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- Dr. Nicolas Gilles | Dr. GPCR Ecosystem
He is pioneering the investigation of animal toxins acting on GPCRs, the largest therapeutic target class GPCR Enjoying the Dr. GPCR Podcast? Leave a Review. Better Questions in Science: A Practical Guide for Emerging Researchers When the Islet Lit Up: Advancing GPCR Imaging in Native Tissue How Collaboration Sparked a GPCR Imaging Breakthrough in Chemical Biology Thanks
- Dr. Qing Fan | Dr. GPCR Ecosystem
Qing is a structural biologist interested in the molecular mechanisms controlling how class C GPCRs transmit GPCR Ecosystem Enjoying the Dr. GPCR Podcast? Leave a Review. Better Questions in Science: A Practical Guide for Emerging Researchers When the Islet Lit Up: Advancing GPCR Imaging in Native Tissue How Collaboration Sparked a GPCR Imaging Breakthrough in Chemical Biology Thanks
- Complimentary Lunch | Adhesion GPCR Workshop 2024 | Dr. GPCR Ecosystem
Full Agenda Adhesion GPCR workshop 2024 CINVESTAV, Mexico City, Mexico October 23-25 Download PDF Program
- Welcoming Remarks | Adhesion GPCR Workshop 2024 | Dr. GPCR Ecosystem
Full Agenda Adhesion GPCR workshop 2024 CINVESTAV, Mexico City, Mexico October 23-25 Download PDF Program
- Closing remarks | Adhesion GPCR Workshop 2024 | Dr. GPCR Ecosystem
Full Agenda Adhesion GPCR workshop 2024 CINVESTAV, Mexico City, Mexico October 23-25 Download PDF Program
- Dr. Randy Hall | Dr. GPCR Ecosystem
lab has published numerous groundbreaking findings shedding light on the signaling and regulation of GPCRs Randy’s lab has a special interest in studying disease-associated mutations to human GPCRs that perturb Join me to learn more about Randy’s work, hear his insights on the GPCR field, and also hear the story GPCR Ecosystem Enjoying the Dr. GPCR Podcast? Leave a Review. Imaging in Native Tissue How Collaboration Sparked a GPCR Imaging Breakthrough in Chemical Biology Thanks
- Dr. Graham Ladds | Dr. GPCR Ecosystem
This project enabled him to return to his interest in GPCRs. pharmacological investigations and mathematical modeling to study factors that control agonist bias at GPCRs GPCR Ecosystem Enjoying the Dr. GPCR Podcast? Leave a Review. Better Questions in Science: A Practical Guide for Emerging Researchers When the Islet Lit Up: Advancing GPCR Imaging in Native Tissue How Collaboration Sparked a GPCR Imaging Breakthrough in Chemical Biology Thanks
- Dr. Debbie Hay | Dr. GPCR Ecosystem
Her work is primarily focused on class B GPCRs and their interactions with RAMPs. GPCR Ecosystem Enjoying the Dr. GPCR Podcast? Leave a Review. Better Questions in Science: A Practical Guide for Emerging Researchers When the Islet Lit Up: Advancing GPCR Imaging in Native Tissue How Collaboration Sparked a GPCR Imaging Breakthrough in Chemical Biology Thanks
- Ben Clements reveals a 10x improvement in efficacy using GPCR-targeted PAMs, in Ep.166 of the Dr.GPCR Podcast,. The catch? It’s all about understanding the system, not replacing it. From neuromas to novel modulators, this episode is full of breakthroughs that matter for patients. 📲 Watch now: Ep 166 with Dr. Ben Clements #GPCRresearch #DrGPCR #GPCRpodcast #OpioidPharmacology #DrugDiscovery | Dr. GPCR Ecosystem
Home → Flash News → Ben Clements reveals a 10x improvement in efficacy using GPCR-targeted PAMs, in Ep GPCR Podcast Ben Clements reveals a 10x improvement in efficacy using GPCR-targeted PAMs, in Ep.166 of Operating cadence Attila Foris Dec 24, 2025 GPCR Binding Affinity Experiments: Interpreting Data With And that’s exactly what carries strong discovery programs into 2026. Dr. Yet discovery teams routinely lose time and misallocate resources because the underlying biology behaves
- Forget one receptor at a time. Go big.Ep.167 of the Dr.GPCR Podcast with Tom Sakmar & Ilana Kotliar is about scaling GPCR research with multiplexing, miniaturization, and collaboration. The tools are built. The data is free. What will you ask next? 📲 Dive in: Ep 167 with Drs. Tom Sakmar & Ilana Kotliar #GPCRtraining #GPCRresearchcommunity #DrGPCR #GPCRdata | Dr. GPCR Ecosystem
Go big.Ep.167 of the Dr.GPCR Podcast with Tom Sakmar & Ilana Kotliar is about scaling GPCR research with GPCR Podcast Forget one receptor at a time. Go big.Ep.167 of the Dr.GPCR Podcast with Tom Sakmar & Ilana Kotliar is about scaling GPCR research with And that’s exactly what carries strong discovery programs into 2026. Dr. Yet discovery teams routinely lose time and misallocate resources because the underlying biology behaves
- State of the Art Talk | Adhesion GPCR Workshop 2024 | Dr. GPCR Ecosystem
Full Agenda Adhesion GPCR workshop 2024 CINVESTAV, Mexico City, Mexico October 23-25 Download PDF Program HERE < Back to Full Agenda State of the Art Talk Adhesion GPCR in Mechanobiology Abstract Only Available
- Biochemical Mechanisms Underlying Location Bias in GPCR Signaling
Retreat 2023 About Program Registration Logo Contest Committee Sponsors GPCR Retreat Program < Back to schedule Biochemical Mechanisms Underlying Location Bias in GPCR Signaling Date & Time Saturday, November His lab is also interested in identifying novel signal transduction mechanisms of GPCRs, such as the GPCR Previous Event Next Event Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires 22nd GPCR Retreat Sponsored by
- GPCR activation is well-known to be a multi-step process. However, current molecular structures only capture the fully activated complex. Check out this paper to see how scientists combine different techniques to elucidate the intermediate GPCR-mini-Gαsβγ complex at 2.6 Å. Did you know that we work hard to bring you the most recent GPCR News, weekly? Catch up today in the Ecosystem using your free site membership! ➡️https://www.ecosystem.drgpcr.com/structural-and-molecular-insights-into-gpcr-function/structure-and-function-of-a-near-fully-activated-intermediate-gpcr-g%CE%B1%CE%B2%CE%B3-complex #gpcr #drgpcr | Dr. GPCR Ecosystem
Home → Flash News → GPCR activation is well-known to be a multi-step process. ➡️https://www.ecosystem.drgpcr.com/structural-and-molecular-insights-into-gpcr-function/structure-and-function-of-a-near-fully-activated-intermediate-gpcr-g %CE%B1%CE%B2%CE%B3-complex #gpcr #drgpcr Published on February 11, 2025 Category GPCR Weekly News GPCR ➡️ https:// www.ecosystem.drgpcr.com/structural-and-molecular-insights-into-gpcr-function/structure-and-function-of-a-near-fully-activated-intermediate-gpcr-g %CE%B1%CE%B2%CE%B3-complex #gpcr #drgpcr Previous Next Recent Articles
- How do GPCRs sense pH changes? New cryo-EM structures of GPR4 and GPR68 reveal how extracellular histidines act as proton sensors-trigger activation and biased G protein coupling! Did you know that we work hard to bring you the most recent GPCR News, weekly? Catch up today in the Ecosystem using your free site membership! ➡️https://www.ecosystem.drgpcr.com/structural-and-molecular-insights-into-gpcr-function/structural-basis-and-biased-signaling-of-proton-sensation-by-gpcrs-mediated-by-extracellular-histidine-rearrangement #gpcr#drgpcr | Dr. GPCR Ecosystem
Home → Flash News → How do GPCRs sense pH changes? Did you know that we work hard to bring you the most recent GPCR News, weekly? #gpcr#drgpcr Published on May 26, 2025 Category GPCR Weekly News How do GPCRs sense pH changes? Did you know that we work hard to bring you the most recent GPCR News, weekly? #gpcr#drgpcr Previous Next Recent Articles
- Dr. Neil Grimsey | Dr. GPCR Ecosystem
Neil Grimsey " During my postdoctoral studies at USCD, I discovered a novel GPCR-dependent atypical kinase GPCR Enjoying the Dr. GPCR Podcast? Leave a Review. Better Questions in Science: A Practical Guide for Emerging Researchers When the Islet Lit Up: Advancing GPCR Imaging in Native Tissue How Collaboration Sparked a GPCR Imaging Breakthrough in Chemical Biology Thanks
- Dr. John Streicher | Dr. GPCR Ecosystem
His encounter and interest in signaling in the context of GPCRs during his postdoctoral training in Dr GPCR Ecosystem Enjoying the Dr. GPCR Podcast? Leave a Review. Better Questions in Science: A Practical Guide for Emerging Researchers When the Islet Lit Up: Advancing GPCR Imaging in Native Tissue How Collaboration Sparked a GPCR Imaging Breakthrough in Chemical Biology Thanks
- Dr. Graciela Pineyro | Dr. GPCR Ecosystem
Graciela Pineyro’s love for GPCR pharmacology started in Uruguay where she first worked on the serotonin GPCR Ecosystem Enjoying the Dr. GPCR Podcast? Leave a Review. Better Questions in Science: A Practical Guide for Emerging Researchers When the Islet Lit Up: Advancing GPCR Imaging in Native Tissue How Collaboration Sparked a GPCR Imaging Breakthrough in Chemical Biology Thanks
- Dr. Kaavya Krishna Kumar | Dr. GPCR Ecosystem
I work on understanding the activation mechanism of different Families of GPCRs." Dr. GPCR Enjoying the Dr. GPCR Podcast? Leave a Review. Better Questions in Science: A Practical Guide for Emerging Researchers When the Islet Lit Up: Advancing GPCR Imaging in Native Tissue How Collaboration Sparked a GPCR Imaging Breakthrough in Chemical Biology Thanks
- How do GRK-specific phosphorylation barcodes influence β-arrestin binding to GPCRs? New cryo-EM structures from Chen et al. (Nature, 2025) reveal that β-arrestin1 and β-arrestin2 form distinct complexes with ACKR3 depending on whether it's phosphorylated by GRK2 or GRK5, shaping arrestin conformation, complex stability, and engagement mode. Surprisingly, arrestin’s finger loop didn’t dive into the receptor core. Instead, it latched onto the micelle surface, breaking canonical expectations. Also, β-arrestin2 lacks a membrane anchor, making it more dynamic — a potential clue to its functional specialization. These findings underscore how barcode location + arrestin isoform = unique signaling outcomes. open book Read the full study: Inside Out: Mapping GPCRs from Membrane Codes to Market Moves #GPCRs #Arrestin #ACKR3 #GRKs #CryoEM #StructuralBiology #SignalingBias #Phosphorylation #DrGPCR | Dr. GPCR Ecosystem
Home → Flash News → How do GRK-specific phosphorylation barcodes influence β-arrestin binding to GPCRs barcodes influence β-arrestin binding to GPCRs? Read the full study: Inside Out: Mapping GPCRs from Membrane Codes to Market Moves #GPCRs #Arrestin # And that’s exactly what carries strong discovery programs into 2026. Dr. Yet discovery teams routinely lose time and misallocate resources because the underlying biology behaves
- Pharmacological and Genetic Preclinical Models of Ghrelin Receptor Functional Selectivity to Investigate Metabolic Disease Pathophysiology
Retreat 2023 About Program Registration Logo Contest Committee Sponsors GPCR Retreat Program < Back to About Joshua Gross "I am a neuropharmacologist interested in exploiting GPCR biased signaling to design With my expertise in reward behavior, neurophysiology, GPCR signaling, and preclinical drug development GPCR Previous Event Next Event Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires 22nd GPCR Retreat Sponsored by
- Dr. Simone Prömel & Dr. Ines Liebscher | Dr. GPCR Ecosystem
of the Adhesion GPCR Latrophilin-1. There she focused on the different modes of action of Adhesion GPCRs and found that they do not only GPCR Ecosystem About Dr. Ines Liebscher Dr. Her postdoctoral work leads her to investigate a whole family of orphan receptors: adhesion GPCRs. GPCR Ecosystem Enjoying the Dr. GPCR Podcast? Leave a Review.
- Dr. Arun Shukla | Dr. GPCR Ecosystem
Arun first started working on GPCRs and their structural characterization at the Max Planck Institute Fascinated by GPCRs he wrote to Dr. GPCR Ecosystem Enjoying the Dr. GPCR Podcast? Leave a Review. Better Questions in Science: A Practical Guide for Emerging Researchers When the Islet Lit Up: Advancing GPCR Imaging in Native Tissue How Collaboration Sparked a GPCR Imaging Breakthrough in Chemical Biology Thanks
- Dr. Kevin Pfleger | Dr. GPCR Ecosystem
I sat down with Kevin to chat about GPCRs, pharmacology, and his contributions to the field in both the binding and function at the molecular and cellular levels over the last 20 years, particularly involving GPCRs GPCR Ecosystem Enjoying the Dr. GPCR Podcast? Leave a Review. Better Questions in Science: A Practical Guide for Emerging Researchers When the Islet Lit Up: Advancing GPCR Imaging in Native Tissue How Collaboration Sparked a GPCR Imaging Breakthrough in Chemical Biology Thanks
- Legal Policies and Disclaimers | Dr. GPCR Ecosystem
GPCR Ecosystem, ensuring transparency and protecting your rights. GPCR, Corp (“Dr. GPCR” or "DrGPCR") provides its Service (as defined below) to you through our websites referred to as GPCR, Ecosystem.DrGPCR.com , DrGPCR.com . GPCR reserves the right to modify these Legal Policies and Disclaimers from time to time without prior
- G Proteins and GPCRs in Cancer: Novel Precision Targeted and Immunotherapies
Retreat 2023 About Program Registration Logo Contest Committee Sponsors GPCR Retreat Program < Back to schedule G Proteins and GPCRs in Cancer: Novel Precision Targeted and Immunotherapies Date & Time Friday His research team has pioneered the study of G proteins and G protein coupled receptors (GPCRs) in human GPCR Previous Event Next Event Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires 22nd GPCR Retreat Sponsored by
- Did you know? 🌟 Researchers have developed reversibly photoswitchable allosteric modulators for Class A GPCRs! 🧬💡 These innovative compounds, “Photo-BQCisA” and “Photo-BQCtrAns,” offer subtype-selective precision by combining allosteric modulation with light control, paving the way for new therapeutic strategies targeting muscarinic receptors (M1-M5). 🔬✨ Learn more about this breakthrough in the Ecosystem! | Dr. GPCR Ecosystem
🌟 Researchers have developed reversibly photoswitchable allosteric modulators for Class A GPCRs! Published on December 3, 2024 Category GPCR Weekly News Did you know? 🌟 Researchers have developed reversibly photoswitchable allosteric modulators for Class A GPCRs! And that’s exactly what carries strong discovery programs into 2026. Dr. Yet discovery teams routinely lose time and misallocate resources because the underlying biology behaves
- Dr. Ilana Kotliar | Dr. GPCR Ecosystem
Ilana uses chemical biology-based methods to study the regulation and protein-protein interactions of GPCRs GPCR Enjoying the Dr. GPCR Podcast? Leave a Review. Better Questions in Science: A Practical Guide for Emerging Researchers When the Islet Lit Up: Advancing GPCR Imaging in Native Tissue How Collaboration Sparked a GPCR Imaging Breakthrough in Chemical Biology Thanks
- Dr. Jennifer Pluznick | Dr. GPCR Ecosystem
Her research is focused on the role of chemosensory GPCRs in regulating renal and cardiovascular function GPCR Ecosystem Enjoying the Dr. GPCR Podcast? Leave a Review. Better Questions in Science: A Practical Guide for Emerging Researchers When the Islet Lit Up: Advancing GPCR Imaging in Native Tissue How Collaboration Sparked a GPCR Imaging Breakthrough in Chemical Biology Thanks
- Targeting adenosine signaling for immuno-oncology
Retreat 2023 About Program Registration Logo Contest Committee Sponsors GPCR Retreat Program < Back to Dr Stagg has served as an expert consultant in the development of adenosine-targeting drugs, several GPCR Previous Event Next Event Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires du Québec Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires du Québec 22nd GPCR Retreat Sponsored by
- Chloe Hicks | Dr. GPCR Ecosystem
GPCR Enjoying the Dr. GPCR Podcast? Leave a Review. Better Questions in Science: A Practical Guide for Emerging Researchers When the Islet Lit Up: Advancing GPCR Imaging in Native Tissue How Collaboration Sparked a GPCR Imaging Breakthrough in Chemical Biology Thanks




















