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Elevate Your GPCR Science with Essential Frameworks for Precision Drug Discovery: An Insight into Advanced , Not Breakdowns In the fast-paced world of GPCR drug discovery, the "go fast" mindset can often lead GPCR-Based Drug Discovery conference is where the future of GPCR therapies will be defined. GPCR scientists, translational pharmacologists, biotech drug discovery teams, and decision-makers who Keywords: GPCR, drug discovery, pharmacology, antagonism, competitive, non-competitive, Terry's Corner

This lecture is a roadmap for understanding why two drugs with similar affinity may behave completely Allosteric Thinking Changes the Game in Drug Discovery For decades, drug discovery pipelines have relied But without understanding how GPCR state changes  influence that affinity—or vice versa—drug discovery Terry’s Pharmacology Corner  delivers trusted, razor-sharp insight to help drug discovery professionals Ask-Me-Anything sessions A growing, curated on-demand library Opportunities to shape future topics Built for discovery-phase

Every September, Boston welcomes the global biotech and drug discovery community. drug discovery. discovery. Axxam Axxam is a leading provider of integrated discovery services, supporting the entire drug discovery important and validated target classes in drug discovery.

Discovery programs rarely fail because a molecule “did nothing.” It was revealed only when the drug encountered the full complexity of the cardiovascular regulatory network Kenakin talked about  the specific allosteric properties orthosteric drugs cannot offer. Why Terry’s Corner Give You The GPCR Pharmacology Insights You Need Terry’s Corner gives discovery scientists It equips pharmacologists, discovery teams, and biotech leaders to see around mechanistic corners, recognize

Watch Episode 175 If your model can’t predict the future of GPCR drug discovery, why build it at all? His lab sits at the crossroads of structure-based modeling, computational chemistry, and drug discovery Carlsson also runs a consulting arm  that advises drug discovery teams on GPCR modeling strategy. For drug discovery executives, the message is clear: predictive modeling can shorten timelines, reduce The next frontier in GPCR drug discovery isn’t more structures—it’s smarter models.

By 2011, she had established her own group within the Drug Discovery Biology theme at Monash Institute Why GPCR Spatial Signaling Is Changing Drug Discovery Today, Michelle leads the Spatial Organization drug discovery and precision targeting. It’s a new language for drug discovery. GPCR Podcast 🔓 Want to go deeper? Join   Dr.

🔹 Elevate your strategy → Building clarity in GPCR drug discovery Even the strongest GPCR programs GPCR University Learner Dr. GPCR Podcast - Surviving Discovery’s Gauntlet Dr. Find your edge:  Dodge the traps that derail real drug discovery careers.   Listen Now – Real Lessons from a GPCR Expert ➤ The future of GPCR isn’t waiting. GPCR Team Read Full Edition ➤

Watch Episode 175 From failed assays to breakthroughs in GPCR modeling , Dr. predictions—a sentiment that highlights the skepticism that still exists around modeling in some corners of drug discovery.   As predictive modeling matures, its role will continue to expand, guiding ligand discovery, informing For early-career researchers, the takeaway is direct: GPCR drug discovery will increasingly depend on

residence time to diffusion-driven pharmacodynamics and the discovery of previously untargetable sites Drugs Change the Game For decades, drug design has treated GPCRs as surface targets. Unlock “Intracellular Drugs” Now Only in Terry’s Corner   Why Terry’s Corner In a world where GPCR science Q&A An expanding on‑demand library of past lessons Influence over upcoming topics Whether you’re in discovery pharmacology and drug discovery.

GPCR News delivers a toolkit of practical innovations—from drug design strategies that anticipate physiological Breakthroughs this week: Lilly to build $5B manufacturing facility in Virginia; Novo Nordisk flags drug Terry's Corner – Designing Drugs That Anticipate Physiological Pushback Most GPCR programs don’t fail GPCR , our mission is simple but urgent: Accelerate GPCR biology and drug discovery by connecting scientists GPCR scientists, translational pharmacologists, biotech discovery teams, and decision-makers who need

His work highlights how foundational GPCR science can drive therapeutic innovation. The GPCR Angle Ben sees GPCRs as untapped goldmines for drug discovery. Ready to dive deeper into GPCR drug discovery? Want to push the boundaries of GPCR drug discovery? Start learning with our GPCR University today. _______________ Keyword Cloud: GPCR research community , GPCR drug discovery, mu-opioid receptor, positive allosteric modulators, GPCR training program, GPCR

Why Pipeline Efficiency Starts with Physiology Drug discovery doesn’t happen in a vacuum. Reflexes as Drug Design Partners Not all reflexes are enemies. Some can make a mediocre drug shine. This insight has huge implications for how you select and rank agonists in discovery campaigns. But drug discovery isn’t static — it’s a moving target. discovery experience If you’re serious about derisking your pipeline, this is where you sharpen the

Welcome back GPCR fans, If your drug discovery strategy still relies on static GPCR models, you’re already discovery and collaboration intersect. Sharpen your discovery decisions ➤ GPCR Signal Transduction Call for Papers: Define What Comes Next Volume On Target: Where the Next Decade of GPCR Drugs Begins If you’re not attending the GPCR-focused sessions GPCR scientists, translational pharmacologists, biotech drug discovery teams, and decision-makers who

Watch Episode 167 Today’s GPCR scientists don’t want to study one interaction, they want to model the protein interactions  (e.g., 14-3-3) Heterodimerization Endogenous vs. overexpressed systems Orphan GPCR scientists are already expanding this work, bringing in computational layers  like AlphaFold to model GPCR-RAMP Listen to the complete episode to learn more. _________________ Keyword Cloud : GPCR scientist network , GPCR online course , GPCR data platform , multiplex assays , GPCR drug discovery

Drugs like Ozempic will change the world GPCR Events, Meetings, and Webinars November 5 - 7, 2024 | 16th Forum Conference November 26 - 28, 2024 | GPCRs-Targeted Drug Discovery Summit Europe NEW December Drug Discovery NEW February 15 - 19, 2025 | BPS 2025 NEW February 16 - 21, 2025 | Harnessing the Power of Advanced Multimodal Approaches to GPCR Drug Discovery NEW March 12 - 14, 2025 | NextGen Biomed 2025 Discovery Chemistry NEW   April 24 - 27, 2025 | American Physiology Summit 2025 NEW April 25 - 30, 2025

A rational drug discovery campaign hinges on a deep understanding of how distinct molecules interact While these structural techniques offer significant advantages in drug discovery, no single method can However, several challenges have limited the use of mutagenesis in drug discovery. In summary, mutagenesis can be a critical tool in drug discovery, particularly for studying GPCRs. discovery.

Welcome GPCR Fans,   In GPCR-targeted drug discovery, precision isn’t optional—it’s a requirement. GPCR Premium Members this week gain curated, early access to: Industry insights : GPCRs and mRNA in drug Upcoming events : Lab-in-the-Loop AI-powered hit discovery (July 29); 5th Transatlantic GPCR Symposium At this international meeting, leaders shared next-gen strategies shaping modern drug discovery: Prof Scientists, drug discovery teams, and pharmacologists who need curated, career-relevant updates.

Watch Episode 170 What We’re Missing in Pain Research In GPCR drug discovery, receptors typically steal explicitly interested in GPCR signaling... but the thing about GPCRs... is you always kind of end up landing at a GPCR as a major target." Serafini highlighted that in modern pain drug development, the field has remained too focused on ion Takeaway Forget what you think you know about GPCR drug targets.

The future of discovery will belong to scientists who know how to build the right partnerships and stay was a set of chemical probes that finally allowed researchers to visualize where receptors exist, how drugs No one person can be excellent at all of it — and pretending otherwise slows discovery. It is the only path to meaningful discovery. And it’s not just about capability. pathways Creating chemical tools that finally show how drugs reach their targets These aren’t solo-lab

Upcoming events:   Preview of Discovery on Target 2025 (Boston, Sept 24‑25), including GPCR‑Track breakout Snapshot of roles spanning PhD entry points to senior translational pharmacology—Protein Expression, Drug Discovery Scientist, and Staff Scientist in Molecular Pharmacology—curated with notes on fit, skill See the full guide and example ligands ➤ Discovery on Target 2025 Speaker Spotlight: Solubilization, GPCR scientists, translational pharmacologists, biotech discovery teams, and decision-makers who need

GPCR and Revvity. If you’re in GPCR discovery or biotech R&D, this is a masterclass in turning deep science into scalable Timeline: The Road to pHSense → Initial lanthanide probe design with Durham University (chemistry) → Discovery It’s a strategic tool for decoding GPCR behavior in drug discovery and systems biology. GPCR   Dr. GPCR X Revvity Collaboration ⸻ Want more like this? 👉 Join the Dr.

of the prime targets for marketed drugs. While traditional drug discovery programs have focused on the development of ligands targeting the binding structure-based discovery and development of allosteric modulators as novel therapeutic candidates. current strategies for the identification of allosteric sites as well as ligand-based and structure-based drug discovery and design."

Transmembrane domains of GPCR dimers – a novel hot spot for drug discovery G-protein-coupled receptors GPCR dimers are therefore emerging drug targets in different therapeutic areas including depression, In this study Xin Cai et al. highlight the importance of GPCR dimers in drug discovery referring to important What is the potential of targeting GPCR dimer interface in drug discovery? dimerization while accelerating drug discovery targeting GPCR dimers.

Read fast, apply faster, and stay ahead in GPCR drug discovery with evidence-based insights—no hype, GPCR Forum to Biophysics; plus targeted summits for discovery teams planning 2025–2026. Drug Discovery In neuroscience drug discovery, the right tool  can be just as critical as the right discovery ➤ Why Dr. GPCR scientists, translational pharmacologists, biotech discovery teams, and decision-makers who need

drug discovery. Superluminal Medicines: AI/ML Meets GPCR Pharmacology As Ajay continued to explore how GPCR signaling could be leveraged for therapeutic innovation, he saw a gap in the drug discovery landscape. The company’s goal is to model receptor dynamics — including biased signaling — to predict drug behavior early career redirection to startup setbacks, each step has added new layers to his thinking about drug

Broichhagen aka JB, the goal was bold and elegant: Create a photo-switchable ligand to remotely control GPCR They had a tool that did bind the GPCR… but not in the light-controlled way they wanted. For metabolic GPCRs (like GLP-1 and GIP receptors): Drug efficacy depends on which cells express the activity in live systems The success wasn’t in the discovery. Clarify brain vs. peripheral contributions to metabolic therapy Guide how next-generation incretin drugs

Historically, drug discovery efforts targeting GPCRs focused on G-protein-dependent signaling pathways discovery. drug discovery (Eishingdrelo & Kongsamut, 2013). Minireview: targeting GPCR activated ERK pathways for drug discovery. Biased receptor signaling in drug discovery. Pharmacological Reviews, 71(2), 267-315.

A central question of GPCR drug discovery is to understand what determines the agonism or antagonism small changes to the ligands that invert their pharmacological activity and thus helps to guide the drug discovery process. This approach can be readily applied to any drug target." Read more at the source #DrGPCR #GPCR #IndustryNews

But Sokhom Pin stayed loyal to GPCRs , even when big pharma turned its gaze to other targets like kinases Riding the GPCR Rollercoaster Early in his career at DuPont and BMS, GPCRs were red hot. “Companies started shutting down neuroscience and GPCR programs. But I stayed,” Sokhom said. The Payoff of Staying Focused Today, GPCRs are making a comeback in popularity. drug discovery , G protein-coupled receptors , GPCR webinar series , GPCR scientist network , GPCR research

High-content screening (HCS) has become a cornerstone in GPCR and phenotypic drug discovery, enabling In this blog, you’ll learn:  How HCS works and why it is increasingly central to GPCR-based drug discovery drug discovery pipeline. Conclusion High-content screening continues to reshape GPCR drug discovery, offering richer biological Image-based high-content screening in drug discovery. Drug Discov Today. 2020.  Way GP et al.