Search Results
Results found for "GPCR data platform"
- N-terminal alterations turn the gut hormone GLP-2 into an antagonist with gradual loss of GLP-2 ...
Read more at the source #DrGPCR #GPCR #IndustryNews
- 📰 Breaking Down the Latest GPCR Discoveries: a Weekly Update (Nov 27-Dec 3, 2023)
Discover our comprehensive coverage of GPCRs, We welcome GPCR paper suggestions! GPCR Podcast featuring Dr. Neil Grimsey and Dr. Katarzyna Marcinkiewicz. in Neuroscience Targeting sensory neuron GPCRs for peripheral neuropathic pain GPCRs in Oncology and Insights into GPCR Function Fully activated structure of the sterol-bound Smoothened GPCR-Gi protein GPCR Ecosystem
- Orthosteric vs Allosteric Interactions— and the pHSense Shift in Internalization
GPCR members save 50%+ (check your Weekly News code). 👉 Explore Trailers & Join Today Inside Revvity's R&D: How pHSense Was Born The day your data surprises They translated a fundamental principle of chemistry into a usable platform for pharmacology—showing Cleaner data: higher signal-to-noise ratios sharpen CNS assays. The pace of GPCR innovation is accelerating.
- Structure-Based Discovery of Negative Allosteric Modulators of the Metabotropic Glutamate Receptor 5
October 2022 "Recently determined structures of class C G protein-coupled receptors (GPCRs) revealed treatment of psychiatric and neurodegenerative diseases, and several allosteric modulators of this GPCR libraries have complementary advantages and illustrate how access to high-resolution structures of GPCRs Read more at the source #DrGPCR #GPCR #IndustryNews
- GPCR News Flash! Top Updates You Can't-Miss! + University CheatSheet is finally available! ❄ Dec 2 - 8, 2024
Hello, hello GPCR Buddies! It's starting to look a lot like Christmas at Dr. GPCR! Don't get left in the dust—upgrade now and keep your GPCR gossip game strong! Classified GPCR News Let’s dive into the Classified GPCR News from December 2nd to 8th, 2024 Industry Phase 3 Clinical Trial of Daridorexant in South Korea Septerna Touches New High, To Report SEP-786 Data function GPCR Activation and Signaling P2X7R-primed keratinocytes are susceptible to apoptosis via GPCR-Gβγ-pERK
- Molecular insights into psychedelic drug action
Read more at the source #DrGPCR #GPCR #IndustryNews
- Endosomal parathyroid hormone receptor signaling
October 2022 "The canonical model for G protein-coupled receptors (GPCRs) activation assumes that stimulation In this model, GPCR signaling is turned-off by receptor phosphorylation via GPCR kinases (GRKs) and subsequent However, over the last decade, this model has been extended by discovering that some internalized GPCRs Accumulative evidence shows that the location of signaling has an impact on the physiological effects of GPCR Read more at the source #DrGPCR #GPCR #IndustryNews
- AlphaFold2 versus experimental structures: evaluation on G protein-coupled receptors
August 2022 "As important drug targets, G protein-coupled receptors (GPCRs) play pivotal roles in a wide Extensive efforts of structural biology have been made on the study of GPCRs. However, a large portion of GPCR structures remain unsolved due to structural instability. Herein we evaluated the accuracy of GPCR structure models predicted by AlphaFold2. Read more at the source #DrGPCR #GPCR #IndustryNews
- The microglial endocannabinoid system similarly regulated by lipopolysaccharide and interferon gamma
Read more at the source #DrGPCR #GPCR #IndustryNews
- Anosmin 1 N-terminal domains modulate prokineticin receptor 2 activation by prokineticin 2
Prokineticins (PKs) exert their biological functions through the activation of the G protein-coupled receptors (GPCRs The whey acidic protein domain (WAP) is necessary for this modulatory activity, although data from GST Our data support the idea of a modulatory role of anosmin 1 in the biological effects controlled by the Read more at the source #DrGPCR #GPCR #IndustryNews
- Endogenous ligand recognition and structural transition of a human PTH receptor
light on the distinct durations of signaling induced by PTH and PTHrP" Read more at the source #DrGPCR #GPCR
- Novel Driver Strength Index highlights important cancer genes in TCGA PanCanAtlas patients
Read more at the source #DrGPCR #GPCR #IndustryNews
- Lysine 101 in the CRAC Motif in Transmembrane Helix 2 Confers Cholesterol-Induced Thermal...
Confers Cholesterol-Induced Thermal Stability to the Serotonin 1A Receptor "G protein-coupled receptors (GPCRs The serotonin1A receptor is a crucial neurotransmitter receptor in the GPCR family involved in a multitude envision that our results could have potential implications in structural biological advancements of GPCRs Read more at the source #DrGPCR #GPCR #IndustryNews
- Structural basis for receptor selectivity and inverse agonism in S1P5 receptors
Accelerator Laboratory X-Ray Free Electron Laser (PAL-XFEL) and analyze its structure-activity relationship data Read more at the source #DrGPCR #GPCR #IndustryNews
- A NanoBRET-Based H 3 R Conformational Biosensor to Study Real-Time H 3 Receptor Pharmacology in...
Read more at the source #DrGPCR #GPCR #IndustryNews
- Differential binding of Δ9-tetrahydrocannabinol derivatives to type 1 cannabinoid receptors (CB1)
Introduction Cannabinoid receptors are GPCRs, and two main types exist, CB1R and CB2R. The data obtained is comparable to those reported in radioligand binding assays (Table 1). Radioligand binding data are from [2,3]. for CB1R in live cells and the PHERAstar FSX is the ideal microplate reader for characterizing the GPCR-ligand
- GB83, an Agonist of PAR2 with a Unique Mechanism of Action Distinct from Trypsin and PAR2-AP
October 2022 "Protease-activated receptor 2 (PAR2) is a G-protein-coupled receptor (GPCR) activated by Read more at the source #DrGPCR #GPCR #IndustryNews
- Coincident Regulation of PLCβ Signaling by Gq-Coupled and μOpioid Receptors Opposes Opioid- Mediated
Finally, inhibition of Gq-GPCR coupling in mice enhanced the antinociceptive effects of morphine. These data support a model where Gq and Gβγ-dependent signaling cooperatively regulate PLC activation that would allow for lower dose utilization of opioid analgesics. " Read more at the source #DrGPCR #GPCR
- A2B Adenosine Receptor Enhances Chemoresistance of Glioblastoma Stem-Like Cells under Hypoxia: New..
Transcript and protein levels were determined by RT-qPCR and Western blot, respectively. These data suggest that hypoxia-dependent activation of A2B adenosine receptor promotes survival of GSCs Read more at the source #DrGPCR #GPCR #IndustryNews
- Radioligands vs. Fluorescent Ligands: Binding Assays
Radioligands have been used to study GPCRs for decades, but with the advances in the fluorescence field This can be done with agonists, antagonists, reverse agonists in the case of GPCRs. Figure 1. If you are curious about fluorescent probes, fluorescent probe design or GPCR tools, feel free to contact GPCR-radioligand binding assays. Fluorescent ligands: Bringing light to emerging GPCR paradigms.
- GBCRdb for beginners
Register today: https://www.ecosystem.drgpcr.com/dr-gpcr-virtual-cafe/ #gpcr #drgpcr #virtualcafe
- Intermolecular Interactions in G Protein-Coupled Receptor Allosteric Sites at the Membrane Interface
Calculations "Allosteric modulators are called promising candidates in G protein-coupled receptor (GPCR Among the allosteric sites known to date, cavities at the receptor-lipid interface represent an uncharacteristic Read more at the source #DrGPCR #GPCR #IndustryNews
- GRK3 is a poor prognosticator and serves as a therapeutic target in advanced gastric adenocarcinoma
September 2022 "Background G protein-coupled receptor (GPCR) is the most targeted protein family by the GPCR-kinase 3 (GRK3) is critical for GPCR signaling. Read more at the source #DrGPCR #GPCR #IndustryNews
- Successful prednisolone or calcimimetic treatment of acquired hypocalciuric hypercalcemia caused...
hypercalcemia caused by biased allosteric CaSR autoantibodies "Biased agonism is a frontier field in GPCR hypercalcemia (AHH) is a rare disease caused by calcium-sensing receptor (CaSR) autoantibodies, to date insights into the phenotype and characteristics of AHH and the mechanisms by which the biased agonism of GPCRs Read more at the source #DrGPCR #GPCR #IndustryNews
- PAR-Induced Harnessing of EZH2 to β-Catenin: Implications for Colorectal Cancer
September 2022 "G-protein-coupled receptors (GPCRs) are involved in a wide array of physiological and In addition, the molecular mechanisms underlying GPCR-induced post-translational signaling regulation Read more at the source #DrGPCR #GPCR #IndustryNews
- Targeting CXCR1 and CXCR2 receptors in cardiovascular diseases
Read more at the source #DrGPCR #GPCR #IndustryNews
- Luciferase-based GloSensor™ cAMP assay: Temperature optimization and application to cell-based kinet
Temperature optimization and application to cell-based kinetic studies "G protein-coupled receptors (GPCRs The second messenger cyclic adenosine monophosphate (cAMP) is a key mediator in many GPCR signaling pathways In this regard, luminescence-based biosensors have revolutionized our ability to monitor GPCR signaling The GloSensor™ cAMP assay enables real-time monitoring of signaling downstream of many GPCRs. for drug discovery" Read more at the source #DrGPCR #GPCR #IndustryNews
- A broad look into the future of systemic sclerosis
Read more at the source #DrGPCR #GPCR #IndustryNews
- Join Us Today!
GPCR Ecosystem is under construction and dozens of your colleagues are enjoying its benefits! Catch up with the latest #GPCR news, start a discussion in the forum, and much more today! Join the #GPCR movement by becoming a site member for FREE! ➡️ https://www.ecosystem.drgpcr.com/ #gpcr #drgpcr
- In vitro assays for the functional characterization of (psychedelic) substances at the serotonin...
Read more at the source #DrGPCR #GPCR #IndustryNews 5-HT2AR, GPCR, hallucinogens, in vitro assay, psychedelics
