📰 GPCR Weekly News, March 20 to 26, 2023

Hello Readers👋,

We're excited to have you in the Dr. GPCR Ecosystem. Every week, we send you the most relevant news, research, and advancements in the field.

For Dr. GPCR News, subscribe to our monthly newsletter. This month on the Dr. GPCR News video edition, we chatted with Dr. Oliver Hartley.

Below is your Classified GPCR News at a glance for March 20th to 26th, 2023.

GPCR Activation and Signaling

• Targeting biased signaling by PAR1: Function and molecular mechanism of parmodulins.

• The Wnt pathway protein Dvl1 targets Somatostatin receptor 2 for lysosome-dependent degradation.

• Loss of biased signaling at a G protein-coupled receptor in overexpressed systems.

GPCR Binders, Drugs, and more

• A snake toxin as a theranostic agent for the type 2 vasopressin receptor

• Small-Molecule Fluorescent Ligands for the CXCR4 Chemokine Receptor.

GPCRs in Cardiology, Endocrinology, and Taste

• Green mamba peptide targets type-2 vasopressin receptor against polycystic kidney disease

GPCRs in Oncology and Immunology

• Purinergic GPCR-integrin interactions drive pancreatic cancer cell invasion.

• CCL5-producing migratory dendritic cells guide CCR5+ monocytes into the draining lymph nodes.

Methods & Updates in GPCR Research

• The application of targeted protein degradation technologies to G protein-coupled receptors.

Structural and Molecular Insights into GPCR Function

• Physiological changes in bilayer thickness induced by cholesterol control GPCR rhodopsin function.

• Evidence that RXFP4 is located in enterochromaffin cells and can regulate production and release of serotonin.

• Ultrafast structural changes direct the first molecular events of vision.

• New insights into GPCR coupling and dimerisation from cryo-EM structures.

Industry News

• Domain Therapeutics was one of the 4 Biotech Trophy nominees at 2023 HealthTech awards.

• The delisting dilemma: Why do so many biotechs face being kicked off the Nasdaq?.

• Exscientia Business and Financial Update for the Full Year 2022.

• Sosei Heptares Confirms Changes to its Board and Executive Management Team at Annual Shareholders’ Meeting.

• Function Therapeutics has been awarded a Phase 1 SBIR grant from NSF.

• Function Therapeutics has a new website.

Call for GPCR Papers

• GPCRs: Signal Transduction. Ends tomorrow - March 31st, 2023.

GPCR Events, Meetings, and Webinars

• FREE 5th ERNEST GPCR ECI zoominar. (March 30, 2023)

• NEW Webinar - Antiverse: Engineering the Future of Drug Discovery (March 30, 2023)

• NEW Molecular Dynamics in Pharma (March 31, 2023)

• NEW FREE Workshop - Challenges in GPCR Drug Discovery (March 31, 2023)

• SLAS 2023 Building Biology in 3D Symposium. (April 20 - 21, 2023)

• Swiss Biotech Day (April 24 - 25, 2023)

• SLAS Europe 2023 Conference and Exhibition. (May 22 - 26, 2023)

• 2nd LEAPS Meets Life Sciences Conference. (May 14 - 19, 2023)

• 8th and final ERNEST Meeting in Crete. (May 3 - 7, 2023).

• The Illuminating the Understudied Druggable Proteome Conference. (June 4 - 8, 2023).

• 2023 Molecular Pharmacology (GRS) Seminar GRC. (June 10 - 11, 2023).

• Progressive Technologies and Approaches Revealing Novel GPCR Biology and Drug Development Potential. (June 11 - 16, 2023).

• NEW FREE Symposium - IPI Surfacing (June 15, 2023)

• Training School on “Cell-based assays to study Adhesion GPCR function". (June 28 - 30, 2023)

• FREE 11th Adrenoceptor Symposium: Adrenoceptors and GPCR Signalling (June 30 - July 1, 2023)

• 19th World Congress of Basic & Clinical Pharmacology 2023. (July 2 - 7, 2023).

• 3rd Annual Meeting IRN I-GPCRNet (October 25 - 27, 2023)

GPCR Jobs

• NEW Team Lead protein production and profiling

• NEW Pharmacologist

• Postdoctoral positions at UC San Diego

• Medical Director

• CADD and Informatics Head or Team Lead (depending on experience) with Structural Bioinformatics Expertise

• Scientist

• Corporate Strategy Analyst

• PhD candidate or Postdoc.

• Director, Head of PMO.

• Associate Scientist, Protein Science.

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