties of ADGRL3 Monserrat Avila Zozaya The ADGRF5/GPR116 receptor is a key regulator of lymphatic endothelial cell identity and function Simeon R. Mihaylov Bai1 Is A Novel Neuronal Substrate Of The Psychiatric Risk Kinase TNIK Sumit Bandekar Structural studies of the CELSR1 extracellular region reveal a compact multidomain module of fourteen domains which regulates signaling Nicole Perry-Hauser Adhesion G protein-coupled receptor latrophilin-3 (ADGRL3) modulation of dopaminergic neurotransmission Anastasia Georgiadi Adhesion GPCR GPR116/Adgrf5 controls a lineage of anti-thermogenic adipocytes with implications for adaptive thermogenesis during prolonged cold exposure Jesse Stillwell Next Generation MBD2 inhibitors for Brain Cancer Therapy Hailey Steichen Identification of Differentially Expressed Gpr116 (Adgrf5) Transcript Variants in Mouse Kidney Sheila Ribalta-Mena Endocytic Cues Determine the Signaling Profile of Adhesion GPCR ADGRL1 / Latrophilin-1 Jianxiang Xue Generation and characterization of collecting duct specific GPR56 knockout mice Demet Araç An ECR-Mediated and TA-independent Mechanism of aGPCR Activation: Direct Communication of Extracellular Region with Transmembrane Domain in a Holo-Adhesion GPCR Yuling Feng Localization of putative ligands for adhesion G protein-coupled receptors in mouse tissues. Joseph Duman BAI1/ADGRB1-mediated Regulation of Mitochondrial Morphology in Axons Yimin Zou ADGRCs in glutamatergic synapse formation, maintenance and degeneration Cheng-Chih Hsiao ADGRG1/GPR56 regulates survival of terminally differentiated CD8+ T cells Alain Garcia De Las Bayonas The Adhesion GPCR Cupidon Regulates Mating In The Closest Relatives Of Animals Alex Torrelli-Diljohn Investigating The Role of ADGRB3 Loss of Expression in Brain Tumor Formation in Li-Fraumeni Syndrome Tyler Bernadyn Elucidating The Role Of GPR97/ADGRG3 In Neutrophil Biology Tingzhen Shen Deorphanization Of The Adhesion GPCRs GPR110 and GPR116 Júlia Rosell Tethered Agonist Dependent ADGRL3 Signaling Activity In The G12/13 Pathway Peng Xiao Tethered Peptide Activation Mechanism of Adhesion GPCRs Stephanie Häfner The NTF Release Sensor Approach for Drug Discovery for Human Adhesion GPCRs Anne Bormann Intricacies Of Complex Assembly And Ligand Interaction In The Adhesion GPCR Latrophilin/Cirl Dimitris Placantonakis Antibody-drug conjugates targeting CD97 in glioblastoma Gabriela Aust Critical role for CD97/ADGRE5 in the induction of allergic airway inflammation Hee-Yong Kim Characterization of Phenotypes Associated with GPR110 Deletion Vasiliki Karagiannakou A single cell GPCR map of thermogenic fat Gavin Zhang NovoiSMART - A new platform for GPCR antibody drug discovery

GPCR Courses Expert knowledge, flexible courses - career-ready skills —build skills that translate at the bench and in the boardroom. Go premium to get access The Practical Assessment of Signaling Bias Signaling bias is an inherent feature of pharmacology, influencing receptor behavior even when unnoticed. Different ligands stabilize distinct receptor states, leading to diverse signaling outcomes. Measuring and understanding bias helps design drugs that maximize therapeutic benefits while minimizing side effects. Terry Kenakin 🔒 Premium Content Watch recording Strategic Project Management for scientists Gain practical project management skills explicitly designed for research and innovation. Learn to plan, execute, and manage scientific projects while balancing timelines, resources, and team coordination. Master strategic planning, risk assessment, and collaboration tools to boost efficiency and project success. Yamina Berchiche 🔒 Premium Content Watch recording Applying Pharmacology to Drug Discovery Class 1 - Fundamentals of Pharmacology Class 2 - Characterizing Agonists Class 3 - Characterizing Antagonists Class 4 - Characterizing Allosteric Modulators Terry Kenakin 🔒 Premium Content Watch recording Advanced data analysis for GPCR pharmacology Class 1 - Concentration-response analysis: Become a CRC super-user Class 2 - Quantifying agonist pharmacology and biased agonism Class 3 - Antagonist pharmacology and binding assay analysis Class 4 - New dimensions of activity: Allosteric modulators and kinetics Sam Hoar 🔒 Premium Content Watch recording Principles of Pharmacology in Drug Discovery II Advanced Methods for the Optimization of Candidate Selection Lecture 1: The Eyes to See- The Importance of Pharmacologic Assays Lecture 2: Drug Disposition in Physiological Tissues as a Therapeutic Variable Lecture 3: The Application of GPCR Ligand Kinetics to Candidate Design Lecture 4: Unconventional GPCR Ligands as Drugs Lecture 5: Unique Exploitable GPCR-Ligand Behaviors for Therapeutic Benefit Terry Kenakin 🔒 Premium Content Watch recording Principles of Pharmacology in Drug Discovery I Techniques for Effective Lead Optimization of Candidate Molecules Lecture 1: GPCR Project Initiation and Design for Discovery of New Molecules Lecture 2: Drug Affinity: Measurement of Antagonism (Binding and Function) / Classifying Antagonists Lecture 3: Agonists and Efficacy: A New World of GPCR Efficacies / Biased Signaling Lecture 4: Allosteric Modulators: NAMs, PAMs, Special Properties, Methods to quantify the allosteric effect Terry Kenakin 🔒 Premium Content Watch recording What others are saying about the courses Dr. Hoare is very experienced in the field. What came as a pleasant surprise was how didactical and well-thought-out his course was—highly recommended. The really unexpected was that the Q&A sessions reached the highest level—beyond excellent. I am a convert! I will keep Dr. GPCR and the offered resources in my work sphere Anonymous Thank you for bringing this course with Dr. Kenakin. I wish Dr. GPCR the best for the sake of promoting more educational opportunities that are sorely needed in the field Anonymous The content had enough depth to satisfy the hunger for theory while being full of practical knowledge Anonymous The best pharmacology teacher teaming up with the best GPCR community platform to help train and inspire the next generation of scientists. Also super-valuable for those of us learning how to teach pharmacology Anonymous Dr. Hoare's extensive and elaborative explanation of the topics at hand was excellent and very digestible. Thoroughly enjoyed learning from him Anonymous Dr. Kenakin is a leading expert in the field. Aside from his vast experience in drug development, not to mention his extensive publication record, Dr. Kenakin is a masterful teacher and communicator. Anonymous The course was very practical and easily translatable to experiments that we could do in our own labs. It was clear that Dr. Hoare is very in touch with the technical and human challenges we encounter in our work Anonymous CoursesListPremium Become a Premium Member Watch Courses Recordings Premium Yearly $ 499 499$ Every year 🚀 Everything you need to master GPCR science — in one membership. Select 🎓 Full GPCR University + 🔬 200+ expert talks 🗞️ Weekly research, careers & event intelligence 🤝 Members-only networking, AMAs & matchmaking 💡 Support open resources for the global GPCR field 🧠 Designed for researchers at every career stage 🚀 Don’t just keep up — lead the way. 🔒 Grandfather Guarantee, your rate never increases Frequently asked questions What is Dr. GPCR University? Dr. GPCR University (https://www.ecosystem.drgpcr.com/gpcr-university)is an educational platform that provides in-depth learning and training resources on G protein-coupled receptors (GPCRs). At Dr.GPCR University, you’ll find: • Courses: Dive deep into curated educational content designed by experts in GPCR research. Our courses provide comprehensive, on-demand learning to help you expand your knowledge and stay current in the field. • Symposia Engage with leading scientists through our symposia, featuring in-depth discussions on cutting-edge research and breakthroughs in GPCR science. Each session brings together a community of experts to share insights and advancements. • Summit A global gathering of researchers and professionals showcasing the latest developments in GPCR research. Participate in presentations, networking opportunities, and collaborative sessions. • Virtual Café Listen to casual, interactive discussions with experts in the field. How do I register for Dr. GPCR University Masterclasses? To register for any course, you must have a FREE Ecosystem member account.(https://www.ecosystem.drgpcr.com/) We carefully screen anyone signing up to ensure they are real humans working on GPCRs, so you might not receive confirmation immediately. When signing up for the first time, try to complete as much information as possible about yourself. Who are the Dr. GPCR University Masterclasses designed for? The classes are designed for researchers, students, and professionals in biology, pharmacology, and biochemistry, but anyone interested in GPCR research is welcome to join. What topics are covered in the masterclasses? Masterclasses cover a variety of track including but not limited to pharmacology foundations, agonists, antagonists & core mechanisms , allosteric modulation & kinetics, advanced quantitative approaches and innovation & strategic application Can I register my team for a Dr. GPCR University Masterclasses? To register as a team, one of you must be a Premium Member.(https://www.ecosystem.drgpcr.com/plans-pricing) This person must email hello@drgpcr.or(mailto:hello@drgpcr.com)g indicating how many people will register for the course, the names of the participants, and their emails. We will contact each person individually to help them set up a FREE Ecosystem Membership.(https://www.ecosystem.drgpcr.com/) They will be asked to join a private group to keep updated with the latest announcements about the course. Are the masterclasses on-demand or live? Dr. GPCR University offers both on-demand and live classes led by experts in the field. On-demand classes are only available for Premium Members.(https://www.ecosystem.drgpcr.com/plans-pricing) Do I need prior knowledge of GPCRs to join the masterclasses? Some classes may require basic knowledge of GPCRs, but many are designed to accommodate beginners as well as advanced learners. What kind of certification will I receive upon completing a masterclass? Participants will receive a certificate of completion from Dr. GPCR University, which can be used to showcase your expertise and enhance your professional credentials. Can I access the course material after completing the course? Yes, if you are a premium member.

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Retreat 2023 About Program Registration Logo Contest Committee Sponsors GPCR Retreat Program Download PDF Program Thursday, November 2nd / 11:00 AM - 1:30 PM Registration Read More Thursday, November 2nd / 1:30 PM Welcome Remarks Read More Thursday, November 2nd / 1:45 PM - 2:45 PM Trainee Symposium I Eric Johansen , Johns Hopkins University Grace Mazarura , McGill University Émile Breault, Université de Sherbrooke Bassam Albraidy , Ottawa Hospital Research Institute Read More Thursday, November 2nd / 2:45 PM Coffee Break 1 Read More Thursday, November 2nd / 3:00 PM - 4:00 PM Trainee Symposium II Amr Mousa , University of Western Ontario Louis-Philippe Picard , University of Toronto Remi Janicot , Boston University Meredith Skiba , Harvard University Read More Thursday, November 2nd / 4:00 PM Check In Read More Thursday, November 2nd / 4:30 PM "Have a nice weekend, and I'll see you tomorrow!": RAMP-interacting GPCR Pathways Inaugural Marc G. Caron Keynote Lecture Kathleen M. Caron University of North Carolina at Chapel Hill Read More Thursday, November 2nd / 5:30 PM Welcome Reception and Poster Session 1 Read More Thursday, November 2nd / 8:00 PM Dinner 1 Read More Friday, November 3rd / 7:30 AM Breakfast 1 Read More Friday, November 3rd / 8:30 AM Dopamine-Mediated Motor Recovery after Ischemic Stroke Mario Tiberi Ottawa Hospital Research Institute Read More Friday, November 3rd / 8:55 AM A journey from Duke to McGill along the dopamine circuit Bruno Giros McGill University Read More Friday, November 3rd / 9:20 AM Cannabinoid compounds to augment L-DOPA treatment in Parkinson's Disease Ali Salahpour University of Toronto Read More Friday, November 3rd / 9:45 AM Pharmacological and Genetic Preclinical Models of Ghrelin Receptor Functional Selectivity to Investigate Metabolic Disease Pathophysiology Joshua Gross Duke University Medical Center Read More Friday, November 3rd / 10:25 AM Coffee Break 3 Read More Friday, November 3rd / 10:40 AM Regulation and role of mitochondria delta opioid receptors Louis Gendron Université de Sherbrooke Read More Friday, November 3rd / 11:05 AM Biased agonism at the GLP-1 receptor: from structure to animal models of disease Patrick Sexton Monash University Read More Friday, November 3rd / 11:30 AM Complex Allosteric Cannabinoid Receptor Pharmacology Robert Laprairie University of Saskatchewan Read More Friday, November 3rd / 11:55 AM Unveiling Non-Canonical Functions for Gαq Signaling Pathways Poster Talk Catalina Ribas University Autonoma of Madrid Read More Friday, November 3rd / 12:10 PM Lunch 1 Read More Friday, November 3rd / 1:30 PM Interaction with the cell adhesion molecule NEGR1 affects mGluR5 cell signalling Fabiola Ribeiro Federal University of Minas Gerais, Brazil Read More Friday, November 3rd / 1:55 PM A positive Allosteric Modulator of M1 Acetylcholine Receptors Improves Cognitive Deficits in Male and Female Alzheimer’s Mice Khaled Abdelrahman The University of British Columbia Read More Friday, November 3rd / 2:10 PM Genetic Deletion of Atypical VGLUT3 Rescues Huntington’s Disease Phenotype and Neurodegeneration in zQ175 Mice Poster Talk Karim Ibrahim University of Ottawa Read More Friday, November 3rd / 2:45 PM Removing the GPCR-mediated brake on exocytosis enhances insulin action, promotes adipocyte browning, and protects against diet-induced obesity Heidi Hamm Vanderbilt University Read More Friday, November 3rd / 3:00 PM Coffee Break 4 Read More Friday, November 3rd / 3:30 PM G Proteins and GPCRs in Cancer: Novel Precision Targeted and Immunotherapies J. Silvio Gutkind UC San Diego Read More Friday, November 3rd / 3:55 PM Inhibition of Relaxin Autocrine Signaling Confers Therapeutic Vulnerability in Ovarian Cancer Robert Rottapel University of Toronto Read More Friday, November 3rd / 4:20 PM Developing a PROTAC to Degrade the Constitutively Active Onco-GPCR in Uveal Melanoma Poster Talk Victoria Rasmussen Rockefeller University Read More Friday, November 3rd / 4:35 PM Targeting adenosine signaling for immuno-oncology John Stagg CHUM, Université de Montréal Read More Friday, November 3rd / 5:00 PM Poster Session #2 Read More Friday, November 3rd / 7:00 PM Dinner 2 Read More Friday, November 3rd / 9:30 PM Board Meeting To discuss the next GPCR Retreat All PIs welcome Read More Saturday, November 4th / 7:30 AM Breakfast 2 Read More Saturday, November 4th / 8:15 AM Distinct sub-cellular signal propagation as a component of functional selectivity Michel Bouvier Université de Montréal Read More Saturday, November 4th / 8:40 AM Biochemical Mechanisms Underlying Location Bias in GPCR Signaling Sudarshan Rajagopal Duke University Medical Center Read More Saturday, November 4th / 9:05 AM Structure-based discovery of functionally selective 5-HT1A receptor agonists Peter Gmeiner Friedrich-Alexander University of Erlangen-Nürnberg Read More Saturday, November 4th / 9:30 AM Atypical Structure and Function of Typical Chemokine Receptors Tracy Handel UC San Diego Read More Saturday, November 4th / 9:55 AM Coffee Break 5 Read More Saturday, November 4th / 10:10 AM Using food perception and bioamine signaling networks to slow aging Scott Leiser University of Michigan Read More Saturday, November 4th / 10:35 AM Interrogating Multiscale Receptors Functions in Space Martin Beaulieu University of Toronto Read More Saturday, November 4th / 11:00 AM Atypical Structure and Function of Typical Chemokine Receptors Amy Ramsey University of Toronto Read More Saturday, November 4th / 11:30 AM Illuminating Functional Selectivity and Allosterism at GPCRs. Hyman B. Niznik Keynote Lecture Stephane Laporte McGill University Read More Saturday, November 4th / 12:30 PM Closing Remarks. Lunch and farewell Read More Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires du Québec Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires du Québec 22nd GPCR Retreat Sponsored by

Applying Pharmacology to Drug Discovery by Terry Kenakin | Dr. GPCR Courses Applying Pharmacology to Drug Discovery Dr. Terry Kenakin The main objective of this course is to give the registrant a good overall understanding of the unique science of pharmacology and how it can describe drug action in system-independent ways. This allows predictions of drug activity in all physiological systems, not only the system where testing is done. Techniques will be described to quantify drug activity in terms of affinity, efficacy, and allosteric function. Pharmacology is a unique discipline and is critical to drug discovery. Registrants will learn: Methods to characterize the three major drug types. What makes each drug type unique to therapeutic pharmacology? 3. Essential information is needed to characterize a drug's profile aimed at therapy. Modules: Week 1 - Fundamentals of Pharmacology Week 2 - Characterizing Agonists Week 3 - Characterizing Antagonists Week 4 - Characterizing Allosteric Modulators Good to know Registrations start on December 15th and close on February 2nd. Classes will be live from Zoom on Thursdays from 10 am to 11:30 am EST. Sessions will include a 1-hour live lecture plus 30 minutes of Q&A. Every participant will also get the chance to have a 1:1 meeting with Dr. Kenakin during the four weeks, scheduled according to the professor's availability. Participants who complete the course will get an online certification signed by the professor and the Dr.GPCR Team. A splendid time is guaranteed for all. What others are saying about the courses Dr. Hoare is very experienced in the field. What came as a pleasant surprise was how didactical and well-thought-out his course was—highly recommended. The really unexpected was that the Q&A sessions reached the highest level—beyond excellent. I am a convert! I will keep Dr. GPCR and the offered resources in my work sphere Anonymous Dr. Hoare's extensive and elaborative explanation of the topics at hand was excellent and very digestible. Thoroughly enjoyed learning from him Anonymous Thank you for bringing this course with Dr. Kenakin. I wish Dr. GPCR the best for the sake of promoting more educational opportunities that are sorely needed in the field Anonymous Dr. Kenakin is a leading expert in the field. Aside from his vast experience in drug development, not to mention his extensive publication record, Dr. Kenakin is a masterful teacher and communicator. Anonymous The content had enough depth to satisfy the hunger for theory while being full of practical knowledge Anonymous The course was very practical and easily translatable to experiments that we could do in our own labs. It was clear that Dr. Hoare is very in touch with the technical and human challenges we encounter in our work Anonymous The best pharmacology teacher teaming up with the best GPCR community platform to help train and inspire the next generation of scientists. Also super-valuable for those of us learning how to teach pharmacology Anonymous What would you like to learn today?

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This multi-dimensional characterization extends across our full obesity and diabetes product portfolio, including GIPR, GCGR, AMY receptors, MC4R, and beyond. Beyond Eurofins DiscoverX Products: The Full Power of Eurofins Discovery Eurofins DiscoverX cell lines, assays, kits, and custom product solutions represent the foundation of tools for GPCR research and drug discovery and development. When these product solutions are combined with Calixar GPCR membrane proteins and Eurofins Discovery GPCR services, the benefits from integration provide the most comprehensive GPCR research and drug discovery platform spanning the entire discovery and development continuum. Eurofins Discovery GPCR services offer hundreds of binding and functional assays, available individually or in panels. These assays use the same platform as the Eurofins DiscoverX assays and beyond. Calixar GPCR membrane proteins , as a service, provides a wide array of GPCRs from various species, purified to the highest standards to ensure purity, integrity, and biological activity. These GPCRs are excellent for use in functional, structural, or identification assays, as they are strictly identical to the ones in membranes. Our Partnership I'm a paragraph. Click here to add your own text and edit me. It's easy. Related Articles How Breakthroughs Happen: Eric Trinquet on Innovation, Serendipity & GPCRs Discover how Dr. Eric Trinquet, creator of HTRF and IP-One assays, turned failure into breakthrough tools for GPCR science. Learn why play, serendipity, and partnerships fuel innovation—and how this mindset can transform your research and biotech career. Dr. GPCR Podcast Oct 16, 2025 4 min read The Truth About GPCR Product Launches: Years in the Making What it really takes to launch a GPCR product—years of failure, science, and strategy. Go behind the scenes of pH-Sense with Revity’s Dr. Eric Trinquet. Dr. GPCR Podcast Oct 8, 2025 4 min read Innovative Data-Driven Solutions: The pHSense Revolution A powerful new tool tracks GPCR internalization in native cells—no imaging, no overexpression. Learn how pH Sense changes the game for drug discovery. Dr. GPCR Podcast Sep 26, 2025 3 min read Eurofins DiscoverX Dr. GPCR Ecosystem Partner Contact a Eurofins DiscoverX Specialist or visit GPCR Product Solutions for more information on GPCR cell-based solutions for basic research, discovery, and therapeutic development.

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One insight, one connection, one ‘aha’ moment — can save months of research time. "I already get what I need from papers." Papers inform. DrGPCR helps you understand and apply that knowledge — through structured training, expert context, and real interaction with peers from academia and industry. "I'm not sure I'll use it often." Even one course or one new collaboration can make a difference. Members often find value in ways they didn’t expect — from expert feedback to career-changing introductions. "Will this really help my career?" Yes. Members grow visibility, confidence, and connections that open doors. It’s not just about learning — it’s about being seen, supported, and part of something bigger . Choose a package that works for you $0 Free Stay in the loop! But know you’re only scratching the surface. 📩 Weekly GPCR Brief (basic) 🎙️ Full access to the podcast 📤 Submit jobs & events to the community 📰 Science, tools & trends — no paywall 💸 Share the mission. Earn as you go Join for Free! 🔥 Upgrade to Premium Premium Yearly $499 $ 499 Every year 🚀 Everything you need to master GPCR science — in one membership. Valid until canceled Join Premium Today! 🎓 Full GPCR University + 🔬 200+ expert talks 🗞️ Weekly research, careers & event intelligence 🤝 Members-only networking, AMAs & matchmaking 💡 Support open resources for the global GPCR field 🧠 Designed for researchers at every career stage 🚀 Don’t just keep up — lead the way. 🔒 Grandfather Guarantee, your rate never increases Premium Yearly for Teams $374.25 • per year • per person • 25% discount • minimum 5 seats How does it work? 1️⃣ Gather Your Team 2️⃣ Submit Your Team Details 3️⃣ Complete the Payment 4️⃣ Activate Memberships Get Your Team Discount Developing Countries $24.99 • per year • per person • 90% discount *subject to verification Eligibility Criteria ✔ Live and work in a developing country. ✔ Be employed by an institution, university, or company based in a developing country. ✔ Provide verifiable information for eligibility review. Check Eligibility Premium Yearly for Academic Teams $0.00 • per year • per person • 100% discount • subject to availability What You’ll Need? 🧩 Step 1: Fill Out the Instructor Form 🧱 Step 2: Plan Your Course Structure 📝 Step 3: Prepare Your Content 🎥 Step 4: Record a Short Video Chat 💬 Step 5: Join Your Private Course Group 💫 Step 6: Teach & Inspire Get Your Team Discount Frequently Asked Questions Premium Pricing University What is Dr. GPCR Premium? Dr. GPCR Premium is a membership program that gives scientists, students, and industry professionals access to expert GPCR courses, 200+ research talks, career resources, and a global network of GPCR specialists. Who should join Dr. GPCR Premium? Researchers, biotech professionals, CRO teams, students, and anyone seeking deeper insights, networking opportunities, and tools to accelerate GPCR-related research and career growth. What’s included in the Premium membership? • 20+ expert courses • Complete GPCR coverage • 200+ research talks • Virtual Café Access • Job board access and career tools • Networking through the Dr. GPCR community • Exclusive partner discounts and events How does Premium differ from the free membership? Free members get limited access to talks and resources, while Premium members enjoy full GPCR content, unlimited event replay access, and advanced networking and career tools. How much does Premium cost? Choose a package that works for you here.(https://www.ecosystem.drgpcr.com/gpcr-university-pricing) Is there a monthly payment option? Currently, the membership is billed annually for maximum savings and uninterrupted access. Choose a package that works for you here.(https://www.ecosystem.drgpcr.com/gpcr-university-pricing) Are the courses self-paced? Yes. All courses and talks are available on-demand so you can learn anytime. Can I register my entire team for Premium? Yes. The Team plan (https://www.ecosystem.drgpcr.com/gpcr-university-group-package-discount)offers discounted rates for groups of 5 or more. Do you offer discounts for students or developing countries? Yes. Members from developing countries can join for $24.99/year. Students please reach out to hello@drgpcr.org What happens after I join? You’ll receive instant access to all Premium resources, your member dashboard, and exclusive community tools to start networking and learning right away. Ready to Advance Your GPCR Research? Join thousands of researchers who trust DrGPCR for cutting-edge insights and resources. Start Your Premium Journey Try Free First

Discover special university group pricing for Dr. GPCR courses. Save with discounted packages and provide your students or faculty access to premium GPCR learning resources. Empower Your Team with Dr. GPCR Premium Give your team the tools to grow together and stay at the forefront of GPCR science. Save 25% on annual Premium Memberships when you enroll five or more members. Access expert-led courses, 200+ talks, community tools, and curated insights designed to keep your team connected, informed, and inspired. Important Information To qualify for the team discount, your group must include at least five members. If fewer than five members are submitted: • Memberships won’t be activated. • You’ll receive a 50% refund to cover processing costs. 👉 Please double-check your team list before submitting to avoid delays. Questions? We’re here to help: Hello@DrGPCR.org . How It Works? 1️⃣ Prepare Your Team Gather at least 5 team members . Each person must have or create a Dr. GPCR Ecosystem account. 3️⃣ Confirm and Pay Securely Review your submission and complete payment. You’ll receive a confirmation email immediately. 2️⃣ Submit the Team Form Provide names, emails, and organization details. This ensures proper access and personalized onboarding. 4️⃣ Membership Activation Our team manually reviews and activates all seats. Activation takes 3–10 business days . You’ll be notified once access is live. 💡 Need to add members later? We’ll help you update your team anytime. Apply for Your Team Discount 👇 📢 Limited-time offer – don’t miss out! First name* Last name* Email* Company name* Company Website* Names & Emails of Each Team Member (minimum 5)* Team Size* Annual Premium Team access. Minimum five seats. Priced per person per year. $374.25 Order Now 💡 Have questions? Contact us at Hello@DGPCR.org Book Plan Your Next Move in GPCR Discovery Meet directly with Dr. Yamina Berchiche for a focused strategy conversation to align your goals, uncover opportunities, and map your next steps.

Get one year of free Dr. GPCR Premium access for your entire academic lab. Teach a course at Dr. GPCR University and unlock expert resources, training, and tools. Academic Team Access Program One Year of Dr. GPCR Premium — Free for Your Entire Lab Empowering academic discoveries with industry-grade GPCR resources. Why We Created This Program? Your research group plays a critical role in advancing GPCR science. We want to support academic labs with the same high-quality tools, courses, and insights used by leading biotech teams—without financial barriers. The Dr. GPCR Academic Team Access Program gives your entire lab one year of Premium membership at no cost, in exchange for contributing to the community’s shared knowledge base through teaching . How does it work? No Cost, No Hidden Requirements The program is 100% free for academic labs who contribute as instructors. No recurring charges. No credit card required. Your Whole Lab Gets One Year of Premium Access Once approved, every member of your team receives free Premium access for 12 months, including: Full access to Dr. GPCR Masterclasses & University Vault Weekly News extended editions Exclusive event recordings, slides, and community decks Premium research insights and ecosystem reports Priority access to certain events and AMAs A Member of Your Lab Teaches at Dr. GPCR University Contribute your expertise by teaching a topic, workshop, or course within the Dr. GPCR University. Format is flexible — we work with your availability. Become part of the Dr. GPCR University Instructor community Learn More & Join the Program To keep things simple, we created a single guide that covers: Eligibility guidelines Teaching formats & examples Instructor expectations Course creation support Application steps Timeline & onboarding What your team receives Renewal options 👉 Everything is explained here *This link takes you to a dedicated page with all the details. Book Ready to Unlock Premium for Your Entire Lab—At No Cost? 👉 Learn More & Get Started Meet directly with Dr. Yamina Berchiche for a focused strategy conversation to align your goals, uncover opportunities, and map your next steps.

Home → Flash News → A new study from the Hudson Lab at the University of Glasgow shows that the FFA receptor antagonist AH7614 is actually an inverse agonist - suppressing fat cell formation, boosting lipolysis and reducing glucose uptake. Explore how targeting FFA4 could help fight metabolic disorders. Catch up with the latest research conducted in the Hudson lab in Ep. 161 of the Dr. GPCR Podcast. Subscribe to the Dr. GPCR Newsletter 📰 and get the latest GPCR News delivered to your inbox ➡️https://www.ecosystem.drgpcr.com/gpcrs-in-cardiology-endocrinology-and-taste/inverse-agonism-of-the-ffa4-free-fatty-acid-receptor-controls-both-adipogenesis-and-mature-adipocyte-function #GPCR #drGPCR #FFA4 #metabolism #adipocytes” Published on April 7, 2025 Category GPCR Weekly News A new study from the Hudson Lab at the University of Glasgow shows that the FFA receptor antagonist AH7614 is actually an inverse agonist - suppressing fat cell formation, boosting lipolysis and reducing glucose uptake. Explore how targeting FFA4 could help fight metabolic disorders. Catch up with the latest research conducted in the Hudson lab in Ep. 161 of the Dr. GPCR Podcast. Subscribe to the Dr. GPCR Newsletter 📰 and get the latest GPCR News delivered to your inbox ➡️ https:// www.ecosystem.drgpcr.com/gpcrs-in-cardiology-endocrinology-and-taste/inverse-agonism-of-the-ffa4-free-fatty-acid-receptor-controls-both-adipogenesis-and-mature-adipocyte-function #GPCR #drGPCR #FFA4 #metabolism #adipocytes Previous Next Recent Articles

Home → Flash News → terrys corner from data to insight Published on July 14, 2025 Category Terry's Corner Pharmacology’s hidden power? The model behind the data 💡 Terry Kenakin shows how experimental snapshots can reveal much more—and how predictive frameworks guide modern drug discovery. 🟢 Built for pharmacologists building stronger pipelines and those rethinking legacy models. ✳️ https://www.terrykenakin.com #GPCR #DrGPCR #pharmacology #drugmodeling #terrykenakin Previous Next Recent Articles

Home → Flash News → What can an updated profile do for you? 🔎 Personalized content, better networking, and collaboration opportunities. Fill in the blanks—update now! ✳️Visit https://bit.ly/4fY4UHV today #gpcr #drgpcr Published on January 15, 2025 Category Dr. GPCR Profiles What can an updated profile do for you? 🔎 Personalized content, better networking, and collaboration opportunities. Fill in the blanks—update now! ✳️Visit https://bit.ly/4fY4UHV today #gpcr #drgpcr Previous Next Recent Articles !

Home → Flash News → The registration deadline for the 1-day workshop “The Practical Assessment of Signaling Bias” is TOMORROW! ⏰ Save your spot in a class with the Master of Pharmacology Dr. Terry Kenakin, and get 25% off with your Premium Membership. An advanced lecture, hands-on exercises, one private call with the professor, and more! ✳️Click here https://www.ecosystem.drgpcr.com/event-details-registration/the-practical-assessment-of-signaling-bias #gpcr #drgpcr Published on February 17, 2025 Category Dr. GPCR Courses The registration deadline for the 1-day workshop “The Practical Assessment of Signaling Bias” is TOMORROW! ⏰ Save your spot in a class with the Master of Pharmacology Dr. Terry Kenakin, and get 25% off with your Premium Membership. An advanced lecture, hands-on exercises, one private call with the professor, and more! ✳️Click here https://www.ecosystem.drgpcr.com/event-details-registration/the-practical-assessment-of-signaling-bias #gpcr #drgpcr Previous Next Recent Articles

<< Back to podcast list Strategic Partner(s) Dr. Brian Bender About Dr. Brian Bender Dr. Bender completed his undergraduate studies at Colgate University in upstate New York with a degree in Biochemistry. Between undergraduate and graduate school Brian worked as a technician in an academic lab before moving to Nashville, TN for graduate work at Vanderbilt University where he joined the Department of Pharmacology. Brain’s work there primarily focused on structure prediction of GPCRs from sparse experimental data. He then moved to the University of California in San Francisco to continue his training as a postdoctoral researcher where he used structural models of GPCRs to virtually screen large compound libraries with the goal of finding new chemical matter to probe understudied and orphan receptors. Brian is involved in organizing the GRC/GRS Molecular Pharmacology meeting, which has been postponed to 2023. Brian is one of the organizers of the upcoming Transatlantic ECI GPCR Symposium . Dr. Brian Bender on the web LinkedIn Twitter ResearchGate Dr.GPCR Member Google Scholar Dr. GPCR Ecosystem Enjoying the Dr. GPCR Podcast? Leave a Review. Leave a quick review to help more scientists find the show—and help us keep improving every episode. It takes <60 seconds and makes a big difference. ★ Review on Apple Podcasts ★ Rate on Spotify ✉️ Send feedback to the team Recent Podcast Articles Asking Better Questions in Science: A Practical Guide for Emerging Researchers When the Islet Lit Up: Advancing GPCR Imaging in Native Tissue How Collaboration Sparked a GPCR Imaging Breakthrough in Chemical Biology Thanks for listening to this podcast episode Follow us on your favorite Podcast Player << Previous Podcast Episode Next Podcast Episode >>

<< Back to podcast list Strategic Partner(s) Dr. Stuart Maudsley About Dr. Stuart Maudsley Stuart graduated from the University of Leeds in the U.K. with a First Class Honors degree in Pharmacology. At the end of his studies, he was awarded the Pfizer Prize for undergraduate research. He then completed his Ph.D. at Leeds as well as the University’s Ackroyd, Brotherton, and Brown Scholar. Following his Ph.D., Dr. Maudsley was awarded a Howard Hughes Medical Institute Fellowship to train with Professor Robert Lefkowitz at Duke University. Following this tremendous experience, he was recruited to be the Principal Investigator of the Receptor Biology Section at the Medical Research Council (MRC) -Human Reproductive Sciences Unit within the University of Edinburgh. At the MRC he developed novel prostate cancer therapeutics based upon his research into GPCR pluridimensional signaling. To broaden his biomedical skill-set Stuart next accepted the position of Head of the Receptor Pharmacology Unit at the National Institutes of Health – National Institute on Aging at the Johns Hopkins University Medical Center. At the NIH he was the recipient of the coveted NIH ‘Bench-to-Bedside’ Translational Research Grant Award, one of the few awards available within the intramural NIH program. Upon starting a new family, and returning to Europe, Dr. Maudsley continued his scientific journey with the award of the highly-valued Odysseus Program Type I Program Grant to work as both the Adjunct Director of the VIB Center for Molecular Neurology and also Vice-Chair of the Department of Biomedical Sciences at the University of Antwerp. Stuart’s current research, in the Receptor Biology Lab, focuses on the development of novel GPCR-based therapeutics that interdict diseases based on their gerontological underpinnings. This research stream is now forming the basis of a new technology-based start-up company, HeptOME , to help screen and develop novel longevity/disease-regulating compounds with multidimensional disease efficacy profiles. Dr. Stuart Maudsley on the web Maudsley Lab LinkedIn Google Scholar ResearchGate Maudsley Lab on Facebook Receptor Biology Lab Facebook Group Twitter Semantic Scholar Instagram Neurotree Dimensions Reddit Dr. GPCR Ecosystem Enjoying the Dr. GPCR Podcast? Leave a Review. Leave a quick review to help more scientists find the show—and help us keep improving every episode. It takes <60 seconds and makes a big difference. ★ Review on Apple Podcasts ★ Rate on Spotify ✉️ Send feedback to the team Recent Podcast Articles Asking Better Questions in Science: A Practical Guide for Emerging Researchers When the Islet Lit Up: Advancing GPCR Imaging in Native Tissue How Collaboration Sparked a GPCR Imaging Breakthrough in Chemical Biology Thanks for listening to this podcast episode Follow us on your favorite Podcast Player << Previous Podcast Episode Next Podcast Episode >>

Home → Flash News → terrys corner model drug response Published on July 10, 2025 Category Terry's Corner What if a single experimental snapshot could predict an entire in vivo drug profile in a range of organs? In Terry’s Corner latest lesson, discover how pharmacologic models do just that. From historical linkage theory to dynamic probability models, the comparison of data to theory will be discussed. 🟢 Read the full breakdown: ✳️ https://www.ecosystem.drgpcr.com/post/what-if-you-could-predict-drug-behavior-with-just-a-snapshot #GPCR #DrGPCR #pharmacology #DrugDiscovery #TerryKenakin #FoundationalScience Previous Next Recent Articles

Home → Flash News → encoding and decoding selectivity and promiscuity in the human chemokine GPCR interaction network Published on July 7, 2025 Category GPCR Weekly News How do chemokines and GPCRs decode selectivity? A landmark Cell paper delivers the answer—mapping how conserved and variable sequence–structure elements govern interaction logic across 46 chemokines and 23 GPCRs. The result: a framework for designing ligands with altered receptor preferences. ♦️ Defines “public” vs. “private” binding determinants ♦️ Highlights role of structured + unstructured regions ♦️ Includes a web tool + viral chemokine engineering demo This is a must-read for GPCR modelers, immunopharmacologists, and ligand engineers. ➡️ Read the paper: https://www.cell.com/cell/fulltext/S0092-8674(25)00398-8 #DrGPCR #GPCR #Chemokines #StructuralBiology #Pharmacology #ProteinEngineering #Immunology #DrugDiscovery Previous Next Recent Articles

Full Agenda Adhesion GPCR workshop 2024 CINVESTAV, Mexico City, Mexico October 23-25 Download PDF Program HERE < Back to Full Agenda Leaving for City Center Coming Soon < Previous Session Next Session >

<< Back to podcast list Strategic Partner(s) Martin Audet About Dr. Martin Audet Structural biologist, pharmacologist, and a professor of pharmacology at Université de Sherbrooke. He is the head of the AudetLab located at the Institute of Pharmacology of Sherbrooke and is an emerging leader in the structural biology of G Protein-Coupled Receptors and passive transporters. Strong education with a Doctor of Philosophy (Ph.D.) in biochemistry under the supervision of Michel Bouvier at Université de Montréal, followed by a Postdoctoral Fellow at Scripps Research in San Diego and the University of Southern California in Los Angeles as a member of Raymond Stevens group. Dr. Martin Audet on the web LinkedIn Twitter Sherbrooke University Google Scholar Dr. GPCR Ecosystem Enjoying the Dr. GPCR Podcast? Leave a Review. Leave a quick review to help more scientists find the show—and help us keep improving every episode. It takes <60 seconds and makes a big difference. ★ Review on Apple Podcasts ★ Rate on Spotify ✉️ Send feedback to the team Recent Podcast Articles Asking Better Questions in Science: A Practical Guide for Emerging Researchers When the Islet Lit Up: Advancing GPCR Imaging in Native Tissue How Collaboration Sparked a GPCR Imaging Breakthrough in Chemical Biology Thanks for listening to this podcast episode Follow us on your favorite Podcast Player << Previous Podcast Episode Next Podcast Episode >>

Retreat 2023 About Program Registration Logo Contest Committee Sponsors GPCR Retreat Program < Back to schedule Registration Date & Time Thursday, November 2nd / 11:00 AM - 1:30 PM Previous Event Next Event Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires du Québec Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires du Québec 22nd GPCR Retreat Sponsored by

Full Agenda Adhesion GPCR workshop 2024 CINVESTAV, Mexico City, Mexico October 23-25 Download PDF Program HERE < Back to Full Agenda Dr. GPCR Community Presentation Breaking Barriers: My Journey from Mexico to the Heart of the Dr. GPCR Ecosystem and beyond About Monserrat Avila Zozaya "My doctoral research was focused on investigating the cellular effects of missense lung cancer-mutations in the G-protein-coupled receptor Autoproteolysis-Inducing (GAIN) domain of Latrophilin 3 receptor under the mentorship of Dr. Antony Boucard. I am currently a postdoctoral researcher fellow in Dr. Kathleen Caron's laboratory at UNC. My research focuses on understanding the molecular mechanisms of adhesion GPCRs (aGPCRs) in lymphatic endothelial cells (LECs), a cellular model with unique junction arrangements where aGPCRs are mainly unexplored. " Monserrat Avila Zozaya on the web LinkedIn Caron Lab Antony Boucard Lab Dr. GPCR < Previous Session Next Session >

Home → Flash News → Subscribe to the Dr. GPCR Newsletter 📰 and get the latest GPCR News delivered to your inbox Unlocking the activation process of PTH1R: New computational insights into its molecular interactions bring us closer to better osteoporosis treatments! ➡️https://www.ecosystem.drgpcr.com/receptor-activation-and-signaling/key-interaction-changes-determine-the-activation-process-of-human-parathyroid-hormone-type-1-receptor #gpcr #drgpcr Published on February 6, 2025 Category GPCR Weekly News Subscribe to the Dr. GPCR Newsletter 📰 and get the latest GPCR News delivered to your inbox Unlocking the activation process of PTH1R: New computational insights into its molecular interactions bring us closer to better osteoporosis treatments! ➡️ https:// www.ecosystem.drgpcr.com/receptor-activation-and-signaling/key-interaction-changes-determine-the-activation-process-of-human-parathyroid-hormone-type-1-receptor #gpcr #drgpcr Previous Next Recent Articles

Retreat 2023 About Program Registration Logo Contest Committee Sponsors GPCR Retreat Program < Back to schedule Illuminating Functional Selectivity and Allosterism at GPCRs. Date & Time Saturday, November 4th / 11:30 AM Abstract Coming Soon About Stéphane Laporte "Dr. Stéphane Laporte is a Professor of Medicine, and the Director of Research of the Division of Endocrinology and Metabolism at McGill University. He is also an Associate Leader of the Experimental Therapeutics and Metabolism Program and the Director of the Molecular Imaging Platform at the Research Institute of the McGill University Health Centre (RI-MUHC). He is a member of the Executive Committee of the Réseau québécois de recherche sur les médicaments. He has received many awards, including a Canada Research Chair, FRSQ scholarships and the CDA/CSEM/Merck Frosst Young Investigator award. His expertise is in molecular pharmacology and his research program focuses on the molecular and cellular mechanisms regulating G protein-coupled receptor (GPCR) responses, a class of receptors involved in many, if not all, physiological responses, with the ultimate goal of improving drug action. He has developed innovative methods for in-cellulo measurement of protein-protein interactions, receptor trafficking and signalling, useful for drug discovery programs. His research program also studies the allosteric, biased signalling regulation of GPCR and has contributed to the validation of small molecules that block myometrial contraction in pre-term birth. He has contributed to the generation of many intellectual property agreements and patents, and published his findings in high-impact journals. The Canadian Institutes for Health Research and March of Dimes currently support his research." Stéphane Laporte on the web Laporte Lab McGill University LinkedIn Dr. GPCR Previous Event Next Event Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires du Québec Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires du Québec 22nd GPCR Retreat Sponsored by