look at and even hold, and the reasoning behind what he calls disease trajectory modifiers, compounds designed It is his argument against monolithic single target drugs and for designing compounds that touch many "My goal as a pharmacologist now is to give drugs to people that aren't unwell. GPCR Learning Ecosystem ✔ Full Masterclass library ✔ Terry's Pharmacology Corner ✔ Advanced GPCR courses GPCR Podcast? Leave a Review.

GPCR Ecosystem. List your services and your brand on the world's first GPCR CRO Bank. Be Discoverable When GPCR Teams Are Actively Evaluating Services and Tools The GPCR CRO Bank is designed GPCR is the world's largest nonprofit community focused on GPCRs. As a CRO partner, you'll gain trusted access to an engaged audience of biotech teams and drug discovery GPCR?

Listeners will gain perspective on how asking broader questions about receptor biology can reshape drug mapping — Identifying already-approved drugs that target overexpressed GPCRs in cancer Reductionism in silico screening, and the limits of computational drug discovery without structures 31:33 Biased Medicine for their discovery of G-proteins and their role in signal transduction in cells, Paul was designated , Paul and his team focus on previously unrecognized receptors with the hopes to use these as novel drug

The experiment that mattered most was not a drug candidate or a clinical advance - it was a designed Endosomal signaling is being missed Conventional GPCR assay design - stimulate, wash, measure endpoint Every positive and negative control performed exactly as designed. The conjugate worked. still a good drug target? "I was convinced that I designed something that worked where it was not at all obvious that it was going

approved drugs may still be getting wrong. << Back to podcast list Strategic Partner(s) Debbie Hay: RAMP is present, and those distinctions determine ligand selectivity, signaling output, and ultimately drug RAMPs since they were first described and when working on them was a high-risk research bet, the CGRP drug This reframes the design challenge for RAMP-selective compounds: the differences between receptor complexes still good drug targets - and what is missing from class B pharmacology 31:41 Reproducibility, target

and drug discovery innovation. << Back to podcast list Strategic Partner(s) From Curiosity to Breakthrough : Ajay Yekkirala on GPCR Innovation What if the key to safer, more effective drugs lies in asking the drug developer and entrepreneur. Ajay reveals how humility, curiosity, and collaboration fuel the future of drug discovery. GPCR Podcast? Leave a Review.

David has over 20+ years of experience working in a drug discovery environment mainly in a specialist current interests include the development of HTS fluorescence-based kinetic binding assays specifically designed GPCR Unlock the Full Dr. GPCR Learning Ecosystem ✔ Full Masterclass library ✔ Terry's Pharmacology Corner ✔ Advanced GPCR courses GPCR Podcast? Leave a Review.

GPCR: Advancing GPCR Drug Discovery Through Collaboration Discovery On Target 2024 GPCR targeted drug discovery Summit 2024 GPCR targeted drug discovery Summit 2023 The Dr. GPCR Podcast GPCR targeted drug discovery Summit 2022 Dr. GPCR: Where all GPCRs are created equal Dr. GPCR: Beyond the lab Dr. GPCR: From idea to Ecosystem Dr. GPCR: Beyond the lab

GPCR, an ecosystem designed to bring together stakeholders interested in using G-Protein Coupled Receptors (GPCRs) that control virtually everything in the body as drug targets. GPCR is to accelerate GPCR drug discovery by sharing the latest research and technology advances in the GPCR podcast. Dr. GPCR Podcast? Leave a Review.

Sokhom Pin shares how he built a biotech career around GPCRs, designed a custom PhD path, and led teams Falling in Love with GPCRs GPCR pharmacology captured his scientific curiosity. Designing a Non-Traditional PhD While working full-time, Sokhom architected a one-of-a-kind PhD program About Sokhom Pin Sokhom Pin is a receptor pharmacologist with over 20 years of drug discovery research He is passionate about mechanistic profiling of therapeutic molecules as well as drug discovery in general

GPCR — an ecosystem of podcasts, newsletters, summits, and working spaces designed to give the field Generate Biomedicines, where she worked on class B peptide receptor engineering using AI-driven protein design Scientific community as infrastructure — what connective tissue a 400-receptor field actually needs Assay design Building during a pandemic is a design constraint, not a footnote. Dr. "If you want to advance the field and you want to drug GPCRs better, the point is not to show that you

Accelerated Program Progression: Design robust assay cascades and establish key go/no-go points to speed Accelerated Preclinical Progression I streamline critical operational processes, from advanced assay design drug discovery. Berchiche, and I understand the intricate challenges of GPCR drug discovery. drug discovery.

Can models predict drug outcomes? Jens Carlsson shares how GPCR modeling is moving from explanation to real prediction in drug discovery With a deep focus on structure-based drug design, Jens discusses how his lab bridges simulation and experiment—and Outside academia, he advises companies through a consulting arm focused on ligand design strategy. GPCR Podcast? Leave a Review.

Whether you're just starting out or 20 years in — this is your place University is designed for GPCR At Dr.GPCR University, you’ll find: Courses: Dive deep into curated educational content designed by experts GPCR University Masterclasses designed for? The classes are designed for researchers, students, and professionals in biology, pharmacology, and biochemistry Some classes may require basic knowledge of GPCRs, but many are designed to accommodate beginners as

A conversation with Charlotte Crauwels exploring computational protein design, hybrid GPCR constructs , and how computational pipelines can accelerate GPCR signaling research and drug discovery. << Back to podcast list Strategic Partner(s) Charlotte Crauwels: Designing Hybrid GPCRs with Computational Protein I would define myself as a computational protein designer focusing on GPCRs. GPCR designs and links them to structural and sequence information.

Discover how Joseph Kim’s curiosity for science led him into GPCR research, drug discovery, and membrane pharmacology and drug discovery. dynamics to pharmacological outcomes relevant for drug discovery. And measurement meant predictions for drug discovery. And now that I work with peptide drug modalities, I’m interested in peptide-binding GPCRs.

I have extensive training in computer-aided drug design. training as a chemist and as an entrepreneur to grow a sustainable service and software provider in drug GPCR Unlock the Full Dr. GPCR Learning Ecosystem ✔ Full Masterclass library ✔ Terry's Pharmacology Corner ✔ Advanced GPCR courses GPCR Podcast? Leave a Review.

He remains affiliated with that institution, and his current research uses molecular docking to design prediction and the necessity of wet lab validation - Extraoral bitter taste receptors as potential drug Sedaghat's group is using databases of natural bitter compounds and molecular docking to design higher affinity ligands, both as research tools and as possible starting points for drug discovery. GPCR Podcast? Leave a Review.

signaling as a kinetic and time-dependent phenomenon NanoBRET and the evolution of live-cell assay design Receptors in Complexes Behave Differently Than Receptors in Isolation Standard drug screens present a receptors, scaffold proteins, and cytoskeletal elements - and those interactions alter its conformation and drug-binding Understanding receptor complexes is where the next layer of selectivity and specificity in drug discovery unsustainable and what to do instead 22:21 What a PhD actually trains you for 25:42 NanoBRET, live-cell assay design

Hall describes the experiment designed to kill receptor signaling that instead amplified it, the tethered drugs will come from - In silico screening, and what human plus machine collaboration means for drug From undruggable to promising Drug development veterans long treated large adhesive proteins as poor Hall's counterpoint is that adhesion GPCRs are not only adhesive proteins, they are also GPCRs, with GPCR Podcast? Leave a Review.

Bryan Roth on the DARPA-funded effort to design a non-psychedelic psychedelic for depression — and why discovery, biased ligand design, and high-throughput functional assays. for complex neuropsychiatric disease Functional assay design — BRET, Tango, and what each captures The Roth argues, belongs to designed polypharmacology. If we make a drug against any GPCR, it's going to be good for some disorder.

as a potential drug target due to its high expression in triple negative breast cancer. GPCR Targeted Drugs and Gene Regulation in Cancer Cells Mike presented research on the effect of GPCR-targeted GPCRs and Cancer Immune Modulation Yamina and Mike had a discussion about their research on GPCRs, specifically GPCR Learning Ecosystem ✔ Full Masterclass library ✔ Terry's Pharmacology Corner ✔ Advanced GPCR courses GPCR Podcast? Leave a Review.

His journey highlights the transition from general drug development to a deep dive into G protein-coupled Allosteric Modulation: The New Frontier of GPCR Drug Discovery Ben reflects on the emerging potential “The goal is to smash all the amazing biology together and make a drug.” understand how and where these compounds interact with the receptor, paving the way for structure-based drug design .

drugs. GPCR x GeneTex partnership. the human nonsensory and orphan GPCRs. GPCR ecosystem Dr. GPCR Dr. GPCR is a nonprofit ecosystem dedicated to advancing GPCR-targeted drug discovery.

As a young researcher fascinated by chemokine receptors, molecular pharmacology, drug discovery, and adhesion GPCRs. GPCR, an ecosystem designed to bring together stakeholders interested in using G-Protein Coupled Receptors (GPCRs), that control virtually everything in the body, as drug targets. GPCR is to accelerate GPCR drug discovery by sharing the latest research and technology advances in the

GPCR Ecosystem – the ultimate hub for GPCR professionals to connect, collaborate, and advance drug discovery Home: About The global hub for GPCR science Accelerating GPCR drug discovery, together Where academia For scientists University Your professional home in GPCR science. GPCR is a 501(c)(3) nonprofit empowering the GPCR field through shared knowledge, collaboration, and open access to tools that accelerate drug discovery. 🤝 Support the Mission

GPCR Affiliate Program and earn commissions by helping connect the global GPCR community. Share our ecosystem, courses, and events to advance drug discovery together. Dr. GPCR community. The Ecosystem is designed for all GPCR professionals to have an affordable and highly effective way to GPCR Ecosystem?

dismissal is partly methodological and partly personal: the proudest moment of her scientific life was designing Nordisk, and into biotech at InterAx — where the next challenge is using functional fingerprints to design InterAx treats GPCR pharmacology the way engineers treat aircraft design: build the mathematical model Her most formative scientific moment was designing a compound in HEK293 cells from a hypothesis at Novo design 21:48 — Comorbidities, aging, and the multi-receptor frontier 24:07 — "What endogenous level

into the structure, dynamics, and function of important classes of membrane proteins and prominent drug To this end, her lab uses several computational structural biology tools and rational drug design approaches GPCR Ecosystem Unlock the Full Dr. GPCR Learning Ecosystem ✔ Full Masterclass library ✔ Terry's Pharmacology Corner ✔ Advanced GPCR courses GPCR Podcast? Leave a Review.

She has advanced the use of computational methods to meet the challenges of designing therapeutics with molecular dynamics simulation methods with emphasis on application to G-protein coupled receptors and drug design." GPCR Unlock the Full Dr. GPCR Podcast? Leave a Review.