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How academia and biotech collaborate to scale GPCR tools—covering fluorescence assays, GPCR internalization Together, we discuss how gpcr drug discovery advances when chemists, biologists, and industry partners innovation translates into tools for high-throughput screening , and why availability can be as impactful as discovery GPCR Learning Ecosystem ✔ Full Masterclass library ✔ Terry's Pharmacology Corner ✔ Advanced GPCR courses GPCR Podcast? Leave a Review.

His journey highlights the transition from general drug development to a deep dive into G protein-coupled Allosteric Modulation: The New Frontier of GPCR Drug Discovery Ben reflects on the emerging potential Translating Discovery into Therapy: Bench to Bedside Vision Ben’s work seeks to merge in vitro mechanistic “The goal is to smash all the amazing biology together and make a drug.” understand how and where these compounds interact with the receptor, paving the way for structure-based drug

at the bench and in translational drug discovery. discovery assays. But we had to learn everything else—IP, market positioning, customer discovery.” — Maria Majellaro This Pivoting: From Chemistry Company to Discovery Partner Initially focused on tool production, Celtarys Whether you're designing assays, developing probes, or seeking better tools for GPCR drug discovery,

Drug Discovery — Using induced pluripotent stem cells differentiated into cardiomyocytes, fibroblasts Navigating Serendipity and Risk in Discovery — From the accidental observation of GPCR dimers to negative Drugging GPCRs on the Nuclear Membrane GPCRs are not confined to the cell surface. Dr. Discovery Requires Being Open to Being Wrong Dr. controls that turned out to be discoveries.

“I got to know computational chemistry through a project on BCL2 proteins and drug discovery… I was in drug discovery pipelines. By bridging structural prediction, molecular dynamics, and ligand discovery, his work not only deciphers leveraging computational structure-based tools and develop specific protocols to accelerate OR ligand discovery GPCR Podcast? Leave a Review.

discovery. << Back to podcast list Strategic Partner(s) Amynah Pradhan: The Delta Opioid Receptor and discovery fails when it pretends otherwise. discovery Ligand-directed signaling and receptor trafficking — how internalization shapes tolerance drug discovery is not out of runway 28:54 Biased ligands after the hype cooled 34:08 How you measure GPCR Podcast? Leave a Review.

receptors — but clinical drug discovery has reached only about 166 of them, leaving more than 250 receptors GPCR ecosystem and the host of the Dr. GPCR Podcast. drug discovery — why ~250 non-olfactory receptors remain outside clinical attention Career architecture The remaining 250+ are not obscure — they are simply not connected to drug-discovery momentum. "If you want to advance the field and you want to drug GPCRs better, the point is not to show that you

receptor pharmacology and drug discovery. << Back to podcast list Strategic Partner(s) David Gloriam drug discovery and receptor classification. INSIGHTS FROM THE CONVERSATION The Human Genome as a Discovery Platform When Gloriam joined a bioinformatics - a pace of discovery that would have been impossible through classical biochemical approaches. function and drug discovery and a Pharmaceutical Data Science unit.

Stay at the Forefront of GPCR Drug Discovery Gain insider methods from the pioneers shaping biased signaling research Access exclusive training from the scientists shaping the future of GPCR drug discovery Dr. Think of Premium as insurance against wasted experiments and failed drug leads. Aside from his vast experience in drug development, not to mention his extensive publication record, The GPCR Field Is Advancing Fast – Don't Fall Behind Stay ahead in drug discovery with insights from

Scientific Themes of the Conversation Chemosensory receptors as a frontier for GPCR drug discovery Trace The drug candidate was never designed as a bitter receptor ligand; the receptor was identified post-hoc GPCR podcast , we meet with Dr. GPCR Ecosystem Unlock the Full Dr. GPCR Podcast? Leave a Review.

Discover how Joseph Kim’s curiosity for science led him into GPCR research, drug discovery, and membrane pharmacology and drug discovery. discovery. dynamics to pharmacological outcomes relevant for drug discovery. And measurement meant predictions for drug discovery.

Advance your GPCR research with expert-led Masterclasses on pharmacology, efficacy, signaling, and drug discovery. experience in GPCR pharmacology and drug discovery. biology, or drug discovery. The Masterclass is designed for GPCR researchers, pharmacologists, and drug discovery scientists working

Masha Niv on bitter taste GPCRs, the drug bitterness blind spot, and what heavy water reveals about the Discovery Blind Spot Taste receptors are among the most overlooked GPCRs in pharmacology - and Masha Drug discovery workflows screen extensively for efficacy, safety, and pharmacokinetics - but bitterness architecture and pharmacological consequences 41:58 - Taste GPCRs as drug targets - asthma, cardiac GPCR Podcast? Leave a Review.

Be Discoverable When GPCR Teams Are Actively Evaluating Services and Tools The GPCR CRO Bank is designed Companies present their services in a structured format so GPCR discovery teams can quickly identify As a CRO partner, you'll gain trusted access to an engaged audience of biotech teams and drug discovery Built for discovery and evaluation These channels are used to support discovery and evaluation — helping Share insights on product launches, scientific discoveries, or customer stories.

Drug Discovery with Tom Sakmar & Ilana Kotliar In this episode, host Dr. This could accelerate discovery of therapeutic targets by combining multiplex data with focused downstream multiplex strategy aligns perfectly with this evolution, providing scalable approaches to biological discovery Key Takeaway This episode is more than a conversation — it’s a masterclass in tool-driven discovery , discovery and chemical biology research, mainly involving GPCRs.

<< Back to podcast list Strategic Partner(s) Empowering Drug Discovery for the GPCR Community with Dr GPCR Unlock the Full Dr. GPCR Learning Ecosystem ✔ Full Masterclass library ✔ Terry's Pharmacology Corner ✔ Advanced GPCR courses GPCR Podcast? Leave a Review.

Deep-dive sessions focused on real pharmacology, real drug discovery challenges, and real translational This is what the community looks like — scientists from around the world, thinking through discovery , pharmacology, signaling, and drug discovery. researchers, discovery teams, postdocs, PIs, and industry scientists. , drug discovery workflows, translational challenges, and the science behind emerging tools and methods

, pharmacology, signaling, and drug discovery. discovery, not just academic theory. discovery. These webinars are designed to support ongoing scientific development in GPCR pharmacology and drug discovery on receptor pharmacology and drug discovery.

This isn't a lecture — it's a conversation with the people shaping GPCR discovery. Each session focuses on a specific pharmacology or GPCR discovery topic, led by a recognized expert. Focused audience of specialists Sessions bring together GPCR researchers, pharmacologists, and discovery biology, or drug discovery. The Masterclass is designed for GPCR researchers, pharmacologists, and drug discovery scientists working

, target validation, and drug discovery strategy. << Back to podcast list Strategic Partner(s) Foord: GPCR pharmacology, receptor signaling, and drug discovery evolved inside one of the world’s largest pharmacology and drug discovery. Drug Discovery Is Constrained by Selectivity, Safety, and Strategy . research and drug discovery.

and drug discovery innovation. << Back to podcast list Strategic Partner(s) From Curiosity to Breakthrough : Ajay Yekkirala on GPCR Innovation What if the key to safer, more effective drugs lies in asking the discovery. Ajay reveals how humility, curiosity, and collaboration fuel the future of drug discovery. Seeing the limits of traditional drug discovery, he later co-founded Superluminal Medicines, a company

How receptor residence time — not affinity — rescued a CRF drug discovery program, and why a career in discovery. , he spent fifteen years at Neurocrin Biosciences working on CRF receptor drug discovery programs that discovery. He guided the in vitro biology efforts of the company for numerous drug discovery campaigns.

(s) Paul Insel: Unbiased Discovery and the GPCRs We've Been Missing The GPCR field has produced thousands discovery priorities. through receptor mapping — Identifying already-approved drugs that target overexpressed GPCRs in cancer The biggest discoveries came from asking what was being overlooked Dr. in silico screening, and the limits of computational drug discovery without structures 31:33 Biased

research at Columbia - from obligate heterodimerization and the inter-subunit latch to an unexpected discovery and, more recently, full-length cryo-EM structures in inactive conformation, leading to an unexpected discovery study Obligate heterodimerization as a functional requirement, not a regulatory option The unexpected discovery Phospholipids inside the transmembrane bundle: a discovery nobody expected When Fan's team solved the "One of our surprising findings is the discovery of a bulky phospholipid that occupied the internal cavity

target discovery. GPCR Targeted Drugs and Gene Regulation in Cancer Cells Mike presented research on the effect of GPCR-targeted lab, which led to the discovery of potential tumor suppressors and oncogenes in melanoma. Scientific Journey and Drug Discovery Challenges Mike shared significant moments in his scientific journey , including the discovery of RGS proteins and its impact on his research approach.

Targets GPCRs account for a substantial fraction of validated drug targets, yet most are drugged by discovery strategy Family-level cross-reactivity as an advantage, not an obstacle, in GPCR antibody discovery Timelines, automation, and the industrialization of antibody workflows Key Insights from the GPCR family architecture is a discovery advantage. surface topography, so an antibody recovered against one member is often a legitimate starting point for discovery

in life science innovation, delivering tools and technologies that bridge the gap between discovery unwavering focus on precision, Revvity empowers scientists to simplify complex workflows, accelerate discovery designing the next generation of therapeutics, Revvity isn’t just a provider—they’re your partner in discovery GPCR, the global nonprofit platform dedicated to advancing GPCR research and drug discovery, is proud Learn how pH Sense changes the game for drug discovery. Dr.

Michelle Halls shares how dissecting the spatial organization of GPCR signaling opens new doors in drug discovery. From early discoveries in cyclic AMP signaling to uncovering ultrasensitive receptor responses at femtomolar the Guest Michelle Halls is an Associate Professor at Monash University and Deputy Theme Leader of Drug Discovery Biology at Monash Institute of Pharmaceutical Sciences.

discovery begins. << Back to podcast list Strategic Partner(s) Michel Bouvier: BRET, Biased Agonism, discovery target - his lab has consistently produced technology before the field knew it needed it. discovery targets. discovery How the tools available define the questions a lab can ask - and the questions that have to discovery.

biology The thermostabilization platform - from concept to systematic mutation screen From academic discovery architecture - what a dimer with no prior blueprint looks like What remains unsolved: why drug discovery Drug discovery's real bottleneck is not structural Tate is direct about where the field now stands: accumulating GPCR structures is no longer the limiting step in drug discovery. GPCR Podcast? Leave a Review.