📰 GPCR Weekly News, February 6 to 12, 2023

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We're excited to share our weekly newsletter with you. Keep up-to-date with the latest research and advancements in the field with our convenient, weekly news delivered to your inbox. You can always adjust your email preferences in your account settings. For Dr. GPCR News, please subscribe to our monthly newsletter.

Below is your Classified GPCR News at a glance for February 6th to 12th, 2023.

GPCR Activation and Signaling

• Ubiquitylation of BBSome is required for ciliary assembly and signaling.

• Isoform- and ligand-specific modulation of the adhesion GPCR ADGRL3/Latrophilin3 by a synthetic binder.

• Unravelling GPCR signalling networks using global phosphoproteomics.

GPCR Binders, Drugs, and more

• An antibody-drug conjugate targeting GPR56 demonstrates efficacy in preclinical models of colorectal cancer.

GPCRs in Neuroscience

• Heterotrimeric G proteins regulate planarian regeneration and behavior.

Methods & Updates in GPCR Research

• Engineered Human Antibody with Improved Endothelin Receptor Type A Binding Affinity, Developability, and Serum Persistence Exhibits Excellent Antitumor Potency.

• Development and Characterization of a Highly Selective Turn-On Fluorescent Ligand for β3-Adrenergic Receptor.

• Quantitative analysis of sterol-modulated monomer-dimer equilibrium of the β1-adrenergic receptor by DEER spectroscopy.

Industry News

• Biotech startup Structure pulls off rare IPO, raising $161M

• 3-drug combo leads to 'unprecedented' response in pancreatic cancer models

• Addex Therapeutics Ltd Strategic Partner Completes Enrollment in ADX71149 Epilepsy Phase 2 Study Part 1

• IPO Raises $161M for GPCR-Based Drug Developer Structure Therapeutics

• Crinetics Pharmaceuticals Announces Inducement Grants Under Nasdaq Listing Rule 5635(c)(4)

• arcoscreen is one of the 13 biotech companies to discover in western in 2023

Call for GPCR Papers

• GPCRs: Signal Transduction. Deadline extended to March 31st, 2023.

GPCR Events, Meetings, and Webinars

• 2nd GPCR-Targeted Drug Discovery Summit, (February 21 - 23, 2023), Boston.

• SLAS2023 International Conference and Exhibition (February 25 - March 1, 2023).

• 2nd ERNEST Training School. (February 20 - March 3, 2023).

• WEBINAR Using integrative biophysical approaches to understand GPCR regulation by β-arrestins. (March 2, 2023)

• GEM2023. (March 14-17, 2023).

• SLAS 2023 B

• Building Biology in 3D Symposium. (April 20 - 21, 2023)

• SLAS Europe 2023 Conference and Exhibition. (May 22 - 26, 2023)

• 2nd LEAPS Meets Life Sciences Conference. (May 14 - 19, 2023)

• 8th and final ERNEST Meeting in Crete. (May 3 - 7, 2023).

• The Illuminating the Understudied Druggable Proteome Conference. (June 4 - 8, 2023).

• 2023 Molecular Pharmacology (GRS) Seminar GRC. (June 10 - 11, 2023).

• Progressive Technologies and Approaches Revealing Novel GPCR Biology and Drug Development Potential. (June 11 - 16, 2023).

• 19th World Congress of Basic & Clinical Pharmacology 2023. (July 2 - 7, 2023).

GPCR Jobs

• Director, Business Development & Strategy

• CADD and Informatics Head or Team Lead (depending on experience) with Structural Bioinformatics Expertise

• Fully Funded Doctoral Training Programme Studentships 2023

• Computational drug design PhD student at the Department of Drug Design and Pharmacology

• Computational drug design postdoc at the Department of Drug Design and Pharmacology

• Software / database development PhD student at Department of Drug Design and Pharmacology

• Software / database development postdoc at the Department of Drug Design and Pharmacology

• Postdoc in Bioinformatics/Data Science at Department of Drug Design and Pharmacology

• Scientist/Senior Scientist (Research Software Engineer)

• Senior Scientist – Native Mass Spectrometry

• Speculative Applications (Protein Biochemistry)

• Speculative Applications (Mass Spectrometry)

• Speculative Applications (Chemistry)

• Post-Doctoral Research Assistant

• Research Fellow - School of Physics and Astronomy

• Postdoctoral Research Associate (Fixed Term)

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