Search Results

Here, we report the structure-based development of fluorescent ligands targeting the intracellular allosteric

and ChemoCentryx, Inc., (NASDAQ: CCXI), a biopharmaceutical company focused on orally administered therapeutics

his interview, Regulators of G protein Signaling (RGS proteins)  might hold some of the most untapped therapeutic

Selective screening assays for ectopic ORs as well as investment on the structural characterization of function of ORs in vivo, development of in vitro systems for functional assays and the availability of structural information for structure-based drug design.

Novo Nordisk is strengthening its position in the obesity space through a collaboration with EraCal Therapeutics

In this review, we discuss the relationship between structure, function, and dynamics of opioid receptors

Employing homology modeling, we describe the putative structural molecular basis underlying our functional

The authors provide a hierarchical structure into the studies of the pathogenesis of SSc starting with

Pina Cardarelli, CSO of GPCR Therapeutics.

It’s about revealing therapeutic liabilities before  they derail development. constitutive activity play in uncovering inverse agonists , and how can you exploit this phenomenon for novel therapeutic

the role of the muscarinic M1 receptor in cognitive and neurodegenerative disorders and the potential therapeutic

Structural and energetic analyses indicated that the palmitoylation of Go can allosterically stabilize

prediction of first-in-class small molecule agonists for a challenging orphan GPCR for a highly relevant therapeutic

Juan Jose Fung, Principal Scientist, at GPCR Therapeutics.

actions and suggest that these discoveries can facilitate new insights into their hallucinogenic and therapeutic

toward exploring the relationship between the actual psychedelic effects and those manifestations of therapeutic

present and demonstrate the newest resources of the GPCRdb: 1) the new G protein resources and 2) the structural

hydrophobic groups of different sizes on both sides of the five-membered ring scaffold guided by the crystal structure

We envision that our results could have potential implications in structural biological advancements

PVT NPSR1 neurons recruit the nucleus accumbens shell and structures in the prefrontal cortex and amygdala

This study examined the therapeutic effect of Ang-(1-7) on secondary injury observed in a murine model

– CXCR4 oligomer disruption boosts therapeutic response in lymphoid neoplasms Dr.

In summary, targeting GPCR-activated ERK pathways represents a promising strategy for developing new therapeutics ERK-dependent apoptosis as a potential therapeutic strategy for cancer. Cells, 10(10), 2509.

of membrane proteins in eukaryotes and the largest drug target family to date, exhibit diversity in structure

procerum Editorial: Advanced biophysical and biochemical technologies to study GPCR signal transduction Structural Clinical Pharmacology 2026 GPCR Jobs NEW Post-Doc position NEW Lead Researcher Senior Researcher in Structural

2-adrenergic receptor in oral squamous cell carcinoma: an emerging prognostic indicator and future therapeutic

animals and opens the way to remotely controlling dopaminergic neurotransmission for fundamental and therapeutic

Open source programming packages for cheminformatics and structural bioinformatics are powerful tools

These can be used either as stand-alone therapeutics or to improve the safety profile of opioid drugs

GHSR1a The growth hormone secretagogue receptor 1a (GHSR1a) is intriguing because of its potential as a therapeutic Initial studies of the receptor focused on the potential therapeutic ability for growth hormone (GH)