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Results found for "Montana Molecular"
- Phenylalanine 193 in Extracellular Loop 2 of the β 2-Adrenergic Receptor Coordinates β-Arrestin ...
Despite decades of research on the signaling consequences of molecule-receptor interactions, conformational
- How to Design GPCR Drugs That Work in Vivo: Strategy, Tools, and Insights
This week’s Terry’s Corner exposes the unseen physiological “opponents” your molecule faces—and how
- Integrating Fluorescent Ligands into Flow Cytometry: Enhancing GPCR Analysis Beyond Traditional Antibody Staining
Fluorescent ligands based on small molecules bind to the functional sites of receptors in live cells,
- Your GPCR Program Decisions Depend on Good Data Interpretation
Ingo Hartung : State-of-the-art design of small molecule drugs, including PROTACs Dr.
- Class B1 GPCR Dimerization: Unveiling Its Role in Receptor Function and Signaling
peptide-1 receptor dimerization differentially regulates agonist signaling but does not affect small molecule
- Decoding Schild Analysis: The Pharmacologist’s Lens on Competitive Antagonism
When these same molecules act as antagonists, their curves shift not only in position but also in shape
- Orthosteric vs. Allosteric Interactions: The Silent Decider of Safety and Success
This means you can design molecules that potentiate beneficial pathways without shutting down basal signaling
- Mechanism vs. Assumption: A Model-First Path to Getting GPCR MoA Right
Breakthroughs this week: 5-MeO-DMT: the "God Molecule"; Novo Nordisk looks to next generation of obesity
- Illuminating GPCR Research: FRET and BRET-Based Sensors Shed Light on Cellular Signaling
operate on the principle of energy transfer between a fluorescent or luminescent donor and acceptor molecules
- Exendin-4 Attenuates Remodeling in the Remote Myocardium of Rats After an Acute Myocardial ...
Administration of Exendin-4 to MI rats reduced the infarct size and reversed the aforementioned signaling molecules
- Regulators of G-protein signaling: essential players in GPCR signaling
proteins has been implicated in a range of diseases, and understanding the mechanisms of these complex molecules
- Odorant receptors – a bit of smell for drug discovery
highly expressed by olfactory sensory neurons of the nose where they are activated by different odorant molecules
- Fluorescence based HTS compatible ligand binding assays for dopamine D3 receptors in baculovirus preparations and live cells
superresolution microscopy methods such as photoactivated localization microscopy (PALM) or other single-molecule
