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adenosine receptor signaling and regulation Novel medications for problematic alcohol use Structural and Molecular

In this study, we established an experimental Sjögren's syndrome (ESS) mouse model to elucidate the molecular

Career opportunities:  Principal Scientist - In Vitro Pharmacology; Senior Scientist, Molecular Pharmacology

strategies for the discovery and development of novel therapeutic agents ranging from biologics to small molecules

receptor dimer: Classification, future prospects, and pathophysiological perspectives Structural and Molecular

International Journal of Molecular Sciences, 20(15). Sugiura, R., Satoh, R., & Takasaki, T. (2021).

(June 4 - 8, 2023). 2023 Molecular Pharmacology (GRS) Seminar GRC. (June 10 - 11, 2023).

IMPORTANCE G protein-coupled receptors (GPCRs) act as cell surface molecular "switches" which regulate

Pascal Neuville; “Domain”) and Université de Montréal (Québec, Canada; “UdM”), to discover novel small molecules

Triple Labeling Resolves a GPCR Intermediate State by Using Three-Color Single Molecule FRET .  

all our French partners who trust us in the generation of their monoclonal antibodies against small molecules

Collaborative efforts aim to accelerate and improve the prediction of first-in-class small molecule agonists

GPCR Symposia Join us on June 7th for our symposium on Structural and Molecular Insights into GPCR Function

Molecules. 2023 Dec 15;28(24):8107.   Molecules. 2023 Dec 15;28(24):8107. doi: 10.3390/molecules28248107 Nørskov-Lauritsen L, Thomsen AR,

Most of them are small molecules capable of going through the BBB , and since their targets are on the Molecules. 2023 Dec 15;28(24):8107. doi: 10.3390/molecules28248107

continued study of their function and mechanism of action, there is a greater understanding of how effector molecules

Pharmacological chaperones are cell-permeant small molecules that engage nascent mutant GPCRs in the mutant follicle-stimulating hormone receptors (FSHRs) with poor cell surface expression using a small-molecule

GPCR dimers are very attractive molecular entities since they have been found to drive biased signalling

Adhesion GPCR with Multiple Roles in Human Diseases, Current Status and Future Perspective Structural and Molecular

former colleagues and their description of the company was very intriguing: a biology focused, small molecule

Good molecules can fail quietly at this stage —not because they’re weak, but because they’re too strong If you’re not designing with persistent enzyme interactions in mind, you’re building risk into your molecule

Therefore, the ascaroside signaling system provides a unique example of a signaling molecule that regulates C. elegans secretes a family of small-molecule pheromones called ascarosides, which serve various functions

class A GPCR-Gi complex structures is observed in CX3CR1, which may correlate with three cholesterol molecules

This 28-day trial will test the pharmacokinetics and safety profile of Inversago’s lead molecule, INV

Overall, our findings supported GPR108 as a promising therapeutic target of cancer, and provided a small molecule

PKA facilitates the actions of hormones, neurotransmitters and other signaling molecules that bind G-protein

, we provide a systematic analysis of the currently available GPCR structures in complex with small-molecule

Protein-Coupled Receptors (GPCRs) with a novel drug modality, proven discovery platform and best-in-class molecules

Keep pushing the boundaries, because your work moves molecules and medicine forward.   

structure-based technology has passed a key test, in enabling the discovery of orally available small molecules