Is Your Agonist Really “Working”—Or Are You Just Seeing What Your System Allows?

Imagine testing a molecule, seeing no response, and shelving it. But what if your system just wasn't sensitive enough to see what it was really doing?

In this eye-opening module, Terry Kenakin explores a concept that could change how you interpret pharmacological data: the interplay between intrinsic efficacy and system sensitivity. It’s not just about what your molecule does—it’s also about how capable your system is at showing it.

Through powerful analogies (think batteries and balance scales), Terry reveals why different tissues—and even different assays—can paint totally different pictures of the same compound. The result? Misinterpreted potency. Missed opportunities. And potential drug candidates left behind.

From oxymetazoline to oxotremorine, discover how drugs can show up as full agonists in one system and antagonists in another.

If you're an emerging drug hunter, this lesson is your bridge from data confusion to predictive clarity.

👉 Dive into Terry’s Vault and see agonism like never before

Unlock "Agonism & Sensitivity" now