protein-coupled receptors (GPCRs) regulate motivated behavior and how these receptors can be targeted for therapeutic distinct signaling pathways with their physiological effects and may serve as the basis for more selective therapeutics

the most clinically validated targets in metabolic disease - yet the signaling logic separating the therapeutic pharmacologists have not yet addressed actually shape signaling output at one of the field's most important therapeutic receptor Transducer coupling as the missing mechanistic layer in GLP-1 receptor pharmacology The expanding therapeutic modulate the functional output at this receptor, and whether that regulatory layer contributes to the therapeutic

Keyvan Sedaghat discussing how GPCR function is shaped by lipid raft compartmentalization, the expanding therapeutic efficacy and diagnostic innovation What the functional diversity of bitter taste receptors means for novel therapeutic

His work carries direct translational relevance to diabetes and obesity therapeutics. opportunities for scientists and biotech leaders working across pharmacology, translational research, and therapeutic

thermostabilization strategy finally made GPCR structures routine, the insight that seeded Heptares Therapeutics She co-founded Heptares Therapeutics and served as Chief Scientific Officer for twelve years, through As a co-founder of Heptares Therapeutics , now called Sosei Heptares , a GPCR-focused drug discovery

development, with 25+ years of expertise and validated cell-based assays spanning basic research through therapeutic opportunities for scientists and biotech leaders working across pharmacology, translational research, and therapeutic

Michael Feigin is an Associate Professor in the Department of Pharmacology and Therapeutics, and Director of Graduate Studies of Experimental Therapeutics at Roswell Park Comprehensive Cancer Center in Buffalo disrupting histone processing on rapidly proliferating cells, such as cancer cells, and suggested a therapeutic

development, with 25+ years of expertise and validated cell-based assays spanning basic research through therapeutic opportunities for scientists and biotech leaders working across pharmacology, translational research, and therapeutic

protein-coupled receptors (GPCRs) regulate motivated behavior and how these receptors can be targeted for therapeutic distinct signaling pathways with their physiological effects and may serve as the basis for more selective therapeutics

Each session explores mechanistic models, translational challenges, and real-world therapeutic implications

molecular explanation of small molecules for their pre-clinical efficacy and to support the design of novel therapeutics

Saraf " My research focuses on evaluating and targeting serotonin 1A receptors for therapeutic outcomes

Yamina will schedule a future talk with Jacek about GPCRs as therapeutic modalities. The discussion revealed their interest in GPCRs as therapeutic modalities and possible future collaborations

biosensors, cryo-EM, photoswitchable ligands, and nanobodies as pharmacological tools and potential therapeutic

how GPCRs signal from internal membranes such as endosomes and the Golgi, work with direct bearing on therapeutic

She has advanced the use of computational methods to meet the challenges of designing therapeutics with

orphan GPCRs from ‘locked’, inaccessible receptors to well-characterized and understood ‘unlocked’ therapeutic

vehicle by which Andrew is translating fundamental findings to commercial products is Keltic Pharma Therapeutics

The ultimate goal of Adriano’s research is to target novel aspects of GPCR signaling for therapeutic

Clear Platform Assessment: Gain rapid, independent insight into GPCR platform risks and true therapeutic Abishek Iyer, CEO Ashta Therapeutics Before working with Yamina, we had solid internal momentum but needed

Brian Collier in the Department of Pharmacology and Therapeutics at McGill University (1994).

nanobodies as research tools, to investigate different GPCR conformations, while also focusing on their therapeutic

Brian Collier in the Department of Pharmacology and Therapeutics at McGill University (1994).

Award and the Goodman and Gilman Award from the American Society for Pharmacology and Experimental Therapeutics Institute, highlighting its translational approach to research and its capacity to translate research into therapeutic

Award and the Goodman and Gilman Award from the American Society for Pharmacology and Experimental Therapeutics Institute, highlighting its translational approach to research and its capacity to translate research into therapeutic

Terry Hebert is a Professor of Pharmacology and Therapeutics at McGill University. The goal is to test therapeutic strategies targeting the AT1R, alpha-adrenergic, and beta-adrenergic

receptors would be a significant breakthrough in cardiovascular biology as they could be targeted for therapeutic

GPR56 as a mechanical sensor and his sustained case for the KLF2 signaling pathway as a GPCR-linked therapeutic His recently published book on signaling bias, Biased Signaling in Physiology, Pharmacology, and Therapeutics

Themes of the Conversation Allosteric modulation of opioid receptors - mechanism, selectivity, and therapeutic The therapeutic logic is that decoupling from the orthosteric site might preserve pain relief while altering

GPCR field, and serves as Deputy Director of the Australian Research Council Centre for Personalised Therapeutics Institute of Medical Research, Deputy Director of the Australian Research Council Centre for Personalised Therapeutics